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Cellosaurus NCI-H526 (CVCL_1569)

[Text version]

Cell line name NCI-H526
Synonyms H526; H-526; NCIH526
Accession CVCL_1569
Resource Identification Initiative To cite this cell line use: NCI-H526 (RRID:CVCL_1569)
Comments Part of: Cancer Cell Line Encyclopedia (CCLE) project.
Part of: COSMIC cell lines project.
Microsatellite instability: Instable (MSI-low) (Sanger).
Omics: Array-based CGH.
Omics: Deep exome analysis.
Omics: Deep proteome analysis.
Omics: Deep RNAseq analysis.
Omics: DNA methylation analysis.
Omics: miRNA expression profiling.
Omics: Protein expression by reverse-phase protein arrays.
Omics: SNP array analysis.
Omics: Transcriptome analysis.
Sequence variations Homozygous for TP53 c.97-1G>C; splice acceptor mutation (PubMed=1312696; PubMed=1565469).
Genome ancestry Source: PubMed=30894373

Origin% genome
African0
Native American0
East Asian, North1.13
East Asian, South0
South Asian1.94
European, North63.44
European, South33.49
Disease Small cell lung carcinoma (NCIt: C4917)
Derived from metastatic site: Bone marrow.
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Male
Age at sampling 55Y
Category Cancer cell line
STR profile Source(s): ATCC; Cosmic-CLP; PubMed=25877200

Markers:
AmelogeninX,Y
CSF1PO11
D3S135817
D5S81811
D7S8209,12
D8S117914
D13S31713
D16S5399
D18S5112,15
D21S1127,32.2
FGA22
Penta D13,14
Penta E5,13
TH016,8
TPOX8,11
vWA16,17

Run an STR similarity search on this cell line
Publications

PubMed=2985257
Carney D.N., Gazdar A.F., Bepler G., Guccion J.G., Marangos P.J., Moody T.W., Zweig M.H., Minna J.D.
Establishment and identification of small cell lung cancer cell lines having classic and variant features.
Cancer Res. 45:2913-2923(1985)

PubMed=1312696
D'Amico D., Carbone D.P., Mitsudomi T., Nau M.M., Fedorko J., Russell E., Johnson B., Buchhagen D.L., Bodner S.M., Phelps R.M., Gazdar A.F., Minna J.D.
High frequency of somatically acquired p53 mutations in small-cell lung cancer cell lines and tumors.
Oncogene 7:339-346(1992)

PubMed=1320893; DOI=10.1159/000163712
Verbeeck M.A.E., Elands J.P.M., de Leij L.F.M.H., Buys C.H.C.M., Carney D.N., Bepler G., Roebroeck A.J.M., van de Ven W.J.M., Burbach J.P.
Expression of the vasopressin and gastrin-releasing peptide genes in small cell lung carcinoma cell lines.
Pathobiology 60:136-142(1992)

PubMed=1565469
Bodner S.M., Minna J.D., Jensen S.M., D'Amico D., Carbone D.P., Mitsudomi T., Fedorko J., Buchhagen D.L., Nau M.M., Gazdar A.F., Linnoila R.I.
Expression of mutant p53 proteins in lung cancer correlates with the class of p53 gene mutation.
Oncogene 7:743-749(1992)

PubMed=8806092; DOI=10.1002/jcb.240630505
Phelps R.M., Johnson B.E., Ihde D.C., Gazdar A.F., Carbone D.P., McClintock P.R., Linnoila R.I., Matthews M.J., Bunn P.A. Jr., Carney D.N., Minna J.D., Mulshine J.L.
NCI-Navy Medical Oncology Branch cell line data base.
J. Cell. Biochem. 63 Suppl. 24:32-91(1996)

PubMed=8806103; DOI=10.1002/jcb.240630516
Johnson B.E., Russell E., Simmons A.M., Phelps R.M., Steinberg S.M., Ihde D.C., Gazdar A.F.
MYC family DNA amplification in 126 tumor cell lines from patients with small cell lung cancer.
J. Cell. Biochem. 63 Suppl. 24:210-217(1996)

PubMed=10037197
Tang X.X., Brodeur G.M., Campling B.G., Ikegaki N.
Coexpression of transcripts encoding EPHB receptor protein tyrosine kinases and their ephrin-B ligands in human small cell lung carcinoma.
Clin. Cancer Res. 5:455-460(1999)

PubMed=11005564; DOI=10.1038/sj.neo.7900094
Kohno T., Sato T., Takakura S., Takei K., Inoue K., Nishioka M., Yokota J.
Mutation and expression of the DCC gene in human lung cancer.
Neoplasia 2:300-305(2000)

PubMed=11030152; DOI=10.1038/sj.onc.1203815
Modi S., Kubo A., Oie H., Coxon A.B., Rehmatulla A., Kaye F.J.
Protein expression of the RB-related gene family and SV40 large T antigen in mesothelioma and lung cancer.
Oncogene 19:4632-4639(2000)

PubMed=17426248; DOI=10.1158/1541-7786.MCR-06-0367
Olejniczak E.T., Van Sant C., Anderson M.G., Wang G., Tahir S.K., Sauter G., Lesniewski R., Semizarov D.
Integrative genomic analysis of small-cell lung carcinoma reveals correlates of sensitivity to bcl-2 antagonists and uncovers novel chromosomal gains.
Mol. Cancer Res. 5:331-339(2007)

PubMed=19472407; DOI=10.1002/humu.21028
Blanco R., Iwakawa R., Tang M., Kohno T., Angulo B., Pio R., Montuenga L.M., Minna J.D., Yokota J., Sanchez-Cespedes M.
A gene-alteration profile of human lung cancer cell lines.
Hum. Mutat. 30:1199-1206(2009)

PubMed=20164919; DOI=10.1038/nature08768
Bignell G.R., Greenman C.D., Davies H., Butler A.P., Edkins S., Andrews J.M., Buck G., Chen L., Beare D., Latimer C., Widaa S., Hinton J., Fahey C., Fu B., Swamy S., Dalgliesh G.L., Teh B.T., Deloukas P., Yang F., Campbell P.J., Futreal P.A., Stratton M.R.
Signatures of mutation and selection in the cancer genome.
Nature 463:893-898(2010)

PubMed=20624269; DOI=10.1186/1756-9966-29-75
Du L., Schageman J.J., Irnov I., Girard L., Hammond S.M., Minna J.D., Gazdar A.F., Pertsemlidis A.
MicroRNA expression distinguishes SCLC from NSCLC lung tumor cells and suggests a possible pathological relationship between SCLCs and NSCLCs.
J. Exp. Clin. Cancer Res. 29:75-75(2010)

PubMed=22460905; DOI=10.1038/nature11003
Barretina J.G., Caponigro G., Stransky N., Venkatesan K., Margolin A.A., Kim S., Wilson C.J., Lehar J., Kryukov G.V., Sonkin D., Reddy A., Liu M., Murray L., Berger M.F., Monahan J.E., Morais P., Meltzer J., Korejwa A., Jane-Valbuena J., Mapa F.A., Thibault J., Bric-Furlong E., Raman P., Shipway A., Engels I.H., Cheng J., Yu G.K., Yu J., Aspesi P. Jr., de Silva M., Jagtap K., Jones M.D., Wang L., Hatton C., Palescandolo E., Gupta S., Mahan S., Sougnez C., Onofrio R.C., Liefeld T., MacConaill L.E., Winckler W., Reich M., Li N., Mesirov J.P., Gabriel S.B., Getz G., Ardlie K., Chan V., Myer V.E., Weber B.L., Porter J., Warmuth M., Finan P., Harris J.L., Meyerson M., Golub T.R., Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.
The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.
Nature 483:603-607(2012)

PubMed=22961666; DOI=10.1158/2159-8290.CD-12-0112
Byers L.A., Wang J., Nilsson M.B., Fujimoto J., Saintigny P., Yordy J., Giri U., Peyton M., Fan Y.H., Diao L., Masrorpour F., Shen L., Liu W., Duchemann B., Tumula P., Bhardwaj V., Welsh J., Weber S., Glisson B.S., Kalhor N., Wistuba I.I., Girard L., Lippman S.M., Mills G.B., Coombes K.R., Weinstein J.N., Minna J.D., Heymach J.V.
Proteomic profiling identifies dysregulated pathways in small cell lung cancer and novel therapeutic targets including PARP1.
Cancer Discov. 2:798-811(2012)

PubMed=23716474; DOI=10.1002/gcc.22076
Iwakawa R., Takenaka M., Kohno T., Shimada Y., Totoki Y., Shibata T., Tsuta K., Nishikawa R., Noguchi M., Sato-Otsubo A., Ogawa S., Yokota J.
Genome-wide identification of genes with amplification and/or fusion in small cell lung cancer.
Genes Chromosomes Cancer 52:802-816(2013)

PubMed=27397505; DOI=10.1016/j.cell.2016.06.017
Iorio F., Knijnenburg T.A., Vis D.J., Bignell G.R., Menden M.P., Schubert M., Aben N., Goncalves E., Barthorpe S., Lightfoot H., Cokelaer T., Greninger P., van Dyk E., Chang H., de Silva H., Heyn H., Deng X., Egan R.K., Liu Q., Mironenko T., Mitropoulos X., Richardson L., Wang J., Zhang T., Moran S., Sayols S., Soleimani M., Tamborero D., Lopez-Bigas N., Ross-Macdonald P., Esteller M., Gray N.S., Haber D.A., Stratton M.R., Benes C.H., Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.
A landscape of pharmacogenomic interactions in cancer.
Cell 166:740-754(2016)

PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747
Dutil J., Chen Z., Monteiro A.N., Teer J.K., Eschrich S.A.
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Cancer Res. 79:1263-1273(2019)

PubMed=31068700; DOI=10.1038/s41586-019-1186-3
Ghandi M., Huang F.W., Jane-Valbuena J., Kryukov G.V., Lo C.C., McDonald E.R. III, Barretina J., Gelfand E.T., Bielski C.M., Li H., Hu K., Andreev-Drakhlin A.Y., Kim J., Hess J.M., Haas B.J., Aguet F., Weir B.A., Rothberg M.V., Paolella B.R., Lawrence M.S., Akbani R., Lu Y., Tiv H.L., Gokhale P.C., de Weck A., Mansour A.A., Oh C., Shih J., Hadi K., Rosen Y., Bistline J., Venkatesan K., Reddy A., Sonkin D., Liu M., Lehar J., Korn J.M., Porter D.A., Jones M.D., Golji J., Caponigro G., Taylor J.E., Dunning C.M., Creech A.L., Warren A.C., McFarland J.M., Zamanighomi M., Kauffmann A., Stransky N., Imielinski M., Maruvka Y.E., Cherniack A.D., Tsherniak A., Vazquez F., Jaffe J.D., Lane A.A., Weinstock D.M., Johannessen C.M., Morrissey M.P., Stegmeier F., Schlegel R., Hahn W.C., Getz G., Mills G.B., Boehm J.S., Golub T.R., Garraway L.A., Sellers W.R.
Next-generation characterization of the Cancer Cell Line Encyclopedia.
Nature 569:503-508(2019)

Cross-references
Cell line collections ATCC; CRL-5811
KCLB; 90526
Cell line databases/resources CCLE; NCIH526_LUNG
Cell_Model_Passport; SIDM01128
Cosmic-CLP; 688025
DepMap; ACH-000767
GDSC; 688025
IGRhCellID; NCIH526
LINCS_LDP; LCL-1858
TOKU-E; 2701
Ontologies BTO; BTO:0005366
CLO; CLO_0008096
Biological sample resources BioSample; SAMN03473065
BioSample; SAMN10988341
Chemistry resources ChEMBL-Cells; CHEMBL3308881
ChEMBL-Targets; CHEMBL2366102
PharmacoDB; NCIH526_1120_2019
Gene expression databases ArrayExpress; E-MTAB-2770
ArrayExpress; E-MTAB-3610
GEO; GSM169439
GEO; GSM170738
GEO; GSM170740
GEO; GSM170741
GEO; GSM380478
GEO; GSM380515
GEO; GSM536330
GEO; GSM784231
GEO; GSM794293
GEO; GSM845549
GEO; GSM844655
GEO; GSM887436
GEO; GSM888516
GEO; GSM1374754
GEO; GSM1670250
Other Wikidata; Q54908076
Polymorphism and mutation databases Cosmic; 688025
Cosmic; 755467
Cosmic; 801615
Cosmic; 844556
Cosmic; 844820
Cosmic; 850439
Cosmic; 876164
Cosmic; 877209
Cosmic; 877359
Cosmic; 918012
Cosmic; 929975
Cosmic; 1021866
Cosmic; 1152473
Cosmic; 1219104
Cosmic; 1239940
Cosmic; 1891905
Cosmic; 1995583
Cosmic; 1998284
Cosmic; 2125214
Cosmic; 2668275
Cosmic; 2668345
IARC_TP53; 995
LiGeA; CCLE_134
Proteomic databases PRIDE; PXD011896
Entry history
Entry creation04-Apr-2012
Last entry updated06-Sep-2019
Version number27