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Cellosaurus MZ-MEL-7 (CVCL_1436)

[Text version]

Cell line name MZ-MEL-7
Synonyms MZ-Mel-7; MZ7-MEL; MZ7-mel; MZ7MEL; MZ7
Accession CVCL_1436
Resource Identification Initiative To cite this cell line use: MZ-MEL-7 (RRID:CVCL_1436)
Comments Part of: Cancer Cell Line Encyclopedia (CCLE) project.
Part of: COSMIC cell lines project.
Microsatellite instability: Stable (MSS) (Sanger).
Omics: Deep exome analysis.
Omics: DNA methylation analysis.
Omics: SNP array analysis.
Omics: Transcriptome analysis.
Genome ancestry Source: PubMed=30894373

Origin% genome
African0.42
Native American0.24
East Asian, North1.19
East Asian, South0.69
South Asian0.03
European, North67.07
European, South30.35
Disease Melanoma (NCIt: C3224)
Derived from metastatic site: Spleen.
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Originate from same individual CVCL_VU72 ! MZ-7-EBV-B
Sex of cell Female
Age at sampling 25-26Y
Category Cancer cell line
STR profile Source(s): Cosmic-CLP

Markers:
AmelogeninX
CSF1PO11
D5S81811,13
D7S8208,11
D13S31711
D16S53911
TH016,8
TPOX9,11
vWA17

Run an STR similarity search on this cell line
Publications

PubMed=16247014; DOI=10.1073/pnas.0500090102
Lennerz V., Fatho M., Gentilini C., Frye R.A., Lifke A., Ferel D., Wolfel C., Huber C., Wolfel T.
The response of autologous T cells to a human melanoma is dominated by mutated neoantigens.
Proc. Natl. Acad. Sci. U.S.A. 102:16013-16018(2005)

PubMed=20164919; DOI=10.1038/nature08768
Bignell G.R., Greenman C.D., Davies H., Butler A.P., Edkins S., Andrews J.M., Buck G., Chen L., Beare D., Latimer C., Widaa S., Hinton J., Fahey C., Fu B., Swamy S., Dalgliesh G.L., Teh B.T., Deloukas P., Yang F., Campbell P.J., Futreal P.A., Stratton M.R.
Signatures of mutation and selection in the cancer genome.
Nature 463:893-898(2010)

PubMed=27397505; DOI=10.1016/j.cell.2016.06.017
Iorio F., Knijnenburg T.A., Vis D.J., Bignell G.R., Menden M.P., Schubert M., Aben N., Goncalves E., Barthorpe S., Lightfoot H., Cokelaer T., Greninger P., van Dyk E., Chang H., de Silva H., Heyn H., Deng X., Egan R.K., Liu Q., Mironenko T., Mitropoulos X., Richardson L., Wang J., Zhang T., Moran S., Sayols S., Soleimani M., Tamborero D., Lopez-Bigas N., Ross-Macdonald P., Esteller M., Gray N.S., Haber D.A., Stratton M.R., Benes C.H., Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.
A landscape of pharmacogenomic interactions in cancer.
Cell 166:740-754(2016)

PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747
Dutil J., Chen Z., Monteiro A.N., Teer J.K., Eschrich S.A.
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Cancer Res. 79:1263-1273(2019)

Cross-references
Cell line databases/resources CCLE; MZ7MEL_SKIN
Cell_Model_Passport; SIDM00516
Cosmic-CLP; 753596
DepMap; ACH-002166
LINCS_HMS; 51006
LINCS_LDP; LCL-1279
Chemistry resources ChEMBL-Cells; CHEMBL3308546
ChEMBL-Targets; CHEMBL2366138
GDSC; 753596
PharmacoDB; MZ7mel_977_2019
Gene expression databases ArrayExpress; E-MTAB-783
ArrayExpress; E-MTAB-3610
GEO; GSM1670141
GEO; GSM3039509
Other Wikidata; Q54907228
Polymorphism and mutation databases Cosmic; 753596
Entry history
Entry creation04-Apr-2012
Last entry update19-Dec-2019
Version number22