Cellosaurus NCI-H2009 (CVCL_1514)

Cell line name NCI-H2009
Synonyms H2009; H-2009
Accession CVCL_1514
Resource Identification Initiative To cite this cell line use: NCI-H2009 (RRID:CVCL_1514)
Comments Part of: Cancer Cell Line Encyclopedia (CCLE) project.
Microsatellite instability: Stable (MSS) (Sanger).
Omics: Deep exome analysis.
Omics: Deep phosphoproteome analysis.
Omics: Deep proteome analysis.
Omics: Deep RNAseq analysis.
Omics: DNA methylation analysis.
Omics: SNP array analysis.
Omics: Transcriptome analysis.
Disease Lung adenocarcinoma (NCIt: C3512)
Derived from metastatic site: Lymph node.
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Children: CVCL_4Y15 (NCI-H2009-Luc)
Originate from same individual CVCL_2645 ! NCI-BL2009
Sex of cell Female
Category Cancer cell line
STR profile Source(s): ATCC; Cosmic-CLP; KCLB; PubMed=11416159; PubMed=25877200

Markers:
AmelogeninX
CSF1PO10,12
D13S31712
D16S53912
D18S5114
D21S1129
D3S135816
D5S81813
D7S8209,11
D8S117910,15
FGA22 (KCLB; PubMed=25877200)
22,26 (PubMed=11416159)
Penta D12
Penta E11
TH019.3
TPOX8
vWA14
Web pages http://www.pawefish.path.cam.ac.uk/LungCellLineDescriptions/NCI-H2009.html
Publications

PubMed=8806092; DOI=10.1002/jcb.240630505
Phelps R.M., Johnson B.E., Ihde D.C., Gazdar A.F., Carbone D.P., McClintock P.R., Linnoila R.I., Matthews M.J., Bunn P.A. Jr., Carney D.N., Minna J.D., Mulshine J.L.
NCI-Navy Medical Oncology Branch cell line data base.
J. Cell. Biochem. 63 Suppl. 24:32-91(1996)

PubMed=10987304
Girard L., Zochbauer-Muller S., Virmani A.K., Gazdar A.F., Minna J.D.
Genome-wide allelotyping of lung cancer identifies new regions of allelic loss, differences between small cell lung cancer and non-small cell lung cancer, and loci clustering.
Cancer Res. 60:4894-4906(2000)

PubMed=11030152; DOI=10.1038/sj.onc.1203815
Modi S., Kubo A., Oie H., Coxon A.B., Rehmatulla A., Kaye F.J.
Protein expression of the RB-related gene family and SV40 large T antigen in mesothelioma and lung cancer.
Oncogene 19:4632-4639(2000)

PubMed=11314036; DOI=10.1038/sj.onc.1204211
Forgacs E., Wren J.D., Kamibayashi C., Kondo M., Xu X.L., Markowitz S.D., Tomlinson G.E., Muller C.Y., Gazdar A.F., Garner H.R., Minna J.D.
Searching for microsatellite mutations in coding regions in lung, breast, ovarian and colorectal cancers.
Oncogene 20:1005-1009(2001)

PubMed=16157194; DOI=10.1016/j.cancergencyto.2005.03.007
Grigorova M., Lyman R.C., Caldas C., Edwards P.A.W.
Chromosome abnormalities in 10 lung cancer cell lines of the NCI-H series analyzed with spectral karyotyping.
Cancer Genet. Cytogenet. 162:1-9(2005)

PubMed=19472407; DOI=10.1002/humu.21028
Blanco R., Iwakawa R., Tang M., Kohno T., Angulo B., Pio R., Montuenga L.M., Minna J.D., Yokota J., Sanchez-Cespedes M.
A gene-alteration profile of human lung cancer cell lines.
Hum. Mutat. 30:1199-1206(2009)

PubMed=22460905; DOI=10.1038/nature11003
Barretina J.G., Caponigro G., Stransky N., Venkatesan K., Margolin A.A., Kim S., Wilson C.J., Lehar J., Kryukov G.V., Sonkin D., Reddy A., Liu M., Murray L., Berger M.F., Monahan J.E., Morais P., Meltzer J., Korejwa A., Jane-Valbuena J., Mapa F.A., Thibault J., Bric-Furlong E., Raman P., Shipway A., Engels I.H., Cheng J., Yu G.K., Yu J., Aspesi P. Jr., de Silva M., Jagtap K., Jones M.D., Wang L., Hatton C., Palescandolo E., Gupta S., Mahan S., Sougnez C., Onofrio R.C., Liefeld T., MacConaill L., Winckler W., Reich M., Li N., Mesirov J.P., Gabriel S.B., Getz G., Ardlie K., Chan V., Myer V.E., Weber B.L., Porter J., Warmuth M., Finan P., Harris J.L., Meyerson M., Golub T.R., Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.
The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.
Nature 483:603-607(2012)

PubMed=24135919; DOI=10.1038/ncomms3617
Balbin O.A., Prensner J.R., Sahu A., Yocum A., Shankar S., Malik R., Fermin D., Dhanasekaran S.M., Chandler B., Thomas D., Beer D.G., Cao X., Nesvizhskii A.I., Chinnaiyan A.M.
Reconstructing targetable pathways in lung cancer by integrating diverse omics data.
Nat. Commun. 4:2617-2617(2013)

PubMed=25485619; DOI=10.1038/nbt.3080
Klijn C., Durinck S., Stawiski E.W., Haverty P.M., Jiang Z., Liu H., Degenhardt J., Mayba O., Gnad F., Liu J., Pau G., Reeder J., Cao Y., Mukhyala K., Selvaraj S.K., Yu M., Zynda G.J., Brauer M.J., Wu T.D., Gentleman R.C., Manning G., Yauch R.L., Bourgon R., Stokoe D., Modrusan Z., Neve R.M., de Sauvage F.J., Settleman J., Seshagiri S., Zhang Z.
A comprehensive transcriptional portrait of human cancer cell lines.
Nat. Biotechnol. 33:306-312(2015)

PubMed=27397505; DOI=10.1016/j.cell.2016.06.017
Iorio F., Knijnenburg T.A., Vis D.J., Bignell G.R., Menden M.P., Schubert M., Aben N., Goncalves E., Barthorpe S., Lightfoot H., Cokelaer T., Greninger P., van Dyk E., Chang H., de Silva H., Heyn H., Deng X., Egan R.K., Liu Q., Mironenko T., Mitropoulos X., Richardson L., Wang J., Zhang T., Moran S., Sayols S., Soleimani M., Tamborero D., Lopez-Bigas N., Ross-Macdonald P., Esteller M., Gray N.S., Haber D.A., Stratton M.R., Benes C.H., Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.
A landscape of pharmacogenomic interactions in cancer.
Cell 166:740-754(2016)

Cross-references
Cell line collections ATCC; CRL-5911
KCLB; 92009
Cell line databases/resources CCLE; NCIH2009_LUNG
CCRID; 3111C0001CCC000383
Cosmic-CLP; 724873
GDSC; 724873
IGRhCellID; NCIH2009
LINCS_LDP; LCL-1647
Ontologies BTO; BTO:0003242
CLO; CLO_0008038
EFO; EFO_0002273
Biological sample resources BioSample; SAMN03471794
Chemistry resources ChEMBL-Cells; CHEMBL3308459
ChEMBL-Targets; CHEMBL1075528
Gene expression databases GEO; GSM63697
GEO; GSM206482
GEO; GSM253369
GEO; GSM274782
GEO; GSM274815
GEO; GSM385518
GEO; GSM385529
GEO; GSM434316
GEO; GSM794342
GEO; GSM827528
GEO; GSM887394
GEO; GSM888472
GEO; GSM1670205
Polymorphism and mutation databases Cosmic; 722054
Cosmic; 724873
Cosmic; 877249
Cosmic; 877436
Cosmic; 903609
Cosmic; 980989
Cosmic; 1032461
Cosmic; 1146896
Cosmic; 1154596
Cosmic; 1188589
Cosmic; 1239889
Cosmic; 1518084
Cosmic; 1802308
Cosmic; 1870267
Cosmic; 1891899
Cosmic; 1995550
Cosmic; 2125240