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Cellosaurus NB69 (CVCL_1448)

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Cell line name NB69
Synonyms NB-69; NB_69; NB 69; NB69-RIKEN
Accession CVCL_1448
Resource Identification Initiative To cite this cell line use: NB69 (RRID:CVCL_1448)
Comments Part of: Cancer Cell Line Encyclopedia (CCLE) project.
Part of: COSMIC cell lines project.
Microsatellite instability: Stable (MSS) (Sanger).
Omics: Deep exome analysis.
Omics: Deep RNAseq analysis.
Omics: DNA methylation analysis.
Omics: SNP array analysis.
Omics: Transcriptome analysis.
Genome ancestry Source: PubMed=30894373

Origin% genome
African0
Native American0.26
East Asian, North0.67
East Asian, South0
South Asian0.54
European, North64.54
European, South34
Disease Neuroblastoma (NCIt: C3270)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Male
Age at sampling 1Y4M
Category Cancer cell line
STR profile Source(s): Cosmic-CLP; ECACC; PubMed=25877200; RCB

Markers:
AmelogeninX,Y
CSF1PO11,12
D2S133817,23
D3S135816,17
D5S81811,12
D7S82010
D8S117913.2,14,15
D13S3178
D16S5399,11
D18S5115,16
D19S43314,15
D21S1130.2,31.2,32
FGA21,25
Penta D7,12
Penta E10,13
TH018
TPOX8,11 (Cosmic-CLP; PubMed=25877200; RCB)
11 (ECACC)
vWA17,18

Run an STR similarity search on this cell line
Publications

DOI=10.1016/B978-0-12-333530-2.50006-X
Israel M.A., Thiele C.J.
Tumor cell lines of the peripheral nervous system.
(In) Atlas of human tumor cell lines; Hay R.J., Park J.-G., Gazdar A.F. (eds.); pp.43-78; Academic Press; New York (1994)

DOI=10.1007/0-306-46872-7_2
Thiele C.J.
Neuroblastoma.
(In) Human cell culture. Vol. 1. Cancer Cell Lines part 1; Masters J.R.W., Palsson B.O. (eds.); pp.21-53; Kluwer Academic Publishers; New York (1999)

PubMed=16822308; DOI=10.1186/1471-2407-6-177
Dam V., Morgan B.T., Mazanek P., Hogarty M.D.
Mutations in PIK3CA are infrequent in neuroblastoma.
BMC Cancer 6:177-177(2006)

PubMed=18923524; DOI=10.1038/nature07399
Chen Y., Takita J., Choi Y.L., Kato M., Ohira M., Sanada M., Wang L., Soda M., Kikuchi A., Igarashi T., Nakagawara A., Hayashi Y., Mano H., Ogawa S.
Oncogenic mutations of ALK kinase in neuroblastoma.
Nature 455:971-974(2008)

PubMed=20164919; DOI=10.1038/nature08768
Bignell G.R., Greenman C.D., Davies H., Butler A.P., Edkins S., Andrews J.M., Buck G., Chen L., Beare D., Latimer C., Widaa S., Hinton J., Fahey C., Fu B., Swamy S., Dalgliesh G.L., Teh B.T., Deloukas P., Yang F., Campbell P.J., Futreal P.A., Stratton M.R.
Signatures of mutation and selection in the cancer genome.
Nature 463:893-898(2010)

PubMed=20215515; DOI=10.1158/0008-5472.CAN-09-3458
Rothenberg S.M., Mohapatra G., Rivera M.N., Winokur D., Greninger P., Nitta M., Sadow P.M., Sooriyakumar G., Brannigan B.W., Ulman M.J., Perera R.M., Wang R., Tam A., Ma X.-J., Erlander M., Sgroi D.C., Rocco J.W., Lingen M.W., Cohen E.E.W., Louis D.N., Settleman J., Haber D.A.
A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers.
Cancer Res. 70:2158-2164(2010)

PubMed=23202128; DOI=10.1038/ng.2493
Sausen M., Leary R.J., Jones S., Wu J., Reynolds C.P., Liu X., Blackford A.L., Parmigiani G., Diaz L.A. Jr., Papadopoulos N., Vogelstein B., Kinzler K.W., Velculescu V.E., Hogarty M.D.
Integrated genomic analyses identify ARID1A and ARID1B alterations in the childhood cancer neuroblastoma.
Nat. Genet. 45:12-17(2013)

PubMed=27397505; DOI=10.1016/j.cell.2016.06.017
Iorio F., Knijnenburg T.A., Vis D.J., Bignell G.R., Menden M.P., Schubert M., Aben N., Goncalves E., Barthorpe S., Lightfoot H., Cokelaer T., Greninger P., van Dyk E., Chang H., de Silva H., Heyn H., Deng X., Egan R.K., Liu Q., Mironenko T., Mitropoulos X., Richardson L., Wang J., Zhang T., Moran S., Sayols S., Soleimani M., Tamborero D., Lopez-Bigas N., Ross-Macdonald P., Esteller M., Gray N.S., Haber D.A., Stratton M.R., Benes C.H., Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.
A landscape of pharmacogenomic interactions in cancer.
Cell 166:740-754(2016)

PubMed=28350380; DOI=10.1038/sdata.2017.33
Harenza J.L., Diamond M.A., Adams R.N., Song M.M., Davidson H.L., Hart L.S., Dent M.H., Fortina P., Reynolds C.P., Maris J.M.
Transcriptomic profiling of 39 commonly-used neuroblastoma cell lines.
Sci. Data 4:170033-170033(2017)

PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747
Dutil J., Chen Z., Monteiro A.N., Teer J.K., Eschrich S.A.
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Cancer Res. 79:1263-1273(2019)

Cross-references
Cell line collections ECACC; 99072802
RCB; RCB0480
Cell line databases/resources CCLE; NB69_AUTONOMIC_GANGLIA
Cell_Model_Passport; SIDM00244
Cosmic-CLP; 908440
DepMap; ACH-002083
GDSC; 908440
LINCS_LDP; LCL-1999
Ontologies BTO; BTO:0005426
CLO; CLO_0050263
Biological sample resources BioSample; SAMN03470996
Chemistry resources ChEMBL-Cells; CHEMBL3308799
ChEMBL-Targets; CHEMBL1075510
Gene expression databases ArrayExpress; E-MTAB-3610
GEO; GSM313807
GEO; GSM563353
GEO; GSM827391
GEO; GSM1670154
GEO; GSM2371245
GEO; GSM2394385
Other Wikidata; Q54907543
Polymorphism and mutation databases Cosmic; 688081
Cosmic; 801739
Cosmic; 908440
Cosmic; 920248
Cosmic; 930069
Cosmic; 947709
Cosmic; 1019930
Cosmic; 1037342
Cosmic; 1099139
Cosmic; 1109123
Cosmic; 1153787
Cosmic; 1890119
Cosmic; 2058110
Cosmic; 2131577
Entry history
Entry creation04-Apr-2012
Last entry updated05-Jul-2019
Version number28