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Cellosaurus RERF-LC-Ad1 (CVCL_1651)

[Text version]

Cell line name RERF-LC-Ad1
Synonyms RERF-LC-AD1; RERFLCAD1; RERFLCAd1; Radiation Effects Research Foundation-Lung Cancer-Adenocarcinoma 1
Accession CVCL_1651
Resource Identification Initiative To cite this cell line use: RERF-LC-Ad1 (RRID:CVCL_1651)
Comments Part of: Cancer Cell Line Encyclopedia (CCLE) project.
Doubling time: ~65 hours (lot 04132008) (JCRB).
Omics: Deep exome analysis.
Omics: Deep RNAseq analysis.
Omics: SNP array analysis.
Omics: Transcriptome analysis.
Sequence variations Heterozygous for KRAS p.Gly12Ala (c.35G>C) (CCLE).
TERT c.228C>T (-124C>T); in promoter (PubMed=31068700).
Homozygous for TP53 p.Pro278Phe (c.832_833CC>TT) (CCLE).
Genome ancestry Source: PubMed=30894373

Origin% genome
African0
Native American0
East Asian, North76.75
East Asian, South22.67
South Asian0
European, North0
European, South0.57
Disease Lung adenocarcinoma (NCIt: C3512)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Male
Age at sampling 70Y
Category Cancer cell line
STR profile Source(s): JCRB

Markers:
AmelogeninX
CSF1PO12,13
D5S81812
D7S82011,12
D13S31713
D16S5399,12
TH016,9
TPOX8,11
vWA14,17

Run an STR similarity search on this cell line
Publications

PubMed=16105816; DOI=10.1158/0008-5472.CAN-05-0331
Nagai Y., Miyazawa H., Huqun X., Tanaka T., Udagawa K., Kato M., Fukuyama S., Yokote A., Kobayashi K., Kanazawa M., Hagiwara K.
Genetic heterogeneity of the epidermal growth factor receptor in non-small cell lung cancer cell lines revealed by a rapid and sensitive detection system, the peptide nucleic acid-locked nucleic acid PCR clamp.
Cancer Res. 65:7276-7282(2005)

PubMed=22460905; DOI=10.1038/nature11003
Barretina J.G., Caponigro G., Stransky N., Venkatesan K., Margolin A.A., Kim S., Wilson C.J., Lehar J., Kryukov G.V., Sonkin D., Reddy A., Liu M., Murray L., Berger M.F., Monahan J.E., Morais P., Meltzer J., Korejwa A., Jane-Valbuena J., Mapa F.A., Thibault J., Bric-Furlong E., Raman P., Shipway A., Engels I.H., Cheng J., Yu G.K., Yu J., Aspesi P. Jr., de Silva M., Jagtap K., Jones M.D., Wang L., Hatton C., Palescandolo E., Gupta S., Mahan S., Sougnez C., Onofrio R.C., Liefeld T., MacConaill L.E., Winckler W., Reich M., Li N., Mesirov J.P., Gabriel S.B., Getz G., Ardlie K., Chan V., Myer V.E., Weber B.L., Porter J., Warmuth M., Finan P., Harris J.L., Meyerson M., Golub T.R., Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.
The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.
Nature 483:603-607(2012)

PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747
Dutil J., Chen Z., Monteiro A.N., Teer J.K., Eschrich S.A.
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Cancer Res. 79:1263-1273(2019)

PubMed=31068700; DOI=10.1038/s41586-019-1186-3
Ghandi M., Huang F.W., Jane-Valbuena J., Kryukov G.V., Lo C.C., McDonald E.R. III, Barretina J., Gelfand E.T., Bielski C.M., Li H., Hu K., Andreev-Drakhlin A.Y., Kim J., Hess J.M., Haas B.J., Aguet F., Weir B.A., Rothberg M.V., Paolella B.R., Lawrence M.S., Akbani R., Lu Y., Tiv H.L., Gokhale P.C., de Weck A., Mansour A.A., Oh C., Shih J., Hadi K., Rosen Y., Bistline J., Venkatesan K., Reddy A., Sonkin D., Liu M., Lehar J., Korn J.M., Porter D.A., Jones M.D., Golji J., Caponigro G., Taylor J.E., Dunning C.M., Creech A.L., Warren A.C., McFarland J.M., Zamanighomi M., Kauffmann A., Stransky N., Imielinski M., Maruvka Y.E., Cherniack A.D., Tsherniak A., Vazquez F., Jaffe J.D., Lane A.A., Weinstock D.M., Johannessen C.M., Morrissey M.P., Stegmeier F., Schlegel R., Hahn W.C., Getz G., Mills G.B., Boehm J.S., Golub T.R., Garraway L.A., Sellers W.R.
Next-generation characterization of the Cancer Cell Line Encyclopedia.
Nature 569:503-508(2019)

Cross-references
Cell line collections JCRB; JCRB1020
JCRB; NIHS0277 - Discontinued
Cell line databases/resources CCLE; RERFLCAD1_LUNG
Cell_Model_Passport; SIDM01331
DepMap; ACH-000791
LINCS_LDP; LCL-1657
Biological sample resources BioSample; SAMN03472535
BioSample; SAMN10988297
Chemistry resources PharmacoDB; RERFLCAd1_1301_2019
Gene expression databases ArrayExpress; E-MTAB-2770
GEO; GSM274668
GEO; GSM887532
GEO; GSM888614
Other Wikidata; Q54949759
Polymorphism and mutation databases Cosmic; 946061
Cosmic; 1571719
IARC_TP53; 28282
LiGeA; CCLE_162
Entry history
Entry creation04-Apr-2012
Last entry updated06-Sep-2019
Version number18