Cellosaurus MUTZ-3 (CVCL_1433)

Cell line name MUTZ-3
Synonyms Mutz-3; MUTZ3; Mutz3
Accession CVCL_1433
Resource Identification Initiative To cite this cell line use: MUTZ-3 (RRID:CVCL_1433)
Comments Part of: Cancer Cell Line Encyclopedia (CCLE) project.
Characteristics: Contains both CD34+ stem cell and CD14+ monocyte/macrophage cell populations and can thus be considered as a hematopoietic progenitor/stem cell line.
Doubling time: ~110 hours (DSMZ); 90-110 hours, in presence of supernatant of 5637 (CVCL_0126) cells (PubMed=8667638).
Omics: Transcriptome analysis.
Derived from sampling site: Peripheral blood.
Disease Adult acute myeloid leukemia (NCIt: C9154)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Male
Category Cancer cell line
STR profile Source(s): DSMZ

Markers:
AmelogeninX,Y
CSF1PO12,13
D13S3178,12
D16S53912
D5S81812,13
D7S82010,12
TH016,9.3
TPOX8,11
vWA14,16
Publications

PubMed=8667638
Hu Z.-B., Ma W., Zaborski M., MacLeod R.A.F., Quentmeier H., Drexler H.G.
Establishment and characterization of two novel cytokine-responsive acute myeloid and monocytic leukemia cell lines, MUTZ-2 and MUTZ-3.
Leukemia 10:1025-1040(1996)

PubMed=12091369; DOI=10.1182/blood.V100.2.701
Masterson A.J., Sombroek C.C., De Gruijl T.D., Graus Y.M.F., van der Vliet H.J.J., Lougheed S.M., van den Eertwegh A.J.M., Pinedo H.M., Scheper R.J.
MUTZ-3, a human cell line model for the cytokine-induced differentiation of dendritic cells from CD34+ precursors.
Blood 100:701-703(2002)

PubMed=16408098; DOI=10.1038/sj.leu.2404081
Quentmeier H., MacLeod R.A.F., Zaborski M., Drexler H.G.
JAK2 V617F tyrosine kinase mutation in cell lines derived from myeloproliferative disorders.
Leukemia 20:471-476(2006)

PubMed=17533051; DOI=10.1016/j.exphem.2007.03.003
Ciraci E., Barisani D., Parafioriti A., Formisano G., Arancia G., Bottazzo G., Berardi A.C.
CD34 human hematopoietic progenitor cell line, MUTZ-3, differentiates into functional osteoclasts.
Exp. Hematol. 35:967-977(2007)

Patent=US8455253
Goletz S., Scheper R.J., Masterson A.J., Pinedo H.M.
Differentiation of MUTZ-3 cells to produce effective dendritic cells.
Patent number US8455253, 04-Jun-2013

Cross-references
Cell line collections DSMZ; ACC-295
Cell line databases/resources CCLE; MUTZ3_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE
Lonza; 53
Ontologies CLO; CLO_0007903
EFO; EFO_0005395
Biological sample resources BioSample; SAMN03473344
Gene expression databases GEO; GSM1374693
Polymorphism and mutation databases Cosmic; 787462
Cosmic; 975281
Cosmic; 1012102
Cosmic; 1281338
Cosmic; 2306224
Cosmic; 2378088