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Cellosaurus MZ-PC-1 (CVCL_1434)

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Cell line name MZ-PC-1
Synonyms MZPC-1; MZ1-PC; MZ1PC; MainZ-Pancreatic Cancer-1
Accession CVCL_1434
Secondary accession CVCL_A657
Resource Identification Initiative To cite this cell line use: MZ-PC-1 (RRID:CVCL_1434)
Comments Part of: Cancer Cell Line Encyclopedia (CCLE) project.
Part of: COSMIC cell lines project.
Doubling time: 45 hours (PubMed=7599790).
Microsatellite instability: Stable (MSS) (Sanger).
Omics: Deep exome analysis.
Omics: DNA methylation analysis.
Omics: SNP array analysis.
Omics: Transcriptome analysis.
Sequence variations Homozygous for CDKN2A p.Arg80Ter (c.238C>T) (p.Pro94Leu; c.281C>T) (ClinVar=VCV000009409) (CCLE; Cosmic-CLP).
Heterozygous for KRAS p.Gly12Val (c.35G>T) (ClinVar=VCV000012583) (CCLE; Cosmic-CLP).
Heterozygous for TP53 p.Arg209Lysfs*6 (c.626_627delGA) (ClinVar=VCV000372539) (CCLE; Cosmic-CLP).
Genome ancestry Source: PubMed=30894373

Origin% genome
African0.66
Native American0
East Asian, North2.92
East Asian, South0
South Asian1.85
European, North62.36
European, South32.2
Disease Pancreatic ductal adenocarcinoma (NCIt: C9120)
Derived from metastatic site: Pleural effusion.
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Originate from same individual CVCL_VU73 ! MZ-1-EBV-B
Sex of cell Male
Age at sampling 46Y
Category Cancer cell line
STR profile Source(s): Cosmic-CLP

Markers:
AmelogeninX
CSF1PO12
D5S81810,11
D7S8209,10
D13S31711,12
D16S53911,12
TH016,8
TPOX8
vWA18

Run an STR similarity search on this cell line
Publications

PubMed=7599790; DOI=10.1007/BF00191347
Heike M., Rohrig O., Gabbert H.E., Moll R., Meyer zum Buschenfelde K.-H., Dippold W.G., Knuth A.
New cell lines of gastric and pancreatic cancer: distinct morphology, growth characteristics, expression of epithelial and immunoregulatory antigens.
Virchows Arch. 426:375-384(1995)

PubMed=20164919; DOI=10.1038/nature08768
Bignell G.R., Greenman C.D., Davies H., Butler A.P., Edkins S., Andrews J.M., Buck G., Chen L., Beare D., Latimer C., Widaa S., Hinton J., Fahey C., Fu B., Swamy S., Dalgliesh G.L., Teh B.T., Deloukas P., Yang F., Campbell P.J., Futreal P.A., Stratton M.R.
Signatures of mutation and selection in the cancer genome.
Nature 463:893-898(2010)

DOI=10.4172/2324-9293.1000104
Wagenhauser M.U., Ruckert F., Niedergethmann M., Grutzmann R., Saeger H.-D.
Distribution of characteristic mutations in native ductal adenocarcinoma of the pancreas and pancreatic cancer cell lines.
Cell Biol. Res. Ther. 2:1000104.1-1000104.5(2013)

PubMed=27397505; DOI=10.1016/j.cell.2016.06.017
Iorio F., Knijnenburg T.A., Vis D.J., Bignell G.R., Menden M.P., Schubert M., Aben N., Goncalves E., Barthorpe S., Lightfoot H., Cokelaer T., Greninger P., van Dyk E., Chang H., de Silva H., Heyn H., Deng X., Egan R.K., Liu Q., Mironenko T., Mitropoulos X., Richardson L., Wang J., Zhang T., Moran S., Sayols S., Soleimani M., Tamborero D., Lopez-Bigas N., Ross-Macdonald P., Esteller M., Gray N.S., Haber D.A., Stratton M.R., Benes C.H., Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.
A landscape of pharmacogenomic interactions in cancer.
Cell 166:740-754(2016)

PubMed=29444439; DOI=10.1016/j.celrep.2018.01.051
Yuan T.L., Amzallag A., Bagni R., Yi M., Afghani S., Burgan W., Fer N., Strathern L.A., Powell K., Smith B., Waters A.M., Drubin D., Thomson T., Liao R., Greninger P., Stein G.T., Murchie E., Cortez E., Egan R.K., Procter L., Bess M., Cheng K.T., Lee C.-S., Lee L.C., Fellmann C., Stephens R., Luo J., Lowe S.W., Benes C.H., McCormick F.
Differential effector engagement by oncogenic KRAS.
Cell Rep. 22:1889-1902(2018)

PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747
Dutil J., Chen Z., Monteiro A.N., Teer J.K., Eschrich S.A.
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Cancer Res. 79:1263-1273(2019)

Cross-references
Cell line databases/resources CCLE; MZ1PC_PANCREAS
Cell_Model_Passport; SIDM00053
Cosmic-CLP; 753595
DepMap; ACH-002164
LINCS_LDP; LCL-1795
Chemistry resources ChEMBL-Cells; CHEMBL3308242
ChEMBL-Targets; CHEMBL2366204
GDSC; 753595
PharmacoDB; MZ1PC_975_2019
Gene expression databases ArrayExpress; E-MTAB-3610
GEO; GSM1670139
Other Wikidata; Q54907230
Polymorphism and mutation databases Cosmic; 753595
Cosmic; 948732
IARC_TP53; 21522
Entry history
Entry creation04-Apr-2012
Last entry update29-Oct-2020
Version number24