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Cellosaurus ONS-76 (CVCL_1624)

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Cell line name ONS-76
Synonyms ONS76
Accession CVCL_1624
Resource Identification Initiative To cite this cell line use: ONS-76 (RRID:CVCL_1624)
Comments Part of: Cancer Cell Line Encyclopedia (CCLE) project.
Part of: COSMIC cell lines project.
Doubling time: 18.6 hours (PubMed=2504489; PubMed=2818910); ~24 hours (lot 08192008), ~32 hours (lot 12042014) (JCRB).
Microsatellite instability: Stable (MSS) (Sanger).
Omics: Deep exome analysis.
Omics: Deep RNAseq analysis.
Omics: DNA methylation analysis.
Omics: SNP array analysis.
Omics: Transcriptome analysis.
Genome ancestry Source: PubMed=30894373

Origin% genome
Native American0
East Asian, North83.83
East Asian, South8.46
South Asian0
European, North0
European, South4.58
Disease Medulloblastoma (NCIt: C3222)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Children:
CVCL_S734 (ONS-B11)CVCL_S735 (ONS-F11)CVCL_S736 (ONS-F8)
Sex of cell Female
Age at sampling 2Y
Category Cancer cell line
STR profile Source(s): Cosmic-CLP; JCRB; PubMed=25877200

Penta D12,13
Penta E15,16

Run an STR similarity search on this cell line

Tamura K., Shimizu K., Yamada M., Okamoto Y., Matsui Y., Park K.C., Mabuchi E., Moriuchi S., Mogami H.
Expression of major histocompatibility complex on human medulloblastoma cells with neuronal differentiation.
Cancer Res. 49:5380-5384(1989)

Yamada M., Shimizu K., Tamura K., Okamoto Y., Matsui Y., Moriuchi S., Park K.-C., Mabuchi E., Yamamoto K., Hayakawa T.
Establishment and biological characterization of human medulloblastoma cell lines.
No To Shinkei 41:695-702(1989)

Shimizu K., Yamada M., Moriuchi S., Tamura K., Okamoto Y., Park K.-C., Mabuchi E., Miyao Y., Hayakawa T.
Human medulloblastoma cell lines: ONS-76 and ONS-81.
Hum. Cell 3:265-266(1990)

Shimizu K., Yamada M., Moriuchi S., Tamura K., Mabuchi E., Okamoto Y., Miyao Y., Park K.C., Hayakawa T.
Biological characterization of human medulloblastoma (ONS-76 and ONS-81) cell lines.
(In) Biological aspects of brain tumors. Proceedings of the 8th Nikko brain tumor conference, Karatsu (Saga) 1990; Tabuchi K. (eds.); pp.442-446; Springer; Tokyo (1991)

Nister M., Westermark B.
Human glioma cell lines.
(In) Atlas of human tumor cell lines; Hay R.J., Park J.-G., Gazdar A.F. (eds.); pp.17-42; Academic Press; New York (1994)

PubMed=20164919; DOI=10.1038/nature08768
Bignell G.R., Greenman C.D., Davies H., Butler A.P., Edkins S., Andrews J.M., Buck G., Chen L., Beare D., Latimer C., Widaa S., Hinton J., Fahey C., Fu B., Swamy S., Dalgliesh G.L., Teh B.T., Deloukas P., Yang F., Campbell P.J., Futreal P.A., Stratton M.R.
Signatures of mutation and selection in the cancer genome.
Nature 463:893-898(2010)

PubMed=22460905; DOI=10.1038/nature11003
Barretina J.G., Caponigro G., Stransky N., Venkatesan K., Margolin A.A., Kim S., Wilson C.J., Lehar J., Kryukov G.V., Sonkin D., Reddy A., Liu M., Murray L., Berger M.F., Monahan J.E., Morais P., Meltzer J., Korejwa A., Jane-Valbuena J., Mapa F.A., Thibault J., Bric-Furlong E., Raman P., Shipway A., Engels I.H., Cheng J., Yu G.K., Yu J., Aspesi P. Jr., de Silva M., Jagtap K., Jones M.D., Wang L., Hatton C., Palescandolo E., Gupta S., Mahan S., Sougnez C., Onofrio R.C., Liefeld T., MacConaill L.E., Winckler W., Reich M., Li N., Mesirov J.P., Gabriel S.B., Getz G., Ardlie K., Chan V., Myer V.E., Weber B.L., Porter J., Warmuth M., Finan P., Harris J.L., Meyerson M., Golub T.R., Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.
The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.
Nature 483:603-607(2012)

PubMed=22951319; DOI=10.1093/jrr/rrs078
Sun L., Moritake T., Zheng Y.W., Suzuki K., Gerelchuluun A., Hong Z., Zenkoh J., Taniguchi H., Tsuboi K.
In vitro stemness characterization of radio-resistant clones isolated from a medulloblastoma cell line ONS-76.
J. Radiat. Res. 54:61-69(2013)

PubMed=27397505; DOI=10.1016/j.cell.2016.06.017
Iorio F., Knijnenburg T.A., Vis D.J., Bignell G.R., Menden M.P., Schubert M., Aben N., Goncalves E., Barthorpe S., Lightfoot H., Cokelaer T., Greninger P., van Dyk E., Chang H., de Silva H., Heyn H., Deng X., Egan R.K., Liu Q., Mironenko T., Mitropoulos X., Richardson L., Wang J., Zhang T., Moran S., Sayols S., Soleimani M., Tamborero D., Lopez-Bigas N., Ross-Macdonald P., Esteller M., Gray N.S., Haber D.A., Stratton M.R., Benes C.H., Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.
A landscape of pharmacogenomic interactions in cancer.
Cell 166:740-754(2016)

PubMed=27498314; DOI=10.1016/j.jbiotec.2016.07.028
Ivanov D.P., Coyle B., Walker D.A., Grabowska A.M.
In vitro models of medulloblastoma: Choosing the right tool for the job.
J. Biotechnol. 236:10-25(2016)

PubMed=27812533; DOI=10.1016/j.dib.2016.10.004
Ivanov D.P., Walker D.A., Coyle B., Grabowska A.M.
Data on the number and frequency of scientific literature citations for established medulloblastoma cell lines.
Data Brief 9:696-698(2016)

PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747
Dutil J., Chen Z., Monteiro A.N., Teer J.K., Eschrich S.A.
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Cancer Res. 79:1263-1273(2019)

Cell line collections BCRJ; 0294
JCRB; IFO50355
Cell line databases/resources CCLE; ONS76_CENTRAL_NERVOUS_SYSTEM
Cell_Model_Passport; SIDM00567
Cosmic-CLP; 909248
GDSC; 909248
Biological sample resources BioSample; SAMN03470886
Chemistry resources ChEMBL-Cells; CHEMBL3308540
ChEMBL-Targets; CHEMBL2366068
Gene expression databases ArrayExpress; E-MTAB-2770
ArrayExpress; E-MTAB-3610
GEO; GSM887477
GEO; GSM888558
GEO; GSM919364
GEO; GSM1670306
Other Wikidata; Q54936426
Polymorphism and mutation databases Cosmic; 909248
Cosmic; 1995603
Entry history
Entry creation04-Apr-2012
Last entry updated24-May-2019
Version number24