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Cellosaurus Mono-Mac-1 (CVCL_1425)

[Text version]

Cell line name Mono-Mac-1
Synonyms MONO-MAC-1; Mono Mac 1; Monomac-1; MONOMAC-1; MonoMac1; MONOMAC1; MM1
Accession CVCL_1425
Resource Identification Initiative To cite this cell line use: Mono-Mac-1 (RRID:CVCL_1425)
Comments Part of: Cancer Cell Line Encyclopedia (CCLE) project.
Doubling time: 40 hours (PubMed=25984343); ~30-50 hours (DSMZ).
Omics: Deep RNAseq analysis.
Omics: shRNA library screening.
Omics: SNP array analysis.
Omics: Transcriptome analysis.
Derived from sampling site: Peripheral blood.
Sequence variations TP53 p.Arg273His (c.818G>A) (PubMed=16142349).
Genome ancestry Source: PubMed=30894373

Origin% genome
African1.61
Native American0.46
East Asian, North2.85
East Asian, South0
South Asian0
European, North54.45
European, South40.63
Disease Adult acute monocytic leukemia (NCIt: C8263)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Originate from same individual CVCL_1426 ! Mono-Mac-6
Sex of cell Male
Age at sampling 64Y
Category Cancer cell line
STR profile Source(s): DSMZ

Markers:
AmelogeninX,Y
CSF1PO11,12
D5S81811,12
D7S82010,11
D13S31711,12
D16S53912
TH018,9.3
TPOX8,10
vWA16,17

Run an STR similarity search on this cell line
Publications

DOI=10.1007/978-1-4757-1647-4_13
Biedler J.L.
Chromosome abnormalities in human tumor cells in culture.
(In) Human tumor cells in vitro; Fogh J. (eds.); pp.359-394; Springer; New York (1975)

PubMed=3162233; DOI=10.1002/ijc.2910410324
Ziegler-Heitbrock H.W., Thiel E., Futterer A., Herzog V., Wirtz A., Riethmuller G.
Establishment of a human cell line (Mono Mac 6) with characteristics of mature monocytes.
Int. J. Cancer 41:456-461(1988)

PubMed=9150350; DOI=10.1016/S0145-2126(96)00129-4
Steube K.G., Teepe D., Meyer C., Zaborski M., Drexler H.G.
A model system in haematology and immunology: the human monocytic cell line MONO-MAC-1.
Leuk. Res. 21:327-335(1997)

PubMed=11129653; DOI=10.1189/jlb.68.6.854
Genois N., Robichaud G.A., Tremblay M.J.
Mono Mac 1: a new in vitro model system to study HIV-1 infection in human cells of the mononuclear phagocyte series.
J. Leukoc. Biol. 68:854-864(2000)

PubMed=16142349; DOI=10.3892/or.14.4.901
Smardova J., Pavlova S., Svitakova M., Grochova D., Ravcukova B.
Analysis of p53 status in human cell lines using a functional assay in yeast: detection of new non-sense p53 mutation in codon 124.
Oncol. Rep. 14:901-907(2005)

PubMed=22460905; DOI=10.1038/nature11003
Barretina J.G., Caponigro G., Stransky N., Venkatesan K., Margolin A.A., Kim S., Wilson C.J., Lehar J., Kryukov G.V., Sonkin D., Reddy A., Liu M., Murray L., Berger M.F., Monahan J.E., Morais P., Meltzer J., Korejwa A., Jane-Valbuena J., Mapa F.A., Thibault J., Bric-Furlong E., Raman P., Shipway A., Engels I.H., Cheng J., Yu G.K., Yu J., Aspesi P. Jr., de Silva M., Jagtap K., Jones M.D., Wang L., Hatton C., Palescandolo E., Gupta S., Mahan S., Sougnez C., Onofrio R.C., Liefeld T., MacConaill L.E., Winckler W., Reich M., Li N., Mesirov J.P., Gabriel S.B., Getz G., Ardlie K., Chan V., Myer V.E., Weber B.L., Porter J., Warmuth M., Finan P., Harris J.L., Meyerson M., Golub T.R., Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.
The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.
Nature 483:603-607(2012)

PubMed=25984343; DOI=10.1038/sdata.2014.35
Cowley G.S., Weir B.A., Vazquez F., Tamayo P., Scott J.A., Rusin S., East-Seletsky A., Ali L.D., Gerath W.F.J., Pantel S.E., Lizotte P.H., Jiang G., Hsiao J., Tsherniak A., Dwinell E., Aoyama S., Okamoto M., Harrington W., Gelfand E., Green T.M., Tomko M.J., Gopal S., Wong T.C., Li H., Howell S., Stransky N., Liefeld T., Jang D., Bistline J., Hill Meyers B., Armstrong S.A., Anderson K.C., Stegmaier K., Reich M., Pellman D., Boehm J.S., Mesirov J.P., Golub T.R., Root D.E., Hahn W.C.
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies.
Sci. Data 1:140035-140035(2014)

PubMed=27397505; DOI=10.1016/j.cell.2016.06.017
Iorio F., Knijnenburg T.A., Vis D.J., Bignell G.R., Menden M.P., Schubert M., Aben N., Goncalves E., Barthorpe S., Lightfoot H., Cokelaer T., Greninger P., van Dyk E., Chang H., de Silva H., Heyn H., Deng X., Egan R.K., Liu Q., Mironenko T., Mitropoulos X., Richardson L., Wang J., Zhang T., Moran S., Sayols S., Soleimani M., Tamborero D., Lopez-Bigas N., Ross-Macdonald P., Esteller M., Gray N.S., Haber D.A., Stratton M.R., Benes C.H., Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.
A landscape of pharmacogenomic interactions in cancer.
Cell 166:740-754(2016)

PubMed=30285677; DOI=10.1186/s12885-018-4840-5
Tan K.-T., Ding L.-W., Sun Q.-Y., Lao Z.-T., Chien W., Ren X., Xiao J.-F., Loh X.-Y., Xu L., Lill M., Mayakonda A., Lin D.-C., Yang H., Koeffler H.P.
Profiling the B/T cell receptor repertoire of lymphocyte derived cell lines.
BMC Cancer 18:940-940(2018)

PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747
Dutil J., Chen Z., Monteiro A.N., Teer J.K., Eschrich S.A.
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Cancer Res. 79:1263-1273(2019)

Cross-references
Cell line collections DSMZ; ACC-252
Cell line databases/resources CLDB; cl3534
CCLE; MONOMAC1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE
Cell_Model_Passport; SIDM01022
LINCS_LDP; LCL-1062
Lonza; 715
Ontologies BTO; BTO:0003928
CLO; CLO_0007827
Biological sample resources BioSample; SAMN03473331
Gene expression databases ArrayExpress; E-MTAB-2770
ArrayExpress; E-MTAB-3610
GEO; GSM482510
GEO; GSM887337
GEO; GSM888413
GEO; GSM1670129
Other Wikidata; Q54906377
Polymorphism and mutation databases Cosmic; 787458
Cosmic; 1089515
IARC_TP53; 21702
Entry history
Entry creation04-Apr-2012
Last entry updated24-May-2019
Version number23