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Cellosaurus MRK-nu-1 (CVCL_1428)

[Text version]

Cell line name MRK-nu-1
Synonyms MRK-NU-1; MRK-nu-I; Mrk-nu1; MRKnu-1; MRKnu1; MRKNU1
Accession CVCL_1428
Resource Identification Initiative To cite this cell line use: MRK-nu-1 (RRID:CVCL_1428)
Comments Part of: Cancer Cell Line Encyclopedia (CCLE) project.
Part of: COSMIC cell lines project.
Characteristics: Established from the ascitic cells from BALB/c nu/nu mice injected intraperitoneal with the parent tumoral cells.
Doubling time: ~47 hours (lot 02072012) (JCRB).
Microsatellite instability: Stable (MSS) (Sanger).
Omics: Deep exome analysis.
Omics: DNA methylation analysis.
Omics: SNP array analysis.
Omics: Transcriptome analysis.
Sequence variations Has no TP53 mutation (PubMed=15900046).
Genome ancestry Source: PubMed=30894373

Origin% genome
African0.98
Native American1.19
East Asian, North73.82
East Asian, South23.21
South Asian0
European, North0.07
European, South0.74
Disease Breast carcinoma (NCIt: C4872)
Derived from metastatic site: Pleural effusion.
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Originate from same individual CVCL_WZ71 ! MRK-nu-2
Sex of cell Female
Age at sampling 46Y
Category Cancer cell line
STR profile Source(s): Cosmic-CLP; JCRB

Markers:
AmelogeninX
CSF1PO9,10
D5S81813
D7S8208,10
D13S3178
D16S53910
TH016,9
TPOX11
vWA17,18

Run an STR similarity search on this cell line
Publications

CLPUB00083
Sekiguchi M., Shiroko Y., Fujii G., Sudo K., Matsuzawa A., Suzuki K.
An ascites form of human mammary carcinoma transplantable in nude mice and isolation of two cell lines cultured in vitro.
Proc. Jpn. Cancer Assoc. 38:139-139(1979)

PubMed=518958
Sekiguchi M., Sudo K., Suzuki K., Matsuzawa A., Fujii G.
An ascites form of human mammary carcinoma transplantable in nude mice.
Biomedicine 30:245-249(1979)

PubMed=9290701; DOI=10.1002/(SICI)1098-2744(199708)19:4<243::AID-MC5>3.0.CO;2-D
Jia L.-Q., Osada M., Ishioka C., Gamo M., Ikawa S., Suzuki T., Shimodaira H., Niitani T., Kudo T., Akiyama M., Kimura N., Matsuo M., Mizusawa H., Tanaka N., Koyama H., Namba M., Kanamaru R., Kuroki T.
Screening the p53 status of human cell lines using a yeast functional assay.
Mol. Carcinog. 19:243-253(1997)

PubMed=15900046; DOI=10.1093/jnci/dji133
Mashima T., Oh-hara T., Sato S., Mochizuki M., Sugimoto Y., Yamazaki K., Hamada J., Tada M., Moriuchi T., Ishikawa Y., Kato Y., Tomoda H., Yamori T., Tsuruo T.
p53-defective tumors with a functional apoptosome-mediated pathway: a new therapeutic target.
J. Natl. Cancer Inst. 97:765-777(2005)

PubMed=20164919; DOI=10.1038/nature08768
Bignell G.R., Greenman C.D., Davies H., Butler A.P., Edkins S., Andrews J.M., Buck G., Chen L., Beare D., Latimer C., Widaa S., Hinton J., Fahey C., Fu B., Swamy S., Dalgliesh G.L., Teh B.T., Deloukas P., Yang F., Campbell P.J., Futreal P.A., Stratton M.R.
Signatures of mutation and selection in the cancer genome.
Nature 463:893-898(2010)

PubMed=20215515; DOI=10.1158/0008-5472.CAN-09-3458
Rothenberg S.M., Mohapatra G., Rivera M.N., Winokur D., Greninger P., Nitta M., Sadow P.M., Sooriyakumar G., Brannigan B.W., Ulman M.J., Perera R.M., Wang R., Tam A., Ma X.-J., Erlander M., Sgroi D.C., Rocco J.W., Lingen M.W., Cohen E.E.W., Louis D.N., Settleman J., Haber D.A.
A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers.
Cancer Res. 70:2158-2164(2010)

PubMed=27397505; DOI=10.1016/j.cell.2016.06.017
Iorio F., Knijnenburg T.A., Vis D.J., Bignell G.R., Menden M.P., Schubert M., Aben N., Goncalves E., Barthorpe S., Lightfoot H., Cokelaer T., Greninger P., van Dyk E., Chang H., de Silva H., Heyn H., Deng X., Egan R.K., Liu Q., Mironenko T., Mitropoulos X., Richardson L., Wang J., Zhang T., Moran S., Sayols S., Soleimani M., Tamborero D., Lopez-Bigas N., Ross-Macdonald P., Esteller M., Gray N.S., Haber D.A., Stratton M.R., Benes C.H., Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.
A landscape of pharmacogenomic interactions in cancer.
Cell 166:740-754(2016)

PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747
Dutil J., Chen Z., Monteiro A.N., Teer J.K., Eschrich S.A.
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Cancer Res. 79:1263-1273(2019)

Cross-references
Cell line collections JCRB; JCRB0616 - Discontinued
JCRB; JCRB0628
Cell line databases/resources CCLE; MRKNU1_BREAST
Cell_Model_Passport; SIDM00562
Cosmic-CLP; 908151
DepMap; ACH-002163
GDSC; 908151
LINCS_LDP; LCL-1487
Ontologies BTO; BTO:0003679
Biological sample resources BioSample; SAMN03471641
Chemistry resources ChEMBL-Cells; CHEMBL3308550
ChEMBL-Targets; CHEMBL2366325
PharmacoDB; MRKnu1_965_2019
Gene expression databases ArrayExpress; E-MTAB-3610
GEO; GSM827236
GEO; GSM1670133
Other Wikidata; Q54906738
Polymorphism and mutation databases Cosmic; 908151
IARC_TP53; 21516
Entry history
Entry creation04-Apr-2012
Last entry updated06-Sep-2019
Version number25