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Cellosaurus NCI-H740 (CVCL_1586)

[Text version]

Cell line name NCI-H740
Synonyms H740; H-740; NCIH740
Accession CVCL_1586
Resource Identification Initiative To cite this cell line use: NCI-H740 (RRID:CVCL_1586)
Comments Part of: Cancer Cell Line Encyclopedia (CCLE) project.
Part of: COSMIC cell lines project.
Microsatellite instability: Stable (MSS) (Sanger).
Omics: Deep exome analysis.
Omics: DNA methylation analysis.
Omics: Transcriptome analysis.
Genome ancestry Source: PubMed=30894373

Origin% genome
African1.71
Native American0
East Asian, North1.31
East Asian, South0
South Asian1.18
European, North64.24
European, South31.56
Disease Small cell lung carcinoma (NCIt: C4917)
Derived from metastatic site: Lymph node.
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Male
Age at sampling 63Y
Category Cancer cell line
STR profile Source(s): ATCC; Cosmic-CLP; PubMed=25877200

Markers:
AmelogeninX,Y
CSF1PO9,12
D3S135817
D5S81812
D7S8209,10
D8S117912,14
D13S31711,14
D16S53912
D18S5114,18
D21S1129,33.2
FGA20,22.2
Penta D11
Penta E5,10
TH016,9
TPOX8,10
vWA15,16

Run an STR similarity search on this cell line
Publications

PubMed=8806092; DOI=10.1002/jcb.240630505
Phelps R.M., Johnson B.E., Ihde D.C., Gazdar A.F., Carbone D.P., McClintock P.R., Linnoila R.I., Matthews M.J., Bunn P.A. Jr., Carney D.N., Minna J.D., Mulshine J.L.
NCI-Navy Medical Oncology Branch cell line data base.
J. Cell. Biochem. 63 Suppl. 24:32-91(1996)

PubMed=8806103; DOI=10.1002/jcb.240630516
Johnson B.E., Russell E., Simmons A.M., Phelps R.M., Steinberg S.M., Ihde D.C., Gazdar A.F.
MYC family DNA amplification in 126 tumor cell lines from patients with small cell lung cancer.
J. Cell. Biochem. 63 Suppl. 24:210-217(1996)

PubMed=11030152; DOI=10.1038/sj.onc.1203815
Modi S., Kubo A., Oie H., Coxon A.B., Rehmatulla A., Kaye F.J.
Protein expression of the RB-related gene family and SV40 large T antigen in mesothelioma and lung cancer.
Oncogene 19:4632-4639(2000)

PubMed=27397505; DOI=10.1016/j.cell.2016.06.017
Iorio F., Knijnenburg T.A., Vis D.J., Bignell G.R., Menden M.P., Schubert M., Aben N., Goncalves E., Barthorpe S., Lightfoot H., Cokelaer T., Greninger P., van Dyk E., Chang H., de Silva H., Heyn H., Deng X., Egan R.K., Liu Q., Mironenko T., Mitropoulos X., Richardson L., Wang J., Zhang T., Moran S., Sayols S., Soleimani M., Tamborero D., Lopez-Bigas N., Ross-Macdonald P., Esteller M., Gray N.S., Haber D.A., Stratton M.R., Benes C.H., Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.
A landscape of pharmacogenomic interactions in cancer.
Cell 166:740-754(2016)

PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747
Dutil J., Chen Z., Monteiro A.N., Teer J.K., Eschrich S.A.
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Cancer Res. 79:1263-1273(2019)

Cross-references
Cell line collections ATCC; CRL-5840
Cell line databases/resources CCLE; NCIH740_LUNG
Cell_Model_Passport; SIDM01118
Cosmic-CLP; 1331055
DepMap; ACH-002175
Ontologies BTO; BTO:0005979
CLO; CLO_0008113
Biological sample resources BioSample; SAMN03473086
Chemistry resources PharmacoDB; NCIH740_1135_2019
Gene expression databases ArrayExpress; E-MTAB-3610
GEO; GSM1670262
Other Wikidata; Q54908117
Polymorphism and mutation databases Cosmic; 844560
Cosmic; 877212
Cosmic; 980935
Cosmic; 1032402
Cosmic; 1152476
Entry history
Entry creation04-Apr-2012
Last entry updated06-Sep-2019
Version number22