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Cellosaurus NCI-H820 (CVCL_1592)

[Text version]

Cell line name NCI-H820
Synonyms H820; H-820; NCIH820
Accession CVCL_1592
Resource Identification Initiative To cite this cell line use: NCI-H820 (RRID:CVCL_1592)
Comments Part of: Cancer Cell Line Encyclopedia (CCLE) project.
Part of: MD Anderson Cell Lines Project.
Omics: Deep exome analysis.
Omics: Deep RNAseq analysis.
Omics: Protein expression by reverse-phase protein arrays.
Omics: SNP array analysis.
Omics: Transcriptome analysis.
Sequence variations Homozygous for TP53 p.Thr284Pro (c.850A>C) (PubMed=1311061; PubMed=1565469; CCLE).
Genome ancestry Source: PubMed=30894373

Origin% genome
African0.6
Native American0
East Asian, North0.97
East Asian, South0
South Asian0.4
European, North65.84
European, South32.19
Disease Papillary lung adenocarcinoma (NCIt: C5650)
Derived from metastatic site: Lymph node.
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Male
Age at sampling 53Y
Category Cancer cell line
STR profile Source(s): ATCC; PubMed=25877200

Markers:
AmelogeninX,Y
CSF1PO11,12
D3S135816
D5S8189,11
D7S82010,13
D8S117910
D13S31712
D16S5399,11
D18S5115
D21S1130
FGA25
Penta D8,9
Penta E15
TH018
TPOX12
vWA18

Run an STR similarity search on this cell line
Web pages http://tcpaportal.org/mclp/
Publications

PubMed=2386953
Gazdar A.F., Linnoila R.I., Kurita Y., Oie H.K., Mulshine J.L., Clark J.C., Whitsett J.A.
Peripheral airway cell differentiation in human lung cancer cell lines.
Cancer Res. 50:5481-5487(1990)

PubMed=1311061
Mitsudomi T., Steinberg S.M., Nau M.M., Carbone D., D'Amico D., Bodner S., Oie H.K., Linnoila R.I., Mulshine J.L., Minna J.D., Gazdar A.F.
p53 gene mutations in non-small-cell lung cancer cell lines and their correlation with the presence of ras mutations and clinical features.
Oncogene 7:171-180(1992)

PubMed=1565469
Bodner S.M., Minna J.D., Jensen S.M., D'Amico D., Carbone D.P., Mitsudomi T., Fedorko J., Buchhagen D.L., Nau M.M., Gazdar A.F., Linnoila R.I.
Expression of mutant p53 proteins in lung cancer correlates with the class of p53 gene mutation.
Oncogene 7:743-749(1992)

PubMed=8626706; DOI=10.1074/jbc.271.19.11477
Quinn K.A., Treston A.M., Unsworth E.J., Miller M.-J., Vos M., Grimley C., Battey J., Mulshine J.L., Cuttitta F.
Insulin-like growth factor expression in human cancer cell lines.
J. Biol. Chem. 271:11477-11483(1996)

PubMed=8806092; DOI=10.1002/jcb.240630505
Phelps R.M., Johnson B.E., Ihde D.C., Gazdar A.F., Carbone D.P., McClintock P.R., Linnoila R.I., Matthews M.J., Bunn P.A. Jr., Carney D.N., Minna J.D., Mulshine J.L.
NCI-Navy Medical Oncology Branch cell line data base.
J. Cell. Biochem. 63 Suppl. 24:32-91(1996)

PubMed=11030152; DOI=10.1038/sj.onc.1203815
Modi S., Kubo A., Oie H., Coxon A.B., Rehmatulla A., Kaye F.J.
Protein expression of the RB-related gene family and SV40 large T antigen in mesothelioma and lung cancer.
Oncogene 19:4632-4639(2000)

PubMed=25485619; DOI=10.1038/nbt.3080
Klijn C., Durinck S., Stawiski E.W., Haverty P.M., Jiang Z., Liu H., Degenhardt J., Mayba O., Gnad F., Liu J., Pau G., Reeder J., Cao Y., Mukhyala K., Selvaraj S.K., Yu M., Zynda G.J., Brauer M.J., Wu T.D., Gentleman R.C., Manning G., Yauch R.L., Bourgon R., Stokoe D., Modrusan Z., Neve R.M., de Sauvage F.J., Settleman J., Seshagiri S., Zhang Z.
A comprehensive transcriptional portrait of human cancer cell lines.
Nat. Biotechnol. 33:306-312(2015)

PubMed=28196595; DOI=10.1016/j.ccell.2017.01.005
Li J., Zhao W., Akbani R., Liu W., Ju Z., Ling S., Vellano C.P., Roebuck P., Yu Q., Eterovic A.K., Byers L.A., Davies M.A., Deng W., Gopal Y.N.V., Chen G., von Euw E.M., Slamon D.J., Conklin D., Heymach J.V., Gazdar A.F., Minna J.D., Myers J.N., Lu Y., Mills G.B., Liang H.
Characterization of human cancer cell lines by reverse-phase protein arrays.
Cancer Cell 31:225-239(2017)

PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747
Dutil J., Chen Z., Monteiro A.N., Teer J.K., Eschrich S.A.
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Cancer Res. 79:1263-1273(2019)

Cross-references
Cell line collections ATCC; HTB-181
Cell line databases/resources Cell_Model_Passport; SIDM00019
CCLE; NCIH820_LUNG
DepMap; ACH-001140
IGRhCellID; H820GEO
Ontologies BTO; BTO:0006024
CLO; CLO_0008119
EFO; EFO_0003125
Biological sample resources BioSample; SAMN03473295
Chemistry resources PharmacoDB; NCIH820_1140_2019
Gene expression databases ArrayExpress; E-MTAB-2706
GEO; GSM434282
GEO; GSM784252
GEO; GSM794301
Other Wikidata; Q54908126
Polymorphism and mutation databases Cosmic; 903579
Cosmic; 1028945
Cosmic; 1128247
Cosmic; 1129778
Cosmic; 1146923
Cosmic; 1333019
Cosmic; 1802301
Cosmic; 2125259
IARC_TP53; 528
Entry history
Entry creation04-Apr-2012
Last entry updated06-Sep-2019
Version number23