Cellosaurus MOLT-16 (CVCL_1424)

Cell line name MOLT-16
Synonyms Molt-16; MOLT 16; MOLT16; Molt16
Accession CVCL_1424
Resource Identification Initiative To cite this cell line use: MOLT-16 (RRID:CVCL_1424)
Comments Part of: Cancer Cell Line Encyclopedia (CCLE) project.
Doubling time: ~30 hours (DSMZ).
Microsatellite instability: Instable (MSI-low) (Sanger).
Omics: Deep exome analysis.
Omics: DNA methylation analysis.
Omics: SNP array analysis.
Omics: Transcriptome analysis.
Derived from sampling site: Peripheral blood.
Disease Childhood T acute lymphoblastic leukemia (NCIt: C7953)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Originate from same individual CVCL_2125 ! MOLT-17
Sex of cell Female
Category Cancer cell line
STR profile Source(s): Cosmic-CLP; DSMZ

Markers:
AmelogeninX
CSF1PO11,12
D13S31712
D16S5399,10
D5S81811,12
D7S82012
TH019,9.3
TPOX8,11
vWA16
Publications

PubMed=2784121; DOI=10.1002/hon.2900070203
Drexler H.G., Minowada J.
Morphological, immunophenotypical and isoenzymatic profiles of human leukemia cells and derived T-cell lines.
Hematol. Oncol. 7:115-125(1989)

PubMed=9408752; DOI=10.1002/(SICI)1098-2264(199712)20:4<363::AID-GCC7>3.0.CO;2-#
Shima-Rich E.A., Harden A.M., McKeithan T.W., Rowley J.D., Diaz M.O.
Molecular analysis of the t(8;14)(q24;q11) chromosomal breakpoint junctions in the T-cell leukemia line MOLT-16.
Genes Chromosomes Cancer 20:363-371(1997)

PubMed=9933131; DOI=10.1016/S0145-2126(98)00133-7
Burger R., Hansen-Hagge T.E., Drexler H.G., Gramatzki M.
Heterogeneity of T-acute lymphoblastic leukemia (T-ALL) cell lines: suggestion for classification by immunophenotype and T-cell receptor studies.
Leuk. Res. 23:19-27(1999)

PubMed=15843827; DOI=10.1038/sj.leu.2403749
Andersson A., Eden P., Lindgren D., Nilsson J., Lassen C., Heldrup J., Fontes M., Borg A., Mitelman F., Johansson B., Hoglund M., Fioretos T.
Gene expression profiling of leukemic cell lines reveals conserved molecular signatures among subtypes with specific genetic aberrations.
Leukemia 19:1042-1050(2005)

PubMed=22460905; DOI=10.1038/nature11003
Barretina J.G., Caponigro G., Stransky N., Venkatesan K., Margolin A.A., Kim S., Wilson C.J., Lehar J., Kryukov G.V., Sonkin D., Reddy A., Liu M., Murray L., Berger M.F., Monahan J.E., Morais P., Meltzer J., Korejwa A., Jane-Valbuena J., Mapa F.A., Thibault J., Bric-Furlong E., Raman P., Shipway A., Engels I.H., Cheng J., Yu G.K., Yu J., Aspesi P. Jr., de Silva M., Jagtap K., Jones M.D., Wang L., Hatton C., Palescandolo E., Gupta S., Mahan S., Sougnez C., Onofrio R.C., Liefeld T., MacConaill L., Winckler W., Reich M., Li N., Mesirov J.P., Gabriel S.B., Getz G., Ardlie K., Chan V., Myer V.E., Weber B.L., Porter J., Warmuth M., Finan P., Harris J.L., Meyerson M., Golub T.R., Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.
The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.
Nature 483:603-607(2012)

PubMed=22675565; DOI=10.1371/journal.pone.0038463
Kalender Atak Z., De Keersmaecker K., Gianfelici V., Geerdens E., Vandepoel R., Pauwels D., Porcu M., Lahortiga I., Brys V., Dirks W.G., Quentmeier H., Cloos J., Cuppens H., Uyttebroeck A., Vandenberghe P., Cools J., Aerts S.
High accuracy mutation detection in leukemia on a selected panel of cancer genes.
PLoS ONE 7:E38463-E38463(2012)

PubMed=27397505; DOI=10.1016/j.cell.2016.06.017
Iorio F., Knijnenburg T.A., Vis D.J., Bignell G.R., Menden M.P., Schubert M., Aben N., Goncalves E., Barthorpe S., Lightfoot H., Cokelaer T., Greninger P., van Dyk E., Chang H., de Silva H., Heyn H., Deng X., Egan R.K., Liu Q., Mironenko T., Mitropoulos X., Richardson L., Wang J., Zhang T., Moran S., Sayols S., Soleimani M., Tamborero D., Lopez-Bigas N., Ross-Macdonald P., Esteller M., Gray N.S., Haber D.A., Stratton M.R., Benes C.H., Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.
A landscape of pharmacogenomic interactions in cancer.
Cell 166:740-754(2016)

Cross-references
Cell line collections DSMZ; ACC-29
Cell line databases/resources CLDB; cl3516
CCLE; MOLT16_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE
Cosmic-CLP; 908147
GDSC; 908147
IGRhCellID; MOLT16
LINCS_LDP; LCL-1018
Lonza; 2
Ontologies BTO; BTO:0004173
EFO; EFO_0002239
Biological sample resources BioSample; SAMN03473343
Chemistry resources ChEMBL-Cells; CHEMBL3308271
ChEMBL-Targets; CHEMBL2366362
Gene expression databases GEO; GSM887335
GEO; GSM888411
GEO; GSM1670127
Polymorphism and mutation databases Cosmic; 908147
Cosmic; 913425
Cosmic; 919155
Cosmic; 922678
Cosmic; 998725
Cosmic; 1115601
Cosmic; 1151787
Cosmic; 1226859
Cosmic; 1281380
Cosmic; 1330491
Cosmic; 1641382
Cosmic; 1760528
Cosmic; 2458764
Cosmic; 2462862
Cosmic; 2602927