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Cellosaurus OS-RC-2 (CVCL_1626)

[Text version]

Cell line name OS-RC-2
Synonyms OSRC2; RC-2
Accession CVCL_1626
Resource Identification Initiative To cite this cell line use: OS-RC-2 (RRID:CVCL_1626)
Comments Part of: Cancer Cell Line Encyclopedia (CCLE) project.
Part of: COSMIC cell lines project.
Doubling time: ~60 hours, at 30th passage (PubMed=4008433).
Microsatellite instability: Stable (MSS) (Sanger).
Omics: Deep exome analysis.
Omics: Deep quantitative proteome analysis.
Omics: Deep RNAseq analysis.
Omics: DNA methylation analysis.
Omics: SNP array analysis.
Omics: Transcriptome analysis.
Sequence variations Heterozygous for PTEN p.Cys211Serfs (c.631_634+12del16) (CCLE; Cosmic-CLP).
TERT c.228C>T (-124C>T); in promoter (PubMed=31068700).
Has no TP53 mutation (CCLE; Cosmic-CLP).
Genome ancestry Source: PubMed=30894373

Origin% genome
African0.1
Native American0
East Asian, North77.03
East Asian, South20.25
South Asian0
European, North0.95
European, South1.66
Disease Renal cell carcinoma (NCIt: C9385)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Male
Age at sampling 52Y
Category Cancer cell line
STR profile Source(s): CCRID; Cosmic-CLP; RCB

Markers:
AmelogeninX,Y
CSF1PO12,13
D2S133820
D3S135817
D5S81811,12
D7S82010,11
D8S117914
D13S3178,12
D16S53911
D18S5114
D19S43313,14
D21S1131.2
FGA24
TH016
TPOX8,11
vWA16

Run an STR similarity search on this cell line
Web pages http://www.cellresource.cn/fdetail.aspx?id=292
http://www.cellresource.cn/fdetail.aspx?id=610
Publications

PubMed=4008433; DOI=10.1007/BF02620929
Kinouchi T., Kotake T., Mori Y., Abe T.
Human renal cell carcinoma: establishment and characterization of a new cell line (OS-RC-2).
In Vitro Cell. Dev. Biol. 21:195-199(1985)

PubMed=14534724; DOI=10.3892/or.10.6.1947
Ikemoto S., Narita K., Yoshida N., Wada S., Kishimoto T., Sugimura K., Nakatani T.
Effects of tumor necrosis factor alpha in renal cell carcinoma.
Oncol. Rep. 10:1947-1955(2003)

PubMed=15604581; DOI=10.1159/000081597
Ikemoto S., Sugimura K., Yoshida N., Kuratsukuri K., Wada S., Nakatani T.
Comparative antitumor activity of 5-fluorouracil and 5'-deoxy-5-fluorouridine in combination with interferon-alpha in renal cell carcinoma cell lines.
Urol. Int. 73:348-353(2004)

PubMed=20164919; DOI=10.1038/nature08768
Bignell G.R., Greenman C.D., Davies H., Butler A.P., Edkins S., Andrews J.M., Buck G., Chen L., Beare D., Latimer C., Widaa S., Hinton J., Fahey C., Fu B., Swamy S., Dalgliesh G.L., Teh B.T., Deloukas P., Yang F., Campbell P.J., Futreal P.A., Stratton M.R.
Signatures of mutation and selection in the cancer genome.
Nature 463:893-898(2010)

PubMed=27397505; DOI=10.1016/j.cell.2016.06.017
Iorio F., Knijnenburg T.A., Vis D.J., Bignell G.R., Menden M.P., Schubert M., Aben N., Goncalves E., Barthorpe S., Lightfoot H., Cokelaer T., Greninger P., van Dyk E., Chang H., de Silva H., Heyn H., Deng X., Egan R.K., Liu Q., Mironenko T., Mitropoulos X., Richardson L., Wang J., Zhang T., Moran S., Sayols S., Soleimani M., Tamborero D., Lopez-Bigas N., Ross-Macdonald P., Esteller M., Gray N.S., Haber D.A., Stratton M.R., Benes C.H., Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.
A landscape of pharmacogenomic interactions in cancer.
Cell 166:740-754(2016)

PubMed=28489074; DOI=10.1038/ncomms15165
Sinha R., Winer A.G., Chevinsky M., Jakubowski C., Chen Y.-B., Dong Y., Tickoo S.K., Reuter V.E., Russo P., Coleman J.A., Sander C., Hsieh J.J., Hakimi A.A.
Analysis of renal cancer cell lines from two major resources enables genomics-guided cell line selection.
Nat. Commun. 8:15165-15165(2017)

PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747
Dutil J., Chen Z., Monteiro A.N., Teer J.K., Eschrich S.A.
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Cancer Res. 79:1263-1273(2019)

PubMed=31068700; DOI=10.1038/s41586-019-1186-3
Ghandi M., Huang F.W., Jane-Valbuena J., Kryukov G.V., Lo C.C., McDonald E.R. III, Barretina J., Gelfand E.T., Bielski C.M., Li H., Hu K., Andreev-Drakhlin A.Y., Kim J., Hess J.M., Haas B.J., Aguet F., Weir B.A., Rothberg M.V., Paolella B.R., Lawrence M.S., Akbani R., Lu Y., Tiv H.L., Gokhale P.C., de Weck A., Mansour A.A., Oh C., Shih J., Hadi K., Rosen Y., Bistline J., Venkatesan K., Reddy A., Sonkin D., Liu M., Lehar J., Korn J.M., Porter D.A., Jones M.D., Golji J., Caponigro G., Taylor J.E., Dunning C.M., Creech A.L., Warren A.C., McFarland J.M., Zamanighomi M., Kauffmann A., Stransky N., Imielinski M., Maruvka Y.E., Cherniack A.D., Tsherniak A., Vazquez F., Jaffe J.D., Lane A.A., Weinstock D.M., Johannessen C.M., Morrissey M.P., Stegmeier F., Schlegel R., Hahn W.C., Getz G., Mills G.B., Boehm J.S., Golub T.R., Garraway L.A., Sellers W.R.
Next-generation characterization of the Cancer Cell Line Encyclopedia.
Nature 569:503-508(2019)

PubMed=31978347; DOI=10.1016/j.cell.2019.12.023
Nusinow D.P., Szpyt J., Ghandi M., Rose C.M., McDonald E.R. III, Kalocsay M., Jane-Valbuena J., Gelfand E., Schweppe D.K., Jedrychowski M., Golji J., Porter D.A., Rejtar T., Wang Y.K., Kryukov G.V., Stegmeier F., Erickson B.K., Garraway L.A., Sellers W.R., Gygi S.P.
Quantitative proteomics of the Cancer Cell Line Encyclopedia.
Cell 180:387-402.e16(2020)

Cross-references
Cell line collections KCB; KCB 200779YJ
RCB; RCB0735
Cell line databases/resources CCLE; OSRC2_KIDNEY
CCRID; 3111C0001CCC000292
CCRID; 3131C0001000700040
Cell_Model_Passport; SIDM00239
Cosmic-CLP; 909250
DepMap; ACH-000159
LINCS_LDP; LCL-1768
Ontologies BTO; BTO:0002403
CLO; CLO_0050889
Biological sample resources BioSample; SAMN03472222
BioSample; SAMN10987712
Chemistry resources ChEMBL-Cells; CHEMBL3308274
ChEMBL-Targets; CHEMBL2366188
GDSC; 909250
PharmacoDB; OSRC2_1203_2019
Gene expression databases ArrayExpress; E-MTAB-783
ArrayExpress; E-MTAB-2770
ArrayExpress; E-MTAB-3610
GEO; GSM1670310
Other Wikidata; Q54936539
Polymorphism and mutation databases Cosmic; 909250
IARC_TP53; 21604
LiGeA; CCLE_815
Entry history
Entry creation04-Apr-2012
Last entry update12-Mar-2020
Version number25