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Cellosaurus MKN28 (CVCL_1416)

Cell line name MKN28
Synonyms MKN-28; MKN 28
Accession CVCL_1416
Resource Identification Initiative To cite this cell line use: MKN28 (RRID:CVCL_1416)
Comments Problematic cell line: Contaminated. Shown to be a MKN74 derivative (PubMed=20143388).
Part of: Cancer Cell Line Encyclopedia (CCLE) project.
Part of: COSMIC cell lines project.
Part of: JFCR39 cancer cell line panel.
Part of: JFCR45 cancer cell line panel.
Registration: International Cell Line Authentication Committee, Register of Misidentified Cell Lines; ICLAC-00328.
Doubling time: 28-32 hours (PubMed=3962675).
Microsatellite instability: Stable (MSS) (PubMed=23671654; Sanger).
Omics: Deep exome analysis.
Omics: DNA methylation analysis.
Omics: Transcriptome analysis.
Sequence variations TP53 p.Ile251Leu (c.751A>C) (PubMed=22490663).
HLA typing Source: PubMed=25960936
Class I
Class II
Disease Gastric tubular adenocarcinoma (NCIt: C5473)
Derived from metastatic site: Liver.
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_2791 (MKN74)
Sex of cell Male
Age at sampling 37Y
Category Cancer cell line
STR profile Source(s): Cosmic-CLP; JCRB; KCLB; RCB

Web pages http://cellbank.nibiohn.go.jp/legacy/cellbank/qualitycontrol/identification/summary.htm

PubMed=3962675; DOI=10.1111/j.1440-1827.1986.tb01461.x
Motoyama T., Hojo H., Watanabe H.
Comparison of seven cell lines derived from human gastric carcinomas.
Acta Pathol. Jpn. 36:65-83(1986)

PubMed=9290701; DOI=10.1002/(SICI)1098-2744(199708)19:4<243::AID-MC5>3.0.CO;2-D
Jia L.-Q., Osada M., Ishioka C., Gamo M., Ikawa S., Suzuki T., Shimodaira H., Niitani T., Kudo T., Akiyama M., Kimura N., Matsuo M., Mizusawa H., Tanaka N., Koyama H., Namba M., Kanamaru R., Kuroki T.
Screening the p53 status of human cell lines using a yeast functional assay.
Mol. Carcinog. 19:243-253(1997)

PubMed=11107048; DOI=10.1046/j.1440-1827.2000.01117.x
Yokozaki H.
Molecular characteristics of eight gastric cancer cell lines established in Japan.
Pathol. Int. 50:767-777(2000)

PubMed=15723654; DOI=10.1111/j.1349-7006.2005.00016.x
Takada H., Imoto I., Tsuda H., Sonoda I., Ichikura T., Mochizuki H., Okanoue T., Inazawa J.
Screening of DNA copy-number aberrations in gastric cancer cell lines by array-based comparative genomic hybridization.
Cancer Sci. 96:100-110(2005)

PubMed=15767549; DOI=10.1158/1535-7163.MCT-04-0234
Nakatsu N., Yoshida Y., Yamazaki K., Nakamura T., Dan S., Fukui Y., Yamori T.
Chemosensitivity profile of cancer cell lines and identification of genes determining chemosensitivity by an integrated bioinformatical approach using cDNA arrays.
Mol. Cancer Ther. 4:399-412(2005)

PubMed=20143388; DOI=10.1002/ijc.25242
Capes-Davis A., Theodosopoulos G., Atkin I., Drexler H.G., Kohara A., MacLeod R.A.F., Masters J.R.W., Nakamura Y., Reid Y.A., Reddel R.R., Freshney R.I.
Check your cultures! A list of cross-contaminated or misidentified cell lines.
Int. J. Cancer 127:1-8(2010)

PubMed=22336246; DOI=10.1016/j.bmc.2012.01.017
Kong D., Yamori T.
JFCR39, a panel of 39 human cancer cell lines, and its application in the discovery and development of anticancer drugs.
Bioorg. Med. Chem. 20:1947-1951(2012)

PubMed=22490663; DOI=10.1016/j.bbrc.2012.03.122
Saiki Y., Yoshino Y., Fujimura H., Manabe T., Kudo Y., Shimada M., Mano N., Nakano T., Lee Y., Shimizu S., Oba S., Fujiwara S., Shimizu H., Chen N., Nezhad Z.K., Jin G., Fukushige S., Sunamura M., Ishida M., Motoi F., Egawa S., Unno M., Horii A.
DCK is frequently inactivated in acquired gemcitabine-resistant human cancer cells.
Biochem. Biophys. Res. Commun. 421:98-104(2012)

PubMed=23671654; DOI=10.1371/journal.pone.0063056
Lu Y., Soong T.D., Elemento O.
A novel approach for characterizing microsatellite instability in cancer cells.
PLoS ONE 8:E63056-E63056(2013)

PubMed=25960936; DOI=10.4161/21624011.2014.954893
Boegel S., Lower M., Bukur T., Sahin U., Castle J.C.
A catalog of HLA type, HLA expression, and neo-epitope candidates in human cancer cell lines.
OncoImmunology 3:E954893-E954893(2014)

PubMed=27397505; DOI=10.1016/j.cell.2016.06.017
Iorio F., Knijnenburg T.A., Vis D.J., Bignell G.R., Menden M.P., Schubert M., Aben N., Goncalves E., Barthorpe S., Lightfoot H., Cokelaer T., Greninger P., van Dyk E., Chang H., de Silva H., Heyn H., Deng X., Egan R.K., Liu Q., Mironenko T., Mitropoulos X., Richardson L., Wang J., Zhang T., Moran S., Sayols S., Soleimani M., Tamborero D., Lopez-Bigas N., Ross-Macdonald P., Esteller M., Gray N.S., Haber D.A., Stratton M.R., Benes C.H., Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.
A landscape of pharmacogenomic interactions in cancer.
Cell 166:740-754(2016)

Cell line collections JCRB; JCRB0253
JCRB; NIHS0324 - Discontinued
JCRB; NIHS0325 - Discontinued
JCRB; FDSC0011 - Discontinued
KCLB; 80102
RCB; RCB1000 - Discontinued
Cell line databases/resources CCLE; MKN28_STOMACH
CGH-DB; 119-1
CGH-DB; 9021-4
Cosmic-CLP; 908139
GDSC; 908139
Ontologies BTO; BTO:0002381
EFO; EFO_0002831
Biological sample resources BioSample; SAMN03151847
Chemistry resources ChEMBL-Cells; CHEMBL3307602
ChEMBL-Targets; CHEMBL614353
Gene expression databases ArrayExpress; E-MTAB-3610
GEO; GSM562396
GEO; GSM1670112
Other Wikidata; Q54905823
Polymorphism and mutation databases Cosmic; 801338
Cosmic; 848146
Cosmic; 848371
Cosmic; 873710
Cosmic; 875905
Cosmic; 877041
Cosmic; 887249
Cosmic; 888826
Cosmic; 897534
Cosmic; 908139
Cosmic; 918496
Cosmic; 922694
Cosmic; 926113
Cosmic; 968348
Cosmic; 983726
Cosmic; 1066230
Cosmic; 1067208
Cosmic; 1090460
Cosmic; 1223588
Cosmic; 1436025
Cosmic; 1460710
Cosmic; 1482081
Cosmic; 1627264
Cosmic; 1995509
Cosmic; 2036660
Cosmic; 2069778