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Cellosaurus MOLT-14 (CVCL_1423)

[Text version]
Cell line name MOLT-14
Synonyms Molt-14; MOLT 14; Molt 14; MOLT14; Molt14
Accession CVCL_1423
Resource Identification Initiative To cite this cell line use: MOLT-14 (RRID:CVCL_1423)
Comments Population: Caucasian.
Doubling time: ~40-50 hours (DSMZ=ACC-437).
Microsatellite instability: Stable (MSS) (PubMed=10739008; PubMed=11226526).
Omics: Deep quantitative proteome analysis.
Omics: Transcriptome analysis by RNAseq.
Derived from site: In situ; Bone marrow; UBERON=UBERON_0002371.
Cell type: T-cell; CL=CL_0000084.
Disease Childhood T acute lymphoblastic leukemia (NCIt: C7953)
Precursor T-cell acute lymphoblastic leukemia (ORDO: Orphanet_99861)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Originate from same individual CVCL_8151 ! MOLT-12
CVCL_1422 ! MOLT-13
Sex of cell Female
Age at sampling 2Y
Category Cancer cell line
STR profile Source(s): DSMZ

Markers:
AmelogeninX
CSF1PO11,13
D2S133819,24
D3S135815,16
D5S81811,12
D7S82010,13
D8S117910,13
D13S31711,12,13
D16S5399,11
D18S5117,18
D19S43314
D21S1128,30
FGA19,22,23
Penta D9,13
Penta E7,12
TH018,9.3
TPOX8
vWA17,18,19

Run an STR similarity search on this cell line
Publications

PubMed=2784121; DOI=10.1002/hon.2900070203
Drexler H.G., Minowada J.
Morphological, immunophenotypical and isoenzymatic profiles of human leukemia cells and derived T-cell lines.
Hematol. Oncol. 7:115-125(1989)

PubMed=10739008; DOI=10.1016/S0145-2126(99)00182-4
Inoue K., Kohno T., Takakura S., Hayashi Y., Mizoguchi H., Yokota J.
Frequent microsatellite instability and BAX mutations in T cell acute lymphoblastic leukemia cell lines.
Leuk. Res. 24:255-262(2000)

DOI=10.1016/B978-0-12-221970-2.50457-5
Drexler H.G.
The leukemia-lymphoma cell line factsbook.
(In) ISBN 9780122219702; pp.1-733; Academic Press; London (2001)

PubMed=11226526; DOI=10.1016/S0145-2126(00)00121-1
Inoue K., Kohno T., Takakura S., Hayashi Y., Mizoguchi H., Yokota J.
Corrigendum to: Frequent microsatellite instability and BAX mutations in T cell acute lymphoblastic leukemia cell lines Leukemia Research 24 (2000),255-262.
Leuk. Res. 25:275-278(2001)

PubMed=35354797; DOI=10.1038/s41467-022-29224-5
Leo I.R., Aswad L., Stahl M., Kunold E., Post F., Erkers T., Struyf N., Mermelekas G., Joshi R.N., Gracia-Villacampa E., Ostling P., Kallioniemi O.-P., Pokrovskaja Tamm K., Siavelis I., Lehtio J., Vesterlund M., Jafari R.
Integrative multi-omics and drug response profiling of childhood acute lymphoblastic leukemia cell lines.
Nat. Commun. 13:1691.1-1691.19(2022)

Cross-references
Cell line collections (Providers) DSMZ; ACC-437
Cell line databases/resources CLO; CLO_0007821
cancercelllines; CVCL_1423
Cell_Model_Passport; SIDM00432
DSMZCellDive; ACC-437
LINCS_LDP; LCL-2061
Anatomy/cell type resources BTO; BTO:0004172
Biological sample resources BioSample; SAMN03473544
Encyclopedic resources Wikidata; Q54906345
Gene expression databases GEO; GSM5137761
Polymorphism and mutation databases Cosmic; 998729
Cosmic; 1037682
Cosmic; 1281379
Cosmic; 1330490
Cosmic; 2602926
Proteomic databases PRIDE; PXD023662
Entry history
Entry creation04-Apr-2012
Last entry update05-Oct-2023
Version number23