ID   Loucy
AC   CVCL_1380
SY   LOUCY
DR   CLO; CLO_0007375
DR   EFO; EFO_0007112
DR   ArrayExpress; E-MTAB-2770
DR   ArrayExpress; E-MTAB-3610
DR   ATCC; CRL-2629
DR   BioSample; SAMN03471756
DR   BioSample; SAMN03473575
DR   BioSample; SAMN10988140
DR   CCLE; LOUCY_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE
DR   Cell_Model_Passport; SIDM00342
DR   ChEMBL-Cells; CHEMBL3308208
DR   ChEMBL-Targets; CHEMBL2366252
DR   Cosmic; 907789
DR   Cosmic; 913420
DR   Cosmic; 1115598
DR   Cosmic; 1151784
DR   Cosmic; 1175133
DR   Cosmic; 1330496
DR   Cosmic; 1524802
DR   Cosmic; 1641381
DR   Cosmic; 1664525
DR   Cosmic; 1760527
DR   Cosmic; 2165717
DR   Cosmic; 2588705
DR   Cosmic; 2588710
DR   Cosmic; 2602920
DR   Cosmic-CLP; 907789
DR   DepMap; ACH-000104
DR   DSMZ; ACC-394
DR   ENCODE; ENCBS080PZG
DR   ENCODE; ENCBS170DPY
DR   ENCODE; ENCBS708EFA
DR   GDSC; 907789
DR   GEO; GSM887272
DR   GEO; GSM888347
DR   GEO; GSM1670053
DR   GEO; GSM2037136
DR   GEO; GSM2037137
DR   IARC_TP53; 9767
DR   LiGeA; CCLE_359
DR   LINCS_LDP; LCL-1017
DR   PharmacoDB; LOUCY_855_2019
DR   Wikidata; Q54902892
RX   DOI=10.1016/B978-0-12-221970-2.50457-5;
RX   PubMed=2208060;
RX   PubMed=15472075;
RX   PubMed=17170727;
RX   PubMed=19166587;
RX   PubMed=20164919;
RX   PubMed=22460905;
RX   PubMed=22675565;
RX   PubMed=27397505;
RX   PubMed=30285677;
RX   PubMed=30894373;
RX   PubMed=31068700;
WW   https://humantallcelllines.wordpress.com/comprehensivetable/loucy/
WW   http://genome.ucsc.edu/ENCODE/protocols/cell/human/Loucy_Bernstein_protocol.pdf
CC   Part of: Cancer Cell Line Encyclopedia (CCLE) project.
CC   Part of: COSMIC cell lines project.
CC   Part of: ENCODE project common cell types; tier 3.
CC   Doubling time: 36-48 hours (PubMed=2208060); ~60 hours (DSMZ).
CC   Microsatellite instability: Stable (MSS) (Sanger).
CC   Sequence variation: SET-NUP214 gene fusion (PubMed=19166587).
CC   Sequence variation: Homozygous for TP53 p.Val272Met (c.814G>A) (PubMed=22675565; Cosmic-CLP).
CC   Omics: Deep exome analysis.
CC   Omics: Deep RNAseq analysis.
CC   Omics: DNA methylation analysis.
CC   Omics: H3K79me1 ChIP-seq epigenome analysis.
CC   Omics: H3K9ac ChIP-seq epigenome analysis.
CC   Omics: SNP array analysis.
CC   Omics: Transcriptome analysis.
CC   Genome ancestry: African=0.63%; Native American=0.51%; East Asian, North=1.01%; East Asian, South=2.78%; South Asian=9.99%; European, North=26.95%; European, South=58.12% (PubMed=30894373).
CC   Derived from sampling site: Peripheral blood.
ST   Source(s): ATCC; Cosmic-CLP; DSMZ
ST   Amelogenin: X
ST   CSF1PO: 11,12
ST   D13S317: 11,13
ST   D16S539: 11
ST   D5S818: 12 (ATCC; Cosmic-CLP)
ST   D5S818: 11,12 (DSMZ)
ST   D7S820: 9,10
ST   TH01: 8,9.3
ST   TPOX: 8,9
ST   vWA: 16,17
DI   NCIt; C9142; Adult T acute lymphoblastic leukemia
OX   NCBI_TaxID=9606; ! Homo sapiens
SX   Female
AG   38Y
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 06-09-19; Version: 27
//
RX   DOI=10.1016/B978-0-12-221970-2.50457-5;
RA   Drexler H.G.;
RT   "The leukemia-lymphoma cell line factsbook.";
RL   (In) ISBN 9780122219702; pp.1-733; Academic Press; London (2001).
//
RX   PubMed=2208060; DOI=10.1016/0165-4608(90)90148-4;
RA   Ben-Bassat H., Shlomai Z., Kohn G., Prokocimer M.;
RT   "Establishment of a human T-acute lymphoblastic leukemia cell line
RT   with a (16;20) chromosome translocation.";
RL   Cancer Genet. Cytogenet. 49:241-248(1990).
//
RX   PubMed=15472075; DOI=10.1126/science.1102160;
RA   Weng A.P., Ferrando A.A., Lee W., Morris J.P. IV, Silverman L.B.,
RA   Sanchez-Irizarry C., Blacklow S.C., Look A.T., Aster J.C.;
RT   "Activating mutations of NOTCH1 in human T cell acute lymphoblastic
RT   leukemia.";
RL   Science 306:269-271(2004).
//
RX   PubMed=17170727; DOI=10.1038/sj.leu.2404486;
RA   Sandberg Y., Verhaaf B., van Gastel-Mol E.J., Wolvers-Tettero I.L.M.,
RA   de Vos J., Macleod R.A.F., Noordzij J.G., Dik W.A., van Dongen J.J.M.,
RA   Langerak A.W.;
RT   "Human T-cell lines with well-defined T-cell receptor gene
RT   rearrangements as controls for the BIOMED-2 multiplex polymerase chain
RT   reaction tubes.";
RL   Leukemia 21:230-237(2007).
//
RX   PubMed=19166587; DOI=10.1186/1756-8722-2-3;
RA   Quentmeier H., Schneider B., Rohrs S., Romani J., Zaborski M.,
RA   MacLeod R.A.F., Drexler H.G.;
RT   "SET-NUP214 fusion in acute myeloid leukemia- and T-cell acute
RT   lymphoblastic leukemia-derived cell lines.";
RL   J. Hematol. Oncol. 2:3-3(2009).
//
RX   PubMed=20164919; DOI=10.1038/nature08768;
RA   Bignell G.R., Greenman C.D., Davies H., Butler A.P., Edkins S.,
RA   Andrews J.M., Buck G., Chen L., Beare D., Latimer C., Widaa S.,
RA   Hinton J., Fahey C., Fu B., Swamy S., Dalgliesh G.L., Teh B.T.,
RA   Deloukas P., Yang F., Campbell P.J., Futreal P.A., Stratton M.R.;
RT   "Signatures of mutation and selection in the cancer genome.";
RL   Nature 463:893-898(2010).
//
RX   PubMed=22460905; DOI=10.1038/nature11003;
RA   Barretina J.G., Caponigro G., Stransky N., Venkatesan K., Margolin A.A.,
RA   Kim S., Wilson C.J., Lehar J., Kryukov G.V., Sonkin D., Reddy A.,
RA   Liu M., Murray L., Berger M.F., Monahan J.E., Morais P., Meltzer J.,
RA   Korejwa A., Jane-Valbuena J., Mapa F.A., Thibault J., Bric-Furlong E.,
RA   Raman P., Shipway A., Engels I.H., Cheng J., Yu G.K., Yu J.,
RA   Aspesi P. Jr., de Silva M., Jagtap K., Jones M.D., Wang L., Hatton C.,
RA   Palescandolo E., Gupta S., Mahan S., Sougnez C., Onofrio R.C.,
RA   Liefeld T., MacConaill L.E., Winckler W., Reich M., Li N., Mesirov J.P.,
RA   Gabriel S.B., Getz G., Ardlie K., Chan V., Myer V.E., Weber B.L.,
RA   Porter J., Warmuth M., Finan P., Harris J.L., Meyerson M., Golub T.R.,
RA   Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.;
RT   "The Cancer Cell Line Encyclopedia enables predictive modelling of
RT   anticancer drug sensitivity.";
RL   Nature 483:603-607(2012).
//
RX   PubMed=22675565; DOI=10.1371/journal.pone.0038463;
RA   Kalender Atak Z., De Keersmaecker K., Gianfelici V., Geerdens E.,
RA   Vandepoel R., Pauwels D., Porcu M., Lahortiga I., Brys V., Dirks W.G.,
RA   Quentmeier H., Cloos J., Cuppens H., Uyttebroeck A., Vandenberghe P.,
RA   Cools J., Aerts S.;
RT   "High accuracy mutation detection in leukemia on a selected panel of
RT   cancer genes.";
RL   PLoS ONE 7:E38463-E38463(2012).
//
RX   PubMed=27397505; DOI=10.1016/j.cell.2016.06.017;
RA   Iorio F., Knijnenburg T.A., Vis D.J., Bignell G.R., Menden M.P.,
RA   Schubert M., Aben N., Goncalves E., Barthorpe S., Lightfoot H.,
RA   Cokelaer T., Greninger P., van Dyk E., Chang H., de Silva H., Heyn H.,
RA   Deng X., Egan R.K., Liu Q., Mironenko T., Mitropoulos X.,
RA   Richardson L., Wang J., Zhang T., Moran S., Sayols S., Soleimani M.,
RA   Tamborero D., Lopez-Bigas N., Ross-Macdonald P., Esteller M.,
RA   Gray N.S., Haber D.A., Stratton M.R., Benes C.H., Wessels L.F.A.,
RA   Saez-Rodriguez J., McDermott U., Garnett M.J.;
RT   "A landscape of pharmacogenomic interactions in cancer.";
RL   Cell 166:740-754(2016).
//
RX   PubMed=30285677; DOI=10.1186/s12885-018-4840-5;
RA   Tan K.-T., Ding L.-W., Sun Q.-Y., Lao Z.-T., Chien W., Ren X.,
RA   Xiao J.-F., Loh X.-Y., Xu L., Lill M., Mayakonda A., Lin D.-C., Yang H.,
RA   Koeffler H.P.;
RT   "Profiling the B/T cell receptor repertoire of lymphocyte derived cell
RT   lines.";
RL   BMC Cancer 18:940-940(2018).
//
RX   PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747;
RA   Dutil J., Chen Z., Monteiro A.N., Teer J.K., Eschrich S.A.;
RT   "An interactive resource to probe genetic diversity and estimated
RT   ancestry in cancer cell lines.";
RL   Cancer Res. 79:1263-1273(2019).
//
RX   PubMed=31068700; DOI=10.1038/s41586-019-1186-3;
RA   Ghandi M., Huang F.W., Jane-Valbuena J., Kryukov G.V., Lo C.C.,
RA   McDonald E.R. III, Barretina J., Gelfand E.T., Bielski C.M., Li H.,
RA   Hu K., Andreev-Drakhlin A.Y., Kim J., Hess J.M., Haas B.J., Aguet F.,
RA   Weir B.A., Rothberg M.V., Paolella B.R., Lawrence M.S., Akbani R.,
RA   Lu Y., Tiv H.L., Gokhale P.C., de Weck A., Mansour A.A., Oh C.,
RA   Shih J., Hadi K., Rosen Y., Bistline J., Venkatesan K., Reddy A.,
RA   Sonkin D., Liu M., Lehar J., Korn J.M., Porter D.A., Jones M.D.,
RA   Golji J., Caponigro G., Taylor J.E., Dunning C.M., Creech A.L.,
RA   Warren A.C., McFarland J.M., Zamanighomi M., Kauffmann A.,
RA   Stransky N., Imielinski M., Maruvka Y.E., Cherniack A.D.,
RA   Tsherniak A., Vazquez F., Jaffe J.D., Lane A.A., Weinstock D.M.,
RA   Johannessen C.M., Morrissey M.P., Stegmeier F., Schlegel R.,
RA   Hahn W.C., Getz G., Mills G.B., Boehm J.S., Golub T.R., Garraway L.A.,
RA   Sellers W.R.;
RT   "Next-generation characterization of the Cancer Cell Line
RT   Encyclopedia.";
RL   Nature 569:503-508(2019).
//