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Cellosaurus OMC-1 [Human cervical carcinoma] (CVCL_1623)

[Text version]

Cell line name OMC-1 [Human cervical carcinoma]
Synonyms OMC1; Osaka Medical College-1
Accession CVCL_1623
Resource Identification Initiative To cite this cell line use: OMC-1 [Human cervical carcinoma] (RRID:CVCL_1623)
Comments Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
Part of: COSMIC cell lines project.
Population: Japanese.
Doubling time: 43 hours, at 15th passage (PubMed=2486664).
Microsatellite instability: Stable (MSS) (Sanger).
Omics: Deep exome analysis.
Omics: DNA methylation analysis.
Omics: SNP array analysis.
Omics: Transcriptome analysis.
Genome ancestry Source: PubMed=30894373

Origin% genome
African0
Native American0
East Asian, North76.41
East Asian, South22.8
South Asian0
European, North0.62
European, South0.16
Disease Cervical squamous cell carcinoma, not otherwise specified (NCIt: C180839)
Squamous cell carcinoma of the cervix uteri (ORDO: Orphanet_213767)
Derived from metastatic site: Left supraclavicular lymph node.
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Female
Age at sampling 52Y
Category Cancer cell line
STR profile Source(s): Cosmic-CLP; RCB

Markers:
AmelogeninX
CSF1PO10,13
D5S81810,11
D7S82011,12
D13S3178,12
D16S53911,12
TH016
TPOX11
vWA16,17

Run an STR similarity search on this cell line
Publications

PubMed=3746026
Ueda M., Maeda T., Yamada T., Miyawaki Y., Otsuki Y., Okamoto Y., Okamura S., Sano T., Ueki M., Sugimoto O.
Establishment and characterization of TA-4 producing cell line (OMC-1) originating from a human squamous cell carcinoma of the uterine cervix.
Nihon Sanka Fujinka Gakkai Zasshi 38:1071-1078(1986)

PubMed=2486664
Ueda M., Ueki M., Yamada T., Okamoto Y., Maeda T., Sugimoto O., Otsuki Y.
Scatchard analysis of EGF receptor and effects of EGF on growth and TA-4 production of newly established uterine cervical cancer cell line (OMC-1).
Hum. Cell 2:401-410(1989)

PubMed=2531191
Ueda M., Misaki O., Yamada T., Okamoto Y., Goto M., Maeda T., Okamura S., Ueki M., Sugimoto O.
In vitro studies of 5-FU sensitivity on uterine cervical cancer cell lines -- comparison between squamous cell carcinoma and adenocarcinoma.
Nihon Sanka Fujinka Gakkai Zasshi 41:1423-1430(1989)

DOI=10.1267/ahc.26.515
Tsuchida K., Okamoto Y., Yamada T., Ueda M., Iijima J., Shiina Y., Hirano H., Rokukawa C., Kasama T., Taki T., Handa S., Ueki M., Adachi K.
Discrimination of metastatic cells from mesothelial cells in effusion cytology by monoclonal antibody AD117m directed against lactotetraosylceramide.
Acta Histochem. Cytochem. 26:515-530(1993)

PubMed=20164919; DOI=10.1038/nature08768
Bignell G.R., Greenman C.D., Davies H., Butler A.P., Edkins S., Andrews J.M., Buck G., Chen L., Beare D., Latimer C., Widaa S., Hinton J., Fahey C., Fu B., Swamy S., Dalgliesh G.L., Teh B.T., Deloukas P., Yang F., Campbell P.J., Futreal P.A., Stratton M.R.
Signatures of mutation and selection in the cancer genome.
Nature 463:893-898(2010)

PubMed=27397505; DOI=10.1016/j.cell.2016.06.017
Iorio F., Knijnenburg T.A., Vis D.J., Bignell G.R., Menden M.P., Schubert M., Aben N., Goncalves E., Barthorpe S., Lightfoot H., Cokelaer T., Greninger P., van Dyk E., Chang H., de Silva H., Heyn H., Deng X.-M., Egan R.K., Liu Q.-S., Mironenko T., Mitropoulos X., Richardson L., Wang J.-H., Zhang T.-H., Moran S., Sayols S., Soleimani M., Tamborero D., Lopez-Bigas N., Ross-Macdonald P., Esteller M., Gray N.S., Haber D.A., Stratton M.R., Benes C.H., Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.
A landscape of pharmacogenomic interactions in cancer.
Cell 166:740-754(2016)

PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747
Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Cancer Res. 79:1263-1273(2019)

Cross-references
Cell line collections RCB; RCB0753
Cell line databases/resources CLO; CLO_0050939
Cell_Model_Passport; SIDM00240
Cosmic-CLP; 949154
DepMap; ACH-002180
LINCS_LDP; LCL-1546
Biological sample resources BioSample; SAMN03472225
Chemistry resources ChEMBL-Cells; CHEMBL3308213
ChEMBL-Targets; CHEMBL2366339
GDSC; 949154
PharmacoDB; OMC1_1199_2019
Encyclopedic resources Wikidata; Q54932030
Gene expression databases ArrayExpress; E-MTAB-783
GEO; GSM1670305
Polymorphism and mutation databases Cosmic; 949154
Cosmic; 1152541
Cosmic; 1995602
IARC_TP53; 27570
Entry history
Entry creation04-Apr-2012
Last entry update23-Jun-2022
Version number31