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Cellosaurus RPMI-8402 (CVCL_1667)

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Cell line name RPMI-8402
Synonyms RPMI 8402; RPMI8402; Roswell Park Memorial Institute 8402; 8402
Accession CVCL_1667
Resource Identification Initiative To cite this cell line use: RPMI-8402 (RRID:CVCL_1667)
Comments Part of: Cancer Cell Line Encyclopedia (CCLE) project.
Part of: COSMIC cell lines project.
Part of: LL-100 blood cancer cell line panel.
Characteristics: Genetically heterogenous.
Doubling time: ~48 hours (DSMZ).
Microsatellite instability: Stable (MSS) (Sanger).
Omics: Array-based CGH.
Omics: Deep exome analysis.
Omics: Deep RNAseq analysis.
Omics: DNA methylation analysis.
Omics: SNP array analysis.
Omics: Transcriptome analysis.
Derived from sampling site: Peripheral blood.
Sequence variations LMO1-TRD gene fusion (PubMed=2501659; PubMed=29496689).
STIL-TAL1 (SIL-TAL1; SIL-SCL) gene fusion (PubMed=2255914; PubMed=29496689).
Homozygous for FBXW7 p.Arg465His (c.1394G>A) (PubMed=22675565; PubMed=26870252; Cosmic-CLP).
Heterozygous for NOTCH1 p.Glu1583_Gln1584insProValGluLeuMetProProGlu (c.4750_4751insCCGTGGAGCTGATGCCGCCGGAGC) (PubMed=15472075).
Heterozygous for PTEN p.Arg159Ser (c.477G>T) (PubMed=22675565; PubMed=26870252; Cosmic-CLP).
Heterozygous for TP53 p.Arg273Cys (c.817C>T) (ClinVar=VCV000043594) (PubMed=22675565; PubMed=26870252; Cosmic-CLP).
Heterozygous for WT1 p.Ser121Ter (c.362C>A) (PubMed=22675565; Cosmic-CLP).
Genome ancestry Source: PubMed=30894373

Origin% genome
African0.88
Native American0
East Asian, North2.78
East Asian, South0
South Asian0
European, North60.56
European, South35.77
Disease Childhood T acute lymphoblastic leukemia (NCIt: C7953)
Precursor T-cell acute lymphoblastic leukemia (ORDO: Orphanet_99861)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Children:
CVCL_2878 (CPT-K5)
Originate from same individual CVCL_WV43 ! RPMI-8432
Sex of cell Female
Age at sampling 16Y
Category Cancer cell line
STR profile Source(s): ATCC; Cosmic-CLP; DSMZ; PubMed=29496689

Markers:
AmelogeninX
CSF1PO11,12
D2S133819,23
D3S135814,16
D5S81812,13
D7S8208,13
D8S117911
D13S31711,12 (ATCC; DSMZ)
12 (Cosmic-CLP; PubMed=29496689)
D16S53910,11
D18S5116,20
D19S43312,13,14
D21S1130
FGA23
TH019,9.3
TPOX8
vWA14,20

Run an STR similarity search on this cell line
Publications

CLPUB00338
Moore G.E., Woods L.K., Minowada J., Mitchen J.R.
Establishment of leukemia cell line with T cell characteristics.
In Vitro 8:434-434(1973)

PubMed=4547172; DOI=10.1093/jnci/53.3.655
Huang C.C., Hou Y., Woods L.K., Moore G.E., Minowada J.
Cytogenetic study of human lymphoid T-cell lines derived from lymphocytic leukemia.
J. Natl. Cancer Inst. 53:655-660(1974)

DOI=10.1007/978-1-4757-1647-4_11
Moore G.E.
Cell lines from humans with hematopoietic malignancies.
(In) Human tumor cells in vitro; Fogh J. (eds.); pp.299-331; Springer; New York (1975)

PubMed=3518877; DOI=10.3109/07357908609038260
Fogh J.
Human tumor lines for cancer research.
Cancer Invest. 4:157-184(1986)

PubMed=3039492; DOI=10.1073/pnas.84.16.5565
Andoh T., Ishii K., Suzuki Y., Ikegami Y., Kusunoki Y., Takemoto Y., Okada K.
Characterization of a mammalian mutant with a camptothecin-resistant DNA topoisomerase I.
Proc. Natl. Acad. Sci. U.S.A. 84:5565-5569(1987)

PubMed=2501659; DOI=10.1128/mcb.9.5.2124
McGuire E.A., Hockett R.D., Pollock K.M., Bartholdi M.F., O'Brien S.J., Korsmeyer S.J.
The t(11;14)(p15;q11) in a T-cell acute lymphoblastic leukemia cell line activates multiple transcripts, including Ttg-1, a gene encoding a potential zinc finger protein.
Mol. Cell. Biol. 9:2124-2132(1989)

PubMed=2255914; DOI=10.1126/science.2255914
Aplan P.D., Lombardi D.P., Ginsberg A.M., Cossman J., Bertness V.L., Kirsch I.R.
Disruption of the human SCL locus by 'illegitimate' V-(D)-J recombinase activity.
Science 250:1426-1429(1990)

PubMed=9933131; DOI=10.1016/S0145-2126(98)00133-7
Burger R., Hansen-Hagge T.E., Drexler H.G., Gramatzki M.
Heterogeneity of T-acute lymphoblastic leukemia (T-ALL) cell lines: suggestion for classification by immunophenotype and T-cell receptor studies.
Leuk. Res. 23:19-27(1999)

DOI=10.1016/B978-0-12-221970-2.50457-5
Drexler H.G.
The leukemia-lymphoma cell line factsbook.
(In) ISBN 9780122219702; pp.1-733; Academic Press; London (2001)

PubMed=15472075; DOI=10.1126/science.1102160
Weng A.P., Ferrando A.A., Lee W., Morris J.P. IV, Silverman L.B., Sanchez-Irizarry C., Blacklow S.C., Look A.T., Aster J.C.
Activating mutations of NOTCH1 in human T cell acute lymphoblastic leukemia.
Science 306:269-271(2004)

PubMed=16408098; DOI=10.1038/sj.leu.2404081
Quentmeier H., MacLeod R.A.F., Zaborski M., Drexler H.G.
JAK2 V617F tyrosine kinase mutation in cell lines derived from myeloproliferative disorders.
Leukemia 20:471-476(2006)

PubMed=17170727; DOI=10.1038/sj.leu.2404486
Sandberg Y., Verhaaf B., van Gastel-Mol E.J., Wolvers-Tettero I.L.M., de Vos J., Macleod R.A.F., Noordzij J.G., Dik W.A., van Dongen J.J.M., Langerak A.W.
Human T-cell lines with well-defined T-cell receptor gene rearrangements as controls for the BIOMED-2 multiplex polymerase chain reaction tubes.
Leukemia 21:230-237(2007)

PubMed=20164919; DOI=10.1038/nature08768
Bignell G.R., Greenman C.D., Davies H., Butler A.P., Edkins S., Andrews J.M., Buck G., Chen L., Beare D., Latimer C., Widaa S., Hinton J., Fahey C., Fu B., Swamy S., Dalgliesh G.L., Teh B.T., Deloukas P., Yang F., Campbell P.J., Futreal P.A., Stratton M.R.
Signatures of mutation and selection in the cancer genome.
Nature 463:893-898(2010)

PubMed=22460905; DOI=10.1038/nature11003
Barretina J.G., Caponigro G., Stransky N., Venkatesan K., Margolin A.A., Kim S., Wilson C.J., Lehar J., Kryukov G.V., Sonkin D., Reddy A., Liu M., Murray L., Berger M.F., Monahan J.E., Morais P., Meltzer J., Korejwa A., Jane-Valbuena J., Mapa F.A., Thibault J., Bric-Furlong E., Raman P., Shipway A., Engels I.H., Cheng J., Yu G.K., Yu J., Aspesi P. Jr., de Silva M., Jagtap K., Jones M.D., Wang L., Hatton C., Palescandolo E., Gupta S., Mahan S., Sougnez C., Onofrio R.C., Liefeld T., MacConaill L.E., Winckler W., Reich M., Li N., Mesirov J.P., Gabriel S.B., Getz G., Ardlie K., Chan V., Myer V.E., Weber B.L., Porter J., Warmuth M., Finan P., Harris J.L., Meyerson M., Golub T.R., Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.
The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.
Nature 483:603-607(2012)

PubMed=26870252; DOI=10.3892/ol.2015.3959
Stoczynska-Fidelus E., Piaskowski S., Pawlowska R., Szybka M., Peciak J., Hulas-Bigoszewska K., Winiecka-Klimek M., Rieske P.
Genetic heterogeneity of RPMI-8402, a T-acute lymphoblastic leukemia cell line.
Oncol. Lett. 11:593-599(2016)

PubMed=27397505; DOI=10.1016/j.cell.2016.06.017
Iorio F., Knijnenburg T.A., Vis D.J., Bignell G.R., Menden M.P., Schubert M., Aben N., Goncalves E., Barthorpe S., Lightfoot H., Cokelaer T., Greninger P., van Dyk E., Chang H., de Silva H., Heyn H., Deng X., Egan R.K., Liu Q., Mironenko T., Mitropoulos X., Richardson L., Wang J., Zhang T., Moran S., Sayols S., Soleimani M., Tamborero D., Lopez-Bigas N., Ross-Macdonald P., Esteller M., Gray N.S., Haber D.A., Stratton M.R., Benes C.H., Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.
A landscape of pharmacogenomic interactions in cancer.
Cell 166:740-754(2016)

PubMed=29496689; DOI=10.21873/cgp.20068
Kjeldsen E., Nielsen C.J.F., Roy A., Tesauro C., Jakobsen A.-K., Stougaard M., Knudsen B.R.
Characterization of camptothecin-induced genomic changes in the camptothecin-resistant T-ALL-derived cell line CPT-K5.
Cancer Genomics Proteomics 15:91-114(2018)

PubMed=30285677; DOI=10.1186/s12885-018-4840-5
Tan K.-T., Ding L.-W., Sun Q.-Y., Lao Z.-T., Chien W., Ren X., Xiao J.-F., Loh X.-Y., Xu L., Lill M., Mayakonda A., Lin D.-C., Yang H., Koeffler H.P.
Profiling the B/T cell receptor repertoire of lymphocyte derived cell lines.
BMC Cancer 18:940-940(2018)

PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747
Dutil J., Chen Z., Monteiro A.N., Teer J.K., Eschrich S.A.
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Cancer Res. 79:1263-1273(2019)

PubMed=31068700; DOI=10.1038/s41586-019-1186-3
Ghandi M., Huang F.W., Jane-Valbuena J., Kryukov G.V., Lo C.C., McDonald E.R. III, Barretina J., Gelfand E.T., Bielski C.M., Li H., Hu K., Andreev-Drakhlin A.Y., Kim J., Hess J.M., Haas B.J., Aguet F., Weir B.A., Rothberg M.V., Paolella B.R., Lawrence M.S., Akbani R., Lu Y., Tiv H.L., Gokhale P.C., de Weck A., Mansour A.A., Oh C., Shih J., Hadi K., Rosen Y., Bistline J., Venkatesan K., Reddy A., Sonkin D., Liu M., Lehar J., Korn J.M., Porter D.A., Jones M.D., Golji J., Caponigro G., Taylor J.E., Dunning C.M., Creech A.L., Warren A.C., McFarland J.M., Zamanighomi M., Kauffmann A., Stransky N., Imielinski M., Maruvka Y.E., Cherniack A.D., Tsherniak A., Vazquez F., Jaffe J.D., Lane A.A., Weinstock D.M., Johannessen C.M., Morrissey M.P., Stegmeier F., Schlegel R., Hahn W.C., Getz G., Mills G.B., Boehm J.S., Golub T.R., Garraway L.A., Sellers W.R.
Next-generation characterization of the Cancer Cell Line Encyclopedia.
Nature 569:503-508(2019)

PubMed=31160637; DOI=10.1038/s41598-019-44491-x
Quentmeier H., Pommerenke C., Dirks W.G., Eberth S., Koeppel M., MacLeod R.A.F., Nagel S., Steube K., Uphoff C.C., Drexler H.G.
The LL-100 panel: 100 cell lines for blood cancer studies.
Sci. Rep. 9:8218-8218(2019)

Cross-references
Cell line collections ATCC; CRL-1994 - Discontinued
DSMZ; ACC-290
NCBI_Iran; C184
Cell line databases/resources CCLE; RPMI8402_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE
Cell_Model_Passport; SIDM00403
Cosmic-CLP; 909702
DepMap; ACH-000636
LINCS_LDP; LCL-1022
Ontologies BTO; BTO:0001880
CLO; CLO_0008874
Biological sample resources BioSample; SAMN03471272
BioSample; SAMN10988543
Chemistry resources ChEMBL-Cells; CHEMBL3307964
ChEMBL-Targets; CHEMBL612517
GDSC; 909702
PharmacoDB; RPMI8402_1328_2019
Gene expression databases ArrayExpress; E-MTAB-783
ArrayExpress; E-MTAB-2770
ArrayExpress; E-MTAB-3610
ArrayExpress; E-MTAB-7721
ArrayExpress; E-MTAB-7722
GEO; GSM887549
GEO; GSM888632
GEO; GSM1670390
Other Wikidata; Q54951273
Polymorphism and mutation databases Cosmic; 801732
Cosmic; 909702
Cosmic; 913427
Cosmic; 932767
Cosmic; 998726
Cosmic; 999753
Cosmic; 1012115
Cosmic; 1037681
Cosmic; 1115587
Cosmic; 1151791
Cosmic; 1175132
Cosmic; 1191706
Cosmic; 1224369
Cosmic; 1281383
Cosmic; 1330501
Cosmic; 1524817
Cosmic; 1641386
Cosmic; 1664527
Cosmic; 1760531
Cosmic; 2458761
Cosmic; 2462860
Cosmic; 2602930
IARC_TP53; 2503
LiGeA; CCLE_140
Entry history
Entry creation04-Apr-2012
Last entry update02-Jul-2020
Version number30