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Cellosaurus NCI-N87 (CVCL_1603)

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Cell line name NCI-N87
Synonyms NCI N87; N87; N-87; NCI-H87; H87; H-87; NCIN87
Accession CVCL_1603
Resource Identification Initiative To cite this cell line use: NCI-N87 (RRID:CVCL_1603)
Comments Part of: Cancer Cell Line Encyclopedia (CCLE) project.
Part of: COSMIC cell lines project.
Part of: MET genetic alteration cell panel (ATCC TCP-1036).
Doubling time: 47 hours (PubMed=2158397); 86 hours (PubMed=25984343); 23 hours (PubMed=26919099).
Microsatellite instability: Stable (MSS) (Sanger).
Omics: Deep exome analysis.
Omics: Deep RNAseq analysis.
Omics: DNA methylation analysis.
Omics: shRNA library screening.
Omics: SNP array analysis.
Omics: Transcriptome analysis.
Misspelling: NU-N87; In PubMed=25960936 and NCBI SRX181255.
Sequence variations ERBB3 p.Thr757Lys (c.2270C>A) (PubMed=26919099).
Homozygous for SMAD4 deletion (ATCC).
Homozygous for TP53 p.Arg248Gln (c.743G>A) (ATCC; PubMed=1676761).
HLA typing Source: PubMed=25960936
Class I
HLA-AA*23:01,01:01
HLA-BB*37:01,07:02
HLA-CC*02:02,07:02
Class II
HLA-DQDQB1*05:02,05:02
HLA-DRDRB1*15:01,15:01
Genome ancestry Source: PubMed=30894373

Origin% genome
African61.23
Native American0
East Asian, North2.17
East Asian, South0
South Asian0
European, North20.57
European, South16.04
Disease Gastric tubular adenocarcinoma (NCIt: C5473)
Derived from metastatic site: Liver.
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Children:
CVCL_JY25 (NCI-hTERT-CL5)CVCL_JY26 (NCI-hTERT-CL6)CVCL_WH01 (NCI-N87 HR)
CVCL_IL03 (NCI-N87/TR)
Sex of cell Male
Age at sampling Age unspecified
Category Cancer cell line
STR profile Source(s): AddexBio; ATCC; Cosmic-CLP; PubMed=25877200; PubMed=27102572

Markers:
AmelogeninX,Y
CSF1PO8,12
D2S133823,24
D3S135814
D5S81812,13
D7S82010,11
D8S117914,15
D13S3178,11
D16S5399,13
D18S5117
D19S43314,14.2
D21S1130
FGA20,21
Penta D12
Penta E5
TH019 (AddexBio; ATCC; Cosmic-CLP; PubMed=25877200)
7,9 (PubMed=27102572)
TPOX9,11
vWA15,16

Run an STR similarity search on this cell line
Web pages http://www.cellresource.cn/fdetail.aspx?id=698
Publications

PubMed=2158397
Park J.-G., Frucht H., La Rocca R.V., Bliss D.P. Jr., Kurita Y., Chen T.-R., Henslee J.G., Trepel J.B., Jensen R.T., Johnson B.E., Bang Y.-J., Kim J.-P., Gazdar A.F.
Characteristics of cell lines established from human gastric carcinoma.
Cancer Res. 50:2773-2780(1990)

PubMed=1676761; DOI=10.1093/jnci/83.13.938
Kim J.-H., Takahashi T., Chiba I., Park J.-G., Birrer M.J., Roh J.K., De Lee H., Kim J.-P., Minna J.D., Gazdar A.F.
Occurrence of p53 gene abnormalities in gastric carcinoma tumors and cell lines.
J. Natl. Cancer Inst. 83:938-943(1991)

PubMed=8806089; DOI=10.1002/jcb.240630502
Gazdar A.F., Minna J.D.
NCI series of cell lines: an historical perspective.
J. Cell. Biochem. 63 Suppl. 24:1-11(1996)

PubMed=8806092; DOI=10.1002/jcb.240630505
Phelps R.M., Johnson B.E., Ihde D.C., Gazdar A.F., Carbone D.P., McClintock P.R., Linnoila R.I., Matthews M.J., Bunn P.A. Jr., Carney D.N., Minna J.D., Mulshine J.L.
NCI-Navy Medical Oncology Branch cell line data base.
J. Cell. Biochem. 63 Suppl. 24:32-91(1996)

PubMed=8806095; DOI=10.1002/jcb.240630508
Park J.-G., Gazdar A.F.
Biology of colorectal and gastric cancer cell lines.
J. Cell. Biochem. 63 Suppl. 24:131-141(1996)

PubMed=18804159; DOI=10.1016/j.ygeno.2008.08.002
Jung J.-J., Jeung H.-C., Chung H.C., Lee J.O., Kim T.S., Kim Y.T., Noh S.H., Rha S.Y.
In vitro pharmacogenomic database and chemosensitivity predictive genes in gastric cancer.
Genomics 93:52-61(2009)

PubMed=20164919; DOI=10.1038/nature08768
Bignell G.R., Greenman C.D., Davies H., Butler A.P., Edkins S., Andrews J.M., Buck G., Chen L., Beare D., Latimer C., Widaa S., Hinton J., Fahey C., Fu B., Swamy S., Dalgliesh G.L., Teh B.T., Deloukas P., Yang F., Campbell P.J., Futreal P.A., Stratton M.R.
Signatures of mutation and selection in the cancer genome.
Nature 463:893-898(2010)

PubMed=20215515; DOI=10.1158/0008-5472.CAN-09-3458
Rothenberg S.M., Mohapatra G., Rivera M.N., Winokur D., Greninger P., Nitta M., Sadow P.M., Sooriyakumar G., Brannigan B.W., Ulman M.J., Perera R.M., Wang R., Tam A., Ma X.-J., Erlander M., Sgroi D.C., Rocco J.W., Lingen M.W., Cohen E.E.W., Louis D.N., Settleman J., Haber D.A.
A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers.
Cancer Res. 70:2158-2164(2010)

PubMed=22460905; DOI=10.1038/nature11003
Barretina J.G., Caponigro G., Stransky N., Venkatesan K., Margolin A.A., Kim S., Wilson C.J., Lehar J., Kryukov G.V., Sonkin D., Reddy A., Liu M., Murray L., Berger M.F., Monahan J.E., Morais P., Meltzer J., Korejwa A., Jane-Valbuena J., Mapa F.A., Thibault J., Bric-Furlong E., Raman P., Shipway A., Engels I.H., Cheng J., Yu G.K., Yu J., Aspesi P. Jr., de Silva M., Jagtap K., Jones M.D., Wang L., Hatton C., Palescandolo E., Gupta S., Mahan S., Sougnez C., Onofrio R.C., Liefeld T., MacConaill L.E., Winckler W., Reich M., Li N., Mesirov J.P., Gabriel S.B., Getz G., Ardlie K., Chan V., Myer V.E., Weber B.L., Porter J., Warmuth M., Finan P., Harris J.L., Meyerson M., Golub T.R., Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.
The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.
Nature 483:603-607(2012)

PubMed=24807215; DOI=10.1038/ncomms4830
Liu J., McCleland M., Stawiski E.W., Gnad F., Mayba O., Haverty P.M., Durinck S., Chen Y.-J., Klijn C., Jhunjhunwala S., Lawrence M., Liu H., Wan Y., Chopra V., Yaylaoglu M.B., Yuan W., Ha C., Gilbert H.N., Reeder J., Pau G., Stinson J., Stern H.M., Manning G., Wu T.D., Neve R.M., de Sauvage F.J., Modrusan Z., Seshagiri S., Firestein R., Zhang Z.
Integrated exome and transcriptome sequencing reveals ZAK isoform usage in gastric cancer.
Nat. Commun. 5:3830-3830(2014)

PubMed=25960936; DOI=10.4161/21624011.2014.954893
Boegel S., Lower M., Bukur T., Sahin U., Castle J.C.
A catalog of HLA type, HLA expression, and neo-epitope candidates in human cancer cell lines.
OncoImmunology 3:E954893-E954893(2014)

PubMed=25984343; DOI=10.1038/sdata.2014.35
Cowley G.S., Weir B.A., Vazquez F., Tamayo P., Scott J.A., Rusin S., East-Seletsky A., Ali L.D., Gerath W.F.J., Pantel S.E., Lizotte P.H., Jiang G., Hsiao J., Tsherniak A., Dwinell E., Aoyama S., Okamoto M., Harrington W., Gelfand E., Green T.M., Tomko M.J., Gopal S., Wong T.C., Li H., Howell S., Stransky N., Liefeld T., Jang D., Bistline J., Hill Meyers B., Armstrong S.A., Anderson K.C., Stegmaier K., Reich M., Pellman D., Boehm J.S., Mesirov J.P., Golub T.R., Root D.E., Hahn W.C.
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies.
Sci. Data 1:140035-140035(2014)

PubMed=25485619; DOI=10.1038/nbt.3080
Klijn C., Durinck S., Stawiski E.W., Haverty P.M., Jiang Z., Liu H., Degenhardt J., Mayba O., Gnad F., Liu J., Pau G., Reeder J., Cao Y., Mukhyala K., Selvaraj S.K., Yu M., Zynda G.J., Brauer M.J., Wu T.D., Gentleman R.C., Manning G., Yauch R.L., Bourgon R., Stokoe D., Modrusan Z., Neve R.M., de Sauvage F.J., Settleman J., Seshagiri S., Zhang Z.
A comprehensive transcriptional portrait of human cancer cell lines.
Nat. Biotechnol. 33:306-312(2015)

PubMed=26919099; DOI=10.18632/oncotarget.7575
Arienti C., Zanoni M., Pignatta S., Del Rio A., Carloni S., Tebaldi M., Tedaldi G., Tesei A.
Preclinical evidence of multiple mechanisms underlying trastuzumab resistance in gastric cancer.
Oncotarget 7:18424-18439(2016)

PubMed=27397505; DOI=10.1016/j.cell.2016.06.017
Iorio F., Knijnenburg T.A., Vis D.J., Bignell G.R., Menden M.P., Schubert M., Aben N., Goncalves E., Barthorpe S., Lightfoot H., Cokelaer T., Greninger P., van Dyk E., Chang H., de Silva H., Heyn H., Deng X., Egan R.K., Liu Q., Mironenko T., Mitropoulos X., Richardson L., Wang J., Zhang T., Moran S., Sayols S., Soleimani M., Tamborero D., Lopez-Bigas N., Ross-Macdonald P., Esteller M., Gray N.S., Haber D.A., Stratton M.R., Benes C.H., Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.
A landscape of pharmacogenomic interactions in cancer.
Cell 166:740-754(2016)

PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747
Dutil J., Chen Z., Monteiro A.N., Teer J.K., Eschrich S.A.
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Cancer Res. 79:1263-1273(2019)

Cross-references
Cell line collections AddexBio; C0023002/4674
ATCC; CRL-5822
BCRC; 60217
BCRJ; 0350
CCTCC; GDC0256
IZSLER; BS TCL 224
KCB; KCB 2010183YJ
KCLB; 60113
KCLB; 60187 - Discontinued
Cell line databases/resources CCLE; NCIN87_STOMACH
CCRID; 3131C0001000700130
Cell_Model_Passport; SIDM01147
Cosmic-CLP; 908461
GDSC; 908461
LINCS_LDP; LCL-1886
Ontologies BTO; BTO:0003053
CLO; CLO_0008129
EFO; EFO_0002841
Biological sample resources BioSample; SAMN03473211
Chemistry resources ChEMBL-Cells; CHEMBL3307326
ChEMBL-Targets; CHEMBL614197
Gene expression databases ArrayExpress; E-MTAB-2706
ArrayExpress; E-MTAB-2770
ArrayExpress; E-MTAB-3610
GEO; GSM267420
GEO; GSM267427
GEO; GSM267434
GEO; GSM267441
GEO; GSM552366
GEO; GSM562405
GEO; GSM827404
GEO; GSM828827
GEO; GSM844665
GEO; GSM887453
GEO; GSM888533
GEO; GSM1237678
GEO; GSM1237703
GEO; GSM1374768
GEO; GSM1374769
GEO; GSM1374770
GEO; GSM1670272
Other Wikidata; Q54908217
Polymorphism and mutation databases Cosmic; 685598
Cosmic; 687556
Cosmic; 868236
Cosmic; 887250
Cosmic; 908461
Cosmic; 1187286
Cosmic; 1482074
Cosmic; 1582431
Cosmic; 1995594
Cosmic; 2036661
Cosmic; 2069775
Cosmic; 2443800
Cosmic; 2484955
IARC_TP53; 305
Entry history
Entry creation04-Apr-2012
Last entry updated24-May-2019
Version number30