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Cellosaurus Lu-65 (CVCL_1392)

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Cell line name Lu-65
Synonyms LU-65M; LU-65; LU65; Lu65; C-Lu-65; C-Lu65
Accession CVCL_1392
Resource Identification Initiative To cite this cell line use: Lu-65 (RRID:CVCL_1392)
Comments Part of: Cancer Cell Line Encyclopedia (CCLE) project.
Part of: COSMIC cell lines project.
Doubling time: 35-40 hours (lot 12162008), 21.7 hours (lot 101093), ~46 hours (lot 01192016) (JCRB).
Microsatellite instability: Stable (MSS) (Sanger).
Omics: Deep exome analysis.
Omics: Deep RNAseq analysis.
Omics: DNA methylation analysis.
Omics: SNP array analysis.
Omics: Transcriptome analysis.
Sequence variations EGFR p.Leu858Arg (c.2573T>G); in 10% of cells (PubMed=16105816).
KRAS p.Gly12Cys (c.34G>T) (PubMed=12068308).
Genome ancestry Source: PubMed=30894373

Origin% genome
African0
Native American0
East Asian, North79.97
East Asian, South18.08
South Asian0.48
European, North0.3
European, South1.17
Disease Lung giant cell carcinoma (NCIt: C4452)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Children:
CVCL_3012 (Lu-65A)CVCL_3013 (Lu-65B)CVCL_3014 (Lu-65C)
Sex of cell Male
Age at sampling 64Y
Category Cancer cell line
STR profile Source(s): Cosmic-CLP; JCRB; RCB; TKG

Markers:
AmelogeninX
CSF1PO10,13
D5S81812
D7S82011,12
D13S31710
D16S5399,11
TH016
TPOX8,11
vWA18 (Cosmic-CLP; JCRB; TKG)
17,18 (RCB)

Run an STR similarity search on this cell line
Publications

PubMed=7116286; DOI=10.1002/1097-0142(19821015)50:8<1518::AID-CNCR2820500812>3.0.CO;2-R
Anger B.R., Bockman R., Andreeff M., Erlandson R., Jhanwar S., Kameya T., Saigo P.E., Wright W., Beattie E.J. Jr., Oettgen H.F., Old L.J.
Characterization of two newly established human cell lines from patients with large-cell anaplastic lung carcinoma.
Cancer 50:1518-1529(1982)

PubMed=3935627; DOI=10.20772/cancersci1985.76.10_967
Yamada T., Hirohashi S., Shimosato Y., Kodama T., Hayashi S., Ogura T., Gamou S., Shimizu N.
Giant cell carcinomas of the lung producing colony-stimulating factor in vitro and in vivo.
Jpn. J. Cancer Res. 76:967-976(1985)

PubMed=9290701; DOI=10.1002/(SICI)1098-2744(199708)19:4<243::AID-MC5>3.0.CO;2-D
Jia L.-Q., Osada M., Ishioka C., Gamo M., Ikawa S., Suzuki T., Shimodaira H., Niitani T., Kudo T., Akiyama M., Kimura N., Matsuo M., Mizusawa H., Tanaka N., Koyama H., Namba M., Kanamaru R., Kuroki T.
Screening the p53 status of human cell lines using a yeast functional assay.
Mol. Carcinog. 19:243-253(1997)

PubMed=11005564; DOI=10.1038/sj.neo.7900094
Kohno T., Sato T., Takakura S., Takei K., Inoue K., Nishioka M., Yokota J.
Mutation and expression of the DCC gene in human lung cancer.
Neoplasia 2:300-305(2000)

PubMed=12068308; DOI=10.1038/nature00766
Davies H., Bignell G.R., Cox C., Stephens P., Edkins S., Clegg S., Teague J.W., Woffendin H., Garnett M.J., Bottomley W., Davis N., Dicks E., Ewing R., Floyd Y., Gray K., Hall S., Hawes R., Hughes J., Kosmidou V., Menzies A., Mould C., Parker A., Stevens C., Watt S., Hooper S., Wilson R., Jayatilake H., Gusterson B.A., Cooper C., Shipley J.M., Hargrave D., Pritchard-Jones K., Maitland N.J., Chenevix-Trench G., Riggins G.J., Bigner D.D., Palmieri G., Cossu A., Flanagan A.M., Nicholson A., Ho J.W.C., Leung S.Y., Yuen S.T., Weber B.L., Seigler H.F., Darrow T.L., Paterson H., Marais R., Marshall C.J., Wooster R., Stratton M.R., Futreal P.A.
Mutations of the BRAF gene in human cancer.
Nature 417:949-954(2002)

PubMed=12569360; DOI=10.1038/sj.onc.1206106
Funakoshi T., Tachibana I., Hoshida Y., Kimura H., Takeda Y., Kijima T., Nishino K., Goto H., Yoneda T., Kumagai T., Osaki T., Hayashi S., Aozasa K., Kawase I.
Expression of tetraspanins in human lung cancer cells: frequent downregulation of CD9 and its contribution to cell motility in small cell lung cancer.
Oncogene 22:674-687(2003)

PubMed=15746151; DOI=10.1093/hmg/ddi092
Izumi H., Inoue J., Yokoi S., Hosoda H., Shibata T., Sunamori M., Hirohashi S., Inazawa J., Imoto I.
Frequent silencing of DBC1 is by genetic or epigenetic mechanisms in non-small cell lung cancers.
Hum. Mol. Genet. 14:997-1007(2005)

PubMed=16105816; DOI=10.1158/0008-5472.CAN-05-0331
Nagai Y., Miyazawa H., Huqun X., Tanaka T., Udagawa K., Kato M., Fukuyama S., Yokote A., Kobayashi K., Kanazawa M., Hagiwara K.
Genetic heterogeneity of the epidermal growth factor receptor in non-small cell lung cancer cell lines revealed by a rapid and sensitive detection system, the peptide nucleic acid-locked nucleic acid PCR clamp.
Cancer Res. 65:7276-7282(2005)

PubMed=19472407; DOI=10.1002/humu.21028
Blanco R., Iwakawa R., Tang M., Kohno T., Angulo B., Pio R., Montuenga L.M., Minna J.D., Yokota J., Sanchez-Cespedes M.
A gene-alteration profile of human lung cancer cell lines.
Hum. Mutat. 30:1199-1206(2009)

PubMed=20164919; DOI=10.1038/nature08768
Bignell G.R., Greenman C.D., Davies H., Butler A.P., Edkins S., Andrews J.M., Buck G., Chen L., Beare D., Latimer C., Widaa S., Hinton J., Fahey C., Fu B., Swamy S., Dalgliesh G.L., Teh B.T., Deloukas P., Yang F., Campbell P.J., Futreal P.A., Stratton M.R.
Signatures of mutation and selection in the cancer genome.
Nature 463:893-898(2010)

PubMed=20215515; DOI=10.1158/0008-5472.CAN-09-3458
Rothenberg S.M., Mohapatra G., Rivera M.N., Winokur D., Greninger P., Nitta M., Sadow P.M., Sooriyakumar G., Brannigan B.W., Ulman M.J., Perera R.M., Wang R., Tam A., Ma X.-J., Erlander M., Sgroi D.C., Rocco J.W., Lingen M.W., Cohen E.E.W., Louis D.N., Settleman J., Haber D.A.
A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers.
Cancer Res. 70:2158-2164(2010)

PubMed=22460905; DOI=10.1038/nature11003
Barretina J.G., Caponigro G., Stransky N., Venkatesan K., Margolin A.A., Kim S., Wilson C.J., Lehar J., Kryukov G.V., Sonkin D., Reddy A., Liu M., Murray L., Berger M.F., Monahan J.E., Morais P., Meltzer J., Korejwa A., Jane-Valbuena J., Mapa F.A., Thibault J., Bric-Furlong E., Raman P., Shipway A., Engels I.H., Cheng J., Yu G.K., Yu J., Aspesi P. Jr., de Silva M., Jagtap K., Jones M.D., Wang L., Hatton C., Palescandolo E., Gupta S., Mahan S., Sougnez C., Onofrio R.C., Liefeld T., MacConaill L.E., Winckler W., Reich M., Li N., Mesirov J.P., Gabriel S.B., Getz G., Ardlie K., Chan V., Myer V.E., Weber B.L., Porter J., Warmuth M., Finan P., Harris J.L., Meyerson M., Golub T.R., Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.
The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.
Nature 483:603-607(2012)

PubMed=27397505; DOI=10.1016/j.cell.2016.06.017
Iorio F., Knijnenburg T.A., Vis D.J., Bignell G.R., Menden M.P., Schubert M., Aben N., Goncalves E., Barthorpe S., Lightfoot H., Cokelaer T., Greninger P., van Dyk E., Chang H., de Silva H., Heyn H., Deng X., Egan R.K., Liu Q., Mironenko T., Mitropoulos X., Richardson L., Wang J., Zhang T., Moran S., Sayols S., Soleimani M., Tamborero D., Lopez-Bigas N., Ross-Macdonald P., Esteller M., Gray N.S., Haber D.A., Stratton M.R., Benes C.H., Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.
A landscape of pharmacogenomic interactions in cancer.
Cell 166:740-754(2016)

PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747
Dutil J., Chen Z., Monteiro A.N., Teer J.K., Eschrich S.A.
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Cancer Res. 79:1263-1273(2019)

Cross-references
Cell line collections JCRB; JCRB0079
RCB; RCB1967
TKG; TKG 0442
Cell line databases/resources CCLE; LU65_LUNG
Cell_Model_Passport; SIDM00547
CGH-DB; 197-1
CGH-DB; 9183-4
Cosmic-CLP; 724863
GDSC; 724863
LINCS_LDP; LCL-1904
Ontologies CLO; CLO_0050059
Biological sample resources BioSample; SAMN03471065
BioSample; SAMN03472047
Chemistry resources ChEMBL-Cells; CHEMBL3308623
ChEMBL-Targets; CHEMBL614694
Gene expression databases ArrayExpress; E-MTAB-2770
ArrayExpress; E-MTAB-3610
GEO; GSM827382
GEO; GSM887282
GEO; GSM888357
GEO; GSM1670067
Other Wikidata; Q54903206
Polymorphism and mutation databases Cosmic; 713875
Cosmic; 716171
Cosmic; 724863
Cosmic; 733170
Cosmic; 801584
Cosmic; 808502
Cosmic; 809127
Cosmic; 844827
Cosmic; 876175
Cosmic; 889093
Cosmic; 917989
Cosmic; 929151
Cosmic; 932930
Cosmic; 946067
Cosmic; 1066164
Cosmic; 1219074
Cosmic; 1239918
Cosmic; 1571732
Cosmic; 1995497
Cosmic; 2125204
Cosmic; 2668333
Entry history
Entry creation04-Apr-2012
Last entry updated24-May-2019
Version number27