Cellosaurus P31/FUJ (CVCL_1632)

Cell line name P31/FUJ
Synonyms P31-FUJ; P31 FUJ; P31FUJ; P31/Fujioka
Accession CVCL_1632
Resource Identification Initiative To cite this cell line use: P31/FUJ (RRID:CVCL_1632)
Comments Part of: Cancer Cell Line Encyclopedia (CCLE) project.
Part of: COSMIC cell lines project.
Doubling time: 80 hours (PubMed=6962783).
Microsatellite instability: Instable (MSI-high) (Sanger).
Sequence variation: NRAS p.Gly12Asp (PubMed=9379676).
Sequence variation: RAD21 p.His208Arg (PubMed=23955599).
Omics: Deep exome analysis.
Omics: DNA methylation analysis.
Omics: SNP array analysis.
Omics: Transcriptome analysis.
Misspelling: P31-FUF; In Cosmic 717683 and PubMed=9379676.
Misspelling: P31/FUF; In PubMed=9379676.
Derived from sampling site: Peripheral blood.
Disease Childhood acute myeloid leukemia (NCIt: C9160)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Male
Age at sampling 7Y
Category Cancer cell line
STR profile Source(s): Cosmic-CLP; JCRB

Markers:
AmelogeninX,Y
CSF1PO13,14
D13S3179,12,13
D16S5399,10
D5S81811
D7S82010
TH019
TPOX7,11
vWA19,21
Publications

DOI=10.1007/978-1-4757-1647-4_13
Biedler J.L.
Chromosome abnormalities in human tumor cells in culture.
(In) Human tumor cells in vitro; Fogh J. (eds.); pp.359-394; Springer; New York (1975)

PubMed=6962783
Hirose M., Minato K., Tobinai K., Shimoyama M., Watanabe S., Abe T.
A novel monocytoid cultured cell line, P31/Fujioka, derived from acute monoblastic leukemia.
Gann 73:735-741(1982)

PubMed=9379676; DOI=10.1016/S0145-2126(97)00036-2
Sheng X.-M., Kawamura M., Ohnishi H., Ida K., Hanada R., Kojima S., Kobayashi M., Bessho F., Yanagisawa M., Hayashi Y.
Mutations of the RAS genes in childhood acute myeloid leukemia, myelodysplastic syndrome and juvenile chronic myelocytic leukemia.
Leuk. Res. 21:697-701(1997)

PubMed=14504097; DOI=10.1182/blood-2003-02-0418
Taketani T., Taki T., Sugita K., Furuichi Y., Ishii E., Hanada R., Tsuchida M., Sugita K., Ida K., Hayashi Y.
FLT3 mutations in the activation loop of tyrosine kinase domain are frequently found in infant ALL with MLL rearrangements and pediatric ALL with hyperdiploidy.
Blood 103:1085-1088(2004)

PubMed=20215515; DOI=10.1158/0008-5472.CAN-09-3458
Rothenberg S.M., Mohapatra G., Rivera M.N., Winokur D., Greninger P., Nitta M., Sadow P.M., Sooriyakumar G., Brannigan B.W., Ulman M.J., Perera R.M., Wang R., Tam A., Ma X.-J., Erlander M., Sgroi D.C., Rocco J.W., Lingen M.W., Cohen E.E.W., Louis D.N., Settleman J., Haber D.A.
A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers.
Cancer Res. 70:2158-2164(2010)

PubMed=22460905; DOI=10.1038/nature11003
Barretina J.G., Caponigro G., Stransky N., Venkatesan K., Margolin A.A., Kim S., Wilson C.J., Lehar J., Kryukov G.V., Sonkin D., Reddy A., Liu M., Murray L., Berger M.F., Monahan J.E., Morais P., Meltzer J., Korejwa A., Jane-Valbuena J., Mapa F.A., Thibault J., Bric-Furlong E., Raman P., Shipway A., Engels I.H., Cheng J., Yu G.K., Yu J., Aspesi P. Jr., de Silva M., Jagtap K., Jones M.D., Wang L., Hatton C., Palescandolo E., Gupta S., Mahan S., Sougnez C., Onofrio R.C., Liefeld T., MacConaill L., Winckler W., Reich M., Li N., Mesirov J.P., Gabriel S.B., Getz G., Ardlie K., Chan V., Myer V.E., Weber B.L., Porter J., Warmuth M., Finan P., Harris J.L., Meyerson M., Golub T.R., Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.
The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.
Nature 483:603-607(2012)

PubMed=23955599; DOI=10.1038/ng.2731
Kon A., Shih L.-Y., Minamino M., Sanada M., Shiraishi Y., Nagata Y., Yoshida K., Okuno Y., Bando M., Nakato R., Ishikawa S., Sato-Otsubo A., Nagae G., Nishimoto A., Haferlach C., Nowak D., Sato Y., Alpermann T., Nagasaki M., Shimamura T., Tanaka H., Chiba K., Yamamoto R., Yamaguchi T., Otsu M., Obara N., Sakata-Yanagimoto M., Nakamaki T., Ishiyama K., Nolte F., Hofmann W.K., Miyawaki S., Chiba S., Mori H., Nakauchi H., Koeffler H.P., Aburatani H., Haferlach T., Shirahige K., Miyano S., Ogawa S.
Recurrent mutations in multiple components of the cohesin complex in myeloid neoplasms.
Nat. Genet. 45:1232-1237(2013)

PubMed=27397505; DOI=10.1016/j.cell.2016.06.017
Iorio F., Knijnenburg T.A., Vis D.J., Bignell G.R., Menden M.P., Schubert M., Aben N., Goncalves E., Barthorpe S., Lightfoot H., Cokelaer T., Greninger P., van Dyk E., Chang H., de Silva H., Heyn H., Deng X., Egan R.K., Liu Q., Mironenko T., Mitropoulos X., Richardson L., Wang J., Zhang T., Moran S., Sayols S., Soleimani M., Tamborero D., Lopez-Bigas N., Ross-Macdonald P., Esteller M., Gray N.S., Haber D.A., Stratton M.R., Benes C.H., Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.
A landscape of pharmacogenomic interactions in cancer.
Cell 166:740-754(2016)

Cross-references
Cell line collections JCRB; JCRB0091
Cell line databases/resources CCLE; P31FUJ_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE
Cosmic-CLP; 909253
GDSC; 909253
LINCS_LDP; LCL-1069
Biological sample resources BioSample; SAMN03471067
Chemistry resources ChEMBL-Cells; CHEMBL3308276
ChEMBL-Targets; CHEMBL2366370
Gene expression databases GEO; GSM827226
GEO; GSM887492
GEO; GSM888574
GEO; GSM1670328
Polymorphism and mutation databases Cosmic; 717683
Cosmic; 909253
Cosmic; 996318
Cosmic; 998749
Cosmic; 1037670
Cosmic; 2089656
Cosmic; 2131555
Proteomic databases PRIDE; PXD000185