Cell line name | Mono-Mac-6 | ||||||||||||||||||
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Synonyms | MONO-MAC-6; Mono-mac-6; MONO-MAC 6; Mono Mac 6; Mono Mac6; MonoMac 6; MonoMac6; MONOMAC6; MM6 | ||||||||||||||||||
Accession | CVCL_1426 | ||||||||||||||||||
Resource Identification Initiative | To cite this cell line use: Mono-Mac-6 (RRID:CVCL_1426) | ||||||||||||||||||
Comments | Part of: Cancer Cell Line Encyclopedia (CCLE) project. Part of: COSMIC cell lines project. Part of: LL-100 blood cancer cell line panel. Doubling time: 40 hours (PubMed=25984343); ~60 hours (DSMZ). Microsatellite instability: Stable (MSS) (Sanger). Omics: Deep exome analysis. Omics: Deep quantitative proteome analysis. Omics: Deep RNAseq analysis. Omics: DNA methylation analysis. Omics: shRNA library screening. Omics: SNP array analysis. Omics: Transcriptome analysis. Derived from sampling site: Peripheral blood. | ||||||||||||||||||
Sequence variations | Gene fusion; KMT2A-MLLT3 (MLL-MLLT3; MLL-AF9) (PubMed=7833491; PubMed=14671638).Gene fusion; RUNX1-ATP8A2 (PubMed=31160637).TP53 p.Arg273His (c.818G>A) (ClinVar=VCV000012366) (from autologous cell line). | ||||||||||||||||||
Genome ancestry | Source: PubMed=30894373
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Disease | Adult acute monocytic leukemia (NCIt: C8263) Acute monoblastic/monocytic leukemia (ORDO: Orphanet_514) | ||||||||||||||||||
Species of origin | Homo sapiens (Human)
(NCBI Taxonomy: 9606)
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Originate from same individual | CVCL_1425 ! Mono-Mac-1 | ||||||||||||||||||
Sex of cell | Male | ||||||||||||||||||
Age at sampling | 64Y | ||||||||||||||||||
Category | Cancer cell line | ||||||||||||||||||
STR profile | Source(s): Cosmic-CLP; DSMZ Markers:
Run an STR similarity search on this cell line | ||||||||||||||||||
Web pages | http://www.cells-talk.com/index.php/page/copelibrary?key=Mono%20Mac%206 http://www.infarktforschung.de/macrophages_cell_lines.html http://www.thermofisher.com/ch/en/home/technical-resources/cell-lines/m/cell-lines-detail-121.html | ||||||||||||||||||
Publications | PubMed=3162233; DOI=10.1002/ijc.2910410324 PubMed=7833491; DOI=10.1182/blood.V85.3.855.bloodjournal853855 DOI=10.1016/B978-0-12-221970-2.50457-5 PubMed=14671638; DOI=10.1038/sj.leu.2403236 PubMed=15843827; DOI=10.1038/sj.leu.2403749 PubMed=16408098; DOI=10.1038/sj.leu.2404081 PubMed=20164919; DOI=10.1038/nature08768 PubMed=22460905; DOI=10.1038/nature11003 PubMed=25984343; DOI=10.1038/sdata.2014.35 PubMed=27397505; DOI=10.1016/j.cell.2016.06.017 PubMed=30285677; DOI=10.1186/s12885-018-4840-5 PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747 PubMed=31068700; DOI=10.1038/s41586-019-1186-3 PubMed=31160637; DOI=10.1038/s41598-019-44491-x PubMed=31978347; DOI=10.1016/j.cell.2019.12.023 | ||||||||||||||||||
Cross-references | |||||||||||||||||||
Cell line collections | BCRJ; 0373
DSMZ; ACC-124 ICLC; HTL01015 | ||||||||||||||||||
Cell line databases/resources | CLDB; cl3535
CLDB; cl7057 CCLE; MONOMAC6_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE Cell_Model_Passport; SIDM01023 Cosmic-CLP; 908148 DepMap; ACH-000006 LINCS_LDP; LCL-1063 Lonza; 4 | ||||||||||||||||||
Ontologies | BTO; BTO:0002333
CLO; CLO_0007828 EFO; EFO_0006287 | ||||||||||||||||||
Biological sample resources | BioSample; SAMN03473411
BioSample; SAMN10988430 | ||||||||||||||||||
Chemistry resources | ChEMBL-Cells; CHEMBL3308335
ChEMBL-Targets; CHEMBL614169 ChEMBL-Targets; CHEMBL2366062 GDSC; 908148 PharmacoDB; MONOMAC6_960_2019 | ||||||||||||||||||
Gene expression databases | ArrayExpress; E-MTAB-783
ArrayExpress; E-MTAB-2770 ArrayExpress; E-MTAB-3610 ArrayExpress; E-MTAB-7721 ArrayExpress; E-MTAB-7722 GEO; GSM236795 GEO; GSM236831 GEO; GSM887338 GEO; GSM888414 GEO; GSM1374692 GEO; GSM1670130 | ||||||||||||||||||
Other | Wikidata; Q54906378 | ||||||||||||||||||
Polymorphism and mutation databases | Cosmic; 787459
Cosmic; 850390 Cosmic; 908148 Cosmic; 975278 Cosmic; 1012100 Cosmic; 1089514 Cosmic; 1281335 Cosmic; 1465950 Cosmic; 1524836 Cosmic; 2131547 Cosmic; 2306198 Cosmic; 2392975 IARC_TP53; 21514 LiGeA; CCLE_095 Progenetix; CVCL_1426 | ||||||||||||||||||
Entry history | |||||||||||||||||||
Entry creation | 04-Apr-2012 | ||||||||||||||||||
Last entry update | 12-Jan-2021 | ||||||||||||||||||
Version number | 35 |