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Cellosaurus MUTZ-3 (CVCL_1433)

[Text version]

Cell line name MUTZ-3
Synonyms Mutz-3; MUTZ3; Mutz3; Menschliche Und Tierische Zellkulture-3
Accession CVCL_1433
Resource Identification Initiative To cite this cell line use: MUTZ-3 (RRID:CVCL_1433)
Comments Part of: Cancer Cell Line Encyclopedia (CCLE) project.
Part of: LL-100 blood cancer cell line panel.
Characteristics: Contains both CD34+ stem cell and CD14+ monocyte/macrophage cell populations and can thus be considered as a hematopoietic progenitor/stem cell line.
Doubling time: ~110 hours (DSMZ); 90-110 hours, in presence of supernatant of 5637 (CVCL_0126) cells (PubMed=8667638).
Omics: Deep exome analysis.
Omics: Deep RNAseq analysis.
Omics: H3K79me1 ChIP-seq epigenome analysis.
Omics: Transcriptome analysis.
Derived from sampling site: Peripheral blood.
Sequence variations KRAS p.Gly10_Ala11insGly (c.31_32insGAG) (CCLE).
Disease Acute myeloid leukemia with inv(3) (q21.3;q26.2) or t(3;3) (q21.3;q26.2) GATA2, MECOM (NCIt: C82426)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Male
Age at sampling 29Y
Category Cancer cell line
STR profile Source(s): DSMZ

Markers:
AmelogeninX,Y
CSF1PO12,13
D5S81812,13
D7S82010,12
D13S3178,12
D16S53912
TH016,9.3
TPOX8,11
vWA14,16

Run an STR similarity search on this cell line
Publications

PubMed=8667638
Hu Z.-B., Ma W., Zaborski M., MacLeod R.A.F., Quentmeier H., Drexler H.G.
Establishment and characterization of two novel cytokine-responsive acute myeloid and monocytic leukemia cell lines, MUTZ-2 and MUTZ-3.
Leukemia 10:1025-1040(1996)

PubMed=9096695; DOI=10.1038/sj.leu.2400621
Drexler H.G., Zaborski M., Quentmeier H.
Thrombopoietin supports the continuous growth of cytokine-dependent human leukemia cell lines.
Leukemia 11:541-551(1997)

DOI=10.1016/B978-0-12-221970-2.50457-5
Drexler H.G.
The leukemia-lymphoma cell line factsbook.
(In) ISBN 9780122219702; pp.1-733; Academic Press; London (2001)

PubMed=12091369; DOI=10.1182/blood.V100.2.701
Masterson A.J., Sombroek C.C., De Gruijl T.D., Graus Y.M.F., van der Vliet H.J.J., Lougheed S.M., van den Eertwegh A.J.M., Pinedo H.M., Scheper R.J.
MUTZ-3, a human cell line model for the cytokine-induced differentiation of dendritic cells from CD34+ precursors.
Blood 100:701-703(2002)

PubMed=16408098; DOI=10.1038/sj.leu.2404081
Quentmeier H., MacLeod R.A.F., Zaborski M., Drexler H.G.
JAK2 V617F tyrosine kinase mutation in cell lines derived from myeloproliferative disorders.
Leukemia 20:471-476(2006)

PubMed=16423051; DOI=10.1111/j.1365-2567.2005.02274.x
Larsson K., Lindstedt M., Borrebaeck C.A.
Functional and transcriptional profiling of MUTZ-3, a myeloid cell line acting as a model for dendritic cells.
Immunology 117:156-166(2006)

PubMed=17533051; DOI=10.1016/j.exphem.2007.03.003
Ciraci E., Barisani D., Parafioriti A., Formisano G., Arancia G., Bottazzo G., Berardi A.C.
CD34 human hematopoietic progenitor cell line, MUTZ-3, differentiates into functional osteoclasts.
Exp. Hematol. 35:967-977(2007)

Patent=US8455253
Goletz S., Scheper R.J., Masterson A.J., Pinedo H.M.
Differentiation of MUTZ-3 cells to produce effective dendritic cells.
Patent number US8455253, 04-Jun-2013

PubMed=30285677; DOI=10.1186/s12885-018-4840-5
Tan K.-T., Ding L.-W., Sun Q.-Y., Lao Z.-T., Chien W., Ren X., Xiao J.-F., Loh X.-Y., Xu L., Lill M., Mayakonda A., Lin D.-C., Yang H., Koeffler H.P.
Profiling the B/T cell receptor repertoire of lymphocyte derived cell lines.
BMC Cancer 18:940-940(2018)

PubMed=31068700; DOI=10.1038/s41586-019-1186-3
Ghandi M., Huang F.W., Jane-Valbuena J., Kryukov G.V., Lo C.C., McDonald E.R. III, Barretina J., Gelfand E.T., Bielski C.M., Li H., Hu K., Andreev-Drakhlin A.Y., Kim J., Hess J.M., Haas B.J., Aguet F., Weir B.A., Rothberg M.V., Paolella B.R., Lawrence M.S., Akbani R., Lu Y., Tiv H.L., Gokhale P.C., de Weck A., Mansour A.A., Oh C., Shih J., Hadi K., Rosen Y., Bistline J., Venkatesan K., Reddy A., Sonkin D., Liu M., Lehar J., Korn J.M., Porter D.A., Jones M.D., Golji J., Caponigro G., Taylor J.E., Dunning C.M., Creech A.L., Warren A.C., McFarland J.M., Zamanighomi M., Kauffmann A., Stransky N., Imielinski M., Maruvka Y.E., Cherniack A.D., Tsherniak A., Vazquez F., Jaffe J.D., Lane A.A., Weinstock D.M., Johannessen C.M., Morrissey M.P., Stegmeier F., Schlegel R., Hahn W.C., Getz G., Mills G.B., Boehm J.S., Golub T.R., Garraway L.A., Sellers W.R.
Next-generation characterization of the Cancer Cell Line Encyclopedia.
Nature 569:503-508(2019)

PubMed=31160637; DOI=10.1038/s41598-019-44491-x
Quentmeier H., Pommerenke C., Dirks W.G., Eberth S., Koeppel M., MacLeod R.A.F., Nagel S., Steube K., Uphoff C.C., Drexler H.G.
The LL-100 panel: 100 cell lines for blood cancer studies.
Sci. Rep. 9:8218-8218(2019)

Cross-references
Cell line collections DSMZ; ACC-295
Cell line databases/resources CCLE; MUTZ3_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE
DepMap; ACH-000084
Lonza; 53
Ontologies CLO; CLO_0007903
EFO; EFO_0005395
Biological sample resources BioSample; SAMN03473344
BioSample; SAMN10989596
Gene expression databases ArrayExpress; E-MTAB-2770
ArrayExpress; E-MTAB-7721
ArrayExpress; E-MTAB-7722
GEO; GSM305093
GEO; GSM305094
GEO; GSM305095
GEO; GSM801964
GEO; GSM1374693
GEO; GSM2037138
GEO; GSM2037139
Other Wikidata; Q54907100
Polymorphism and mutation databases Cosmic; 787462
Cosmic; 975281
Cosmic; 1012102
Cosmic; 1281338
Cosmic; 2306224
Cosmic; 2378088
LiGeA; CCLE_080
Entry history
Entry creation04-Apr-2012
Last entry updated05-Jul-2019
Version number20