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Cellosaurus Lu-139 (CVCL_1390)

[Text version]

Cell line name Lu-139
Synonyms NCC-c-Lu-139; LU-139; Lu139; LU139
Accession CVCL_1390
Resource Identification Initiative To cite this cell line use: Lu-139 (RRID:CVCL_1390)
Comments Part of: Cancer Cell Line Encyclopedia (CCLE) project.
Part of: COSMIC cell lines project.
Doubling time: 29 hours (PubMed=3022030).
Microsatellite instability: Stable (MSS) (Sanger).
Omics: Deep exome analysis.
Omics: Deep proteome analysis.
Omics: Deep RNAseq analysis.
Omics: DNA methylation analysis.
Omics: SNP array analysis.
Omics: Transcriptome analysis.
Sequence variations TP53 p.Val157Phe (c.469G>T) (PubMed=1312700).
Genome ancestry Source: PubMed=30894373

Origin% genome
African1.34
Native American0
East Asian, North86.97
East Asian, South5.88
South Asian2.89
European, North2.93
European, South0
Disease Small cell lung carcinoma (NCIt: C4917)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Male
Age at sampling 63Y
Category Cancer cell line
STR profile Source(s): Cosmic-CLP; RCB

Markers:
AmelogeninX,Y
CSF1PO11
D5S81813
D7S82012
D13S31711
D16S5399
TH019
TPOX8,12
vWA17

Run an STR similarity search on this cell line
Publications

PubMed=3022030
Terasaki T., Shimosato Y., Nakajima T., Tsumuraya M., Morinaga S., Hirohashi S., Yamaguchi K., Kato K., Ichinose H., Nagatsu T.
Changes in cell characteristics due to culture conditions in cell lines from human small cell lung cancer.
Jpn. J. Clin. Oncol. 16:203-212(1986)

PubMed=1847845; DOI=10.1007/BF00685110
Sasaki Y., Shinkai T., Eguchi K., Tamura T., Ohe Y., Ohmori T., Saijo N.
Prediction of the antitumor activity of new platinum analogs based on their ex vivo pharmacodynamics as determined by bioassay.
Cancer Chemother. Pharmacol. 27:263-270(1991)

PubMed=1312700
Sameshima Y., Matsuno Y., Hirohashi S., Shimosato Y., Mizoguchi H., Sugimura T., Terada M., Yokota J.
Alterations of the p53 gene are common and critical events for the maintenance of malignant phenotypes in small-cell lung carcinoma.
Oncogene 7:451-457(1992)

PubMed=11005564; DOI=10.1038/sj.neo.7900094
Kohno T., Sato T., Takakura S., Takei K., Inoue K., Nishioka M., Yokota J.
Mutation and expression of the DCC gene in human lung cancer.
Neoplasia 2:300-305(2000)

PubMed=12107105; DOI=10.1016/S0002-9440(10)64172-7
Yokoi S., Yasui K., Saito-Ohara F., Koshikawa K., Iizasa T., Fujisawa T., Terasaki T., Horii A., Takahashi T., Hirohashi S., Inazawa J.
A novel target gene, SKP2, within the 5p13 amplicon that is frequently detected in small cell lung cancers.
Am. J. Pathol. 161:207-216(2002)

PubMed=19472407; DOI=10.1002/humu.21028
Blanco R., Iwakawa R., Tang M., Kohno T., Angulo B., Pio R., Montuenga L.M., Minna J.D., Yokota J., Sanchez-Cespedes M.
A gene-alteration profile of human lung cancer cell lines.
Hum. Mutat. 30:1199-1206(2009)

PubMed=20164919; DOI=10.1038/nature08768
Bignell G.R., Greenman C.D., Davies H., Butler A.P., Edkins S., Andrews J.M., Buck G., Chen L., Beare D., Latimer C., Widaa S., Hinton J., Fahey C., Fu B., Swamy S., Dalgliesh G.L., Teh B.T., Deloukas P., Yang F., Campbell P.J., Futreal P.A., Stratton M.R.
Signatures of mutation and selection in the cancer genome.
Nature 463:893-898(2010)

PubMed=23716474; DOI=10.1002/gcc.22076
Iwakawa R., Takenaka M., Kohno T., Shimada Y., Totoki Y., Shibata T., Tsuta K., Nishikawa R., Noguchi M., Sato-Otsubo A., Ogawa S., Yokota J.
Genome-wide identification of genes with amplification and/or fusion in small cell lung cancer.
Genes Chromosomes Cancer 52:802-816(2013)

PubMed=27397505; DOI=10.1016/j.cell.2016.06.017
Iorio F., Knijnenburg T.A., Vis D.J., Bignell G.R., Menden M.P., Schubert M., Aben N., Goncalves E., Barthorpe S., Lightfoot H., Cokelaer T., Greninger P., van Dyk E., Chang H., de Silva H., Heyn H., Deng X., Egan R.K., Liu Q., Mironenko T., Mitropoulos X., Richardson L., Wang J., Zhang T., Moran S., Sayols S., Soleimani M., Tamborero D., Lopez-Bigas N., Ross-Macdonald P., Esteller M., Gray N.S., Haber D.A., Stratton M.R., Benes C.H., Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.
A landscape of pharmacogenomic interactions in cancer.
Cell 166:740-754(2016)

PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747
Dutil J., Chen Z., Monteiro A.N., Teer J.K., Eschrich S.A.
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Cancer Res. 79:1263-1273(2019)

Cross-references
Cell line collections RCB; RCB0469
Cell line databases/resources CCLE; LU139_LUNG
Cell_Model_Passport; SIDM00293
CGH-DB; 93-1
CGH-DB; 9063-4
Cosmic-CLP; 713878
DepMap; ACH-002052
GDSC; 713878
LINCS_LDP; LCL-1872
Ontologies CLO; CLO_0050031
Biological sample resources BioSample; SAMN03472318
Chemistry resources ChEMBL-Cells; CHEMBL3308238
ChEMBL-Targets; CHEMBL2366248
PharmacoDB; LU139_867_2019
Gene expression databases ArrayExpress; E-MTAB-3610
GEO; GSM1670065
Other Wikidata; Q54903195
Polymorphism and mutation databases Cosmic; 713878
Cosmic; 801607
Cosmic; 809123
Cosmic; 844822
Cosmic; 876156
Cosmic; 918007
Cosmic; 929158
Cosmic; 1212195
Cosmic; 1239931
Cosmic; 1571751
Cosmic; 1995495
Cosmic; 2125268
Cosmic; 2668340
IARC_TP53; 1017
Proteomic databases PRIDE; PXD011896
Entry history
Entry creation04-Apr-2012
Last entry updated06-Sep-2019
Version number25