Cellosaurus RERF-LC-KJ (CVCL_1654)

Cell line name RERF-LC-KJ
Synonyms RERFLCKJ; Radiation Effects Research Foundation-Lung Cancer-KJ
Accession CVCL_1654
Resource Identification Initiative To cite this cell line use: RERF-LC-KJ (RRID:CVCL_1654)
Comments Part of: Cancer Cell Line Encyclopedia (CCLE) project.
Part of: COSMIC cell lines project.
Doubling time: 56 hours (lot 092499), 53 hours (lot 070599) (JCRB).
Microsatellite instability: Stable (MSS) (Sanger).
Omics: Deep exome analysis.
Omics: Deep RNAseq analysis.
Omics: DNA methylation analysis.
Omics: SNP array analysis.
Omics: Transcriptome analysis.
Misspelling: REAF-LC-KJ2; In Cosmic 1571721.
Disease Lung adenocarcinoma (NCIt: C3512)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Children:
CVCL_4Y17 (RERF-LC-KJ/CMV-Luc)
Sex of cell Male
Age at sampling 78Y
Category Cancer cell line
STR profile Source(s): Cosmic-CLP; JCRB; PubMed=25877200; RCB

Markers:
AmelogeninX,Y
CSF1PO12
D13S31710
D16S53911
D18S5112
D21S1129
D3S135817
D5S81810
D7S82010,11
D8S117912,14
FGA21,26
Penta D10
Penta E11,17
TH017,9
TPOX11
vWA17
Publications

PubMed=21559605; DOI=10.3892/ijo.5.3.501
Teraoka S., Kyoizumi S., Seyama T., Yamakido M., Akiyama M.
Scid mice model for the in-vivo study of human oncotherapy - studies on the growth and metastasis of human lung-cancer.
Int. J. Oncol. 5:501-508(1994)

PubMed=7790314; DOI=10.1111/j.1349-7006.1995.tb03073.x
Teraoka S., Kyoizumi S., Seyama T., Yamakido M., Akiyama M.
A novel SCID mouse model for studying spontaneous metastasis of human lung cancer to human tissue.
Jpn. J. Cancer Res. 86:419-423(1995)

PubMed=15746151; DOI=10.1093/hmg/ddi092
Izumi H., Inoue J., Yokoi S., Hosoda H., Shibata T., Sunamori M., Hirohashi S., Inazawa J., Imoto I.
Frequent silencing of DBC1 is by genetic or epigenetic mechanisms in non-small cell lung cancers.
Hum. Mol. Genet. 14:997-1007(2005)

PubMed=20215515; DOI=10.1158/0008-5472.CAN-09-3458
Rothenberg S.M., Mohapatra G., Rivera M.N., Winokur D., Greninger P., Nitta M., Sadow P.M., Sooriyakumar G., Brannigan B.W., Ulman M.J., Perera R.M., Wang R., Tam A., Ma X.-J., Erlander M., Sgroi D.C., Rocco J.W., Lingen M.W., Cohen E.E.W., Louis D.N., Settleman J., Haber D.A.
A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers.
Cancer Res. 70:2158-2164(2010)

PubMed=22460905; DOI=10.1038/nature11003
Barretina J.G., Caponigro G., Stransky N., Venkatesan K., Margolin A.A., Kim S., Wilson C.J., Lehar J., Kryukov G.V., Sonkin D., Reddy A., Liu M., Murray L., Berger M.F., Monahan J.E., Morais P., Meltzer J., Korejwa A., Jane-Valbuena J., Mapa F.A., Thibault J., Bric-Furlong E., Raman P., Shipway A., Engels I.H., Cheng J., Yu G.K., Yu J., Aspesi P. Jr., de Silva M., Jagtap K., Jones M.D., Wang L., Hatton C., Palescandolo E., Gupta S., Mahan S., Sougnez C., Onofrio R.C., Liefeld T., MacConaill L., Winckler W., Reich M., Li N., Mesirov J.P., Gabriel S.B., Getz G., Ardlie K., Chan V., Myer V.E., Weber B.L., Porter J., Warmuth M., Finan P., Harris J.L., Meyerson M., Golub T.R., Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.
The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.
Nature 483:603-607(2012)

PubMed=25485619; DOI=10.1038/nbt.3080
Klijn C., Durinck S., Stawiski E.W., Haverty P.M., Jiang Z., Liu H., Degenhardt J., Mayba O., Gnad F., Liu J., Pau G., Reeder J., Cao Y., Mukhyala K., Selvaraj S.K., Yu M., Zynda G.J., Brauer M.J., Wu T.D., Gentleman R.C., Manning G., Yauch R.L., Bourgon R., Stokoe D., Modrusan Z., Neve R.M., de Sauvage F.J., Settleman J., Seshagiri S., Zhang Z.
A comprehensive transcriptional portrait of human cancer cell lines.
Nat. Biotechnol. 33:306-312(2015)

PubMed=27397505; DOI=10.1016/j.cell.2016.06.017
Iorio F., Knijnenburg T.A., Vis D.J., Bignell G.R., Menden M.P., Schubert M., Aben N., Goncalves E., Barthorpe S., Lightfoot H., Cokelaer T., Greninger P., van Dyk E., Chang H., de Silva H., Heyn H., Deng X., Egan R.K., Liu Q., Mironenko T., Mitropoulos X., Richardson L., Wang J., Zhang T., Moran S., Sayols S., Soleimani M., Tamborero D., Lopez-Bigas N., Ross-Macdonald P., Esteller M., Gray N.S., Haber D.A., Stratton M.R., Benes C.H., Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.
A landscape of pharmacogenomic interactions in cancer.
Cell 166:740-754(2016)

Cross-references
Cell line collections JCRB; JCRB0137
JCRB; NIHS0210 - Discontinued
RCB; RCB1313
Cell line databases/resources CCLE; RERFLCKJ_LUNG
CGH-DB; 208-1
Cosmic-CLP; 1298537
GDSC; 1298537
LINCS_LDP; LCL-1658
Ontologies CLO; CLO_0050047
EFO; EFO_0002851
Biological sample resources BioSample; SAMN03470804
BioSample; SAMN03472623
Gene expression databases ArrayExpress; E-MTAB-2706
GEO; GSM274674
GEO; GSM784282
GEO; GSM827375
GEO; GSM887535
GEO; GSM888617
GEO; GSM1670372
Polymorphism and mutation databases Cosmic; 946063
Cosmic; 1154603
Cosmic; 1571721