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Cellosaurus NEC8 (CVCL_1604)

Cell line name NEC8
Synonyms NEC-8
Accession CVCL_1604
Resource Identification Initiative To cite this cell line use: NEC8 (RRID:CVCL_1604)
Comments Part of: Cancer Cell Line Encyclopedia (CCLE) project.
Part of: COSMIC cell lines project.
Microsatellite instability: Stable (MSS) (Sanger).
Omics: Deep exome analysis.
Omics: DNA methylation analysis.
Omics: SNP array analysis.
Omics: Transcriptome analysis.
Disease Testicular embryonal carcinoma (NCIt: C6341)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Children:
CVCL_IW43 (NEC8 cl-1)
Sex of cell Male
Age at sampling 24Y
Category Cancer cell line
STR profile Source(s): Cosmic-CLP; JCRB; RCB

Markers:
AmelogeninX
CSF1PO13,15
D5S81810,14
D7S8208
D13S31712
D16S5399,10
TH016,7
TPOX8,11
vWA14,15
Publications

PubMed=520758; DOI=10.20772/cancersci1959.70.5_677
Yamamoto T., Komatsubara S., Suzuki T., Oboshi S.
In vitro cultivation of human testicular embryonal carcinoma and establishment of a new cell line.
Gann 70:677-680(1979)

PubMed=3518877; DOI=10.3109/07357908609038260
Fogh J.
Human tumor lines for cancer research.
Cancer Invest. 4:157-184(1986)

PubMed=2445169; DOI=10.1111/j.1440-1827.1987.tb00459.x
Motoyama T., Watanabe H., Yamamoto T., Sekiguchi M.
Production of alpha-fetoprotein by human germ cell tumors in vivo and in vitro.
Acta Pathol. Jpn. 37:1263-1277(1987)

PubMed=3618218; DOI=10.1111/j.1440-1827.1987.tb00377.x
Motoyama T., Watanabe H., Yamamoto T., Sekiguchi M.
Human testicular germ cell tumors in vitro and in athymic nude mice.
Acta Pathol. Jpn. 37:431-448(1987)

PubMed=9290701; DOI=10.1002/(SICI)1098-2744(199708)19:4<243::AID-MC5>3.0.CO;2-D
Jia L.-Q., Osada M., Ishioka C., Gamo M., Ikawa S., Suzuki T., Shimodaira H., Niitani T., Kudo T., Akiyama M., Kimura N., Matsuo M., Mizusawa H., Tanaka N., Koyama H., Namba M., Kanamaru R., Kuroki T.
Screening the p53 status of human cell lines using a yeast functional assay.
Mol. Carcinog. 19:243-253(1997)

PubMed=20215515; DOI=10.1158/0008-5472.CAN-09-3458
Rothenberg S.M., Mohapatra G., Rivera M.N., Winokur D., Greninger P., Nitta M., Sadow P.M., Sooriyakumar G., Brannigan B.W., Ulman M.J., Perera R.M., Wang R., Tam A., Ma X.-J., Erlander M., Sgroi D.C., Rocco J.W., Lingen M.W., Cohen E.E.W., Louis D.N., Settleman J., Haber D.A.
A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers.
Cancer Res. 70:2158-2164(2010)

PubMed=27397505; DOI=10.1016/j.cell.2016.06.017
Iorio F., Knijnenburg T.A., Vis D.J., Bignell G.R., Menden M.P., Schubert M., Aben N., Goncalves E., Barthorpe S., Lightfoot H., Cokelaer T., Greninger P., van Dyk E., Chang H., de Silva H., Heyn H., Deng X., Egan R.K., Liu Q., Mironenko T., Mitropoulos X., Richardson L., Wang J., Zhang T., Moran S., Sayols S., Soleimani M., Tamborero D., Lopez-Bigas N., Ross-Macdonald P., Esteller M., Gray N.S., Haber D.A., Stratton M.R., Benes C.H., Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.
A landscape of pharmacogenomic interactions in cancer.
Cell 166:740-754(2016)

Cross-references
Cell line collections JCRB; JCRB0250
JCRB; FDSC0005 - Discontinued
RCB; RCB0489
Cell line databases/resources CCLE; NEC8_TESTIS
Cosmic-CLP; 910942
GDSC; 910942
LINCS_LDP; LCL-1900
Ontologies CLO; CLO_0051391
Biological sample resources BioSample; SAMN03471665
Chemistry resources ChEMBL-Cells; CHEMBL3308176
ChEMBL-Targets; CHEMBL2366340
Gene expression databases ArrayExpress; E-MTAB-3610
GEO; GSM827251
GEO; GSM1670276
Other Wikidata; Q54930382
Polymorphism and mutation databases Cosmic; 910942