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Cellosaurus Lu-134-A (CVCL_1387)

[Text version]

Cell line name Lu-134-A
Synonyms Lu-134-a; LU-134-A; LU-134A; Lu-134A; Lu134A; LU-134; Lu-134; Lu134; NCC-c-Lu-134-A-H; Lu-134-A-H; LU-134-A-H; Lu-134-AH; LU-134-AH; Lu134-A-H; Lu134AH
Accession CVCL_1387
Secondary accession CVCL_2790
Resource Identification Initiative To cite this cell line use: Lu-134-A (RRID:CVCL_1387)
Comments Part of: Cancer Cell Line Encyclopedia (CCLE) project.
Part of: COSMIC cell lines project.
Doubling time: 46 hours (PubMed=3022030; PubMed=6098504); 51.9 hours (PubMed=8286010).
Microsatellite instability: Stable (MSS) (Sanger).
Omics: Deep exome analysis.
Omics: DNA methylation analysis.
Omics: SNP array analysis.
Omics: Transcriptome analysis.
Sequence variations TP53 p.Pro278Leu (c.833C>T) (PubMed=1312700).
Genome ancestry Source: PubMed=30894373

Origin% genome
African0.6
Native American0
East Asian, North73.6
East Asian, South23.8
South Asian1.7
European, North0.3
European, South0
Disease Small cell lung carcinoma (NCIt: C4917)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Children:
CVCL_6862 (Lu-130)
Originate from same individual CVCL_1388 ! Lu-134-B
Sex of cell Male
Age at sampling 80Y
Category Cancer cell line
STR profile Source(s): Cosmic-CLP; JCRB; RCB

Markers:
AmelogeninX
CSF1PO12
D5S81811
D7S82011
D13S3179
D16S5399
TH019
TPOX11
vWA17

Run an STR similarity search on this cell line
Publications

PubMed=6098504; DOI=10.20772/cancersci1959.75.12_1089
Terasaki T., Kameya T., Nakajima T., Tsumuraya M., Shimosato Y., Kato K., Ichinose H., Nagatsu T., Hasegawa T.
Interconversion of biological characteristics of small cell lung cancer depending on culture conditions.
Gann 75:1089-1099(1984)

DOI=10.5795/jjscc.24.451
Tsumuraya M., Nakajima T., Terasaki T., Kodama T., Shimosato Y., Higuchi H., Uei Y.
Analysis of LDH isoenzyme patterns in cell lines of the small cell carcinoma (lung) and retinoblastoma.
Nihon Rinsho Saibo Gakkai Zasshi 24:451-456(1985)

PubMed=3022030
Terasaki T., Shimosato Y., Nakajima T., Tsumuraya M., Morinaga S., Hirohashi S., Yamaguchi K., Kato K., Ichinose H., Nagatsu T.
Changes in cell characteristics due to culture conditions in cell lines from human small cell lung cancer.
Jpn. J. Clin. Oncol. 16:203-212(1986)

PubMed=1312700
Sameshima Y., Matsuno Y., Hirohashi S., Shimosato Y., Mizoguchi H., Sugimura T., Terada M., Yokota J.
Alterations of the p53 gene are common and critical events for the maintenance of malignant phenotypes in small-cell lung carcinoma.
Oncogene 7:451-457(1992)

PubMed=8286010
Kiura K., Watarai S., Shibayama T., Ohnoshi T., Kimura I., Yasuda T.
Inhibitory effects of cholera toxin on in vitro growth of human lung cancer cell lines.
Anticancer Drug Des. 8:417-428(1993)

PubMed=9413215
Yamane H., Kiura K., Tabata M., Bessho A., Tsuchida T., Motoda K., Hiraki A., Ueoka H., Harada M.
Small cell lung cancer can express CD34 antigen.
Anticancer Res. 17:3627-3632(1997)

PubMed=10358721; DOI=10.18926/AMO/31626
Matsushita A., Tabata M., Ueoka H., Kiura K., Shibayama T., Aoe K., Kohara H., Harada M.
Establishment of a drug sensitivity panel using human lung cancer cell lines.
Acta Med. Okayama 53:67-75(1999)

PubMed=11005564; DOI=10.1038/sj.neo.7900094
Kohno T., Sato T., Takakura S., Takei K., Inoue K., Nishioka M., Yokota J.
Mutation and expression of the DCC gene in human lung cancer.
Neoplasia 2:300-305(2000)

PubMed=12107105; DOI=10.1016/S0002-9440(10)64172-7
Yokoi S., Yasui K., Saito-Ohara F., Koshikawa K., Iizasa T., Fujisawa T., Terasaki T., Horii A., Takahashi T., Hirohashi S., Inazawa J.
A novel target gene, SKP2, within the 5p13 amplicon that is frequently detected in small cell lung cancers.
Am. J. Pathol. 161:207-216(2002)

PubMed=15016488; DOI=10.1016/S0140-6736(04)15693-6
Jones M.H., Virtanen C., Honjoh D., Miyoshi T., Satoh Y., Okumura S., Nakagawa K., Nomura H., Ishikawa Y.
Two prognostically significant subtypes of high-grade lung neuroendocrine tumours independent of small-cell and large-cell neuroendocrine carcinomas identified by gene expression profiles.
Lancet 363:775-781(2004)

PubMed=19472407; DOI=10.1002/humu.21028
Blanco R., Iwakawa R., Tang M., Kohno T., Angulo B., Pio R., Montuenga L.M., Minna J.D., Yokota J., Sanchez-Cespedes M.
A gene-alteration profile of human lung cancer cell lines.
Hum. Mutat. 30:1199-1206(2009)

PubMed=20164919; DOI=10.1038/nature08768
Bignell G.R., Greenman C.D., Davies H., Butler A.P., Edkins S., Andrews J.M., Buck G., Chen L., Beare D., Latimer C., Widaa S., Hinton J., Fahey C., Fu B., Swamy S., Dalgliesh G.L., Teh B.T., Deloukas P., Yang F., Campbell P.J., Futreal P.A., Stratton M.R.
Signatures of mutation and selection in the cancer genome.
Nature 463:893-898(2010)

PubMed=27397505; DOI=10.1016/j.cell.2016.06.017
Iorio F., Knijnenburg T.A., Vis D.J., Bignell G.R., Menden M.P., Schubert M., Aben N., Goncalves E., Barthorpe S., Lightfoot H., Cokelaer T., Greninger P., van Dyk E., Chang H., de Silva H., Heyn H., Deng X., Egan R.K., Liu Q., Mironenko T., Mitropoulos X., Richardson L., Wang J., Zhang T., Moran S., Sayols S., Soleimani M., Tamborero D., Lopez-Bigas N., Ross-Macdonald P., Esteller M., Gray N.S., Haber D.A., Stratton M.R., Benes C.H., Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.
A landscape of pharmacogenomic interactions in cancer.
Cell 166:740-754(2016)

PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747
Dutil J., Chen Z., Monteiro A.N., Teer J.K., Eschrich S.A.
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Cancer Res. 79:1263-1273(2019)

Cross-references
Cell line collections JCRB; JCRB0235
RCB; RCB0466
Cell line databases/resources CCLE; LU134A_LUNG
Cell_Model_Passport; SIDM00296
CGH-DB; 100-1
CGH-DB; 9059-4
Cosmic-CLP; 753588
GDSC; 753588
LINCS_LDP; LCL-1871
LINCS_LDP; LCL-1877
Ontologies CLO; CLO_0050028
Biological sample resources BioSample; SAMN03471661
Chemistry resources ChEMBL-Cells; CHEMBL3308292
ChEMBL-Targets; CHEMBL2366236
Gene expression databases ArrayExpress; E-MTAB-3610
GEO; GSM17310
GEO; GSM1670063
Other Wikidata; Q54903191
Polymorphism and mutation databases Cosmic; 713881
Cosmic; 753588
Cosmic; 801604
Cosmic; 809119
Cosmic; 844808
Cosmic; 876158
Cosmic; 918005
Cosmic; 929157
Cosmic; 1212193
Cosmic; 1219094
Cosmic; 1239929
Cosmic; 1571749
Cosmic; 1995493
Cosmic; 2125172
Cosmic; 2668338
IARC_TP53; 1014
Entry history
Entry creation04-Apr-2012
Last entry updated24-May-2019
Version number24