Cell line name | MZ-PC-1 | ||||||||||||||||||
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Synonyms | MZPC-1; MZ1-PC; MZ1PC; MainZ-Pancreatic Cancer-1 | ||||||||||||||||||
Accession | CVCL_1434 | ||||||||||||||||||
Secondary accession | CVCL_A657 | ||||||||||||||||||
Resource Identification Initiative | To cite this cell line use: MZ-PC-1 (RRID:CVCL_1434) | ||||||||||||||||||
Comments | Part of: Cancer Cell Line Encyclopedia (CCLE) project. Part of: COSMIC cell lines project. Doubling time: 45 hours (PubMed=7599790). Microsatellite instability: Stable (MSS) (Sanger). Omics: Deep exome analysis. Omics: DNA methylation analysis. Omics: SNP array analysis. Omics: Transcriptome analysis. | ||||||||||||||||||
Sequence variations | Homozygous for CDKN2A p.Arg80Ter (c.238C>T) (p.Pro94Leu; c.281C>T) (ClinVar=VCV000009409) (CCLE; Cosmic-CLP).Heterozygous for KRAS p.Gly12Val (c.35G>T) (ClinVar=VCV000012583) (CCLE; Cosmic-CLP).Heterozygous for TP53 p.Arg209Lysfs*6 (c.626_627delGA) (ClinVar=VCV000372539) (CCLE; Cosmic-CLP). | ||||||||||||||||||
Genome ancestry | Source: PubMed=30894373
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Disease | Pancreatic ductal adenocarcinoma (NCIt: C9120) Derived from metastatic site: Pleural effusion. | ||||||||||||||||||
Species of origin | Homo sapiens (Human)
(NCBI Taxonomy: 9606)
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Originate from same individual | CVCL_VU73 ! MZ-1-EBV-B | ||||||||||||||||||
Sex of cell | Male | ||||||||||||||||||
Age at sampling | 46Y | ||||||||||||||||||
Category | Cancer cell line | ||||||||||||||||||
STR profile | Source(s): Cosmic-CLP Markers:
Run an STR similarity search on this cell line | ||||||||||||||||||
Publications | PubMed=7599790; DOI=10.1007/BF00191347 PubMed=20164919; DOI=10.1038/nature08768 DOI=10.4172/2324-9293.1000104 PubMed=27397505; DOI=10.1016/j.cell.2016.06.017 PubMed=29444439; DOI=10.1016/j.celrep.2018.01.051 PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747 | ||||||||||||||||||
Cross-references | |||||||||||||||||||
Cell line databases/resources | CCLE; MZ1PC_PANCREAS
Cell_Model_Passport; SIDM00053 Cosmic-CLP; 753595 DepMap; ACH-002164 LINCS_LDP; LCL-1795 | ||||||||||||||||||
Chemistry resources | ChEMBL-Cells; CHEMBL3308242
ChEMBL-Targets; CHEMBL2366204 GDSC; 753595 PharmacoDB; MZ1PC_975_2019 | ||||||||||||||||||
Gene expression databases | ArrayExpress; E-MTAB-3610
GEO; GSM1670139 | ||||||||||||||||||
Other | Wikidata; Q54907230 | ||||||||||||||||||
Polymorphism and mutation databases | Cosmic; 753595
Cosmic; 948732 IARC_TP53; 21522 | ||||||||||||||||||
Entry history | |||||||||||||||||||
Entry creation | 04-Apr-2012 | ||||||||||||||||||
Last entry update | 29-Oct-2020 | ||||||||||||||||||
Version number | 24 |