ID   NCI-H1184
AC   CVCL_1458
SY   H1184; H-1184; NCIH1184
DR   CLO; CLO_0007983
DR   ArrayExpress; E-MTAB-2770
DR   ATCC; CRL-5858
DR   BioSample; SAMN03472574
DR   BioSample; SAMN03473568
DR   BioSample; SAMN10987606
DR   CCLE; NCIH1184_LUNG
DR   Cosmic; 688000
DR   Cosmic; 852001
DR   Cosmic; 877218
DR   Cosmic; 980943
DR   Cosmic; 1032412
DR   Cosmic; 1518089
DR   Cosmic; 1891910
DR   Cosmic; 2125225
DR   Cosmic; 2560233
DR   Cosmic; 2628356
DR   DepMap; ACH-000523
DR   DSMZ; ACC-502
DR   GDSC; 688000
DR   GEO; GSM794309
DR   GEO; GSM845539
DR   GEO; GSM844616
DR   GEO; GSM887354
DR   GEO; GSM888432
DR   IARC_TP53; 426
DR   LiGeA; CCLE_745
DR   PharmacoDB; NCIH1184_1004_2019
DR   Wikidata; Q54907775
RX   PubMed=1312696;
RX   PubMed=1565469;
RX   PubMed=8806092;
RX   PubMed=8806103;
RX   PubMed=10987304;
RX   PubMed=11030152;
RX   PubMed=11314036;
RX   PubMed=20679594;
RX   PubMed=22460905;
RX   PubMed=23716474;
RX   PubMed=24586258;
RX   PubMed=30894373;
RX   PubMed=31068700;
CC   Part of: Cancer Cell Line Encyclopedia (CCLE) project.
CC   Doubling time: ~50-70 hours (DSMZ).
CC   Sequence variation: TP53 p.Gly334Val (c.1001G>T) (PubMed=1312696; PubMed=1565469).
CC   Omics: Deep exome analysis.
CC   Omics: Deep RNAseq analysis.
CC   Omics: SNP array analysis.
CC   Omics: Transcriptome analysis.
CC   Genome ancestry: African=0.45%; Native American=0.52%; East Asian, North=0.92%; East Asian, South=0%; South Asian=0.72%; European, North=65.61%; European, South=31.77% (PubMed=30894373).
CC   Derived from metastatic site: Lymph node.
ST   Source(s): ATCC; DSMZ; PubMed=20679594; PubMed=24586258
ST   Amelogenin: X,Y
ST   CSF1PO: 10
ST   D13S317: 11
ST   D16S539: 11,12 (ATCC; DSMZ; PubMed=20679594)
ST   D16S539: 11 (PubMed=24586258)
ST   D18S51: 16,20
ST   D21S11: 32.2
ST   D3S1358: 14
ST   D5S818: 12
ST   D7S820: 10,12 (ATCC; DSMZ; PubMed=24586258)
ST   D7S820: 12 (PubMed=20679594)
ST   D8S1179: 10,11
ST   FGA: 22
ST   Penta D: 12
ST   Penta E: 5,7
ST   TH01: 6,9.3
ST   TPOX: 8,9
ST   vWA: 16 (ATCC)
ST   vWA: 16,17 (DSMZ; PubMed=20679594; PubMed=24586258)
DI   NCIt; C4917; Small cell lung carcinoma
OX   NCBI_TaxID=9606; ! Homo sapiens
OI   CVCL_2635 ! NCI-BL1184
SX   Male
AG   42Y
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 06-09-19; Version: 26
//
RX   PubMed=1312696;
RA   D'Amico D., Carbone D.P., Mitsudomi T., Nau M.M., Fedorko J.,
RA   Russell E., Johnson B., Buchhagen D.L., Bodner S.M., Phelps R.M.,
RA   Gazdar A.F., Minna J.D.;
RT   "High frequency of somatically acquired p53 mutations in small-cell
RT   lung cancer cell lines and tumors.";
RL   Oncogene 7:339-346(1992).
//
RX   PubMed=1565469;
RA   Bodner S.M., Minna J.D., Jensen S.M., D'Amico D., Carbone D.P.,
RA   Mitsudomi T., Fedorko J., Buchhagen D.L., Nau M.M., Gazdar A.F.,
RA   Linnoila R.I.;
RT   "Expression of mutant p53 proteins in lung cancer correlates with the
RT   class of p53 gene mutation.";
RL   Oncogene 7:743-749(1992).
//
RX   PubMed=8806092; DOI=10.1002/jcb.240630505;
RA   Phelps R.M., Johnson B.E., Ihde D.C., Gazdar A.F., Carbone D.P.,
RA   McClintock P.R., Linnoila R.I., Matthews M.J., Bunn P.A. Jr.,
RA   Carney D.N., Minna J.D., Mulshine J.L.;
RT   "NCI-Navy Medical Oncology Branch cell line data base.";
RL   J. Cell. Biochem. 63 Suppl. 24:32-91(1996).
//
RX   PubMed=8806103; DOI=10.1002/jcb.240630516;
RA   Johnson B.E., Russell E., Simmons A.M., Phelps R.M., Steinberg S.M.,
RA   Ihde D.C., Gazdar A.F.;
RT   "MYC family DNA amplification in 126 tumor cell lines from patients
RT   with small cell lung cancer.";
RL   J. Cell. Biochem. 63 Suppl. 24:210-217(1996).
//
RX   PubMed=10987304;
RA   Girard L., Zochbauer-Muller S., Virmani A.K., Gazdar A.F., Minna J.D.;
RT   "Genome-wide allelotyping of lung cancer identifies new regions of
RT   allelic loss, differences between small cell lung cancer and non-small
RT   cell lung cancer, and loci clustering.";
RL   Cancer Res. 60:4894-4906(2000).
//
RX   PubMed=11030152; DOI=10.1038/sj.onc.1203815;
RA   Modi S., Kubo A., Oie H., Coxon A.B., Rehmatulla A., Kaye F.J.;
RT   "Protein expression of the RB-related gene family and SV40 large T
RT   antigen in mesothelioma and lung cancer.";
RL   Oncogene 19:4632-4639(2000).
//
RX   PubMed=11314036; DOI=10.1038/sj.onc.1204211;
RA   Forgacs E., Wren J.D., Kamibayashi C., Kondo M., Xu X.L.,
RA   Markowitz S.D., Tomlinson G.E., Muller C.Y., Gazdar A.F., Garner H.R.,
RA   Minna J.D.;
RT   "Searching for microsatellite mutations in coding regions in lung,
RT   breast, ovarian and colorectal cancers.";
RL   Oncogene 20:1005-1009(2001).
//
RX   PubMed=20679594; DOI=10.1093/jnci/djq279;
RA   Gazdar A.F., Girard L., Lockwood W.W., Lam W.L., Minna J.D.;
RT   "Lung cancer cell lines as tools for biomedical discovery and
RT   research.";
RL   J. Natl. Cancer Inst. 102:1310-1321(2010).
//
RX   PubMed=22460905; DOI=10.1038/nature11003;
RA   Barretina J.G., Caponigro G., Stransky N., Venkatesan K., Margolin A.A.,
RA   Kim S., Wilson C.J., Lehar J., Kryukov G.V., Sonkin D., Reddy A.,
RA   Liu M., Murray L., Berger M.F., Monahan J.E., Morais P., Meltzer J.,
RA   Korejwa A., Jane-Valbuena J., Mapa F.A., Thibault J., Bric-Furlong E.,
RA   Raman P., Shipway A., Engels I.H., Cheng J., Yu G.K., Yu J.,
RA   Aspesi P. Jr., de Silva M., Jagtap K., Jones M.D., Wang L., Hatton C.,
RA   Palescandolo E., Gupta S., Mahan S., Sougnez C., Onofrio R.C.,
RA   Liefeld T., MacConaill L.E., Winckler W., Reich M., Li N., Mesirov J.P.,
RA   Gabriel S.B., Getz G., Ardlie K., Chan V., Myer V.E., Weber B.L.,
RA   Porter J., Warmuth M., Finan P., Harris J.L., Meyerson M., Golub T.R.,
RA   Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.;
RT   "The Cancer Cell Line Encyclopedia enables predictive modelling of
RT   anticancer drug sensitivity.";
RL   Nature 483:603-607(2012).
//
RX   PubMed=23716474; DOI=10.1002/gcc.22076;
RA   Iwakawa R., Takenaka M., Kohno T., Shimada Y., Totoki Y., Shibata T.,
RA   Tsuta K., Nishikawa R., Noguchi M., Sato-Otsubo A., Ogawa S.,
RA   Yokota J.;
RT   "Genome-wide identification of genes with amplification and/or fusion
RT   in small cell lung cancer.";
RL   Genes Chromosomes Cancer 52:802-816(2013).
//
RX   PubMed=24586258; DOI=10.1371/journal.pone.0086910;
RA   Murmann T., Carrillo-Garcia C., Veit N., Courts C., Glassmann A.,
RA   Janzen V., Madea B., Reinartz M., Harzen A., Nowak M., Perner S.,
RA   Winter J., Probstmeier R.;
RT   "Staurosporine and extracellular matrix proteins mediate the
RT   conversion of small cell lung carcinoma cells into a neuron-like
RT   phenotype.";
RL   PLoS ONE 9:E86910-E86910(2014).
//
RX   PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747;
RA   Dutil J., Chen Z., Monteiro A.N., Teer J.K., Eschrich S.A.;
RT   "An interactive resource to probe genetic diversity and estimated
RT   ancestry in cancer cell lines.";
RL   Cancer Res. 79:1263-1273(2019).
//
RX   PubMed=31068700; DOI=10.1038/s41586-019-1186-3;
RA   Ghandi M., Huang F.W., Jane-Valbuena J., Kryukov G.V., Lo C.C.,
RA   McDonald E.R. III, Barretina J., Gelfand E.T., Bielski C.M., Li H.,
RA   Hu K., Andreev-Drakhlin A.Y., Kim J., Hess J.M., Haas B.J., Aguet F.,
RA   Weir B.A., Rothberg M.V., Paolella B.R., Lawrence M.S., Akbani R.,
RA   Lu Y., Tiv H.L., Gokhale P.C., de Weck A., Mansour A.A., Oh C.,
RA   Shih J., Hadi K., Rosen Y., Bistline J., Venkatesan K., Reddy A.,
RA   Sonkin D., Liu M., Lehar J., Korn J.M., Porter D.A., Jones M.D.,
RA   Golji J., Caponigro G., Taylor J.E., Dunning C.M., Creech A.L.,
RA   Warren A.C., McFarland J.M., Zamanighomi M., Kauffmann A.,
RA   Stransky N., Imielinski M., Maruvka Y.E., Cherniack A.D.,
RA   Tsherniak A., Vazquez F., Jaffe J.D., Lane A.A., Weinstock D.M.,
RA   Johannessen C.M., Morrissey M.P., Stegmeier F., Schlegel R.,
RA   Hahn W.C., Getz G., Mills G.B., Boehm J.S., Golub T.R., Garraway L.A.,
RA   Sellers W.R.;
RT   "Next-generation characterization of the Cancer Cell Line
RT   Encyclopedia.";
RL   Nature 569:503-508(2019).
//