Cellosaurus ML-2 (CVCL_1418)

Cell line name ML-2
Synonyms ML2
Accession CVCL_1418
Resource Identification Initiative To cite this cell line use: ML-2 (RRID:CVCL_1418)
Comments Doubling time: ~60 hours (DSMZ).
Microsatellite instability: Stable (MSS) (Sanger).
Sequence variation: KRAS p.Ala146Thr (PubMed=16969076).
Omics: Deep exome analysis.
Omics: Deep RNAseq analysis.
Omics: DNA methylation analysis.
Omics: SNP array analysis.
Omics: Transcriptome analysis.
Derived from sampling site: Peripheral blood.
Disease Adult acute myeloid leukemia (NCIt: C9154)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Originate from same individual CVCL_0436 ! ML-1 [Human leukemia]
CVCL_H526 ! ML-3
Sex of cell Male
Category Cancer cell line
STR profile Source(s): Cosmic-CLP; DSMZ; PubMed=25877200

Markers:
AmelogeninX
CSF1PO10,11
D13S3179,12
D16S5399,12
D18S5115,18
D21S1129
D3S135815
D5S81812
D7S8209,11
D8S11798,13
FGA23,25
Penta D12
Penta E5,7
TH017,9.3
TPOX8,10
vWA16
Publications

PubMed=6091813
Palumbo A., Minowada J., Erikson J., Croce C.M., Rovera G.
Lineage infidelity of a human myelogenous leukemia cell line.
Blood 64:1059-1063(1984)

PubMed=3458526
Ohyashiki K., Ohyashiki J.H., Sandberg A.A.
Cytogenetic characterization of putative human myeloblastic leukemia cell lines (ML-1, -2, and -3): origin of the cells.
Cancer Res. 46:3642-3647(1986)

PubMed=14671638; DOI=10.1038/sj.leu.2403236
Drexler H.G., Quentmeier H., MacLeod R.A.F.
Malignant hematopoietic cell lines: in vitro models for the study of MLL gene alterations.
Leukemia 18:227-232(2004)

PubMed=15843827; DOI=10.1038/sj.leu.2403749
Andersson A., Eden P., Lindgren D., Nilsson J., Lassen C., Heldrup J., Fontes M., Borg A., Mitelman F., Johansson B., Hoglund M., Fioretos T.
Gene expression profiling of leukemic cell lines reveals conserved molecular signatures among subtypes with specific genetic aberrations.
Leukemia 19:1042-1050(2005)

PubMed=16408098; DOI=10.1038/sj.leu.2404081
Quentmeier H., MacLeod R.A.F., Zaborski M., Drexler H.G.
JAK2 V617F tyrosine kinase mutation in cell lines derived from myeloproliferative disorders.
Leukemia 20:471-476(2006)

PubMed=16969076; DOI=10.4161/cbt.5.8.3251
Edkins S., O'Meara S., Parker A., Stevens C., Reis M., Jones S., Greenman C., Davies H., Dalgliesh G., Forbes S., Hunter C., Smith R., Stephens P., Goldstraw P., Nicholson A., Chan T.L., Velculescu V.E., Yuen S.T., Leung S.Y., Stratton M.R., Futreal P.A.
Recurrent KRAS codon 146 mutations in human colorectal cancer.
Cancer Biol. Ther. 5:928-932(2006)

PubMed=25485619; DOI=10.1038/nbt.3080
Klijn C., Durinck S., Stawiski E.W., Haverty P.M., Jiang Z., Liu H., Degenhardt J., Mayba O., Gnad F., Liu J., Pau G., Reeder J., Cao Y., Mukhyala K., Selvaraj S.K., Yu M., Zynda G.J., Brauer M.J., Wu T.D., Gentleman R.C., Manning G., Yauch R.L., Bourgon R., Stokoe D., Modrusan Z., Neve R.M., de Sauvage F.J., Settleman J., Seshagiri S., Zhang Z.
A comprehensive transcriptional portrait of human cancer cell lines.
Nat. Biotechnol. 33:306-312(2015)

PubMed=27397505; DOI=10.1016/j.cell.2016.06.017
Iorio F., Knijnenburg T.A., Vis D.J., Bignell G.R., Menden M.P., Schubert M., Aben N., Goncalves E., Barthorpe S., Lightfoot H., Cokelaer T., Greninger P., van Dyk E., Chang H., de Silva H., Heyn H., Deng X., Egan R.K., Liu Q., Mironenko T., Mitropoulos X., Richardson L., Wang J., Zhang T., Moran S., Sayols S., Soleimani M., Tamborero D., Lopez-Bigas N., Ross-Macdonald P., Esteller M., Gray N.S., Haber D.A., Stratton M.R., Benes C.H., Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.
A landscape of pharmacogenomic interactions in cancer.
Cell 166:740-754(2016)

Cross-references
Cell line collections DSMZ; ACC-15
Cell line databases/resources CLDB; cl3490
Cosmic-CLP; 908141
GDSC; 908141
IGRhCellID; ML2
LINCS_LDP; LCL-1060
Ontologies BTO; BTO:0001885
CLO; CLO_0007736
EFO; EFO_0002238
Biological sample resources BioSample; SAMN03472168
Chemistry resources ChEMBL-Cells; CHEMBL3307604
ChEMBL-Targets; CHEMBL614356
Gene expression databases GEO; GSM236791
GEO; GSM236827
GEO; GSM482497
GEO; GSM1374683
GEO; GSM1446737
GEO; GSM1670116
Polymorphism and mutation databases Cosmic; 787454
Cosmic; 908141
Cosmic; 975271
Cosmic; 999728
Cosmic; 1012092
Cosmic; 1078727
Cosmic; 1078739
Cosmic; 1151785
Cosmic; 1181602
Cosmic; 1281329
Cosmic; 1524834
Cosmic; 2131545
Cosmic; 2391904