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Cellosaurus OS-RC-2 (CVCL_1626)

Cell line name OS-RC-2
Synonyms RC-2
Accession CVCL_1626
Resource Identification Initiative To cite this cell line use: OS-RC-2 (RRID:CVCL_1626)
Comments Part of: Cancer Cell Line Encyclopedia (CCLE) project.
Part of: COSMIC cell lines project.
Doubling time: ~60 hours, at 30th passage (PubMed=4008433).
Microsatellite instability: Stable (MSS) (Sanger).
Omics: Deep exome analysis.
Omics: Deep RNAseq analysis.
Omics: DNA methylation analysis.
Omics: Transcriptome analysis.
Disease Renal cell carcinoma (NCIt: C9385)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Male
Age at sampling 52Y
Category Cancer cell line
STR profile Source(s): Cosmic-CLP; RCB

Markers:
AmelogeninX,Y
CSF1PO12,13
D13S3178,12
D16S53911
D5S81811,12
D7S82010,11
TH016
TPOX8,11
vWA16
Publications

PubMed=4008433; DOI=10.1007/BF02620929
Kinouchi T., Kotake T., Mori Y., Abe T.
Human renal cell carcinoma: establishment and characterization of a new cell line (OS-RC-2).
In Vitro Cell. Dev. Biol. 21:195-199(1985)

PubMed=14534724; DOI=10.3892/or.10.6.1947
Ikemoto S., Narita K., Yoshida N., Wada S., Kishimoto T., Sugimura K., Nakatani T.
Effects of tumor necrosis factor alpha in renal cell carcinoma.
Oncol. Rep. 10:1947-1955(2003)

PubMed=15604581; DOI=10.1159/000081597
Ikemoto S., Sugimura K., Yoshida N., Kuratsukuri K., Wada S., Nakatani T.
Comparative antitumor activity of 5-fluorouracil and 5'-deoxy-5-fluorouridine in combination with interferon-alpha in renal cell carcinoma cell lines.
Urol. Int. 73:348-353(2004)

PubMed=27397505; DOI=10.1016/j.cell.2016.06.017
Iorio F., Knijnenburg T.A., Vis D.J., Bignell G.R., Menden M.P., Schubert M., Aben N., Goncalves E., Barthorpe S., Lightfoot H., Cokelaer T., Greninger P., van Dyk E., Chang H., de Silva H., Heyn H., Deng X., Egan R.K., Liu Q., Mironenko T., Mitropoulos X., Richardson L., Wang J., Zhang T., Moran S., Sayols S., Soleimani M., Tamborero D., Lopez-Bigas N., Ross-Macdonald P., Esteller M., Gray N.S., Haber D.A., Stratton M.R., Benes C.H., Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.
A landscape of pharmacogenomic interactions in cancer.
Cell 166:740-754(2016)

PubMed=28489074; DOI=10.1038/ncomms15165
Sinha R., Winer A.G., Chevinsky M., Jakubowski C., Chen Y.-B., Dong Y., Tickoo S.K., Reuter V.E., Russo P., Coleman J.A., Sander C., Hsieh J.J., Hakimi A.A.
Analysis of renal cancer cell lines from two major resources enables genomics-guided cell line selection.
Nat. Commun. 8:15165-15165(2017)

Cross-references
Cell line collections KCB; KCB 200779YJ
RCB; RCB0735
Cell line databases/resources CCLE; OSRC2_KIDNEY
CCRID; 3111C0001CCC000292
CCRID; 3131C0001000700040
Cosmic-CLP; 909250
GDSC; 909250
LINCS_LDP; LCL-1768
Ontologies BTO; BTO:0002403
CLO; CLO_0050889
Biological sample resources BioSample; SAMN03472222
Chemistry resources ChEMBL-Cells; CHEMBL3308274
ChEMBL-Targets; CHEMBL2366188
Gene expression databases ArrayExpress; E-MTAB-2770
ArrayExpress; E-MTAB-3610
GEO; GSM1670310
Other Wikidata; Q54936539
Polymorphism and mutation databases Cosmic; 909250