Cellosaurus RPMI-7951 (CVCL_1666)

Cell line name RPMI-7951
Synonyms RPMI 7951; RPMI7951; Roswell Park Memorial Institute 7951
Accession CVCL_1666
Resource Identification Initiative To cite this cell line use: RPMI-7951 (RRID:CVCL_1666)
Comments Part of: BRAF genetic alteration cell panel (ATCC TCP-1032).
Part of: Cancer Cell Line Encyclopedia (CCLE) project.
Part of: ENCODE project common cell types; tier 3.
Part of: PTEN genetic alteration cell panel (ATCC TCP-1030).
Doubling time: 50 hours (PubMed=1161259); ~60 hours (DSMZ).
Microsatellite instability: Stable (MSS) (Sanger).
Sequence variation: Heterozygous for BRAF p.Val600Glu (ATCC).
Omics: Deep exome analysis.
Omics: Deep RNAseq analysis.
Omics: DNA methylation analysis.
Omics: SNP array analysis.
Omics: Transcriptome analysis.
Disease Melanoma (NCIt: C3224)
Derived from metastatic site: Lymph node.
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Female
Category Cancer cell line
STR profile Source(s): ATCC; Cosmic-CLP; DSMZ; PubMed=25877200

Markers:
AmelogeninX
CSF1PO12
D13S31711,12
D16S53911,12 (ATCC; PubMed=25877200)
12 (Cosmic-CLP; DSMZ)
D18S5117,18
D21S1128,31.2
D3S135816,18
D5S81811
D7S82011,12
D8S117912,13
FGA27
Penta D12,13
Penta E7,18
TH019,9.3
TPOX8
vWA17,19
Web pages https://dtp.cancer.gov/discovery_development/nci-60/cell_list.htm
http://genome.ucsc.edu/ENCODE/protocols/cell/human/RPMI7951_Stam_protocol.pdf
Publications

PubMed=1161259; DOI=10.1159/000225003
Gerner R.E., Kitamura H., Moore G.E.
Studies of tumor cell lines derived from patients with malignant melanoma.
Oncology 31:31-43(1975)

PubMed=833871; DOI=10.1093/jnci/58.2.209
Fogh J., Wright W.C., Loveless J.D.
Absence of HeLa cell contamination in 169 cell lines derived from human tumors.
J. Natl. Cancer Inst. 58:209-214(1977)

PubMed=15467732; DOI=10.1038/sj.onc.1208152
Tanami H., Imoto I., Hirasawa A., Yuki Y., Sonoda I., Inoue J., Yasui K., Misawa-Furihata A., Kawakami Y., Inazawa J.
Involvement of overexpressed wild-type BRAF in the growth of malignant melanoma cell lines.
Oncogene 23:8796-8804(2004)

PubMed=22460905; DOI=10.1038/nature11003
Barretina J.G., Caponigro G., Stransky N., Venkatesan K., Margolin A.A., Kim S., Wilson C.J., Lehar J., Kryukov G.V., Sonkin D., Reddy A., Liu M., Murray L., Berger M.F., Monahan J.E., Morais P., Meltzer J., Korejwa A., Jane-Valbuena J., Mapa F.A., Thibault J., Bric-Furlong E., Raman P., Shipway A., Engels I.H., Cheng J., Yu G.K., Yu J., Aspesi P. Jr., de Silva M., Jagtap K., Jones M.D., Wang L., Hatton C., Palescandolo E., Gupta S., Mahan S., Sougnez C., Onofrio R.C., Liefeld T., MacConaill L., Winckler W., Reich M., Li N., Mesirov J.P., Gabriel S.B., Getz G., Ardlie K., Chan V., Myer V.E., Weber B.L., Porter J., Warmuth M., Finan P., Harris J.L., Meyerson M., Golub T.R., Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.
The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.
Nature 483:603-607(2012)

PubMed=25485619; DOI=10.1038/nbt.3080
Klijn C., Durinck S., Stawiski E.W., Haverty P.M., Jiang Z., Liu H., Degenhardt J., Mayba O., Gnad F., Liu J., Pau G., Reeder J., Cao Y., Mukhyala K., Selvaraj S.K., Yu M., Zynda G.J., Brauer M.J., Wu T.D., Gentleman R.C., Manning G., Yauch R.L., Bourgon R., Stokoe D., Modrusan Z., Neve R.M., de Sauvage F.J., Settleman J., Seshagiri S., Zhang Z.
A comprehensive transcriptional portrait of human cancer cell lines.
Nat. Biotechnol. 33:306-312(2015)

PubMed=27397505; DOI=10.1016/j.cell.2016.06.017
Iorio F., Knijnenburg T.A., Vis D.J., Bignell G.R., Menden M.P., Schubert M., Aben N., Goncalves E., Barthorpe S., Lightfoot H., Cokelaer T., Greninger P., van Dyk E., Chang H., de Silva H., Heyn H., Deng X., Egan R.K., Liu Q., Mironenko T., Mitropoulos X., Richardson L., Wang J., Zhang T., Moran S., Sayols S., Soleimani M., Tamborero D., Lopez-Bigas N., Ross-Macdonald P., Esteller M., Gray N.S., Haber D.A., Stratton M.R., Benes C.H., Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.
A landscape of pharmacogenomic interactions in cancer.
Cell 166:740-754(2016)

Cross-references
Cell line collections ATCC; HTB-66
BCRC; 60274
DSMZ; ACC-66
KCLB; 30066 - Discontinued
NCI-DTP; RPMI-7951
Cell line databases/resources CLDB; cl4187
CCLE; RPMI7951_SKIN
CGH-DB; 9320-4
Cosmic-CLP; 910903
GDSC; 910903
LINCS_LDP; LCL-1254
Ontologies BTO; BTO:0003508
CLO; CLO_0008877
EFO; EFO_0005712
Biological sample resources BioSample; SAMN03471611
BioSample; SAMN03473473
ENCODE; ENCBS262AAA
ENCODE; ENCBS457YHI
ENCODE; ENCBS493TPA
Chemistry resources ChEMBL-Cells; CHEMBL3307962
ChEMBL-Targets; CHEMBL612447
Gene expression databases GEO; GSM206540
GEO; GSM274689
GEO; GSM827474
GEO; GSM887547
GEO; GSM888630
GEO; GSM1670388
Polymorphism and mutation databases Cosmic; 687439
Cosmic; 905233
Cosmic; 910903
Cosmic; 933001
Cosmic; 1022287
Cosmic; 1303050
Cosmic; 1507596
Cosmic; 2233666