Cellosaurus ONS-76 (CVCL_1624)

Cell line name ONS-76
Synonyms ONS76
Accession CVCL_1624
Resource Identification Initiative To cite this cell line use: ONS-76 (RRID:CVCL_1624)
Comments Part of: Cancer Cell Line Encyclopedia (CCLE) project.
Doubling time: 18.6 hours (PubMed=2504489).
Microsatellite instability: Stable (MSS) (Sanger).
Omics: Deep exome analysis.
Omics: DNA methylation analysis.
Omics: SNP array analysis.
Omics: Transcriptome analysis.
Disease Medulloblastoma (NCIt: C3222)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Children: CVCL_S734 (ONS-B11); CVCL_S735 (ONS-F11); CVCL_S736 (ONS-F8)
Sex of cell Female
Category Cancer cell line
STR profile Source(s): Cosmic-CLP; JCRB; PubMed=25877200

Markers:
AmelogeninX
CSF1PO10,12
D13S3178,13
D16S5399,10
D18S5114,21
D19S43314,15.2
D21S1129,30.3
D2S133817,19
D3S135815
D5S8189,10
D7S82011,12
D8S117910
FGA24
Penta D12,13
Penta E15,16
TH019
TPOX8
vWA14,16
Publications

PubMed=2504489
Tamura K., Shimizu K., Yamada M., Okamoto Y., Matsui Y., Park K.C., Mabuchi E., Moriuchi S., Mogami H.
Expression of major histocompatibility complex on human medulloblastoma cells with neuronal differentiation.
Cancer Res. 49:5380-5384(1989)

PubMed=2818910
Yamada M., Shimizu K., Tamura K., Okamoto Y., Matsui Y., Moriuchi S., Park K.-C., Mabuchi E., Yamamoto K., Hayakawa T.
Establishment and biological characterization of human medulloblastoma cell lines.
No To Shinkei 41:695-702(1989)

CLPUB00094
Shimizu K., Yamada M., Moriuchi S., Tamura K., Okamoto Y., Park K.-C., Mabuchi E., Miyao Y., Hayakawa T.
Human medulloblastoma cell lines: ONS-76 and ONS-81.
Hum. Cell 3:265-266(1990)

DOI=10.1007/978-4-431-68150-2_63
Shimizu K., Yamada M., Moriuchi S., Tamura K., Mabuchi E., Okamoto Y., Miyao Y., Park K.C., Hayakawa T.
Biological characterization of human medulloblastoma (ONS-76 and ONS- 81) cell lines.
(In) Biological aspects of brain tumors. Proceedings of the 8th Nikko brain tumor conference, Karatsu (Saga) 1990; Tabuchi K. (eds.); pp.442-446; Springer; Tokyo (1991)

DOI=10.1016/B978-0-12-333530-2.50005-8
Nister M., Westermark B.
Human glioma cell lines.
(In) Atlas of human tumor cell lines; Hay R.J., Park J.-G., Gazdar A.F. (eds.); pp.17-42; Academic Press; New York (1994)

PubMed=22460905; DOI=10.1038/nature11003
Barretina J.G., Caponigro G., Stransky N., Venkatesan K., Margolin A.A., Kim S., Wilson C.J., Lehar J., Kryukov G.V., Sonkin D., Reddy A., Liu M., Murray L., Berger M.F., Monahan J.E., Morais P., Meltzer J., Korejwa A., Jane-Valbuena J., Mapa F.A., Thibault J., Bric-Furlong E., Raman P., Shipway A., Engels I.H., Cheng J., Yu G.K., Yu J., Aspesi P. Jr., de Silva M., Jagtap K., Jones M.D., Wang L., Hatton C., Palescandolo E., Gupta S., Mahan S., Sougnez C., Onofrio R.C., Liefeld T., MacConaill L., Winckler W., Reich M., Li N., Mesirov J.P., Gabriel S.B., Getz G., Ardlie K., Chan V., Myer V.E., Weber B.L., Porter J., Warmuth M., Finan P., Harris J.L., Meyerson M., Golub T.R., Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.
The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.
Nature 483:603-607(2012)

PubMed=22951319; DOI=10.1093/jrr/rrs078
Sun L., Moritake T., Zheng Y.W., Suzuki K., Gerelchuluun A., Hong Z., Zenkoh J., Taniguchi H., Tsuboi K.
In vitro stemness characterization of radio-resistant clones isolated from a medulloblastoma cell line ONS-76.
J. Radiat. Res. 54:61-69(2013)

PubMed=27397505; DOI=10.1016/j.cell.2016.06.017
Iorio F., Knijnenburg T.A., Vis D.J., Bignell G.R., Menden M.P., Schubert M., Aben N., Goncalves E., Barthorpe S., Lightfoot H., Cokelaer T., Greninger P., van Dyk E., Chang H., de Silva H., Heyn H., Deng X., Egan R.K., Liu Q., Mironenko T., Mitropoulos X., Richardson L., Wang J., Zhang T., Moran S., Sayols S., Soleimani M., Tamborero D., Lopez-Bigas N., Ross-Macdonald P., Esteller M., Gray N.S., Haber D.A., Stratton M.R., Benes C.H., Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.
A landscape of pharmacogenomic interactions in cancer.
Cell 166:740-754(2016)

Cross-references
Cell line collections BCRJ; 0294
IFO; IFO50355
Cell line databases/resources CCLE; ONS76_CENTRAL_NERVOUS_SYSTEM
Cosmic-CLP; 909248
GDSC; 909248
LINCS_LDP; LCL-1578
Biological sample resources BioSample; SAMN03470886
Chemistry resources ChEMBL-Cells; CHEMBL3308540
ChEMBL-Targets; CHEMBL2366068
Gene expression databases GEO; GSM887477
GEO; GSM888558
GEO; GSM919364
GEO; GSM1670306
Polymorphism and mutation databases Cosmic; 909248
Cosmic; 1995603