ID   ONS-76
AC   CVCL_1624
SY   ONS76; Osaka Neurological Surgery-76
DR   CLO; CLO_0009900
DR   ArrayExpress; E-MTAB-783
DR   ArrayExpress; E-MTAB-2770
DR   ArrayExpress; E-MTAB-3610
DR   BCRJ; 0294
DR   BioGRID_ORCS_Cell_line; 513
DR   BioSample; SAMN03470886
DR   BioSample; SAMN10988186
DR   cancercelllines; CVCL_1624
DR   Cell_Model_Passport; SIDM00567
DR   ChEMBL-Cells; CHEMBL3308540
DR   ChEMBL-Targets; CHEMBL2366068
DR   Cosmic; 909248
DR   Cosmic; 1995603
DR   Cosmic-CLP; 909248
DR   DepMap; ACH-000776
DR   EGA; EGAS00001000978
DR   GDSC; 909248
DR   GEO; GSM887477
DR   GEO; GSM888558
DR   GEO; GSM919364
DR   GEO; GSM1670306
DR   IARC_TP53; 21602
DR   JCRB; IFO50355
DR   LiGeA; CCLE_428
DR   LINCS_LDP; LCL-1578
DR   PharmacoDB; ONS76_1201_2019
DR   PRIDE; PXD030304
DR   Progenetix; CVCL_1624
DR   PubChem_Cell_line; CVCL_1624
DR   Wikidata; Q54936426
RX   CelloPub=CLPUB00094;
RX   DOI=10.1007/978-4-431-68150-2_63;
RX   DOI=10.1016/B978-0-12-333530-2.50005-8;
RX   PubMed=1992917;
RX   PubMed=2504489;
RX   PubMed=2818910;
RX   PubMed=20164919;
RX   PubMed=22460905;
RX   PubMed=22951319;
RX   PubMed=25877200;
RX   PubMed=26589293;
RX   PubMed=27397505;
RX   PubMed=27498314;
RX   PubMed=27812533;
RX   PubMed=30894373;
RX   PubMed=31068700;
RX   PubMed=31346954;
RX   PubMed=35839778;
CC   Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
CC   Part of: COSMIC cell lines project.
CC   Population: Japanese.
CC   Doubling time: 18.6 hours (CelloPub=CLPUB00094; PubMed=2504489; PubMed=2818910); 22 +- 0.3 hours (PubMed=31346954); ~24 hours (Note=Lot 08192008), ~32 hours (Note=Lot 12042014) (JCRB=IFO50355).
CC   HLA typing: A*24:02,26:03; B*54:01,54:01; C*01:02,03:03; DRB1*07:01,09:07 (PubMed=26589293).
CC   Microsatellite instability: Stable (MSS) (Sanger).
CC   Sequence variation: Mutation; HGNC; 7989; NRAS; Simple; p.Gln61Arg (c.182A>G); ClinVar=VCV000013900; Zygosity=Heterozygous (Cosmic-CLP; DepMap).
CC   Sequence variation: Mutation; HGNC; 11730; TERT; Simple; c.1-124C>T (c.228C>T) (C228T); Zygosity=Unspecified; Note=In promoter (PubMed=31068700).
CC   Sequence variation: Mutation; HGNC; 11998; TP53; None_reported; -; Zygosity=- (Cosmic-CLP; DepMap).
CC   Omics: Deep exome analysis.
CC   Omics: Deep quantitative proteome analysis.
CC   Omics: DNA methylation analysis.
CC   Omics: SNP array analysis.
CC   Omics: Transcriptome analysis by microarray.
CC   Omics: Transcriptome analysis by RNAseq.
CC   Genome ancestry: African=3.13%; Native American=0%; East Asian, North=83.83%; East Asian, South=8.46%; South Asian=0%; European, North=0%; European, South=4.58% (PubMed=30894373).
CC   Derived from site: In situ; Brain; UBERON=UBERON_0000955.
ST   Source(s): Cosmic-CLP; JCRB; PubMed=25877200
ST   Amelogenin: X
ST   CSF1PO: 10,12
ST   D13S317: 8,13
ST   D16S539: 9,10
ST   D18S51: 14,21
ST   D19S433: 14,15.2
ST   D21S11: 29,30.3
ST   D2S1338: 17,19
ST   D3S1358: 15
ST   D5S818: 9,10
ST   D7S820: 11,12
ST   D8S1179: 10
ST   FGA: 24
ST   Penta D: 12,13
ST   Penta E: 15,16
ST   TH01: 9
ST   TPOX: 8
ST   vWA: 14,16
DI   NCIt; C129443; Medulloblastoma, SHH-activated, TP53-wildtype
DI   ORDO; Orphanet_616; Medulloblastoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Female
AG   2Y
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 30-01-24; Version: 41
//
RX   CelloPub=CLPUB00094;
RA   Shimizu K., Yamada M., Moriuchi S., Tamura K., Okamoto Y., Park K.C.,
RA   Mabuchi E., Miyao Y., Hayakawa T.;
RT   "Human medulloblastoma cell lines: ONS-76 and ONS-81.";
RL   Hum. Cell 3:265-266(1990).
//
RX   DOI=10.1007/978-4-431-68150-2_63;
RA   Shimizu K., Yamada M., Moriuchi S., Tamura K., Mabuchi E., Okamoto Y.,
RA   Miyao Y., Park K.C., Hayakawa T.;
RT   "Biological characterization of human medulloblastoma (ONS-76 and
RT   ONS-81) cell lines.";
RL   (In) Biological aspects of brain tumors. Proceedings of the 8th Nikko brain tumor conference, Karatsu (Saga) 1990; Tabuchi K. (eds.); pp.442-446; Springer; Tokyo (1991).
//
RX   DOI=10.1016/B978-0-12-333530-2.50005-8;
RA   Nister M., Westermark B.;
RT   "Human glioma cell lines.";
RL   (In) Atlas of human tumor cell lines; Hay R.J., Park J.-G., Gazdar A.F. (eds.); pp.17-42; Academic Press; New York (1994).
//
RX   PubMed=1992917;
RA   Mabuchi E., Shimizu K., Yamada M., Moriuchi S., Park K., Tamura K.,
RA   Hayakawa T., Mogami H.;
RT   "In vitro chemosensitivity test with several antitumor agents against
RT   eight malignant brain tumor cell-lines.";
RL   Gan To Kagaku Ryoho 18:233-238(1991).
//
RX   PubMed=2504489;
RA   Tamura K., Shimizu K., Yamada M., Okamoto Y., Matsui Y., Park K.C.,
RA   Mabuchi E., Moriuchi S., Mogami H.;
RT   "Expression of major histocompatibility complex on human
RT   medulloblastoma cells with neuronal differentiation.";
RL   Cancer Res. 49:5380-5384(1989).
//
RX   PubMed=2818910;
RA   Yamada M., Shimizu K., Tamura K., Okamoto Y., Matsui Y., Moriuchi S.,
RA   Park K.C., Mabuchi E., Yamamoto K., Hayakawa T., Mogami H.;
RT   "Establishment and biological characterization of human
RT   medulloblastoma cell lines.";
RL   No To Shinkei 41:695-702(1989).
//
RX   PubMed=20164919; DOI=10.1038/nature08768;
RA   Bignell G.R., Greenman C.D., Davies H., Butler A.P., Edkins S.,
RA   Andrews J.M., Buck G., Chen L., Beare D., Latimer C., Widaa S.,
RA   Hinton J., Fahey C., Fu B.-Y., Swamy S., Dalgliesh G.L., Teh B.T.,
RA   Deloukas P., Yang F.-T., Campbell P.J., Futreal P.A., Stratton M.R.;
RT   "Signatures of mutation and selection in the cancer genome.";
RL   Nature 463:893-898(2010).
//
RX   PubMed=22460905; DOI=10.1038/nature11003;
RA   Barretina J.G., Caponigro G., Stransky N., Venkatesan K., Margolin A.A.,
RA   Kim S., Wilson C.J., Lehar J., Kryukov G.V., Sonkin D., Reddy A.,
RA   Liu M., Murray L., Berger M.F., Monahan J.E., Morais P., Meltzer J.,
RA   Korejwa A., Jane-Valbuena J., Mapa F.A., Thibault J., Bric-Furlong E.,
RA   Raman P., Shipway A., Engels I.H., Cheng J., Yu G.-Y.K., Yu J.-J.,
RA   Aspesi P. Jr., de Silva M., Jagtap K., Jones M.D., Wang L., Hatton C.,
RA   Palescandolo E., Gupta S., Mahan S., Sougnez C., Onofrio R.C.,
RA   Liefeld T., MacConaill L.E., Winckler W., Reich M., Li N.-X., Mesirov J.P.,
RA   Gabriel S.B., Getz G., Ardlie K., Chan V., Myer V.E., Weber B.L.,
RA   Porter J., Warmuth M., Finan P., Harris J.L., Meyerson M.L., Golub T.R.,
RA   Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.;
RT   "The Cancer Cell Line Encyclopedia enables predictive modelling of
RT   anticancer drug sensitivity.";
RL   Nature 483:603-607(2012).
//
RX   PubMed=22951319; DOI=10.1093/jrr/rrs078;
RA   Sun L., Moritake T., Zheng Y.-W., Suzuki K., Gerelchuluun A., Hong Z.-S.,
RA   Zenkoh J., Taniguchi H., Tsuboi K.;
RT   "In vitro stemness characterization of radio-resistant clones isolated
RT   from a medulloblastoma cell line ONS-76.";
RL   J. Radiat. Res. 54:61-69(2013).
//
RX   PubMed=25877200; DOI=10.1038/nature14397;
RA   Yu M., Selvaraj S.K., Liang-Chu M.M.Y., Aghajani S., Busse M.,
RA   Yuan J., Lee G., Peale F.V., Klijn C., Bourgon R., Kaminker J.S.,
RA   Neve R.M.;
RT   "A resource for cell line authentication, annotation and quality
RT   control.";
RL   Nature 520:307-311(2015).
//
RX   PubMed=26589293; DOI=10.1186/s13073-015-0240-5;
RA   Scholtalbers J., Boegel S., Bukur T., Byl M., Goerges S., Sorn P.,
RA   Loewer M., Sahin U., Castle J.C.;
RT   "TCLP: an online cancer cell line catalogue integrating HLA type,
RT   predicted neo-epitopes, virus and gene expression.";
RL   Genome Med. 7:118.1-118.7(2015).
//
RX   PubMed=27397505; DOI=10.1016/j.cell.2016.06.017;
RA   Iorio F., Knijnenburg T.A., Vis D.J., Bignell G.R., Menden M.P.,
RA   Schubert M., Aben N., Goncalves E., Barthorpe S., Lightfoot H.,
RA   Cokelaer T., Greninger P., van Dyk E., Chang H., de Silva H., Heyn H.,
RA   Deng X.-M., Egan R.K., Liu Q.-S., Mironenko T., Mitropoulos X.,
RA   Richardson L., Wang J.-H., Zhang T.-H., Moran S., Sayols S.,
RA   Soleimani M., Tamborero D., Lopez-Bigas N., Ross-Macdonald P.,
RA   Esteller M., Gray N.S., Haber D.A., Stratton M.R., Benes C.H.,
RA   Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.;
RT   "A landscape of pharmacogenomic interactions in cancer.";
RL   Cell 166:740-754(2016).
//
RX   PubMed=27498314; DOI=10.1016/j.jbiotec.2016.07.028;
RA   Ivanov D.P., Coyle B., Walker D.A., Grabowska A.M.;
RT   "In vitro models of medulloblastoma: choosing the right tool for the
RT   job.";
RL   J. Biotechnol. 236:10-25(2016).
//
RX   PubMed=27812533; DOI=10.1016/j.dib.2016.10.004;
RA   Ivanov D.P., Walker D.A., Coyle B., Grabowska A.M.;
RT   "Data on the number and frequency of scientific literature citations
RT   for established medulloblastoma cell lines.";
RL   Data Brief 9:696-698(2016).
//
RX   PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747;
RA   Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.;
RT   "An interactive resource to probe genetic diversity and estimated
RT   ancestry in cancer cell lines.";
RL   Cancer Res. 79:1263-1273(2019).
//
RX   PubMed=31068700; DOI=10.1038/s41586-019-1186-3;
RA   Ghandi M., Huang F.W., Jane-Valbuena J., Kryukov G.V., Lo C.C.,
RA   McDonald E.R. III, Barretina J.G., Gelfand E.T., Bielski C.M., Li H.-X.,
RA   Hu K., Andreev-Drakhlin A.Y., Kim J., Hess J.M., Haas B.J., Aguet F.,
RA   Weir B.A., Rothberg M.V., Paolella B.R., Lawrence M.S., Akbani R.,
RA   Lu Y.-L., Tiv H.L., Gokhale P.C., de Weck A., Mansour A.A., Oh C.,
RA   Shih J., Hadi K., Rosen Y., Bistline J., Venkatesan K., Reddy A.,
RA   Sonkin D., Liu M., Lehar J., Korn J.M., Porter D.A., Jones M.D.,
RA   Golji J., Caponigro G., Taylor J.E., Dunning C.M., Creech A.L.,
RA   Warren A.C., McFarland J.M., Zamanighomi M., Kauffmann A.,
RA   Stransky N., Imielinski M., Maruvka Y.E., Cherniack A.D.,
RA   Tsherniak A., Vazquez F., Jaffe J.D., Lane A.A., Weinstock D.M.,
RA   Johannessen C.M., Morrissey M.P., Stegmeier F., Schlegel R.,
RA   Hahn W.C., Getz G., Mills G.B., Boehm J.S., Golub T.R., Garraway L.A.,
RA   Sellers W.R.;
RT   "Next-generation characterization of the Cancer Cell Line
RT   Encyclopedia.";
RL   Nature 569:503-508(2019).
//
RX   PubMed=31346954; DOI=10.1007/s10616-019-00332-3;
RA   Bonfim Silva R., Salomao K.B., de Andrade Pimentel T.V.C.,
RA   de Oliveira Menezes C.C.B., Palma P.V.B., Fontes A.M.;
RT   "Biological characterization of the UW402, UW473, ONS-76 and DAOY
RT   pediatric medulloblastoma cell lines.";
RL   Cytotechnology 71:893-903(2019).
//
RX   PubMed=35839778; DOI=10.1016/j.ccell.2022.06.010;
RA   Goncalves E., Poulos R.C., Cai Z.-X., Barthorpe S., Manda S.S., Lucas N.,
RA   Beck A., Bucio-Noble D., Dausmann M., Hall C., Hecker M., Koh J.,
RA   Lightfoot H., Mahboob S., Mali I., Morris J., Richardson L.,
RA   Seneviratne A.J., Shepherd R., Sykes E., Thomas F., Valentini S.,
RA   Williams S.G., Wu Y.-X., Xavier D., MacKenzie K.L., Hains P.G., Tully B.,
RA   Robinson P.J., Zhong Q., Garnett M.J., Reddel R.R.;
RT   "Pan-cancer proteomic map of 949 human cell lines.";
RL   Cancer Cell 40:835-849.e8(2022).
//