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Cellosaurus OCUB-M (CVCL_1621)

[Text version]

Cell line name OCUB-M
Synonyms OCUBM; OCUB-1M; OCUB-1 Monolayered
Accession CVCL_1621
Resource Identification Initiative To cite this cell line use: OCUB-M (RRID:CVCL_1621)
Comments Part of: Cancer Cell Line Encyclopedia (CCLE) project.
Part of: COSMIC cell lines project.
Microsatellite instability: Instable (MSI-low) (PubMed=15677628; PubMed=31068700; Sanger).
Omics: Deep exome analysis.
Omics: DNA methylation analysis.
Omics: SNP array analysis.
Omics: Transcriptome analysis.
Sequence variations Heterozygous for CHD4 p.Lys945fs*28 (c.2835delA) (Cosmic-CLP).
Homozygous for PIK3CA p.His1047Arg (c.3140A>G) (Cosmic-CLP).
Heterozygous for RET p.Gly383Asp (c.1148G>A) (Cosmic-CLP).
Homozygous for TP53 p.Gly244Ser (c.730G>A) (Cosmic-CLP).
Genome ancestry Source: PubMed=30894373

Origin% genome
African2.46
Native American1.63
East Asian, North78.49
East Asian, South13.1
South Asian0
European, North0
European, South4.31
Disease Breast carcinoma (NCIt: C4872)
Derived from metastatic site: Pleural effusion.
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_L114 (OCUB-1)
Sex of cell Female
Age at sampling 53Y
Category Cancer cell line
STR profile Source(s): Cosmic-CLP; RCB

Markers:
AmelogeninX
CSF1PO10,11
D5S81810
D7S8209,13
D13S3178
D16S53911
TH019
TPOX7,8
vWA18

Run an STR similarity search on this cell line
Publications

PubMed=7873497
Sawada T., Chung Y.-S., Nakata B., Kubo T., Kondo Y., Sogabe T., Onoda N., Ogawa Y., Yamada N., Sowa M.
Establishment and characterization of a human breast cancer cell line, OCUB-1.
Hum. Cell 7:138-144(1994)

PubMed=15677628; DOI=10.1093/carcin/bgi032
Gorringe K.L., Chin S.-F., Pharoah P., Staines J.M., Oliveira C., Edwards P.A.W., Caldas C.
Evidence that both genetic instability and selection contribute to the accumulation of chromosome alterations in cancer.
Carcinogenesis 26:923-930(2005)

PubMed=20164919; DOI=10.1038/nature08768
Bignell G.R., Greenman C.D., Davies H., Butler A.P., Edkins S., Andrews J.M., Buck G., Chen L., Beare D., Latimer C., Widaa S., Hinton J., Fahey C., Fu B., Swamy S., Dalgliesh G.L., Teh B.T., Deloukas P., Yang F., Campbell P.J., Futreal P.A., Stratton M.R.
Signatures of mutation and selection in the cancer genome.
Nature 463:893-898(2010)

PubMed=27397505; DOI=10.1016/j.cell.2016.06.017
Iorio F., Knijnenburg T.A., Vis D.J., Bignell G.R., Menden M.P., Schubert M., Aben N., Goncalves E., Barthorpe S., Lightfoot H., Cokelaer T., Greninger P., van Dyk E., Chang H., de Silva H., Heyn H., Deng X., Egan R.K., Liu Q., Mironenko T., Mitropoulos X., Richardson L., Wang J., Zhang T., Moran S., Sayols S., Soleimani M., Tamborero D., Lopez-Bigas N., Ross-Macdonald P., Esteller M., Gray N.S., Haber D.A., Stratton M.R., Benes C.H., Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.
A landscape of pharmacogenomic interactions in cancer.
Cell 166:740-754(2016)

PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747
Dutil J., Chen Z., Monteiro A.N., Teer J.K., Eschrich S.A.
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Cancer Res. 79:1263-1273(2019)

PubMed=31068700; DOI=10.1038/s41586-019-1186-3
Ghandi M., Huang F.W., Jane-Valbuena J., Kryukov G.V., Lo C.C., McDonald E.R. III, Barretina J., Gelfand E.T., Bielski C.M., Li H., Hu K., Andreev-Drakhlin A.Y., Kim J., Hess J.M., Haas B.J., Aguet F., Weir B.A., Rothberg M.V., Paolella B.R., Lawrence M.S., Akbani R., Lu Y., Tiv H.L., Gokhale P.C., de Weck A., Mansour A.A., Oh C., Shih J., Hadi K., Rosen Y., Bistline J., Venkatesan K., Reddy A., Sonkin D., Liu M., Lehar J., Korn J.M., Porter D.A., Jones M.D., Golji J., Caponigro G., Taylor J.E., Dunning C.M., Creech A.L., Warren A.C., McFarland J.M., Zamanighomi M., Kauffmann A., Stransky N., Imielinski M., Maruvka Y.E., Cherniack A.D., Tsherniak A., Vazquez F., Jaffe J.D., Lane A.A., Weinstock D.M., Johannessen C.M., Morrissey M.P., Stegmeier F., Schlegel R., Hahn W.C., Getz G., Mills G.B., Boehm J.S., Golub T.R., Garraway L.A., Sellers W.R.
Next-generation characterization of the Cancer Cell Line Encyclopedia.
Nature 569:503-508(2019)

Cross-references
Cell line collections RCB; RCB0881
Cell line databases/resources CCLE; OCUBM_BREAST
Cell_Model_Passport; SIDM00241
Cosmic-CLP; 909256
DepMap; ACH-002179
GDSC; 909256
LINCS_LDP; LCL-1489
Ontologies CLO; CLO_0051609
Biological sample resources BioSample; SAMN03472188
Chemistry resources ChEMBL-Cells; CHEMBL3308245
ChEMBL-Targets; CHEMBL2366121
Gene expression databases ArrayExpress; E-MTAB-3610
GEO; GSM217594
GEO; GSM1661987
GEO; GSM1670300
Other Wikidata; Q54931816
Polymorphism and mutation databases Cosmic; 909256
IARC_TP53; 21599
Entry history
Entry creation04-Apr-2012
Last entry updated05-Jul-2019
Version number23