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Cellosaurus NCI-H630 (CVCL_1572)

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Cell line name NCI-H630
Synonyms H630; H-630
Accession CVCL_1572
Resource Identification Initiative To cite this cell line use: NCI-H630 (RRID:CVCL_1572)
Comments Problematic cell line: Contaminated. The contaminant is not known. Seems to be a mixture of cell lines. Originally said to originate from a 60 year old male rectal carcinoma patient.
Part of: Cancer Cell Line Encyclopedia (CCLE) project.
Part of: COSMIC cell lines project.
Registration: International Cell Line Authentication Committee, Register of Misidentified Cell Lines; ICLAC-00417.
Microsatellite instability: Instable (MSI-high) (PubMed=25926053; Sanger).
Omics: Deep exome analysis.
Omics: Deep quantitative phosphoproteome analysis.
Omics: Deep quantitative proteome analysis.
Omics: DNA methylation analysis.
Omics: SNP array analysis.
Omics: Transcriptome analysis.
Genome ancestry Source: PubMed=30894373

Origin% genome
African0
Native American0.04
East Asian, North0
East Asian, South1.38
South Asian1.38
European, North67.59
European, South29.61
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Sex unspecified
Age at sampling Age unspecified
Category Undefined cell line type
STR profile Source(s): ATCC; Cosmic-CLP; PubMed=25926053

Markers:
AmelogeninX,Y
CSF1PO10,11
D5S81812
D7S8208,11,12 (ATCC; Cosmic-CLP)
8,11 (PubMed=25926053)
D13S31711,12,13,14 (ATCC; PubMed=25926053)
11,12,13 (Cosmic-CLP)
D16S53911,12
D21S1130,33.2
TH017,9
TPOX8,9
vWA15,16,17,18

Run an STR similarity search on this cell line
Web pages https://www.atcc.org/support/faqs/8fa42/NCIH630%20ATCC%20CRL5833-1065.aspx
http://iclac.org/wp-content/uploads/Cross-Contaminations_v9_distribution.xlsx
Publications

PubMed=3479249
Park J.-G., Oie H.K., Sugarbaker P.H., Henslee J.G., Chen T.-R., Johnson B.E., Gazdar A.F.
Characteristics of cell lines established from human colorectal carcinoma.
Cancer Res. 47:6710-6718(1987)

PubMed=8806092; DOI=10.1002/jcb.240630505
Phelps R.M., Johnson B.E., Ihde D.C., Gazdar A.F., Carbone D.P., McClintock P.R., Linnoila R.I., Matthews M.J., Bunn P.A. Jr., Carney D.N., Minna J.D., Mulshine J.L.
NCI-Navy Medical Oncology Branch cell line data base.
J. Cell. Biochem. 63 Suppl. 24:32-91(1996)

PubMed=8806095; DOI=10.1002/jcb.240630508
Park J.-G., Gazdar A.F.
Biology of colorectal and gastric cancer cell lines.
J. Cell. Biochem. 63 Suppl. 24:131-141(1996)

PubMed=20164919; DOI=10.1038/nature08768
Bignell G.R., Greenman C.D., Davies H., Butler A.P., Edkins S., Andrews J.M., Buck G., Chen L., Beare D., Latimer C., Widaa S., Hinton J., Fahey C., Fu B., Swamy S., Dalgliesh G.L., Teh B.T., Deloukas P., Yang F., Campbell P.J., Futreal P.A., Stratton M.R.
Signatures of mutation and selection in the cancer genome.
Nature 463:893-898(2010)

PubMed=20215515; DOI=10.1158/0008-5472.CAN-09-3458
Rothenberg S.M., Mohapatra G., Rivera M.N., Winokur D., Greninger P., Nitta M., Sadow P.M., Sooriyakumar G., Brannigan B.W., Ulman M.J., Perera R.M., Wang R., Tam A., Ma X.-J., Erlander M., Sgroi D.C., Rocco J.W., Lingen M.W., Cohen E.E.W., Louis D.N., Settleman J., Haber D.A.
A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers.
Cancer Res. 70:2158-2164(2010)

PubMed=25926053; DOI=10.1038/ncomms8002
Medico E., Russo M., Picco G., Cancelliere C., Valtorta E., Corti G., Buscarino M., Isella C., Lamba S., Martinoglio B., Veronese S., Siena S., Sartore-Bianchi A., Beccuti M., Mottolese M., Linnebacher M., Cordero F., Di Nicolantonio F., Bardelli A.
The molecular landscape of colorectal cancer cell lines unveils clinically actionable kinase targets.
Nat. Commun. 6:7002-7002(2015)

PubMed=27397505; DOI=10.1016/j.cell.2016.06.017
Iorio F., Knijnenburg T.A., Vis D.J., Bignell G.R., Menden M.P., Schubert M., Aben N., Goncalves E., Barthorpe S., Lightfoot H., Cokelaer T., Greninger P., van Dyk E., Chang H., de Silva H., Heyn H., Deng X., Egan R.K., Liu Q., Mironenko T., Mitropoulos X., Richardson L., Wang J., Zhang T., Moran S., Sayols S., Soleimani M., Tamborero D., Lopez-Bigas N., Ross-Macdonald P., Esteller M., Gray N.S., Haber D.A., Stratton M.R., Benes C.H., Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.
A landscape of pharmacogenomic interactions in cancer.
Cell 166:740-754(2016)

PubMed=28854368; DOI=10.1016/j.celrep.2017.08.010
Roumeliotis T.I., Williams S.P., Goncalves E., Alsinet C., Del Castillo Velasco-Herrera M., Aben N., Ghavidel F.Z., Michaut M., Schubert M., Price S., Wright J.C., Yu L., Yang M., Dienstmann R., Guinney J., Beltrao P., Brazma A., Pardo M., Stegle O., Adams D.J., Wessels L.F.A., Saez-Rodriguez J., McDermott U., Choudhary J.S.
Genomic determinants of protein abundance variation in colorectal cancer cells.
Cell Rep. 20:2201-2214(2017)

PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747
Dutil J., Chen Z., Monteiro A.N., Teer J.K., Eschrich S.A.
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Cancer Res. 79:1263-1273(2019)

Cross-references
Cell line collections ATCC; CRL-5833 - Discontinued
IZSLER; BS TCL 191
KCLB; 90630 - Discontinued
Cell line databases/resources CCLE; NCIH630_LARGE_INTESTINE
Cosmic-CLP; 908482
GDSC; 908482
IGRhCellID; NCIH630
LINCS_LDP; LCL-1287
Ontologies CLO; CLO_0008099
EFO; EFO_0002297
Biological sample resources BioSample; SAMN03151846
BioSample; SAMN03481113
Chemistry resources ChEMBL-Cells; CHEMBL3307966
ChEMBL-Targets; CHEMBL612540
Gene expression databases ArrayExpress; E-MTAB-3610
GEO; GSM452725
GEO; GSM452756
GEO; GSM453572
GEO; GSM454623
GEO; GSM454643
GEO; GSM454644
GEO; GSM454645
GEO; GSM1448143
GEO; GSM1670252
Other Wikidata; Q54908089
Polymorphism and mutation databases Cosmic; 687535
Cosmic; 908482
Cosmic; 1187327
Proteomic databases PRIDE; PXD005235
Entry history
Entry creation04-Apr-2012
Last entry updated24-May-2019
Version number24