ID   Lu-135
AC   CVCL_1389
SY   NCC-c-Lu-135; LU-135; LU135; Lu135
DR   CLO; CLO_0050030
DR   EFO; EFO_0002828
DR   ArrayExpress; E-MTAB-783
DR   ArrayExpress; E-MTAB-3610
DR   BioSample; SAMN03470818
DR   Cell_Model_Passport; SIDM00294
DR   CGH-DB; 91-1
DR   CGH-DB; 9061-4
DR   ChEMBL-Cells; CHEMBL3308136
DR   ChEMBL-Targets; CHEMBL1075492
DR   Cosmic; 713899
DR   Cosmic; 801605
DR   Cosmic; 809120
DR   Cosmic; 844821
DR   Cosmic; 876157
DR   Cosmic; 918006
DR   Cosmic; 929159
DR   Cosmic; 1239930
DR   Cosmic; 1995494
DR   Cosmic; 2125203
DR   Cosmic; 2668339
DR   Cosmic-CLP; 713899
DR   DepMap; ACH-001549
DR   EGA; EGAS00001000978
DR   GDSC; 713899
DR   GEO; GSM1670064
DR   IARC_TP53; 1015
DR   PharmacoDB; LU135_866_2019
DR   RCB; RCB0468
DR   Wikidata; Q54903193
RX   PubMed=1312700;
RX   PubMed=1847845;
RX   PubMed=3022030;
RX   PubMed=10536175;
RX   PubMed=11005564;
RX   PubMed=12107105;
RX   PubMed=19472407;
RX   PubMed=20164919;
RX   PubMed=20557307;
RX   PubMed=23716474;
RX   PubMed=27397505;
RX   PubMed=30894373;
CC   Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
CC   Part of: COSMIC cell lines project.
CC   Population: Japanese.
CC   Doubling time: 88 hours (PubMed=3022030).
CC   Microsatellite instability: Stable (MSS) (Sanger).
CC   Sequence variation: Mutation; HGNC; 11998; TP53; Simple; p.Gly244Cys (c.730G>T); ClinVar=VCV000376599; Zygosity=Unspecified (PubMed=1312700; PubMed=10536175; PubMed=20557307).
CC   Omics: Deep exome analysis.
CC   Omics: Deep RNAseq analysis.
CC   Omics: DNA methylation analysis.
CC   Omics: SNP array analysis.
CC   Omics: Transcriptome analysis.
CC   Genome ancestry: African=1.7%; Native American=0.34%; East Asian, North=77.4%; East Asian, South=17.05%; South Asian=0%; European, North=0%; European, South=3.52% (PubMed=30894373).
CC   Discontinued: JCRB; FDSC0039; true.
CC   Derived from sampling site: Lung.
ST   Source(s): Cosmic-CLP; DepMap; JCRB; RCB
ST   Amelogenin: X,Y
ST   CSF1PO: 10
ST   D13S317: 7
ST   D16S539: 11
ST   D18S51: 17,19
ST   D21S11: 29,30
ST   D3S1358: 17
ST   D5S818: 13
ST   D7S820: 11
ST   D8S1179: 11,15
ST   FGA: 22
ST   Penta D: 9,11
ST   Penta E: 11
ST   TH01: 9
ST   TPOX: 11
ST   vWA: 16
DI   NCIt; C4917; Lung small cell carcinoma
DI   ORDO; Orphanet_70573; Small cell lung cancer
OX   NCBI_TaxID=9606; ! Homo sapiens
SX   Male
AG   69Y
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 16-12-21; Version: 33
RX   PubMed=1312700;
RA   Sameshima Y., Matsuno Y., Hirohashi S., Shimosato Y., Mizoguchi H.,
RA   Sugimura T., Terada M., Yokota J.;
RT   "Alterations of the p53 gene are common and critical events for the
RT   maintenance of malignant phenotypes in small-cell lung carcinoma.";
RL   Oncogene 7:451-457(1992).
RX   PubMed=1847845; DOI=10.1007/BF00685110;
RA   Sasaki Y., Shinkai T., Eguchi K., Tamura T., Ohe Y., Ohmori T.,
RA   Saijo N.;
RT   "Prediction of the antitumor activity of new platinum analogs based on
RT   their ex vivo pharmacodynamics as determined by bioassay.";
RL   Cancer Chemother. Pharmacol. 27:263-270(1991).
RX   PubMed=3022030; DOI=10.1093/oxfordjournals.jjco.a039144;
RA   Terasaki T., Shimosato Y., Nakajima T., Tsumuraya M., Morinaga S.,
RA   Hirohashi S., Yamaguchi K., Kato K., Ichinose H., Nagatsu T.;
RT   "Changes in cell characteristics due to culture conditions in cell
RT   lines from human small cell lung cancer.";
RL   Jpn. J. Clin. Oncol. 16:203-212(1986).
RX   PubMed=10536175; DOI=10.3892/ijo.15.5.927;
RA   Fujita T., Kiyama M., Tomizawa Y., Kohno T., Yokota J.;
RT   "Comprehensive analysis of p53 gene mutation characteristics in lung
RT   carcinoma with special reference to histological subtypes.";
RL   Int. J. Oncol. 15:927-934(1999).
RX   PubMed=11005564; DOI=10.1038/sj.neo.7900094;
RA   Kohno T., Sato T., Takakura S., Takei K., Inoue K., Nishioka M.,
RA   Yokota J.;
RT   "Mutation and expression of the DCC gene in human lung cancer.";
RL   Neoplasia 2:300-305(2000).
RX   PubMed=12107105; DOI=10.1016/S0002-9440(10)64172-7;
RA   Yokoi S., Yasui K., Saito-Ohara F., Koshikawa K., Iizasa T.,
RA   Fujisawa T., Terasaki T., Horii A., Takahashi T., Hirohashi S.,
RA   Inazawa J.;
RT   "A novel target gene, SKP2, within the 5p13 amplicon that is
RT   frequently detected in small cell lung cancers.";
RL   Am. J. Pathol. 161:207-216(2002).
RX   PubMed=19472407; DOI=10.1002/humu.21028;
RA   Blanco R., Iwakawa R., Tang M., Kohno T., Angulo B., Pio R.,
RA   Montuenga L.M., Minna J.D., Yokota J., Sanchez-Cespedes M.;
RT   "A gene-alteration profile of human lung cancer cell lines.";
RL   Hum. Mutat. 30:1199-1206(2009).
RX   PubMed=20164919; DOI=10.1038/nature08768;
RA   Bignell G.R., Greenman C.D., Davies H., Butler A.P., Edkins S.,
RA   Andrews J.M., Buck G., Chen L., Beare D., Latimer C., Widaa S.,
RA   Hinton J., Fahey C., Fu B., Swamy S., Dalgliesh G.L., Teh B.T.,
RA   Deloukas P., Yang F., Campbell P.J., Futreal P.A., Stratton M.R.;
RT   "Signatures of mutation and selection in the cancer genome.";
RL   Nature 463:893-898(2010).
RX   PubMed=20557307; DOI=10.1111/j.1349-7006.2010.01622.x;
RA   Iwakawa R., Kohno T., Enari M., Kiyono T., Yokota J.;
RT   "Prevalence of human papillomavirus 16/18/33 infection and p53
RT   mutation in lung adenocarcinoma.";
RL   Cancer Sci. 101:1891-1896(2010).
RX   PubMed=23716474; DOI=10.1002/gcc.22076;
RA   Iwakawa R., Takenaka M., Kohno T., Shimada Y., Totoki Y., Shibata T.,
RA   Tsuta K., Nishikawa R., Noguchi M., Sato-Otsubo A., Ogawa S.,
RA   Yokota J.;
RT   "Genome-wide identification of genes with amplification and/or fusion
RT   in small cell lung cancer.";
RL   Genes Chromosomes Cancer 52:802-816(2013).
RX   PubMed=27397505; DOI=10.1016/j.cell.2016.06.017;
RA   Iorio F., Knijnenburg T.A., Vis D.J., Bignell G.R., Menden M.P.,
RA   Schubert M., Aben N., Goncalves E., Barthorpe S., Lightfoot H.,
RA   Cokelaer T., Greninger P., van Dyk E., Chang H., de Silva H., Heyn H.,
RA   Deng X.-M., Egan R.K., Liu Q.-S., Mironenko T., Mitropoulos X.,
RA   Richardson L., Wang J.-H., Zhang T.-H., Moran S., Sayols S.,
RA   Soleimani M., Tamborero D., Lopez-Bigas N., Ross-Macdonald P.,
RA   Esteller M., Gray N.S., Haber D.A., Stratton M.R., Benes C.H.,
RA   Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.;
RT   "A landscape of pharmacogenomic interactions in cancer.";
RL   Cell 166:740-754(2016).
RX   PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747;
RA   Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.;
RT   "An interactive resource to probe genetic diversity and estimated
RT   ancestry in cancer cell lines.";
RL   Cancer Res. 79:1263-1273(2019).