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Cellosaurus MUTZ-3 (CVCL_1433)

[Text version]

Cell line name MUTZ-3
Synonyms Mutz-3; MUTZ3; Mutz3; Menschliche Und Tierische Zellkulture-3
Accession CVCL_1433
Resource Identification Initiative To cite this cell line use: MUTZ-3 (RRID:CVCL_1433)
Comments Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
Part of: LL-100 blood cancer cell line panel.
Characteristics: Contains both CD34+ stem cell and CD14+ monocyte/macrophage cell populations and can thus be considered as a hematopoietic progenitor/stem cell line.
Doubling time: ~110 hours (DSMZ); 90-110 hours, in presence of supernatant of 5637 (CVCL_0126) cells (PubMed=8667638).
Omics: Deep exome analysis.
Omics: Deep RNAseq analysis.
Omics: H3K79me1 ChIP-seq epigenome analysis.
Omics: Transcriptome analysis.
Derived from sampling site: Peripheral blood.
Sequence variations
  • Mutation; HGNC; 6407; KRAS; Simple; p.Gly10_Ala11insGly (c.31_32insGAG); Zygosity=Unspecified (DepMap).
Disease Acute myeloid leukemia with inv(3) (q21.3;q26.2) or t(3;3) (q21.3;q26.2) GATA2, MECOM (NCIt: C82426)
Acute myeloid leukemia with inv3(q21;q26.2) or t(3;3)(q21;q26.2) (ORDO: Orphanet_402020)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Male
Age at sampling 29Y
Category Cancer cell line
STR profile Source(s): DSMZ


Run an STR similarity search on this cell line

Hu Z.-B., Ma W., Zaborski M., MacLeod R.A.F., Quentmeier H., Drexler H.G.
Establishment and characterization of two novel cytokine-responsive acute myeloid and monocytic leukemia cell lines, MUTZ-2 and MUTZ-3.
Leukemia 10:1025-1040(1996)

PubMed=9096695; DOI=10.1038/sj.leu.2400621
Drexler H.G., Zaborski M., Quentmeier H.
Thrombopoietin supports the continuous growth of cytokine-dependent human leukemia cell lines.
Leukemia 11:541-551(1997)

Drexler H.G.
The leukemia-lymphoma cell line factsbook.
(In) ISBN 9780122219702; pp.1-733; Academic Press; London (2001)

PubMed=12091369; DOI=10.1182/blood.V100.2.701
Masterson A.J., Sombroek C.C., de Gruijl T.D., Graus Y.M.F., van der Vliet H.J.J., Lougheed S.M., van den Eertwegh A.J.M., Pinedo H.M., Scheper R.J.
MUTZ-3, a human cell line model for the cytokine-induced differentiation of dendritic cells from CD34+ precursors.
Blood 100:701-703(2002)

PubMed=16408098; DOI=10.1038/sj.leu.2404081
Quentmeier H., MacLeod R.A.F., Zaborski M., Drexler H.G.
JAK2 V617F tyrosine kinase mutation in cell lines derived from myeloproliferative disorders.
Leukemia 20:471-476(2006)

PubMed=16423051; DOI=10.1111/j.1365-2567.2005.02274.x
Larsson K., Lindstedt M., Borrebaeck C.A.
Functional and transcriptional profiling of MUTZ-3, a myeloid cell line acting as a model for dendritic cells.
Immunology 117:156-166(2006)

PubMed=17533051; DOI=10.1016/j.exphem.2007.03.003
Ciraci E., Barisani D., Parafioriti A., Formisano G., Arancia G., Bottazzo G., Berardi A.C.
CD34 human hematopoietic progenitor cell line, MUTZ-3, differentiates into functional osteoclasts.
Exp. Hematol. 35:967-977(2007)

Goletz S., Scheper R.J., Masterson A.J., Pinedo H.M.
MUTZ-3 dendritic cells.
Patent number US9029143, 15-May-2015

PubMed=30285677; DOI=10.1186/s12885-018-4840-5
Tan K.-T., Ding L.-W., Sun Q.-Y., Lao Z.-T., Chien W., Ren X., Xiao J.-F., Loh X.-Y., Xu L., Lill M., Mayakonda A., Lin D.-C., Yang H., Koeffler H.P.
Profiling the B/T cell receptor repertoire of lymphocyte derived cell lines.
BMC Cancer 18:940.1-940.13(2018)

PubMed=30629668; DOI=10.1371/journal.pone.0210404
Uphoff C.C., Pommerenke C., Denkmann S.A., Drexler H.G.
Screening human cell lines for viral infections applying RNA-Seq data analysis.
PLoS ONE 14:E0210404-E0210404(2019)

PubMed=31068700; DOI=10.1038/s41586-019-1186-3
Ghandi M., Huang F.W., Jane-Valbuena J., Kryukov G.V., Lo C.C., McDonald E.R. III, Barretina J., Gelfand E.T., Bielski C.M., Li H., Hu K., Andreev-Drakhlin A.Y., Kim J., Hess J.M., Haas B.J., Aguet F., Weir B.A., Rothberg M.V., Paolella B.R., Lawrence M.S., Akbani R., Lu Y., Tiv H.L., Gokhale P.C., de Weck A., Mansour A.A., Oh C., Shih J., Hadi K., Rosen Y., Bistline J., Venkatesan K., Reddy A., Sonkin D., Liu M., Lehar J., Korn J.M., Porter D.A., Jones M.D., Golji J., Caponigro G., Taylor J.E., Dunning C.M., Creech A.L., Warren A.C., McFarland J.M., Zamanighomi M., Kauffmann A., Stransky N., Imielinski M., Maruvka Y.E., Cherniack A.D., Tsherniak A., Vazquez F., Jaffe J.D., Lane A.A., Weinstock D.M., Johannessen C.M., Morrissey M.P., Stegmeier F., Schlegel R., Hahn W.C., Getz G., Mills G.B., Boehm J.S., Golub T.R., Garraway L.A., Sellers W.R.
Next-generation characterization of the Cancer Cell Line Encyclopedia.
Nature 569:503-508(2019)

PubMed=31160637; DOI=10.1038/s41598-019-44491-x
Quentmeier H., Pommerenke C., Dirks W.G., Eberth S., Koeppel M., MacLeod R.A.F., Nagel S., Steube K., Uphoff C.C., Drexler H.G.
The LL-100 panel: 100 cell lines for blood cancer studies.
Sci. Rep. 9:8218-8218(2019)

Cell line collections DSMZ; ACC-295
Cell line databases/resources CLO; CLO_0007903
Cell_Model_Passport; SIDM01873
DepMap; ACH-000084
Lonza; 53
Biological sample resources BioSample; SAMN03473344
BioSample; SAMN10989596
Chemistry resources PharmacoDB; MUTZ3_970_2019
Encyclopedic resources Wikidata; Q54907100
Experimental variables resources EFO; EFO_0005395
Gene expression databases ArrayExpress; E-MTAB-2770
ArrayExpress; E-MTAB-7721
ArrayExpress; E-MTAB-7722
GEO; GSM305093
GEO; GSM305094
GEO; GSM305095
GEO; GSM801964
GEO; GSM1374693
GEO; GSM2037138
GEO; GSM2037139
Polymorphism and mutation databases Cosmic; 787462
Cosmic; 975281
Cosmic; 1012102
Cosmic; 1281338
Cosmic; 2306224
Cosmic; 2378088
Cosmic; 2733530
LiGeA; CCLE_080
Entry history
Entry creation04-Apr-2012
Last entry update16-Dec-2021
Version number26