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Cellosaurus MFE-296 (CVCL_1406)

[Text version]

Cell line name MFE-296
Synonyms MFE 296; MFE296
Accession CVCL_1406
Resource Identification Initiative To cite this cell line use: MFE-296 (RRID:CVCL_1406)
Comments Part of: Cancer Cell Line Encyclopedia (CCLE) project.
Part of: COSMIC cell lines project.
Part of: MD Anderson Cell Lines Project.
Doubling time: ~50-60 hours (DSMZ).
Microsatellite instability: Instable (MSI-high) (PubMed=31068700; Sanger).
Omics: Deep exome analysis.
Omics: Deep RNAseq analysis.
Omics: DNA methylation analysis.
Omics: Protein expression by reverse-phase protein arrays.
Omics: SNP array analysis.
Omics: Transcriptome analysis.
Sequence variations Heterozygous for ERBB3 p.Cys186fs*20 (c.550delC) (CCLE; Cosmic-CLP).
Heterozygous for JAK1 p.Lys860fs*16 (c.2580delA) (CCLE; Cosmic-CLP).
Homozygous for PTEN p.Arg130Gln (c.389G>A) (CCLE; Cosmic-CLP).
Heterozygous for PTEN p.Thr321fs*23 (c.963delA) (CCLE; Cosmic-CLP).
Heterozygous for TP53 p.Tyr220Cys (c.659A>G) and p.Arg306Ter (c.916C>T) (CCLE; Cosmic-CLP).
Genome ancestry Source: PubMed=30894373

Origin% genome
African0
Native American0
East Asian, North0
East Asian, South0
South Asian0.72
European, North71.44
European, South27.84
Disease Endometrial adenocarcinoma (NCIt: C7359)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Female
Age at sampling 68Y
Category Cancer cell line
STR profile Source(s): Cosmic-CLP; DSMZ; ECACC

Markers:
AmelogeninX
CSF1PO10
D5S81811,12 (Cosmic-CLP; DSMZ)
11,13 (ECACC)
D7S8208,10
D13S3178,13
D16S53911,14
TH016,9.3
TPOX8
vWA14,18

Run an STR similarity search on this cell line
Web pages http://tcpaportal.org/mclp/
Publications

PubMed=8150529; DOI=10.1002/ijc.2910570121
Hackenberg R., Beck S., Filmer A., Hushmand Nia A., Kunzmann R., Koch M., Slater E.P., Schulz K.-D.
Androgen responsiveness of the new human endometrial cancer cell line MFE-296.
Int. J. Cancer 57:117-122(1994)

PubMed=9620227; DOI=10.1007/s004320050122
Hackenberg R., Hawighorst T., Hild F., Schulz K.-D.
Establishment of new epithelial carcinoma cell lines by blocking monolayer formation.
J. Cancer Res. Clin. Oncol. 123:669-673(1997)

PubMed=20164919; DOI=10.1038/nature08768
Bignell G.R., Greenman C.D., Davies H., Butler A.P., Edkins S., Andrews J.M., Buck G., Chen L., Beare D., Latimer C., Widaa S., Hinton J., Fahey C., Fu B., Swamy S., Dalgliesh G.L., Teh B.T., Deloukas P., Yang F., Campbell P.J., Futreal P.A., Stratton M.R.
Signatures of mutation and selection in the cancer genome.
Nature 463:893-898(2010)

PubMed=22460905; DOI=10.1038/nature11003
Barretina J.G., Caponigro G., Stransky N., Venkatesan K., Margolin A.A., Kim S., Wilson C.J., Lehar J., Kryukov G.V., Sonkin D., Reddy A., Liu M., Murray L., Berger M.F., Monahan J.E., Morais P., Meltzer J., Korejwa A., Jane-Valbuena J., Mapa F.A., Thibault J., Bric-Furlong E., Raman P., Shipway A., Engels I.H., Cheng J., Yu G.K., Yu J., Aspesi P. Jr., de Silva M., Jagtap K., Jones M.D., Wang L., Hatton C., Palescandolo E., Gupta S., Mahan S., Sougnez C., Onofrio R.C., Liefeld T., MacConaill L.E., Winckler W., Reich M., Li N., Mesirov J.P., Gabriel S.B., Getz G., Ardlie K., Chan V., Myer V.E., Weber B.L., Porter J., Warmuth M., Finan P., Harris J.L., Meyerson M., Golub T.R., Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.
The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.
Nature 483:603-607(2012)

PubMed=27397505; DOI=10.1016/j.cell.2016.06.017
Iorio F., Knijnenburg T.A., Vis D.J., Bignell G.R., Menden M.P., Schubert M., Aben N., Goncalves E., Barthorpe S., Lightfoot H., Cokelaer T., Greninger P., van Dyk E., Chang H., de Silva H., Heyn H., Deng X., Egan R.K., Liu Q., Mironenko T., Mitropoulos X., Richardson L., Wang J., Zhang T., Moran S., Sayols S., Soleimani M., Tamborero D., Lopez-Bigas N., Ross-Macdonald P., Esteller M., Gray N.S., Haber D.A., Stratton M.R., Benes C.H., Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.
A landscape of pharmacogenomic interactions in cancer.
Cell 166:740-754(2016)

PubMed=28196595; DOI=10.1016/j.ccell.2017.01.005
Li J., Zhao W., Akbani R., Liu W., Ju Z., Ling S., Vellano C.P., Roebuck P., Yu Q., Eterovic A.K., Byers L.A., Davies M.A., Deng W., Gopal Y.N.V., Chen G., von Euw E.M., Slamon D.J., Conklin D., Heymach J.V., Gazdar A.F., Minna J.D., Myers J.N., Lu Y., Mills G.B., Liang H.
Characterization of human cancer cell lines by reverse-phase protein arrays.
Cancer Cell 31:225-239(2017)

PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747
Dutil J., Chen Z., Monteiro A.N., Teer J.K., Eschrich S.A.
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Cancer Res. 79:1263-1273(2019)

PubMed=31068700; DOI=10.1038/s41586-019-1186-3
Ghandi M., Huang F.W., Jane-Valbuena J., Kryukov G.V., Lo C.C., McDonald E.R. III, Barretina J., Gelfand E.T., Bielski C.M., Li H., Hu K., Andreev-Drakhlin A.Y., Kim J., Hess J.M., Haas B.J., Aguet F., Weir B.A., Rothberg M.V., Paolella B.R., Lawrence M.S., Akbani R., Lu Y., Tiv H.L., Gokhale P.C., de Weck A., Mansour A.A., Oh C., Shih J., Hadi K., Rosen Y., Bistline J., Venkatesan K., Reddy A., Sonkin D., Liu M., Lehar J., Korn J.M., Porter D.A., Jones M.D., Golji J., Caponigro G., Taylor J.E., Dunning C.M., Creech A.L., Warren A.C., McFarland J.M., Zamanighomi M., Kauffmann A., Stransky N., Imielinski M., Maruvka Y.E., Cherniack A.D., Tsherniak A., Vazquez F., Jaffe J.D., Lane A.A., Weinstock D.M., Johannessen C.M., Morrissey M.P., Stegmeier F., Schlegel R., Hahn W.C., Getz G., Mills G.B., Boehm J.S., Golub T.R., Garraway L.A., Sellers W.R.
Next-generation characterization of the Cancer Cell Line Encyclopedia.
Nature 569:503-508(2019)

Cross-references
Cell line collections DSMZ; ACC-419
ECACC; 98031101
Cell line databases/resources CLDB; cl5081
CCLE; MFE296_ENDOMETRIUM
Cell_Model_Passport; SIDM00334
Cosmic-CLP; 908130
DepMap; ACH-000879
GDSC; 908130
LINCS_LDP; LCL-1501
Ontologies CLO; CLO_0007693
Biological sample resources BioSample; SAMN03473590
BioSample; SAMN10987797
Chemistry resources ChEMBL-Cells; CHEMBL3308374
ChEMBL-Targets; CHEMBL1075503
Gene expression databases ArrayExpress; E-MTAB-2770
ArrayExpress; E-MTAB-3610
GEO; GSM374975
GEO; GSM375434
GEO; GSM844604
GEO; GSM844605
GEO; GSM887312
GEO; GSM888388
GEO; GSM1670099
Other Wikidata; Q54905382
Polymorphism and mutation databases Cosmic; 908130
Cosmic; 1105621
Cosmic; 1177684
Cosmic; 1434195
Cosmic; 1576463
Cosmic; 2030479
IARC_TP53; 21496
LiGeA; CCLE_405
Entry history
Entry creation04-Apr-2012
Last entry updated05-Jul-2019
Version number23