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Cellosaurus MC/CAR (CVCL_1397)

Cell line name MC/CAR
Synonyms MC-CAR; MCCAR
Accession CVCL_1397
Resource Identification Initiative To cite this cell line use: MC/CAR (RRID:CVCL_1397)
Comments Problematic cell line: Misidentified. Originally thought to be a myeloma cell line but is a B-lymphoblastoid cell line (PubMed=10516762).
Part of: Cancer Cell Line Encyclopedia (CCLE) project.
Part of: COSMIC cell lines project.
Characteristics: Produces IgG1 kappa.
Microsatellite instability: Stable (MSS) (Sanger).
Transformant: NCBI_TaxID; 10376; Epstein-Barr virus (EBV).
Omics: Deep exome analysis.
Omics: DNA methylation analysis.
Omics: SNP array analysis.
Omics: Transcriptome analysis.
Sequence variations Heterozygous for HRAS p.Gln61Arg (c.182A>G) (ATCC).
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Children:
CVCL_6671 (MC/CAR-Z2)
Sex of cell Male
Age at sampling 81Y
Category Transformed cell line
STR profile Source(s): ATCC; Cosmic-CLP

Markers:
AmelogeninX,Y
CSF1PO11,12
D13S31711,13
D16S53911,12
D5S81811,14
D7S8209,13
TH016,9
TPOX8
vWA17,18
Publications

Patent=US4434230
Ritts R.E. Jr.
Human nonsecretory plasmacytoid cell line.
Patent number US4434230, 28-Feb-1984

PubMed=2537114
Duperray C., Klein B., Durie B.G.M., Zhang X., Jourdan M., Poncelet P., Favier F., Vincent C., Brochier J., Lenoir G.M., Bataille R.
Phenotypic analysis of human myeloma cell lines.
Blood 73:566-572(1989)

PubMed=10516762; DOI=10.1038/sj.leu.2401510
Drexler H.G., Dirks W.G., MacLeod R.A.F.
False human hematopoietic cell lines: cross-contaminations and misinterpretations.
Leukemia 13:1601-1607(1999)

PubMed=10936422; DOI=10.1016/S0145-2126(99)00195-2
Drexler H.G., Matsuo Y.
Malignant hematopoietic cell lines: in vitro models for the study of multiple myeloma and plasma cell leukemia.
Leuk. Res. 24:681-703(2000)

PubMed=20215515; DOI=10.1158/0008-5472.CAN-09-3458
Rothenberg S.M., Mohapatra G., Rivera M.N., Winokur D., Greninger P., Nitta M., Sadow P.M., Sooriyakumar G., Brannigan B.W., Ulman M.J., Perera R.M., Wang R., Tam A., Ma X.-J., Erlander M., Sgroi D.C., Rocco J.W., Lingen M.W., Cohen E.E.W., Louis D.N., Settleman J., Haber D.A.
A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers.
Cancer Res. 70:2158-2164(2010)

PubMed=27397505; DOI=10.1016/j.cell.2016.06.017
Iorio F., Knijnenburg T.A., Vis D.J., Bignell G.R., Menden M.P., Schubert M., Aben N., Goncalves E., Barthorpe S., Lightfoot H., Cokelaer T., Greninger P., van Dyk E., Chang H., de Silva H., Heyn H., Deng X., Egan R.K., Liu Q., Mironenko T., Mitropoulos X., Richardson L., Wang J., Zhang T., Moran S., Sayols S., Soleimani M., Tamborero D., Lopez-Bigas N., Ross-Macdonald P., Esteller M., Gray N.S., Haber D.A., Stratton M.R., Benes C.H., Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.
A landscape of pharmacogenomic interactions in cancer.
Cell 166:740-754(2016)

Cross-references
Cell line collections ATCC; CRL-8083
IZSLER; BS TCL 134
Cell line databases/resources CLDB; cl5227
CCLE; MCCAR_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE
Cosmic-CLP; 683665
GDSC; 683665
IGRhCellID; MCCAR
LINCS_LDP; LCL-1538
Ontologies CLO; CLO_0007575
EFO; EFO_0002229
Biological sample resources BioSample; SAMN03471132
Chemistry resources ChEMBL-Cells; CHEMBL3308240
ChEMBL-Targets; CHEMBL2366274
Gene expression databases ArrayExpress; E-MTAB-3610
GEO; GSM1670075
Other Wikidata; Q54904190
Polymorphism and mutation databases Cosmic; 683665
Cosmic; 2131565