Cellosaurus NCI-H1993 (CVCL_1512)

Cell line name NCI-H1993
Synonyms H1993; H-1993
Accession CVCL_1512
Resource Identification Initiative To cite this cell line use: NCI-H1993 (RRID:CVCL_1512)
Comments Part of: MD Anderson Cell Lines Project.
Microsatellite instability: Stable (MSS) (Sanger).
Omics: Deep exome analysis.
Omics: Deep RNAseq analysis.
Omics: DNA methylation analysis.
Omics: Genome sequenced.
Omics: Protein expression by reverse-phase protein arrays.
Omics: SNP array analysis.
Omics: Transcriptome analysis.
Disease Lung adenocarcinoma (NCIt: C3512)
Derived from metastatic site: Lymph node.
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Originate from same individual CVCL_E102 ! NCI-BL1993
CVCL_1521 ! NCI-H2073
Sex of cell Female
Category Cancer cell line
STR profile Source(s): ATCC; Cosmic-CLP; PubMed=20679594; PubMed=25877200

Markers:
AmelogeninX (ATCC; Cosmic-CLP; PubMed=25877200)
X,Y (PubMed=20679594)
CSF1PO10,13
D13S31713
D16S53912
D18S5113,18
D21S1129
D3S135817
D5S81811,12
D7S82012
D8S117914
FGA22,23
Penta D10
Penta E12
TH016,9.3
TPOX9
vWA17
Web pages http://tcpaportal.org/mclp/
Publications

PubMed=8806092; DOI=10.1002/jcb.240630505
Phelps R.M., Johnson B.E., Ihde D.C., Gazdar A.F., Carbone D.P., McClintock P.R., Linnoila R.I., Matthews M.J., Bunn P.A. Jr., Carney D.N., Minna J.D., Mulshine J.L.
NCI-Navy Medical Oncology Branch cell line data base.
J. Cell. Biochem. 63 Suppl. 24:32-91(1996)

PubMed=10987304
Girard L., Zochbauer-Muller S., Virmani A.K., Gazdar A.F., Minna J.D.
Genome-wide allelotyping of lung cancer identifies new regions of allelic loss, differences between small cell lung cancer and non-small cell lung cancer, and loci clustering.
Cancer Res. 60:4894-4906(2000)

PubMed=11030152; DOI=10.1038/sj.onc.1203815
Modi S., Kubo A., Oie H., Coxon A.B., Rehmatulla A., Kaye F.J.
Protein expression of the RB-related gene family and SV40 large T antigen in mesothelioma and lung cancer.
Oncogene 19:4632-4639(2000)

PubMed=20679594; DOI=10.1093/jnci/djq279
Gazdar A.F., Girard L., Lockwood W.W., Lam W.L., Minna J.D.
Lung cancer cell lines as tools for biomedical discovery and research.
J. Natl. Cancer Inst. 102:1310-1321(2010)

PubMed=24297535; DOI=10.1142/9789814583220_0008
Mayba O., Gnad F., Peyton M., Zhang F., Walter K., Du P., Huntley M.A., Jiang Z., Liu J., Haverty P.M., Gentleman R.C., Li R.-Q., Minna J.D., Li Y.-R., Shames D.S., Zhang Z.
Integrative analysis of two cell lines derived from a non-small-lung cancer patient -- a panomics approach.
Pac. Symp. Biocomput. 2014:75-86(2014)

PubMed=27397505; DOI=10.1016/j.cell.2016.06.017
Iorio F., Knijnenburg T.A., Vis D.J., Bignell G.R., Menden M.P., Schubert M., Aben N., Goncalves E., Barthorpe S., Lightfoot H., Cokelaer T., Greninger P., van Dyk E., Chang H., de Silva H., Heyn H., Deng X., Egan R.K., Liu Q., Mironenko T., Mitropoulos X., Richardson L., Wang J., Zhang T., Moran S., Sayols S., Soleimani M., Tamborero D., Lopez-Bigas N., Ross-Macdonald P., Esteller M., Gray N.S., Haber D.A., Stratton M.R., Benes C.H., Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.
A landscape of pharmacogenomic interactions in cancer.
Cell 166:740-754(2016)

PubMed=28196595; DOI=10.1016/j.ccell.2017.01.005
Li J., Zhao W., Akbani R., Liu W., Ju Z., Ling S., Vellano C.P., Roebuck P., Yu Q., Eterovic A.K., Byers L.A., Davies M.A., Deng W., Gopal Y.N.V., Chen G., von Euw E.M., Slamon D.J., Conklin D., Heymach J.V., Gazdar A.F., Minna J.D., Myers J.N., Lu Y., Mills G.B., Liang H.
Characterization of human cancer cell lines by reverse-phase protein arrays.
Cancer Cell 31:225-239(2017)

Cross-references
Cell line collections ATCC; CRL-5909
NCI-DTP; NCI-H1993
Cell line databases/resources Cosmic-CLP; 908476
GDSC; 908476
IGRhCellID; NCIH1993
LINCS_LDP; LCL-1646
Ontologies CLO; CLO_0008036
EFO; EFO_0002272
Biological sample resources BioSample; SAMN03473255
Chemistry resources ChEMBL-Cells; CHEMBL3308138
ChEMBL-Targets; CHEMBL1075527
Gene expression databases GEO; GSM62328
GEO; GSM274706
GEO; GSM434315
GEO; GSM513952
GEO; GSM514337
GEO; GSM794341
GEO; GSM1670204
Polymorphism and mutation databases Cosmic; 687809
Cosmic; 877248
Cosmic; 903608
Cosmic; 908476
Cosmic; 980988
Cosmic; 1032460
Cosmic; 1146895
Cosmic; 1694669
Cosmic; 1870266
Cosmic; 1891898
Cosmic; 1995549
Cosmic; 2125239
Cosmic; 2630415