Cellosaurus NCI-H647 (CVCL_1574)

Cell line name NCI-H647
Synonyms H647; H-647; H647ell; NCIH647
Accession CVCL_1574
Resource Identification Initiative To cite this cell line use: NCI-H647 (RRID:CVCL_1574)
Comments Part of: Cancer Cell Line Encyclopedia (CCLE) project.
Microsatellite instability: Stable (MSS) (Sanger).
Omics: Deep exome analysis.
Omics: DNA methylation analysis.
Omics: SNP array analysis.
Omics: Transcriptome analysis.
Disease Adenosquamous lung carcinoma (NCIt: C9133)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Male
Category Cancer cell line
STR profile Source(s): ATCC; Cosmic-CLP; PubMed=25877200

Markers:
AmelogeninX
CSF1PO10
D13S3179,11
D16S5399
D18S5112,15
D21S1128,32.2
D3S135817
D5S81812
D7S82010
D8S117911,13
FGA22,24
Penta D12,13
Penta E7
TH016,9.3
TPOX11
vWA17
Publications

PubMed=8806092; DOI=10.1002/jcb.240630505
Phelps R.M., Johnson B.E., Ihde D.C., Gazdar A.F., Carbone D.P., McClintock P.R., Linnoila R.I., Matthews M.J., Bunn P.A. Jr., Carney D.N., Minna J.D., Mulshine J.L.
NCI-Navy Medical Oncology Branch cell line data base.
J. Cell. Biochem. 63 Suppl. 24:32-91(1996)

PubMed=11030152; DOI=10.1038/sj.onc.1203815
Modi S., Kubo A., Oie H., Coxon A.B., Rehmatulla A., Kaye F.J.
Protein expression of the RB-related gene family and SV40 large T antigen in mesothelioma and lung cancer.
Oncogene 19:4632-4639(2000)

PubMed=22460905; DOI=10.1038/nature11003
Barretina J.G., Caponigro G., Stransky N., Venkatesan K., Margolin A.A., Kim S., Wilson C.J., Lehar J., Kryukov G.V., Sonkin D., Reddy A., Liu M., Murray L., Berger M.F., Monahan J.E., Morais P., Meltzer J., Korejwa A., Jane-Valbuena J., Mapa F.A., Thibault J., Bric-Furlong E., Raman P., Shipway A., Engels I.H., Cheng J., Yu G.K., Yu J., Aspesi P. Jr., de Silva M., Jagtap K., Jones M.D., Wang L., Hatton C., Palescandolo E., Gupta S., Mahan S., Sougnez C., Onofrio R.C., Liefeld T., MacConaill L., Winckler W., Reich M., Li N., Mesirov J.P., Gabriel S.B., Getz G., Ardlie K., Chan V., Myer V.E., Weber B.L., Porter J., Warmuth M., Finan P., Harris J.L., Meyerson M., Golub T.R., Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.
The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.
Nature 483:603-607(2012)

PubMed=27397505; DOI=10.1016/j.cell.2016.06.017
Iorio F., Knijnenburg T.A., Vis D.J., Bignell G.R., Menden M.P., Schubert M., Aben N., Goncalves E., Barthorpe S., Lightfoot H., Cokelaer T., Greninger P., van Dyk E., Chang H., de Silva H., Heyn H., Deng X., Egan R.K., Liu Q., Mironenko T., Mitropoulos X., Richardson L., Wang J., Zhang T., Moran S., Sayols S., Soleimani M., Tamborero D., Lopez-Bigas N., Ross-Macdonald P., Esteller M., Gray N.S., Haber D.A., Stratton M.R., Benes C.H., Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.
A landscape of pharmacogenomic interactions in cancer.
Cell 166:740-754(2016)

Cross-references
Cell line collections ATCC; CRL-5834
KCLB; 90647 - Discontinued
Cell line databases/resources CCLE; NCIH647_LUNG
Cosmic-CLP; 1240191
GDSC; 1240191
IGRhCellID; H647GEO
LINCS_LDP; LCL-1629
Ontologies BTO; BTO:0005294
CLO; CLO_0008100
Biological sample resources BioSample; SAMN03471319
Chemistry resources ChEMBL-Cells; CHEMBL3308691
ChEMBL-Targets; CHEMBL614999
Gene expression databases GEO; GSM206497
GEO; GSM274809
GEO; GSM274810
GEO; GSM434311
GEO; GSM513970
GEO; GSM514351
GEO; GSM784213
GEO; GSM794295
GEO; GSM827587
GEO; GSM844657
GEO; GSM844658
GEO; GSM887438
GEO; GSM888518
GEO; GSM1374758
GEO; GSM1670254
Polymorphism and mutation databases Cosmic; 722060
Cosmic; 903577
Cosmic; 931370
Cosmic; 980966
Cosmic; 1032438
Cosmic; 1146921
Cosmic; 1891887