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Cellosaurus NCI-H1184 (CVCL_1458)

Cell line name NCI-H1184
Synonyms H1184; H-1184; NCIH1184
Accession CVCL_1458
Resource Identification Initiative To cite this cell line use: NCI-H1184 (RRID:CVCL_1458)
Comments Part of: Cancer Cell Line Encyclopedia (CCLE) project.
Doubling time: ~50-70 hours (DSMZ).
Omics: Deep RNAseq analysis.
Omics: SNP array analysis.
Omics: Transcriptome analysis.
Disease Small cell lung carcinoma (NCIt: C4917)
Derived from metastatic site: Lymph node.
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Originate from same individual CVCL_2635 ! NCI-BL1184
Sex of cell Male
Age at sampling 42Y
Category Cancer cell line
STR profile Source(s): ATCC; DSMZ; PubMed=20679594; PubMed=24586258

D7S82010,12 (ATCC; DSMZ; PubMed=24586258)
12 (PubMed=20679594)
D16S53911,12 (ATCC; DSMZ; PubMed=20679594)
11 (PubMed=24586258)
Penta D12
Penta E5,7
vWA16 (ATCC)
16,17 (DSMZ; PubMed=20679594; PubMed=24586258)

PubMed=8806092; DOI=10.1002/jcb.240630505
Phelps R.M., Johnson B.E., Ihde D.C., Gazdar A.F., Carbone D.P., McClintock P.R., Linnoila R.I., Matthews M.J., Bunn P.A. Jr., Carney D.N., Minna J.D., Mulshine J.L.
NCI-Navy Medical Oncology Branch cell line data base.
J. Cell. Biochem. 63 Suppl. 24:32-91(1996)

PubMed=8806103; DOI=10.1002/jcb.240630516
Johnson B.E., Russell E., Simmons A.M., Phelps R.M., Steinberg S.M., Ihde D.C., Gazdar A.F.
MYC family DNA amplification in 126 tumor cell lines from patients with small cell lung cancer.
J. Cell. Biochem. 63 Suppl. 24:210-217(1996)

Girard L., Zochbauer-Muller S., Virmani A.K., Gazdar A.F., Minna J.D.
Genome-wide allelotyping of lung cancer identifies new regions of allelic loss, differences between small cell lung cancer and non-small cell lung cancer, and loci clustering.
Cancer Res. 60:4894-4906(2000)

PubMed=11030152; DOI=10.1038/sj.onc.1203815
Modi S., Kubo A., Oie H., Coxon A.B., Rehmatulla A., Kaye F.J.
Protein expression of the RB-related gene family and SV40 large T antigen in mesothelioma and lung cancer.
Oncogene 19:4632-4639(2000)

PubMed=11314036; DOI=10.1038/sj.onc.1204211
Forgacs E., Wren J.D., Kamibayashi C., Kondo M., Xu X.L., Markowitz S.D., Tomlinson G.E., Muller C.Y., Gazdar A.F., Garner H.R., Minna J.D.
Searching for microsatellite mutations in coding regions in lung, breast, ovarian and colorectal cancers.
Oncogene 20:1005-1009(2001)

PubMed=20679594; DOI=10.1093/jnci/djq279
Gazdar A.F., Girard L., Lockwood W.W., Lam W.L., Minna J.D.
Lung cancer cell lines as tools for biomedical discovery and research.
J. Natl. Cancer Inst. 102:1310-1321(2010)

PubMed=22460905; DOI=10.1038/nature11003
Barretina J.G., Caponigro G., Stransky N., Venkatesan K., Margolin A.A., Kim S., Wilson C.J., Lehar J., Kryukov G.V., Sonkin D., Reddy A., Liu M., Murray L., Berger M.F., Monahan J.E., Morais P., Meltzer J., Korejwa A., Jane-Valbuena J., Mapa F.A., Thibault J., Bric-Furlong E., Raman P., Shipway A., Engels I.H., Cheng J., Yu G.K., Yu J., Aspesi P. Jr., de Silva M., Jagtap K., Jones M.D., Wang L., Hatton C., Palescandolo E., Gupta S., Mahan S., Sougnez C., Onofrio R.C., Liefeld T., MacConaill L., Winckler W., Reich M., Li N., Mesirov J.P., Gabriel S.B., Getz G., Ardlie K., Chan V., Myer V.E., Weber B.L., Porter J., Warmuth M., Finan P., Harris J.L., Meyerson M., Golub T.R., Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.
The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.
Nature 483:603-607(2012)

PubMed=24586258; DOI=10.1371/journal.pone.0086910
Murmann T., Carrillo-Garcia C., Veit N., Courts C., Glassmann A., Janzen V., Madea B., Reinartz M., Harzen A., Nowak M., Perner S., Winter J., Probstmeier R.
Staurosporine and extracellular matrix proteins mediate the conversion of small cell lung carcinoma cells into a neuron-like phenotype.
PLoS ONE 9:E86910-E86910(2014)

Cell line collections ATCC; CRL-5858
Cell line databases/resources CCLE; NCIH1184_LUNG
GDSC; 688000
Ontologies CLO; CLO_0007983
Biological sample resources BioSample; SAMN03472574
BioSample; SAMN03473568
Gene expression databases ArrayExpress; E-MTAB-2770
GEO; GSM794309
GEO; GSM845539
GEO; GSM844616
GEO; GSM887354
GEO; GSM888432
Other Wikidata; Q54907775
Polymorphism and mutation databases Cosmic; 688000
Cosmic; 852001
Cosmic; 877218
Cosmic; 980943
Cosmic; 1032412
Cosmic; 1518089
Cosmic; 1891910
Cosmic; 2125225
Cosmic; 2560233
Cosmic; 2628356