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Cellosaurus NKM-1 (CVCL_1607)

[Text version]

Cell line name NKM-1
Synonyms NKM1
Accession CVCL_1607
Resource Identification Initiative To cite this cell line use: NKM-1 (RRID:CVCL_1607)
Comments Part of: Cancer Cell Line Encyclopedia (CCLE) project.
Part of: COSMIC cell lines project.
Population: Japanese.
Doubling time: 36-48 hours (PubMed=1701353).
Microsatellite instability: Stable (MSS) (Sanger).
Omics: Deep exome analysis.
Omics: DNA methylation analysis.
Omics: SNP array analysis.
Omics: Transcriptome analysis.
Derived from sampling site: Peripheral blood.
Genome ancestry Source: PubMed=30894373

Origin% genome
Native American0
East Asian, North76.96
East Asian, South21.17
South Asian0.96
European, North0.9
European, South0.01
Disease Adult acute myeloid leukemia (NCIt: C9154)
Acute myeloid leukemia (ORDO: Orphanet_519)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Male
Age at sampling 33Y
Category Cancer cell line
STR profile Source(s): Cosmic-CLP; JCRB


Run an STR similarity search on this cell line

Towatari M., Ito Y., Morishita Y., Tanimoto M., Kawashima K., Morishima Y., Andoh T., Saito H.
Enhanced expression of DNA topoisomerase II by recombinant human granulocyte colony-stimulating factor in human leukemia cells.
Cancer Res. 50:7198-7202(1990)

Kataoka T., Morishita Y., Ogura M., Morishima Y., Towatari M., Kato Y., Inoue H., Saito H.
A novel human myeloid leukemia cell line, NKM-1, coexpressing granulocyte colony-stimulating factor receptors and macrophage colony-stimulating factor receptors.
Cancer Res. 50:7703-7709(1990)

Morishita Y., Kataoka T., Towatari M., Ito T., Inoue H., Ogura M., Morishima Y., Saito H.
Up-regulation of transferrin receptor gene expression by granulocyte colony-stimulating factor in human myeloid leukemia cells.
Cancer Res. 50:7955-7961(1990)

PubMed=9737686; DOI=10.1038/sj.leu.2401112
Zhang W., Ohnishi K., Shigeno K., Fujisawa S., Naito K., Nakamura S., Takeshita K., Takeshita A., Ohno R.
The induction of apoptosis and cell cycle arrest by arsenic trioxide in lymphoid neoplasms.
Leukemia 12:1383-1391(1998)

PubMed=9738977; DOI=10.1111/j.1349-7006.1998.tb03275.x
Takizawa J., Suzuki R., Kuroda H., Utsunomiya A., Kagami Y., Joh T., Aizawa Y., Ueda R., Seto M.
Expression of the TCL1 gene at 14q32 in B-cell malignancies but not in adult T-cell leukemia.
Jpn. J. Cancer Res. 89:712-718(1998)

Drexler H.G.
The leukemia-lymphoma cell line factsbook.
(In) ISBN 9780122219702; pp.1-733; Academic Press; London (2001)

PubMed=20164919; DOI=10.1038/nature08768
Bignell G.R., Greenman C.D., Davies H., Butler A.P., Edkins S., Andrews J.M., Buck G., Chen L., Beare D., Latimer C., Widaa S., Hinton J., Fahey C., Fu B., Swamy S., Dalgliesh G.L., Teh B.T., Deloukas P., Yang F., Campbell P.J., Futreal P.A., Stratton M.R.
Signatures of mutation and selection in the cancer genome.
Nature 463:893-898(2010)

PubMed=27397505; DOI=10.1016/j.cell.2016.06.017
Iorio F., Knijnenburg T.A., Vis D.J., Bignell G.R., Menden M.P., Schubert M., Aben N., Goncalves E., Barthorpe S., Lightfoot H., Cokelaer T., Greninger P., van Dyk E., Chang H., de Silva H., Heyn H., Deng X., Egan R.K., Liu Q., Mironenko T., Mitropoulos X., Richardson L., Wang J., Zhang T., Moran S., Sayols S., Soleimani M., Tamborero D., Lopez-Bigas N., Ross-Macdonald P., Esteller M., Gray N.S., Haber D.A., Stratton M.R., Benes C.H., Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.
A landscape of pharmacogenomic interactions in cancer.
Cell 166:740-754(2016)

PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747
Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Cancer Res. 79:1263-1273(2019)

Cell line collections JCRB; IFO50476
Cell_Model_Passport; SIDM00576
Cosmic-CLP; 908448
DepMap; ACH-002290
Biological sample resources BioSample; SAMN03472796
Chemistry resources ChEMBL-Cells; CHEMBL3308212
ChEMBL-Targets; CHEMBL2366133
GDSC; 908448
PharmacoDB; NKM1_1161_2019
Gene expression databases ArrayExpress; E-MTAB-783
ArrayExpress; E-MTAB-3610
GEO; GSM1670279
Other Wikidata; Q54930681
Polymorphism and mutation databases Cosmic; 908448
Cosmic; 1523824
Cosmic; 2131549
Cosmic; 2306228
IARC_TP53; 21586
Entry history
Entry creation04-Apr-2012
Last entry update23-Sep-2021
Version number28