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Cellosaurus NCC-IT (CVCL_1451)

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Cell line name NCC-IT
Synonyms NCCIT
Accession CVCL_1451
Resource Identification Initiative To cite this cell line use: NCC-IT (RRID:CVCL_1451)
Comments Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
Part of: COSMIC cell lines project.
Population: Japanese.
Microsatellite instability: Stable (MSS) (Sanger).
Omics: Deep exome analysis.
Omics: DNA methylation analysis.
Omics: Deep quantitative proteome analysis.
Omics: SNP array analysis.
Omics: Transcriptome analysis.
Misspelling: NCC15; In PubMed=24812411 and Cosmic 2163758.
Sequence variations
  • Mutation; HGNC; 6844; MAP2K4; Simple; p.Lys309Asn (c.927G>C); Zygosity=Unspecified (PubMed=9331070).
  • Mutation; HGNC; 9588; PTEN; Simple; p.Arg173Pro (c.518G>C); ClinVar=VCV000185195; Zygosity=Heterozygous (Cosmic-CLP; DepMap).
  • Mutation; HGNC; 11998; TP53; Simple; p.Val272Cysfs*73 (c.814delG); Zygosity=Homozygous (Cosmic-CLP; DepMap).
Genome ancestry Source: PubMed=30894373

Origin% genome
Native American0
East Asian, North81.79
East Asian, South18.2
South Asian0
European, North0
European, South0
Disease Testicular embryonal carcinoma (NCIt: C6341)
Non-central nervous system-localized embryonal carcinoma (ORDO: Orphanet_289362)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Children:
Sex of cell Male
Age at sampling 24Y
Category Cancer cell line
STR profile Source(s): ATCC; DepMap; Cosmic-CLP

Penta D10,12
Penta E5,14

Run an STR similarity search on this cell line
Web pages https://de.wikipedia.org/wiki/NCC-IT

Teshima S.-I., Shimosato Y., Hirohashi S., Tome Y., Hayashi I., Kanazawa H., Kakizoe T.
Four new human germ cell tumor cell lines.
Lab. Invest. 59:328-336(1988)

Teng D.H.-F., Perry W.L. III, Hogan J.K., Baumgard M., Bell R., Berry S., Davis T., Frank D., Frye C., Hattier T., Hu R., Jammulapati S., Janecki T., Leavitt A., Mitchell J.T., Pero R., Sexton D., Schroeder M., Su P.-H., Swedlund B., Kyriakis J.M., Avruch J., Bartel P., Wong A.K.C., Oliphant A., Thomas A., Skolnick M.H., Tavtigian S.V.
Human mitogen-activated protein kinase kinase 4 as a candidate tumor suppressor.
Cancer Res. 57:4177-4182(1997)

PubMed=20164919; DOI=10.1038/nature08768
Bignell G.R., Greenman C.D., Davies H., Butler A.P., Edkins S., Andrews J.M., Buck G., Chen L., Beare D., Latimer C., Widaa S., Hinton J., Fahey C., Fu B., Swamy S., Dalgliesh G.L., Teh B.T., Deloukas P., Yang F., Campbell P.J., Futreal P.A., Stratton M.R.
Signatures of mutation and selection in the cancer genome.
Nature 463:893-898(2010)

PubMed=27397505; DOI=10.1016/j.cell.2016.06.017
Iorio F., Knijnenburg T.A., Vis D.J., Bignell G.R., Menden M.P., Schubert M., Aben N., Goncalves E., Barthorpe S., Lightfoot H., Cokelaer T., Greninger P., van Dyk E., Chang H., de Silva H., Heyn H., Deng X.-M., Egan R.K., Liu Q.-S., Mironenko T., Mitropoulos X., Richardson L., Wang J.-H., Zhang T.-H., Moran S., Sayols S., Soleimani M., Tamborero D., Lopez-Bigas N., Ross-Macdonald P., Esteller M., Gray N.S., Haber D.A., Stratton M.R., Benes C.H., Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.
A landscape of pharmacogenomic interactions in cancer.
Cell 166:740-754(2016)

PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747
Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Cancer Res. 79:1263-1273(2019)

PubMed=31500094; DOI=10.3390/cancers11091316
Bakardjieva-Mihaylova V., Skvarova Kramarzova K., Slamova M., Svaton M., Rejlova K., Zaliova M., Dobiasova A., Fiser K., Stuchly J., Grega M., Rosova B., Zachoval R., Klezl P., Eis V., Kindlova E., Buchler T., Trka J., Boublikova L.
Molecular basis of cisplatin resistance in testicular germ cell tumors.
Cancers (Basel) 11:1316.1-1316.18(2019)

PubMed=35084545; DOI=10.1007/s00345-022-03936-1
Fichtner A., Bohnenberger H., Elakad O., Richter A., Lenz C., Oing C., Strobel P., Kueffer S., Nettersheim D., Bremmer F.
Proteomic profiling of cisplatin-resistant and cisplatin-sensitive germ cell tumour cell lines using quantitative mass spectrometry.
World J. Urol. 40:373-383(2022)

Cell line collections ATCC; CRL-2073
BCRC; 60314
BCRJ; 0369
NCBI_Iran; C624
Cell line databases/resources CLO; CLO_0007955
Cell_Model_Passport; SIDM00655
Cosmic-CLP; 908441
DepMap; ACH-001578
Anatomy/cell type resources BTO; BTO:0004180
Biological sample resources BioSample; SAMN03471433
Chemistry resources ChEMBL-Cells; CHEMBL3308379
ChEMBL-Targets; CHEMBL1075511
PharmacoDB; NCCIT_999_2019
Encyclopedic resources Wikidata; Q17578676
Gene expression databases ArrayExpress; E-MTAB-783
GEO; GSM1670159
Polymorphism and mutation databases Cosmic; 687051
Cosmic; 908441
Cosmic; 1090412
Cosmic; 2077186
Cosmic; 2163758
Cosmic; 2807074
IARC_TP53; 21532
Proteomic databases PRIDE; PXD030251
Entry history
Entry creation04-Apr-2012
Last entry update23-Jun-2022
Version number34