ID   Lu-165
AC   CVCL_1391
SY   LU-165; LU165
DR   CLO; CLO_0037024
DR   CLO; CLO_0050069
DR   ArrayExpress; E-MTAB-3610
DR   BioSample; SAMN03472172
DR   cancercelllines; CVCL_1391
DR   Cell_Model_Passport; SIDM00292
DR   CGH-DB; 99-1
DR   CGH-DB; 9067-4
DR   ChEMBL-Cells; CHEMBL3308239
DR   ChEMBL-Targets; CHEMBL2366132
DR   Cosmic; 753589
DR   Cosmic; 1212197
DR   Cosmic; 1571740
DR   Cosmic; 1995496
DR   Cosmic; 2125173
DR   Cosmic-CLP; 753589
DR   DepMap; ACH-002077
DR   EGA; EGAS00001000978
DR   GDSC; 753589
DR   GEO; GSM1670066
DR   IARC_TP53; 21481
DR   LINCS_LDP; LCL-1873
DR   PharmacoDB; LU165_868_2019
DR   PRIDE; PXD030304
DR   PubChem_Cell_line; CVCL_1391
DR   RCB; RCB1184
DR   Wikidata; Q54903204
RX   PubMed=8071114;
RX   PubMed=12107105;
RX   PubMed=20164919;
RX   PubMed=27397505;
RX   PubMed=30894373;
RX   PubMed=35839778;
CC   Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
CC   Part of: COSMIC cell lines project.
CC   Population: Indonesian.
CC   Characteristics: Produces high level of vasopressin.
CC   Microsatellite instability: Stable (MSS) (Sanger).
CC   Sequence variation: Mutation; HGNC; 9588; PTEN; Simple; p.Gly36Arg (c.106G>A); ClinVar=VCV001334551; Zygosity=Heterozygous (Cosmic-CLP; DepMap).
CC   Sequence variation: Mutation; HGNC; 11998; TP53; Simple; p.Val157Profs*9 (c.468_480delCGTCCGCGCCATG); Zygosity=Heterozygous (Cosmic-CLP; DepMap).
CC   Omics: Deep exome analysis.
CC   Omics: Deep quantitative proteome analysis.
CC   Omics: DNA methylation analysis.
CC   Omics: SNP array analysis.
CC   Omics: Transcriptome analysis by microarray.
CC   Genome ancestry: African=0%; Native American=0.53%; East Asian, North=28.73%; East Asian, South=70.74%; South Asian=0%; European, North=0%; European, South=0% (PubMed=30894373).
CC   Derived from site: Metastatic; Lymph node; UBERON=UBERON_0000027.
ST   Source(s): Cosmic-CLP; RCB
ST   Amelogenin: X,Y
ST   CSF1PO: 10,12
ST   D13S317: 10
ST   D16S539: 9,11
ST   D5S818: 9,13
ST   D7S820: 12
ST   TH01: 9
ST   TPOX: 8,9
ST   vWA: 16
DI   NCIt; C4917; Lung small cell carcinoma
DI   ORDO; Orphanet_70573; Small cell lung cancer
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Male
AG   50Y
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 05-10-23; Version: 36
//
RX   PubMed=8071114; DOI=10.1111/j.1349-7006.1994.tb02420.x;
RA   Terasaki T., Matsuno Y., Shimosato Y., Yamaguchi K., Ichinose H.,
RA   Nagatsu T., Kato K.;
RT   "Establishment of a human small cell lung cancer cell line producing a
RT   large amount of anti-diuretic hormone.";
RL   Jpn. J. Cancer Res. 85:718-722(1994).
//
RX   PubMed=12107105; DOI=10.1016/S0002-9440(10)64172-7;
RA   Yokoi S., Yasui K., Saito-Ohara F., Koshikawa K., Iizasa T.,
RA   Fujisawa T., Terasaki T., Horii A., Takahashi T., Hirohashi S.,
RA   Inazawa J.;
RT   "A novel target gene, SKP2, within the 5p13 amplicon that is
RT   frequently detected in small cell lung cancers.";
RL   Am. J. Pathol. 161:207-216(2002).
//
RX   PubMed=20164919; DOI=10.1038/nature08768;
RA   Bignell G.R., Greenman C.D., Davies H., Butler A.P., Edkins S.,
RA   Andrews J.M., Buck G., Chen L., Beare D., Latimer C., Widaa S.,
RA   Hinton J., Fahey C., Fu B.-Y., Swamy S., Dalgliesh G.L., Teh B.T.,
RA   Deloukas P., Yang F.-T., Campbell P.J., Futreal P.A., Stratton M.R.;
RT   "Signatures of mutation and selection in the cancer genome.";
RL   Nature 463:893-898(2010).
//
RX   PubMed=27397505; DOI=10.1016/j.cell.2016.06.017;
RA   Iorio F., Knijnenburg T.A., Vis D.J., Bignell G.R., Menden M.P.,
RA   Schubert M., Aben N., Goncalves E., Barthorpe S., Lightfoot H.,
RA   Cokelaer T., Greninger P., van Dyk E., Chang H., de Silva H., Heyn H.,
RA   Deng X.-M., Egan R.K., Liu Q.-S., Mironenko T., Mitropoulos X.,
RA   Richardson L., Wang J.-H., Zhang T.-H., Moran S., Sayols S.,
RA   Soleimani M., Tamborero D., Lopez-Bigas N., Ross-Macdonald P.,
RA   Esteller M., Gray N.S., Haber D.A., Stratton M.R., Benes C.H.,
RA   Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.;
RT   "A landscape of pharmacogenomic interactions in cancer.";
RL   Cell 166:740-754(2016).
//
RX   PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747;
RA   Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.;
RT   "An interactive resource to probe genetic diversity and estimated
RT   ancestry in cancer cell lines.";
RL   Cancer Res. 79:1263-1273(2019).
//
RX   PubMed=35839778; DOI=10.1016/j.ccell.2022.06.010;
RA   Goncalves E., Poulos R.C., Cai Z.-X., Barthorpe S., Manda S.S., Lucas N.,
RA   Beck A., Bucio-Noble D., Dausmann M., Hall C., Hecker M., Koh J.,
RA   Lightfoot H., Mahboob S., Mali I., Morris J., Richardson L.,
RA   Seneviratne A.J., Shepherd R., Sykes E., Thomas F., Valentini S.,
RA   Williams S.G., Wu Y.-X., Xavier D., MacKenzie K.L., Hains P.G., Tully B.,
RA   Robinson P.J., Zhong Q., Garnett M.J., Reddel R.R.;
RT   "Pan-cancer proteomic map of 949 human cell lines.";
RL   Cancer Cell 40:835-849.e8(2022).
//