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Cellosaurus Lu-135 (CVCL_1389)

[Text version]

Cell line name Lu-135
Synonyms NCC-c-Lu-135; LU-135; LU135; Lu135
Accession CVCL_1389
Resource Identification Initiative To cite this cell line use: Lu-135 (RRID:CVCL_1389)
Comments Part of: Cancer Cell Line Encyclopedia (CCLE) project.
Part of: COSMIC cell lines project.
Doubling time: 88 hours (PubMed=3022030).
Microsatellite instability: Stable (MSS) (Sanger).
Omics: Deep exome analysis.
Omics: DNA methylation analysis.
Omics: Transcriptome analysis.
Sequence variations TP53 p.Gly244Cys (c.730G>T) (PubMed=1312700).
Disease Small cell lung carcinoma (NCIt: C4917)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Male
Age at sampling 69Y
Category Cancer cell line
STR profile Source(s): Cosmic-CLP; JCRB; RCB

Markers:
AmelogeninX,Y
CSF1PO10
D5S81813
D7S82011
D13S3177
D16S53911
TH019
TPOX11
vWA16

Run an STR similarity search on this cell line
Publications

PubMed=3022030
Terasaki T., Shimosato Y., Nakajima T., Tsumuraya M., Morinaga S., Hirohashi S., Yamaguchi K., Kato K., Ichinose H., Nagatsu T.
Changes in cell characteristics due to culture conditions in cell lines from human small cell lung cancer.
Jpn. J. Clin. Oncol. 16:203-212(1986)

PubMed=1312700
Sameshima Y., Matsuno Y., Hirohashi S., Shimosato Y., Mizoguchi H., Sugimura T., Terada M., Yokota J.
Alterations of the p53 gene are common and critical events for the maintenance of malignant phenotypes in small-cell lung carcinoma.
Oncogene 7:451-457(1992)

PubMed=11005564; DOI=10.1038/sj.neo.7900094
Kohno T., Sato T., Takakura S., Takei K., Inoue K., Nishioka M., Yokota J.
Mutation and expression of the DCC gene in human lung cancer.
Neoplasia 2:300-305(2000)

PubMed=12107105; DOI=10.1016/S0002-9440(10)64172-7
Yokoi S., Yasui K., Saito-Ohara F., Koshikawa K., Iizasa T., Fujisawa T., Terasaki T., Horii A., Takahashi T., Hirohashi S., Inazawa J.
A novel target gene, SKP2, within the 5p13 amplicon that is frequently detected in small cell lung cancers.
Am. J. Pathol. 161:207-216(2002)

PubMed=19472407; DOI=10.1002/humu.21028
Blanco R., Iwakawa R., Tang M., Kohno T., Angulo B., Pio R., Montuenga L.M., Minna J.D., Yokota J., Sanchez-Cespedes M.
A gene-alteration profile of human lung cancer cell lines.
Hum. Mutat. 30:1199-1206(2009)

PubMed=27397505; DOI=10.1016/j.cell.2016.06.017
Iorio F., Knijnenburg T.A., Vis D.J., Bignell G.R., Menden M.P., Schubert M., Aben N., Goncalves E., Barthorpe S., Lightfoot H., Cokelaer T., Greninger P., van Dyk E., Chang H., de Silva H., Heyn H., Deng X., Egan R.K., Liu Q., Mironenko T., Mitropoulos X., Richardson L., Wang J., Zhang T., Moran S., Sayols S., Soleimani M., Tamborero D., Lopez-Bigas N., Ross-Macdonald P., Esteller M., Gray N.S., Haber D.A., Stratton M.R., Benes C.H., Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.
A landscape of pharmacogenomic interactions in cancer.
Cell 166:740-754(2016)

Cross-references
Cell line collections JCRB; JCRB0170
JCRB; FDSC0039 - Discontinued
RCB; RCB0468
Cell line databases/resources CCLE; LU135_LUNG
Cell_Model_Passport; SIDM00294
CGH-DB; 91-1
CGH-DB; 9061-4
Cosmic-CLP; 713899
GDSC; 713899
LINCS_LDP; LCL-1809
Ontologies CLO; CLO_0050030
EFO; EFO_0002828
Biological sample resources BioSample; SAMN03470818
Chemistry resources ChEMBL-Cells; CHEMBL3308136
ChEMBL-Targets; CHEMBL1075492
Gene expression databases ArrayExpress; E-MTAB-3610
GEO; GSM1670064
Other Wikidata; Q54903193
Polymorphism and mutation databases Cosmic; 713899
Cosmic; 801605
Cosmic; 809120
Cosmic; 844821
Cosmic; 876157
Cosmic; 918006
Cosmic; 929159
Cosmic; 1239930
Cosmic; 1995494
Cosmic; 2125203
Cosmic; 2668339
IARC_TP53; 1015