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Cellosaurus Mo (CVCL_1439)

[Text version]

Cell line name Mo
Synonyms MO; Mo-T; Mo T; MoT; MOT
Accession CVCL_1439
Resource Identification Initiative To cite this cell line use: Mo (RRID:CVCL_1439)
Comments Group: Patented cell line.
Part of: Cancer Cell Line Encyclopedia (CCLE) project.
Part of: COSMIC cell lines project.
Registration: International Depositary Authority, American Type Culture Collection (ATCC); CRL-8066.
Microsatellite instability: Stable (MSS) (Sanger).
Transformant: NCBI_TaxID; 11909; Human T-lymphotropic virus 2 (HTLV-2).
Omics: Deep exome analysis.
Omics: DNA methylation analysis.
Omics: Transcriptome analysis.
Anecdotal: John Moore, the patient from which this cell line is derived, sued David Golde and the University of California over the patent that they deposited on the Mo cell line. Although his claims of ownership were rejected, his physician was deemed to have breached his fiduciary duty by not informing Moore of the economic and financial interests arising from the derivation of the cell line.
Genome ancestry Source: PubMed=30894373

Origin% genome
Native American0.37
East Asian, North0
East Asian, South1.84
South Asian0.34
European, North68.22
European, South29.24
Disease Hairy cell leukemia (NCIt: C7402)
Classic hairy cell leukemia (ORDO: Orphanet_58017)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Originate from same individual CVCL_2302 ! Mo-B
Sex of cell Male
Age at sampling 33Y
Category Cancer cell line
STR profile Source(s): ATCC; Cosmic-CLP


Run an STR similarity search on this cell line
Web pages https://en.wikipedia.org/wiki/Moore_v._Regents_of_the_University_of_California

PubMed=305224; DOI=10.7326/0003-4819-88-3-323
Saxon A., Stevens R.H., Golde D.W.
T-lymphocyte variant of hairy-cell leukemia.
Ann. Intern. Med. 88:323-326(1978)

Gauwerky C.E., Lusis A.J., Golde D.W.
Erythroid-potentiating activity: characterization and target cells.
Exp. Hematol. 8 Suppl. 8:117-127(1980)

PubMed=6987658; DOI=10.1073/pnas.77.1.593
Golde D.W., Bersch N., Quan S.G., Lusis A.J.
Production of erythroid-potentiating activity by a human T-lymphoblast cell line.
Proc. Natl. Acad. Sci. U.S.A. 77:593-596(1980)

PubMed=6600440; DOI=10.1007/BF02617996
Uittenbogaart C.H., Cantor Y., Fahey J.L.
Growth of human malignant lymphoid cell lines in serum-free medium.
In Vitro 19:67-72(1983)

Golde D.W., Quan S.G.
Unique T-lymphocyte line and products derived therefrom.
Patent number US4438032, 20-Mar-1984

Javitt G.
Why not take all of me? Reflections on the immortal life of Henrietta Lacks and the status of participants in research using human specimens.
Minn. J. Law Sci. Technol. 11:713-755(2010)

PubMed=27397505; DOI=10.1016/j.cell.2016.06.017
Iorio F., Knijnenburg T.A., Vis D.J., Bignell G.R., Menden M.P., Schubert M., Aben N., Goncalves E., Barthorpe S., Lightfoot H., Cokelaer T., Greninger P., van Dyk E., Chang H., de Silva H., Heyn H., Deng X., Egan R.K., Liu Q., Mironenko T., Mitropoulos X., Richardson L., Wang J., Zhang T., Moran S., Sayols S., Soleimani M., Tamborero D., Lopez-Bigas N., Ross-Macdonald P., Esteller M., Gray N.S., Haber D.A., Stratton M.R., Benes C.H., Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.
A landscape of pharmacogenomic interactions in cancer.
Cell 166:740-754(2016)

PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747
Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Cancer Res. 79:1263-1273(2019)

Cell line collections ATCC; CRL-8066
Cell_Model_Passport; SIDM00623
Cosmic-CLP; 908149
DepMap; ACH-002339
Lonza; 1308
Ontologies BTO; BTO:0001014
CLO; CLO_0007815
Biological sample resources BioSample; SAMN03471131
Chemistry resources ChEMBL-Cells; CHEMBL3308631
ChEMBL-Targets; CHEMBL614722
GDSC; 908149
PharmacoDB; MoT_947_2019
Gene expression databases ArrayExpress; E-MTAB-3610
GEO; GSM1670121
GEO; GSM1670131
Other Wikidata; Q54906275
Polymorphism and mutation databases Cosmic; 683660
Cosmic; 908149
Cosmic; 1120712
IARC_TP53; 21525
Entry history
Entry creation04-Apr-2012
Last entry update23-Sep-2021
Version number29