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Cellosaurus NB1 (CVCL_1440)

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Cell line name NB1
Synonyms NB-1; NB-I; NB 1
Accession CVCL_1440
Resource Identification Initiative To cite this cell line use: NB1 (RRID:CVCL_1440)
Comments Part of: Cancer Cell Line Encyclopedia (CCLE) project.
Part of: COSMIC cell lines project.
Doubling time: 40-50 hours (PubMed=174024); ~1 day (lot 12092005) (JCRB).
Microsatellite instability: Stable (MSS) (Sanger).
Omics: Deep exome analysis.
Omics: Deep RNAseq analysis.
Omics: DNA methylation analysis.
Omics: SNP array analysis.
Omics: Transcriptome analysis.
Sequence variations TERT c.228C>T (-124C>T); in promoter (PubMed=31068700).
Has no TP53 mutation (CCLE; Cosmic-CLP).
Genome ancestry Source: PubMed=30894373

Origin% genome
African2.29
Native American0.21
East Asian, North80.53
East Asian, South13.17
South Asian0
European, North0
European, South3.8
Disease Neuroblastoma (NCIt: C3270)
Derived from metastatic site: Cervical lymph node.
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Male
Age at sampling 2Y3M
Category Cancer cell line
STR profile Source(s): Cosmic-CLP; JCRB; PubMed=25877200; RCB; TKG

Markers:
AmelogeninX
CSF1PO10,12
D2S133817,27
D3S135815,17
D5S8189,11
D7S8208,12 (Cosmic-CLP; JCRB; PubMed=25877200; RCB)
12 (TKG)
D8S117912,16
D13S31710,13
D16S5399 (Cosmic-CLP; JCRB; PubMed=25877200; TKG)
9,12 (RCB)
D18S5116
D19S43313.2,15.2
D21S1130,31.2
FGA19,23
Penta D8,9
Penta E17,18
TH017
TPOX11
vWA16,19

Run an STR similarity search on this cell line
Publications

CLPUB00086
Miyake S., Shimo T., Kitamura Y., Nojyo T., Nakamura S., Imashuku S., Abe T.
Characteristics of continuous and functional cell line NB-I, derived from a human neuroblastoma.
Jiritsu Shinkei 10:115-120(1973)

PubMed=4144593; DOI=10.1210/jcem-36-5-931
Imashuku S., Inui A., Nakamura T., Tanaka J., Miyake S.
Catecholamine metabolism in tissue culture cells of a neuroblastoma.
J. Clin. Endocrinol. Metab. 36:931-936(1973)

PubMed=174024
Miyake S., Shimo Y., Kitamura T.
Morphological differentiation in vitro of human continuous and functional neuroblastoma cell line, NB-I under treatment of (But)2cAMP.
No Shinkei Geka 3:407-414(1975)

PubMed=590688; DOI=10.20772/cancersci1959.68.5_711
Ohnuma N., Kasuga T., Nojiri I., Furuse T.
Radiosensitivity of human neuroblastoma cell line (NB-1).
Gann 68:711-712(1977)

PubMed=9290701; DOI=10.1002/(SICI)1098-2744(199708)19:4<243::AID-MC5>3.0.CO;2-D
Jia L.-Q., Osada M., Ishioka C., Gamo M., Ikawa S., Suzuki T., Shimodaira H., Niitani T., Kudo T., Akiyama M., Kimura N., Matsuo M., Mizusawa H., Tanaka N., Koyama H., Namba M., Kanamaru R., Kuroki T.
Screening the p53 status of human cell lines using a yeast functional assay.
Mol. Carcinog. 19:243-253(1997)

PubMed=11129446; DOI=10.1097/00019606-200012000-00007
Sugimoto T., Mine H., Horii Y., Takahashi K., Nagai R., Morishita R., Komada M., Asada Y., Sawada T.
Neuroblastoma cell lines showing smooth muscle cell phenotypes.
Diagn. Mol. Pathol. 9:221-228(2000)

PubMed=12210830; DOI=10.1002/jnr.10330
Yoshida S., Narita T., Taga T., Ohta S., Takeuchi Y.
Malignant rhabdoid tumor shows incomplete neural characteristics as revealed by expression of SNARE complex.
J. Neurosci. Res. 69:642-652(2002)

PubMed=12702577
Saito-Ohara F., Imoto I., Inoue J., Hosoi H., Nakagawara A., Sugimoto T., Inazawa J.
PPM1D is a potential target for 17q gain in neuroblastoma.
Cancer Res. 63:1876-1883(2003)

PubMed=18923524; DOI=10.1038/nature07399
Chen Y., Takita J., Choi Y.L., Kato M., Ohira M., Sanada M., Wang L., Soda M., Kikuchi A., Igarashi T., Nakagawara A., Hayashi Y., Mano H., Ogawa S.
Oncogenic mutations of ALK kinase in neuroblastoma.
Nature 455:971-974(2008)

PubMed=20164919; DOI=10.1038/nature08768
Bignell G.R., Greenman C.D., Davies H., Butler A.P., Edkins S., Andrews J.M., Buck G., Chen L., Beare D., Latimer C., Widaa S., Hinton J., Fahey C., Fu B., Swamy S., Dalgliesh G.L., Teh B.T., Deloukas P., Yang F., Campbell P.J., Futreal P.A., Stratton M.R.
Signatures of mutation and selection in the cancer genome.
Nature 463:893-898(2010)

PubMed=22460905; DOI=10.1038/nature11003
Barretina J.G., Caponigro G., Stransky N., Venkatesan K., Margolin A.A., Kim S., Wilson C.J., Lehar J., Kryukov G.V., Sonkin D., Reddy A., Liu M., Murray L., Berger M.F., Monahan J.E., Morais P., Meltzer J., Korejwa A., Jane-Valbuena J., Mapa F.A., Thibault J., Bric-Furlong E., Raman P., Shipway A., Engels I.H., Cheng J., Yu G.K., Yu J., Aspesi P. Jr., de Silva M., Jagtap K., Jones M.D., Wang L., Hatton C., Palescandolo E., Gupta S., Mahan S., Sougnez C., Onofrio R.C., Liefeld T., MacConaill L.E., Winckler W., Reich M., Li N., Mesirov J.P., Gabriel S.B., Getz G., Ardlie K., Chan V., Myer V.E., Weber B.L., Porter J., Warmuth M., Finan P., Harris J.L., Meyerson M., Golub T.R., Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.
The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.
Nature 483:603-607(2012)

PubMed=27397505; DOI=10.1016/j.cell.2016.06.017
Iorio F., Knijnenburg T.A., Vis D.J., Bignell G.R., Menden M.P., Schubert M., Aben N., Goncalves E., Barthorpe S., Lightfoot H., Cokelaer T., Greninger P., van Dyk E., Chang H., de Silva H., Heyn H., Deng X., Egan R.K., Liu Q., Mironenko T., Mitropoulos X., Richardson L., Wang J., Zhang T., Moran S., Sayols S., Soleimani M., Tamborero D., Lopez-Bigas N., Ross-Macdonald P., Esteller M., Gray N.S., Haber D.A., Stratton M.R., Benes C.H., Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.
A landscape of pharmacogenomic interactions in cancer.
Cell 166:740-754(2016)

PubMed=28350380; DOI=10.1038/sdata.2017.33
Harenza J.L., Diamond M.A., Adams R.N., Song M.M., Davidson H.L., Hart L.S., Dent M.H., Fortina P., Reynolds C.P., Maris J.M.
Transcriptomic profiling of 39 commonly-used neuroblastoma cell lines.
Sci. Data 4:170033-170033(2017)

PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747
Dutil J., Chen Z., Monteiro A.N., Teer J.K., Eschrich S.A.
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Cancer Res. 79:1263-1273(2019)

PubMed=31068700; DOI=10.1038/s41586-019-1186-3
Ghandi M., Huang F.W., Jane-Valbuena J., Kryukov G.V., Lo C.C., McDonald E.R. III, Barretina J., Gelfand E.T., Bielski C.M., Li H., Hu K., Andreev-Drakhlin A.Y., Kim J., Hess J.M., Haas B.J., Aguet F., Weir B.A., Rothberg M.V., Paolella B.R., Lawrence M.S., Akbani R., Lu Y., Tiv H.L., Gokhale P.C., de Weck A., Mansour A.A., Oh C., Shih J., Hadi K., Rosen Y., Bistline J., Venkatesan K., Reddy A., Sonkin D., Liu M., Lehar J., Korn J.M., Porter D.A., Jones M.D., Golji J., Caponigro G., Taylor J.E., Dunning C.M., Creech A.L., Warren A.C., McFarland J.M., Zamanighomi M., Kauffmann A., Stransky N., Imielinski M., Maruvka Y.E., Cherniack A.D., Tsherniak A., Vazquez F., Jaffe J.D., Lane A.A., Weinstock D.M., Johannessen C.M., Morrissey M.P., Stegmeier F., Schlegel R., Hahn W.C., Getz G., Mills G.B., Boehm J.S., Golub T.R., Garraway L.A., Sellers W.R.
Next-generation characterization of the Cancer Cell Line Encyclopedia.
Nature 569:503-508(2019)

Cross-references
Cell line collections JCRB; IFO50295
JCRB; JCRB0621
RCB; RCB1953
TKG; TKG 0486
Cell line databases/resources CCLE; NB1_AUTONOMIC_GANGLIA
Cell_Model_Passport; SIDM00578
CGH-DB; 74-1
CGH-DB; 9097-4
Cosmic-CLP; 949179
DepMap; ACH-000804
GDSC; 949179
LINCS_LDP; LCL-1977
Ontologies BTO; BTO:0005103
CLO; CLO_0051419
Biological sample resources BioSample; SAMN03470966
BioSample; SAMN03472043
BioSample; SAMN10988531
Chemistry resources PharmacoDB; NB1_984_2019
Gene expression databases ArrayExpress; E-MTAB-2770
ArrayExpress; E-MTAB-3610
GEO; GSM333816
GEO; GSM333825
GEO; GSM887348
GEO; GSM888425
GEO; GSM1670145
GEO; GSM2371241
GEO; GSM2394388
Other Wikidata; Q54907515
Polymorphism and mutation databases Cosmic; 801736
Cosmic; 920243
Cosmic; 947696
Cosmic; 949179
Cosmic; 1037339
Cosmic; 1099136
Cosmic; 1153784
Cosmic; 1526632
Cosmic; 2131573
IARC_TP53; 27699
LiGeA; CCLE_099
Entry history
Entry creation04-Apr-2012
Last entry updated06-Sep-2019
Version number27