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Cellosaurus NEC8 (CVCL_1604)

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Cell line name NEC8
Synonyms NEC-8
Accession CVCL_1604
Resource Identification Initiative To cite this cell line use: NEC8 (RRID:CVCL_1604)
Comments Part of: Cancer Cell Line Encyclopedia (CCLE) project.
Part of: COSMIC cell lines project.
Population: Japanese.
Microsatellite instability: Stable (MSS) (Sanger).
Omics: Deep exome analysis.
Omics: DNA methylation analysis.
Omics: SNP array analysis.
Omics: Transcriptome analysis.
Derived from sampling site: Testis.
Genome ancestry Source: PubMed=30894373

Origin% genome
Native American0.61
East Asian, North79.76
East Asian, South13.39
South Asian0
European, North0
European, South4.15
Disease Testicular embryonal carcinoma (NCIt: C6341)
Non-central nervous system-localized embryonal carcinoma (ORDO: Orphanet_289362)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Children:
CVCL_IW43 (NEC8 cl-1)
Sex of cell Male
Age at sampling 24Y
Category Cancer cell line
STR profile Source(s): Cosmic-CLP; JCRB; RCB


Run an STR similarity search on this cell line

PubMed=520758; DOI=10.20772/cancersci1959.70.5_677
Yamamoto T., Komatsubara S., Suzuki T., Oboshi S.
In vitro cultivation of human testicular embryonal carcinoma and establishment of a new cell line.
Gann 70:677-680(1979)

PubMed=3518877; DOI=10.3109/07357908609038260
Fogh J.
Human tumor lines for cancer research.
Cancer Invest. 4:157-184(1986)

PubMed=2445169; DOI=10.1111/j.1440-1827.1987.tb00459.x
Motoyama T., Watanabe H., Yamamoto T., Sekiguchi M.
Production of alpha-fetoprotein by human germ cell tumors in vivo and in vitro.
Acta Pathol. Jpn. 37:1263-1277(1987)

PubMed=3618218; DOI=10.1111/j.1440-1827.1987.tb00377.x
Motoyama T., Watanabe H., Yamamoto T., Sekiguchi M.
Human testicular germ cell tumors in vitro and in athymic nude mice.
Acta Pathol. Jpn. 37:431-448(1987)

PubMed=9290701; DOI=10.1002/(SICI)1098-2744(199708)19:4<243::AID-MC5>3.0.CO;2-D
Jia L.-Q., Osada M., Ishioka C., Gamo M., Ikawa S., Suzuki T., Shimodaira H., Niitani T., Kudo T., Akiyama M., Kimura N., Matsuo M., Mizusawa H., Tanaka N., Koyama H., Namba M., Kanamaru R., Kuroki T.
Screening the p53 status of human cell lines using a yeast functional assay.
Mol. Carcinog. 19:243-253(1997)

PubMed=20164919; DOI=10.1038/nature08768
Bignell G.R., Greenman C.D., Davies H., Butler A.P., Edkins S., Andrews J.M., Buck G., Chen L., Beare D., Latimer C., Widaa S., Hinton J., Fahey C., Fu B., Swamy S., Dalgliesh G.L., Teh B.T., Deloukas P., Yang F., Campbell P.J., Futreal P.A., Stratton M.R.
Signatures of mutation and selection in the cancer genome.
Nature 463:893-898(2010)

PubMed=20215515; DOI=10.1158/0008-5472.CAN-09-3458
Rothenberg S.M., Mohapatra G., Rivera M.N., Winokur D., Greninger P., Nitta M., Sadow P.M., Sooriyakumar G., Brannigan B.W., Ulman M.J., Perera R.M., Wang R., Tam A., Ma X.-J., Erlander M., Sgroi D.C., Rocco J.W., Lingen M.W., Cohen E.E.W., Louis D.N., Settleman J., Haber D.A.
A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers.
Cancer Res. 70:2158-2164(2010)

PubMed=27397505; DOI=10.1016/j.cell.2016.06.017
Iorio F., Knijnenburg T.A., Vis D.J., Bignell G.R., Menden M.P., Schubert M., Aben N., Goncalves E., Barthorpe S., Lightfoot H., Cokelaer T., Greninger P., van Dyk E., Chang H., de Silva H., Heyn H., Deng X., Egan R.K., Liu Q., Mironenko T., Mitropoulos X., Richardson L., Wang J., Zhang T., Moran S., Sayols S., Soleimani M., Tamborero D., Lopez-Bigas N., Ross-Macdonald P., Esteller M., Gray N.S., Haber D.A., Stratton M.R., Benes C.H., Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.
A landscape of pharmacogenomic interactions in cancer.
Cell 166:740-754(2016)

PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747
Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Cancer Res. 79:1263-1273(2019)

Cell line collections JCRB; JCRB0250
JCRB; FDSC0005 - Discontinued
RCB; RCB0489
Cell line databases/resources CCLE; NEC8_TESTIS
Cell_Model_Passport; SIDM00243
Cosmic-CLP; 910942
DepMap; ACH-002288
Ontologies CLO; CLO_0051391
Biological sample resources BioSample; SAMN03471665
Chemistry resources ChEMBL-Cells; CHEMBL3308176
ChEMBL-Targets; CHEMBL2366340
GDSC; 910942
PharmacoDB; NEC8_1156_2019
Gene expression databases ArrayExpress; E-MTAB-783
ArrayExpress; E-MTAB-3610
GEO; GSM827251
GEO; GSM1670276
Other Wikidata; Q54930382
Polymorphism and mutation databases Cosmic; 910942
IARC_TP53; 21583
Progenetix; CVCL_1604
Entry history
Entry creation04-Apr-2012
Last entry update23-Sep-2021
Version number28