ID   LS174T
AC   CVCL_1384
AS   CVCL_D190
SY   Ls174T; LS174t; Ls-174-T; LS-174-T; LS 174 T; LS-174T; Ls-174T; LS 174T; LS-174; LS174; Laboratory of Surgery 174T
DR   BTO; BTO:0001553
DR   CLO; CLO_0007393
DR   CLO; CLO_0007403
DR   EFO; EFO_0002227
DR   MCCL; MCC:0000504
DR   CLDB; cl3261
DR   AddexBio; C0009013/379
DR   ArrayExpress; E-MTAB-38
DR   ArrayExpress; E-MTAB-783
DR   ArrayExpress; E-MTAB-2706
DR   ATCC; CL-188
DR   ATCC; CCL-188
DR   BCRC; 60053
DR   BioSample; SAMN03470826
DR   BioSample; SAMN03471296
DR   cancercelllines; CVCL_1384
DR   CCRID; 1101HUM-PUMC000248
DR   CCRID; 3101HUMTCHu32
DR   CCRID; 4201HUM-CCTCC00135
DR   CCTCC; GDC0135
DR   Cell_Model_Passport; SIDM01200
DR   ChEMBL-Cells; CHEMBL3307536
DR   ChEMBL-Targets; CHEMBL614097
DR   CLS; 300392
DR   ColonAtlas; LS174T
DR   Cosmic; 711255
DR   Cosmic; 719679
DR   Cosmic; 724843
DR   Cosmic; 738927
DR   Cosmic; 873703
DR   Cosmic; 875424
DR   Cosmic; 876717
DR   Cosmic; 887219
DR   Cosmic; 889533
DR   Cosmic; 907793
DR   Cosmic; 934563
DR   Cosmic; 948131
DR   Cosmic; 948856
DR   Cosmic; 985998
DR   Cosmic; 995405
DR   Cosmic; 1043822
DR   Cosmic; 1057755
DR   Cosmic; 1066210
DR   Cosmic; 1122328
DR   Cosmic; 1132565
DR   Cosmic; 1132692
DR   Cosmic; 1187310
DR   Cosmic; 1184087
DR   Cosmic; 1184334
DR   Cosmic; 1312305
DR   Cosmic; 1479573
DR   Cosmic; 1486134
DR   Cosmic; 1524341
DR   Cosmic; 1676738
DR   Cosmic; 1708419
DR   Cosmic; 1805263
DR   Cosmic; 2301546
DR   Cosmic; 2301997
DR   Cosmic; 2646768
DR   Cosmic; 2651866
DR   Cosmic; 2668256
DR   Cosmic; 2760087
DR   Cosmic; 2787546
DR   DSMZ; ACC-759
DR   DSMZCellDive; ACC-759
DR   ECACC; 87060401
DR   EGA; EGAS00001000610
DR   EGA; EGAS00001002554
DR   GEO; GSM513911
DR   GEO; GSM514297
DR   GEO; GSM741264
DR   GEO; GSM784021
DR   GEO; GSM827345
DR   GEO; GSM1346883
DR   GEO; GSM1374632
DR   GEO; GSM1374633
DR   GEO; GSM1448164
DR   GEO; GSM2550009
DR   IARC_TP53; 21478
DR   IARC_TP53; 21708
DR   IGRhCellID; LS174T
DR   KCB; KCB 200829YJ
DR   KCLB; 10188
DR   LINCS_LDP; LCL-1182
DR   Lonza; 1127
DR   MetaboLights; MTBLS227
DR   NCBI_Iran; C568
DR   PharmacoDB; LS174T_862_2019
DR   PRIDE; PXD005354
DR   PRIDE; PXD005355
DR   Progenetix; CVCL_1384
DR   PubChem_Cell_line; CVCL_1384
DR   RCB; RCB1961
DR   TKG; TKG 0406
DR   TOKU-E; 2235
DR   Ubigene; YC-C088
DR   Wikidata; Q54903053
RX   Patent=US4228236;
RX   PubMed=327080;
RX   PubMed=833871;
RX   PubMed=1262041;
RX   PubMed=1999484;
RX   PubMed=3335022;
RX   PubMed=3349466;
RX   PubMed=3518877;
RX   PubMed=3664476;
RX   PubMed=6401685;
RX   PubMed=6652615;
RX   PubMed=6935474;
RX   PubMed=7370982;
RX   PubMed=7459858;
RX   PubMed=7972006;
RX   PubMed=8422623;
RX   PubMed=8464898;
RX   PubMed=8895552;
RX   PubMed=9000147;
RX   PubMed=9290701;
RX   PubMed=9294210;
RX   PubMed=10674020;
RX   PubMed=10737795;
RX   PubMed=11226274;
RX   PubMed=11414198;
RX   PubMed=11416159;
RX   PubMed=11526487;
RX   PubMed=12068308;
RX   PubMed=12606785;
RX   PubMed=15900046;
RX   PubMed=16418264;
RX   PubMed=16854228;
RX   PubMed=18258742;
RX   PubMed=19132987;
RX   PubMed=20164919;
RX   PubMed=20215515;
RX   PubMed=20570890;
RX   PubMed=20606684;
RX   PubMed=23272949;
RX   PubMed=24042735;
RX   PubMed=24755471;
RX   PubMed=24840470;
RX   PubMed=25485619;
RX   PubMed=25877200;
RX   PubMed=25926053;
RX   PubMed=25944804;
RX   PubMed=26537799;
RX   PubMed=26589293;
RX   PubMed=28196595;
RX   PubMed=28683746;
RX   PubMed=29101300;
WW   https://www.cellosaurus.org/pawefish/ColonCellLineDescriptions/LS174T.html
WW   https://tcpaportal.org/mclp/
CC   Group: Patented cell line.
CC   Part of: AstraZeneca Colorectal cell line (AZCL) panel.
CC   Part of: MD Anderson Cell Lines Project.
CC   Registration: International Depositary Authority, American Type Culture Collection (ATCC); CL-188.
CC   Population: Caucasian.
CC   Doubling time: 26 hours (Note=At 20th passage) (PubMed=1262041); 18-20 hours (PubMed=7370982); 38.01 hours (PubMed=25944804); ~30-40 hours (DSMZ=ACC-759).
CC   HLA typing: A*02; B*13,50 (ATCC=CL-188).
CC   HLA typing: A*02,30 (PubMed=8464898).
CC   HLA typing: A*30:01,30:01; B*15:50,35:114; C*04:01,06:02 (PubMed=26589293).
CC   Microsatellite instability: Instable (MSI) (PubMed=9000147; PubMed=10674020; PubMed=24042735; PubMed=24755471; PubMed=25926053; PubMed=28683746).
CC   Sequence variation: Mutation; HGNC; 2514; CTNNB1; Simple; p.Ser45Phe (c.134C>T); ClinVar=VCV000017588; Zygosity=Homozygous (PubMed=24755471; ATCC).
CC   Sequence variation: Mutation; HGNC; 6407; KRAS; Simple; p.Gly12Asp (c.35G>A); ClinVar=VCV000012582; Zygosity=Heterozygous (PubMed=12068308; PubMed=20570890; PubMed=24042735; PubMed=24755471; PubMed=28683746).
CC   Sequence variation: Mutation; HGNC; 8975; PIK3CA; Simple; p.His1047Arg (c.3140A>G); ClinVar=VCV000013652; Zygosity=Unspecified (PubMed=20570890; PubMed=24042735; PubMed=24755471; PubMed=28683746).
CC   Sequence variation: Mutation; HGNC; 11998; TP53; None_reported; -; Zygosity=- (PubMed=15900046; PubMed=16418264; PubMed=24042735).
CC   Omics: Deep exome analysis.
CC   Omics: Deep proteome analysis.
CC   Omics: miRNA expression profiling.
CC   Omics: N-glycan profiling.
CC   Omics: O-glycan profiling.
CC   Omics: Protein expression by reverse-phase protein arrays.
CC   Omics: SNP array analysis.
CC   Omics: Transcriptome analysis by microarray.
CC   Omics: Transcriptome analysis by RNAseq.
CC   Misspelling: LV1747; Cosmic=1187310; PubMed=19132987.
CC   Misspelling: L5174T; Note=Occasionally.
CC   Discontinued: ATCC; CCL-188; probable.
CC   Discontinued: RCB; RCB1961; true.
CC   Derived from site: In situ; Colon; UBERON=UBERON_0001155.
CC   Cell type: Epithelial cell of colon; CL=CL_0011108.
ST   Source(s): AddexBio; ATCC; CCRID; CLS; DSMZ; KCLB; PubMed=11416159; PubMed=25877200; PubMed=25926053; TKG
ST   Amelogenin: X
ST   CSF1PO: 10,11,13,14 (DSMZ)
ST   CSF1PO: 10,13,14 (AddexBio; ATCC; PubMed=25926053)
ST   CSF1PO: 10,14 (CCRID; CLS; KCLB; PubMed=25877200; TKG)
ST   D13S317: 9,10,11 (DSMZ)
ST   D13S317: 10 (AddexBio; ATCC; CCRID; PubMed=25877200; PubMed=25926053)
ST   D13S317: 10,11 (CLS; KCLB; TKG)
ST   D16S539: 11,12,13 (DSMZ)
ST   D16S539: 11,13 (AddexBio; ATCC; CCRID; CLS; PubMed=25877200; PubMed=25926053; TKG)
ST   D18S51: 11,12,13 (DSMZ)
ST   D18S51: 11,13 (CLS; PubMed=25877200)
ST   D19S433: 13,14,15 (CLS)
ST   D19S433: 13,15,23 (DSMZ)
ST   D21S11: 29,31 (PubMed=11416159; PubMed=25877200; PubMed=25926053)
ST   D21S11: 29,30,31 (CLS)
ST   D21S11: 30,31,31.3,32,32.3,33 (DSMZ)
ST   D2S1338: 18,22 (CLS)
ST   D2S1338: 18,21,22 (DSMZ)
ST   D3S1358: 15,17 (CLS; KCLB; PubMed=25877200)
ST   D3S1358: 14,15,16,17 (DSMZ)
ST   D5S818: 11,14,15 (DSMZ)
ST   D5S818: 11,15 (AddexBio; CCRID; CLS; KCLB; PubMed=25877200; PubMed=25926053; TKG)
ST   D5S818: 11,15,16 (ATCC)
ST   D7S820: 10,10.3 (TKG)
ST   D7S820: 10.3,11 (ATCC; DSMZ; PubMed=25877200)
ST   D7S820: 11 (AddexBio; CCRID; CLS; KCLB; PubMed=25926053)
ST   D8S1179: 11,12,16 (CLS)
ST   D8S1179: 12,15 (DSMZ)
ST   D8S1179: 12,16 (PubMed=25877200)
ST   FGA: 14,20,21,22 (DSMZ)
ST   FGA: 21,22 (CLS; KCLB; PubMed=25877200)
ST   Penta D: 10
ST   Penta E: 14,15,16 (DSMZ)
ST   Penta E: 15,16 (CLS; PubMed=25877200)
ST   TH01: 6,7
ST   TPOX: 8,9
ST   vWA: 15,16,17,18,19 (DSMZ)
ST   vWA: 15,17 (AddexBio; CCRID; CLS; KCLB; PubMed=11416159; PubMed=25877200; PubMed=25926053; TKG)
ST   vWA: 15,17,18 (ATCC)
DI   NCIt; C4349; Colon adenocarcinoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_0397 ! LS180
SX   Female
AG   58Y
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 30-01-24; Version: 46
//
RX   Patent=US4228236;
RA   Jakstys M.M., Tom B.H., Kahan B.D.;
RT   "Process of producing carcinoembryonic antigen.";
RL   Patent number US4228236, 14-Oct-1980.
//
RX   PubMed=327080; DOI=10.1093/jnci/59.1.221;
RA   Fogh J., Fogh J.M., Orfeo T.;
RT   "One hundred and twenty-seven cultured human tumor cell lines
RT   producing tumors in nude mice.";
RL   J. Natl. Cancer Inst. 59:221-226(1977).
//
RX   PubMed=833871; DOI=10.1093/jnci/58.2.209;
RA   Fogh J., Wright W.C., Loveless J.D.;
RT   "Absence of HeLa cell contamination in 169 cell lines derived from
RT   human tumors.";
RL   J. Natl. Cancer Inst. 58:209-214(1977).
//
RX   PubMed=1262041; DOI=10.1007/BF02796440;
RA   Tom B.H., Rutzky L.P., Jakstys M.M., Oyasu R., Kaye C.I., Kahan B.D.;
RT   "Human colonic adenocarcinoma cells. I. Establishment and description
RT   of a new line.";
RL   In Vitro 12:180-191(1976).
//
RX   PubMed=1999484; DOI=10.1172/JCI115063;
RA   Bresalier R.S., Niv Y., Byrd J.C., Duh Q.-Y., Toribara N.W.,
RA   Rockwell R.W., Dahiya R., Kim Y.S.;
RT   "Mucin production by human colonic carcinoma cells correlates with
RT   their metastatic potential in animal models of colon cancer
RT   metastasis.";
RL   J. Clin. Invest. 87:1037-1045(1991).
//
RX   PubMed=3335022;
RA   Alley M.C., Scudiero D.A., Monks A., Hursey M.L., Czerwinski M.J.,
RA   Fine D.L., Abbott B.J., Mayo J.G., Shoemaker R.H., Boyd M.R.;
RT   "Feasibility of drug screening with panels of human tumor cell lines
RT   using a microculture tetrazolium assay.";
RL   Cancer Res. 48:589-601(1988).
//
RX   PubMed=3349466;
RA   Chantret I., Barbat A., Dussaulx E., Brattain M.G., Zweibaum A.;
RT   "Epithelial polarity, villin expression, and enterocytic
RT   differentiation of cultured human colon carcinoma cells: a survey of
RT   twenty cell lines.";
RL   Cancer Res. 48:1936-1942(1988).
//
RX   PubMed=3518877; DOI=10.3109/07357908609038260;
RA   Fogh J.;
RT   "Human tumor lines for cancer research.";
RL   Cancer Invest. 4:157-184(1986).
//
RX   PubMed=3664476;
RA   Kuan S.-F., Byrd J.C., Basbaum C.B., Kim Y.S.;
RT   "Characterization of quantitative mucin variants from a human colon
RT   cancer cell line.";
RL   Cancer Res. 47:5715-5724(1987).
//
RX   PubMed=6401685; DOI=10.1007/BF02617989;
RA   Halton D.M., Peterson W.D. Jr., Hukku B.;
RT   "Cell culture quality control by rapid isoenzymatic
RT   characterization.";
RL   In Vitro 19:16-24(1983).
//
RX   PubMed=6652615; DOI=10.1016/0165-4608(83)90092-4;
RA   Chen T.-R., Hay R.J., Macy M.L.;
RT   "Intercellular karyotypic similarity in near-diploid cell lines of
RT   human tumor origins.";
RL   Cancer Genet. Cytogenet. 10:351-362(1983).
//
RX   PubMed=6935474; DOI=10.1093/jnci/66.2.239;
RA   Wright W.C., Daniels W.P., Fogh J.;
RT   "Distinction of seventy-one cultured human tumor cell lines by
RT   polymorphic enzyme analysis.";
RL   J. Natl. Cancer Inst. 66:239-247(1981).
//
RX   PubMed=7370982;
RA   Rutzky L.P., Kaye C.I., Siciliano M.J., Chao M., Kahan B.D.;
RT   "Longitudinal karyotype and genetic signature analysis of cultured
RT   human colon adenocarcinoma cell lines LS180 and LS174T.";
RL   Cancer Res. 40:1443-1448(1980).
//
RX   PubMed=7459858;
RA   Rousset M., Zweibaum A., Fogh J.;
RT   "Presence of glycogen and growth-related variations in 58 cultured
RT   human tumor cell lines of various tissue origins.";
RL   Cancer Res. 41:1165-1170(1981).
//
RX   PubMed=7972006; DOI=10.1073/pnas.91.23.11045;
RA   Okamoto A., Demetrick D.J., Spillare E.A., Hagiwara K., Hussain S.P.,
RA   Bennett W.P., Forrester K., Gerwin B.I., Serrano M., Beach D.H.,
RA   Harris C.C.;
RT   "Mutations and altered expression of p16INK4 in human cancer.";
RL   Proc. Natl. Acad. Sci. U.S.A. 91:11045-11049(1994).
//
RX   PubMed=8422623; DOI=10.1002/1097-0142(19930115)71:2<315::AID-CNCR2820710208>3.0.CO;2-B;
RA   Tibbetts L.M., Doremus C.M., Tzanakakis G.N., Vezeridis M.P.;
RT   "Liver metastases with 10 human colon carcinoma cell lines in nude
RT   mice and association with carcinoembryonic antigen production.";
RL   Cancer 71:315-321(1993).
//
RX   PubMed=8464898; DOI=10.1073/pnas.90.7.2842;
RA   Browning M.J., Krausa P., Rowan A.J., Bicknell D.C., Bodmer J.G.,
RA   Bodmer W.F.;
RT   "Tissue typing the HLA-A locus from genomic DNA by sequence-specific
RT   PCR: comparison of HLA genotype and surface expression on colorectal
RT   tumor cell lines.";
RL   Proc. Natl. Acad. Sci. U.S.A. 90:2842-2845(1993).
//
RX   PubMed=8895552; DOI=10.1002/(SICI)1097-0215(19960927)68:1<126::AID-IJC22>3.0.CO;2-8;
RA   Suardet L., Li C., Little J.B.;
RT   "Radio-induced modulation of transforming growth factor beta1
RT   sensitivity in a p53 wild-type human colorectal-cancer cell line.";
RL   Int. J. Cancer 68:126-131(1996).
//
RX   PubMed=9000147;
RA   Cottu P.H., Muzeau F., Estreicher A., Flejou J.-F., Iggo R.D.,
RA   Thomas G., Hamelin R.;
RT   "Inverse correlation between RER+ status and p53 mutation in
RT   colorectal cancer cell lines.";
RL   Oncogene 13:2727-2730(1996).
//
RX   PubMed=9290701; DOI=10.1002/(SICI)1098-2744(199708)19:4<243::AID-MC5>3.0.CO;2-D;
RA   Jia L.-Q., Osada M., Ishioka C., Gamo M., Ikawa S., Suzuki T.,
RA   Shimodaira H., Niitani T., Kudo T., Akiyama M., Kimura N., Matsuo M.,
RA   Mizusawa H., Tanaka N., Koyama H., Namba M., Kanamaru R., Kuroki T.;
RT   "Screening the p53 status of human cell lines using a yeast functional
RT   assay.";
RL   Mol. Carcinog. 19:243-253(1997).
//
RX   PubMed=9294210; DOI=10.1073/pnas.94.19.10330;
RA   Ilyas M., Tomlinson I.P.M., Rowan A.J., Pignatelli M., Bodmer W.F.;
RT   "Beta-catenin mutations in cell lines established from human
RT   colorectal cancers.";
RL   Proc. Natl. Acad. Sci. U.S.A. 94:10330-10334(1997).
//
RX   PubMed=10674020; DOI=10.1016/S0959-8049(99)00206-3;
RA   Ku J.-L., Yoon K.-A., Kim D.-Y., Park J.-G.;
RT   "Mutations in hMSH6 alone are not sufficient to cause the
RT   microsatellite instability in colorectal cancer cell lines.";
RL   Eur. J. Cancer 35:1724-1729(1999).
//
RX   PubMed=10737795; DOI=10.1073/pnas.97.7.3352;
RA   Rowan A.J., Lamlum H., Ilyas M., Wheeler J., Straub J.,
RA   Papadopoulou A., Bicknell D.C., Bodmer W.F., Tomlinson I.P.M.;
RT   "APC mutations in sporadic colorectal tumors: a mutational 'hotspot'
RT   and interdependence of the 'two hits'.";
RL   Proc. Natl. Acad. Sci. U.S.A. 97:3352-3357(2000).
//
RX   PubMed=11226274; DOI=10.1073/pnas.041603298;
RA   Abdel-Rahman W.M., Katsura K., Rens W., Gorman P.A., Sheer D.,
RA   Bicknell D.C., Bodmer W.F., Arends M.J., Wyllie A.H., Edwards P.A.W.;
RT   "Spectral karyotyping suggests additional subsets of colorectal
RT   cancers characterized by pattern of chromosome rearrangement.";
RL   Proc. Natl. Acad. Sci. U.S.A. 98:2538-2543(2001).
//
RX   PubMed=11414198; DOI=10.1007/s004320000207;
RA   Lahm H., Andre S., Hoeflich A., Fischer J.R., Sordat B., Kaltner H.,
RA   Wolf E., Gabius H.-J.;
RT   "Comprehensive galectin fingerprinting in a panel of 61 human tumor
RT   cell lines by RT-PCR and its implications for diagnostic and
RT   therapeutic procedures.";
RL   J. Cancer Res. Clin. Oncol. 127:375-386(2001).
//
RX   PubMed=11416159; DOI=10.1073/pnas.121616198;
RA   Masters J.R.W., Thomson J.A., Daly-Burns B., Reid Y.A., Dirks W.G.,
RA   Packer P., Toji L.H., Ohno T., Tanabe H., Arlett C.F., Kelland L.R.,
RA   Harrison M., Virmani A.K., Ward T.H., Ayres K.L., Debenham P.G.;
RT   "Short tandem repeat profiling provides an international reference
RT   standard for human cell lines.";
RL   Proc. Natl. Acad. Sci. U.S.A. 98:8012-8017(2001).
//
RX   PubMed=11526487; DOI=10.1038/sj.onc.1204611;
RA   Gayet J., Zhou X.-P., Duval A., Rolland S., Hoang J.-M., Cottu P.H.,
RA   Hamelin R.;
RT   "Extensive characterization of genetic alterations in a series of
RT   human colorectal cancer cell lines.";
RL   Oncogene 20:5025-5032(2001).
//
RX   PubMed=12068308; DOI=10.1038/nature00766;
RA   Davies H., Bignell G.R., Cox C., Stephens P.J., Edkins S., Clegg S.,
RA   Teague J.W., Woffendin H., Garnett M.J., Bottomley W., Davis N.,
RA   Dicks E., Ewing R., Floyd Y., Gray K., Hall S., Hawes R., Hughes J.,
RA   Kosmidou V., Menzies A., Mould C., Parker A., Stevens C., Watt S.,
RA   Hooper S., Wilson R., Jayatilake H., Gusterson B.A., Cooper C.S.,
RA   Shipley J.M., Hargrave D., Pritchard-Jones K., Maitland N.J.,
RA   Chenevix-Trench G., Riggins G.J., Bigner D.D., Palmieri G., Cossu A.,
RA   Flanagan A.M., Nicholson A., Ho J.W.C., Leung S.Y., Yuen S.T.,
RA   Weber B.L., Seigler H.F., Darrow T.L., Paterson H.F., Marais R.,
RA   Marshall C.J., Wooster R., Stratton M.R., Futreal P.A.;
RT   "Mutations of the BRAF gene in human cancer.";
RL   Nature 417:949-954(2002).
//
RX   PubMed=12606785; DOI=10.1124/mol.63.3.742;
RA   Briz O., Macias R.I.R., Vallejo M., Silva A., Serrano M.A.,
RA   Marin J.J.G.;
RT   "Usefulness of liposomes loaded with cytostatic bile acid derivatives
RT   to circumvent chemotherapy resistance of enterohepatic tumors.";
RL   Mol. Pharmacol. 63:742-750(2003).
//
RX   PubMed=15900046; DOI=10.1093/jnci/dji133;
RA   Mashima T., Oh-hara T., Sato S., Mochizuki M., Sugimoto Y.,
RA   Yamazaki K., Hamada J.-i., Tada M., Moriuchi T., Ishikawa Y., Kato Y.,
RA   Tomoda H., Yamori T., Tsuruo T.;
RT   "p53-defective tumors with a functional apoptosome-mediated pathway: a
RT   new therapeutic target.";
RL   J. Natl. Cancer Inst. 97:765-777(2005).
//
RX   PubMed=16418264; DOI=10.1073/pnas.0510146103;
RA   Liu Y., Bodmer W.F.;
RT   "Analysis of P53 mutations and their expression in 56 colorectal
RT   cancer cell lines.";
RL   Proc. Natl. Acad. Sci. U.S.A. 103:976-981(2006).
//
RX   PubMed=16854228; DOI=10.1186/1476-4598-5-29;
RA   Bandres E., Cubedo E., Agirre X., Malumbres R., Zarate R., Ramirez N.,
RA   Abajo A., Navarro A., Moreno I., Monzo M., Garcia-Foncillas J.;
RT   "Identification by real-time PCR of 13 mature microRNAs differentially
RT   expressed in colorectal cancer and non-tumoral tissues.";
RL   Mol. Cancer 5:29.1-29.10(2006).
//
RX   PubMed=18258742; DOI=10.1073/pnas.0712176105;
RA   Emaduddin M., Bicknell D.C., Bodmer W.F., Feller S.M.;
RT   "Cell growth, global phosphotyrosine elevation, and c-Met
RT   phosphorylation through Src family kinases in colorectal cancer
RT   cells.";
RL   Proc. Natl. Acad. Sci. U.S.A. 105:2358-2362(2008).
//
RX   PubMed=19132987; DOI=10.1111/j.1600-0463.2008.01042.x;
RA   Li Y., Tanaka Y., Tada M., Hua R., Seto M., Asaoka Y., Ohta M.,
RA   Kanai F., Yoshida H., Kawabe T., Sano T., Motojima T., Yokosuka O.,
RA   Omata M.;
RT   "Absence of the AKT1 pleckstrin homology domain mutation in Japanese
RT   gastrointestinal and liver cancer patients.";
RL   APMIS 116:931-933(2008).
//
RX   PubMed=20164919; DOI=10.1038/nature08768;
RA   Bignell G.R., Greenman C.D., Davies H., Butler A.P., Edkins S.,
RA   Andrews J.M., Buck G., Chen L., Beare D., Latimer C., Widaa S.,
RA   Hinton J., Fahey C., Fu B.-Y., Swamy S., Dalgliesh G.L., Teh B.T.,
RA   Deloukas P., Yang F.-T., Campbell P.J., Futreal P.A., Stratton M.R.;
RT   "Signatures of mutation and selection in the cancer genome.";
RL   Nature 463:893-898(2010).
//
RX   PubMed=20215515; DOI=10.1158/0008-5472.CAN-09-3458;
RA   Rothenberg S.M., Mohapatra G., Rivera M.N., Winokur D., Greninger P.,
RA   Nitta M., Sadow P.M., Sooriyakumar G., Brannigan B.W., Ulman M.J.,
RA   Perera R.M., Wang R., Tam A., Ma X.-J., Erlander M., Sgroi D.C.,
RA   Rocco J.W., Lingen M.W., Cohen E.E.W., Louis D.N., Settleman J.,
RA   Haber D.A.;
RT   "A genome-wide screen for microdeletions reveals disruption of
RT   polarity complex genes in diverse human cancers.";
RL   Cancer Res. 70:2158-2164(2010).
//
RX   PubMed=20570890; DOI=10.1158/0008-5472.CAN-10-0192;
RA   Janakiraman M., Vakiani E., Zeng Z.-S., Pratilas C.A., Taylor B.S.,
RA   Chitale D., Halilovic E., Wilson M., Huberman K., Ricarte Filho J.C.M.,
RA   Persaud Y., Levine D.A., Fagin J.A., Jhanwar S.C., Mariadason J.M.,
RA   Lash A., Ladanyi M., Saltz L.B., Heguy A., Paty P.B., Solit D.B.;
RT   "Genomic and biological characterization of exon 4 KRAS mutations in
RT   human cancer.";
RL   Cancer Res. 70:5901-5911(2010).
//
RX   PubMed=20606684; DOI=10.1038/sj.bjc.6605780;
RA   Bracht K., Nicholls A.M., Liu Y., Bodmer W.F.;
RT   "5-fluorouracil response in a large panel of colorectal cancer cell
RT   lines is associated with mismatch repair deficiency.";
RL   Br. J. Cancer 103:340-346(2010).
//
RX   PubMed=23272949; DOI=10.1186/1755-8794-5-66;
RA   Schlicker A., Beran G., Chresta C.M., McWalter G., Pritchard A.,
RA   Weston S., Runswick S., Davenport S., Heathcote K., Castro D.A.,
RA   Orphanides G., French T., Wessels L.F.A.;
RT   "Subtypes of primary colorectal tumors correlate with response to
RT   targeted treatment in colorectal cell lines.";
RL   BMC Med. Genomics 5:66.1-66.15(2012).
//
RX   PubMed=24042735; DOI=10.1038/oncsis.2013.35;
RA   Ahmed D., Eide P.W., Eilertsen I.A., Danielsen S.A., Eknaes M.,
RA   Hektoen M., Lind G.E., Lothe R.A.;
RT   "Epigenetic and genetic features of 24 colon cancer cell lines.";
RL   Oncogenesis 2:e71.1-e71.8(2013).
//
RX   PubMed=24755471; DOI=10.1158/0008-5472.CAN-14-0013;
RA   Mouradov D., Sloggett C., Jorissen R.N., Love C.G., Li S.,
RA   Burgess A.W., Arango D., Strausberg R.L., Buchanan D., Wormald S.,
RA   O'Connor L., Wilding J.L., Bicknell D.C., Tomlinson I.P.M., Bodmer W.F.,
RA   Mariadason J.M., Sieber O.M.;
RT   "Colorectal cancer cell lines are representative models of the main
RT   molecular subtypes of primary cancer.";
RL   Cancer Res. 74:3238-3247(2014).
//
RX   PubMed=24840470; DOI=10.1016/j.jprot.2014.05.002;
RA   Chik J.H.L., Zhou J., Moh E.S.X., Christopherson R., Clarke S.J.,
RA   Molloy M.P., Packer N.H.;
RT   "Comprehensive glycomics comparison between colon cancer cell cultures
RT   and tumours: implications for biomarker studies.";
RL   J. Proteomics 108:146-162(2014).
//
RX   PubMed=25485619; DOI=10.1038/nbt.3080;
RA   Klijn C., Durinck S., Stawiski E.W., Haverty P.M., Jiang Z.-S.,
RA   Liu H.-B., Degenhardt J., Mayba O., Gnad F., Liu J.-F., Pau G.,
RA   Reeder J., Cao Y., Mukhyala K., Selvaraj S.K., Yu M.-M., Zynda G.J.,
RA   Brauer M.J., Wu T.D., Gentleman R.C., Manning G., Yauch R.L.,
RA   Bourgon R., Stokoe D., Modrusan Z., Neve R.M., de Sauvage F.J.,
RA   Settleman J., Seshagiri S., Zhang Z.-M.;
RT   "A comprehensive transcriptional portrait of human cancer cell
RT   lines.";
RL   Nat. Biotechnol. 33:306-312(2015).
//
RX   PubMed=25877200; DOI=10.1038/nature14397;
RA   Yu M., Selvaraj S.K., Liang-Chu M.M.Y., Aghajani S., Busse M.,
RA   Yuan J., Lee G., Peale F.V., Klijn C., Bourgon R., Kaminker J.S.,
RA   Neve R.M.;
RT   "A resource for cell line authentication, annotation and quality
RT   control.";
RL   Nature 520:307-311(2015).
//
RX   PubMed=25926053; DOI=10.1038/ncomms8002;
RA   Medico E., Russo M., Picco G., Cancelliere C., Valtorta E., Corti G.,
RA   Buscarino M., Isella C., Lamba S., Martinoglio B., Veronese S.,
RA   Siena S., Sartore-Bianchi A., Beccuti M., Mottolese M.,
RA   Linnebacher M., Cordero F., Di Nicolantonio F., Bardelli A.;
RT   "The molecular landscape of colorectal cancer cell lines unveils
RT   clinically actionable kinase targets.";
RL   Nat. Commun. 6:7002.1-7002.10(2015).
//
RX   PubMed=25944804; DOI=10.1158/1078-0432.CCR-14-2457;
RA   Bazzocco S., Dopeso H., Carton-Garcia F., Macaya I., Andretta E.,
RA   Chionh F., Rodrigues P., Garrido M., Alazzouzi H., Nieto R.,
RA   Sanchez A., Schwartz S. Jr., Bilic J., Mariadason J.M., Arango D.;
RT   "Highly expressed genes in rapidly proliferating tumor cells as new
RT   targets for colorectal cancer treatment.";
RL   Clin. Cancer Res. 21:3695-3704(2015).
//
RX   PubMed=26537799; DOI=10.1074/mcp.M115.051235;
RA   Holst S., Deuss A.J.M., van Pelt G.W., van Vliet S.J.,
RA   Garcia-Vallejo J.J., Koeleman C.A.M., Deelder A.M., Mesker W.E.,
RA   Tollenaar R.A., Rombouts Y., Wuhrer M.;
RT   "N-glycosylation profiling of colorectal cancer cell lines reveals
RT   association of fucosylation with differentiation and caudal type
RT   homebox 1 (CDX1)/villin mRNA expression.";
RL   Mol. Cell. Proteomics 15:124-140(2016).
//
RX   PubMed=26589293; DOI=10.1186/s13073-015-0240-5;
RA   Scholtalbers J., Boegel S., Bukur T., Byl M., Goerges S., Sorn P.,
RA   Loewer M., Sahin U., Castle J.C.;
RT   "TCLP: an online cancer cell line catalogue integrating HLA type,
RT   predicted neo-epitopes, virus and gene expression.";
RL   Genome Med. 7:118.1-118.7(2015).
//
RX   PubMed=28196595; DOI=10.1016/j.ccell.2017.01.005;
RA   Li J., Zhao W., Akbani R., Liu W.-B., Ju Z.-L., Ling S.-Y., Vellano C.P.,
RA   Roebuck P., Yu Q.-H., Eterovic A.K., Byers L.A., Davies M.A., Deng W.-L.,
RA   Gopal Y.N.V., Chen G., von Euw E.M., Slamon D.J., Conklin D.,
RA   Heymach J.V., Gazdar A.F., Minna J.D., Myers J.N., Lu Y.-L., Mills G.B.,
RA   Liang H.;
RT   "Characterization of human cancer cell lines by reverse-phase protein
RT   arrays.";
RL   Cancer Cell 31:225-239(2017).
//
RX   PubMed=28683746; DOI=10.1186/s12943-017-0691-y;
RA   Berg K.C.G., Eide P.W., Eilertsen I.A., Johannessen B., Bruun J.,
RA   Danielsen S.A., Bjornslett M., Meza-Zepeda L.A., Eknaes M., Lind G.E.,
RA   Myklebost O., Skotheim R.I., Sveen A., Lothe R.A.;
RT   "Multi-omics of 34 colorectal cancer cell lines -- a resource for
RT   biomedical studies.";
RL   Mol. Cancer 16:116.1-116.16(2017).
//
RX   PubMed=29101300; DOI=10.15252/msb.20177701;
RA   Frejno M., Zenezini Chiozzi R., Wilhelm M., Koch H., Zheng R.-S.,
RA   Klaeger S., Ruprecht B., Meng C., Kramer K., Jarzab A., Heinzlmeir S.,
RA   Johnstone E., Domingo E., Kerr D., Jesinghaus M., Slotta-Huspenina J.,
RA   Weichert W., Knapp S., Feller S.M., Kuster B.;
RT   "Pharmacoproteomic characterisation of human colon and rectal
RT   cancer.";
RL   Mol. Syst. Biol. 13:951-951(2017).
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