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Cellosaurus PFSK-1 (CVCL_1642)

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Cell line name PFSK-1
Synonyms PFSk-1; PFSK1; PFSK
Accession CVCL_1642
Resource Identification Initiative To cite this cell line use: PFSK-1 (RRID:CVCL_1642)
Comments Part of: Cancer Cell Line Encyclopedia (CCLE) project.
Part of: COSMIC cell lines project.
Part of: ENCODE project common cell types; tier 3.
Microsatellite instability: Stable (MSS) (Sanger).
Omics: Deep exome analysis.
Omics: Deep RNAseq analysis.
Omics: DNA methylation analysis.
Omics: SNP array analysis.
Omics: Transcriptome analysis.
Sequence variations Homozygous for TP53 p.Cys275Gly (c.823T>G) (Cosmic-CLP).
Genome ancestry Source: PubMed=30894373

Origin% genome
Native American0
East Asian, North2.03
East Asian, South0
South Asian0.77
European, North66.34
European, South30.55
Disease Primitive neuroectodermal tumor (NCIt: C3716)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Male
Age at sampling 1Y10M
Category Cancer cell line
STR profile Source(s): ATCC; Cosmic-CLP


Run an STR similarity search on this cell line
Web pages http://genome.ucsc.edu/ENCODE/protocols/cell/human/PFSK-1_protocol.pdf

PubMed=1316433; DOI=10.1097/00005072-199205000-00005
Fults D., Pedone C.A., Morse H.G., Rose J.W., McKay R.D.G.
Establishment and characterization of a human primitive neuroectodermal tumor cell line from the cerebral hemisphere.
J. Neuropathol. Exp. Neurol. 51:272-280(1992)

Nister M., Westermark B.
Human glioma cell lines.
(In) Atlas of human tumor cell lines; Hay R.J., Park J.-G., Gazdar A.F. (eds.); pp.17-42; Academic Press; New York (1994)

PubMed=20164919; DOI=10.1038/nature08768
Bignell G.R., Greenman C.D., Davies H., Butler A.P., Edkins S., Andrews J.M., Buck G., Chen L., Beare D., Latimer C., Widaa S., Hinton J., Fahey C., Fu B., Swamy S., Dalgliesh G.L., Teh B.T., Deloukas P., Yang F., Campbell P.J., Futreal P.A., Stratton M.R.
Signatures of mutation and selection in the cancer genome.
Nature 463:893-898(2010)

PubMed=23325432; DOI=10.1101/gr.147942.112
Varley K.E., Gertz J., Bowling K.M., Parker S.L., Reddy T.E., Pauli-Behn F., Cross M.K., Williams B.A., Stamatoyannopoulos J.A., Crawford G.E., Absher D.M., Wold B.J., Myers R.M.
Dynamic DNA methylation across diverse human cell lines and tissues.
Genome Res. 23:555-567(2013)

PubMed=27397505; DOI=10.1016/j.cell.2016.06.017
Iorio F., Knijnenburg T.A., Vis D.J., Bignell G.R., Menden M.P., Schubert M., Aben N., Goncalves E., Barthorpe S., Lightfoot H., Cokelaer T., Greninger P., van Dyk E., Chang H., de Silva H., Heyn H., Deng X., Egan R.K., Liu Q., Mironenko T., Mitropoulos X., Richardson L., Wang J., Zhang T., Moran S., Sayols S., Soleimani M., Tamborero D., Lopez-Bigas N., Ross-Macdonald P., Esteller M., Gray N.S., Haber D.A., Stratton M.R., Benes C.H., Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.
A landscape of pharmacogenomic interactions in cancer.
Cell 166:740-754(2016)

PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747
Dutil J., Chen Z., Monteiro A.N., Teer J.K., Eschrich S.A.
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Cancer Res. 79:1263-1273(2019)

Cell line collections ATCC; CRL-2060
Cell line databases/resources CCLE; PFSK1_CENTRAL_NERVOUS_SYSTEM
Cell_Model_Passport; SIDM01132
Cosmic-CLP; 683667
DepMap; ACH-001711
Ontologies CLO; CLO_0008425
EFO; EFO_0005234
Biological sample resources BioSample; SAMN03471425
Chemistry resources ChEMBL-Cells; CHEMBL3308802
ChEMBL-Targets; CHEMBL1075560
GDSC; 683667
PharmacoDB; PFSK1_1264_2019
Gene expression databases ArrayExpress; E-MTAB-783
ArrayExpress; E-MTAB-3610
GEO; GSM923430
GEO; GSM1670349
Other Wikidata; Q54947302
Polymorphism and mutation databases Cosmic; 683667
Cosmic; 923655
Cosmic; 973260
Cosmic; 1728490
Cosmic; 1995615
IARC_TP53; 21279
Entry history
Entry creation04-Apr-2012
Last entry updated19-Dec-2019
Version number27