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Cellosaurus RPMI-8866 (CVCL_1668)

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Cell line name RPMI-8866
Synonyms RPMI 8866; RPMI8866; Roswell Park Memorial Institute 8866; R8866; 8866
Accession CVCL_1668
Resource Identification Initiative To cite this cell line use: RPMI-8866 (RRID:CVCL_1668)
Comments Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
Part of: COSMIC cell lines project.
Population: Caucasian.
Microsatellite instability: Stable (MSS) (Sanger).
Omics: Deep exome analysis.
Omics: Deep quantitative proteome analysis.
Omics: DNA methylation analysis.
Omics: SNP array analysis.
Omics: Transcriptome analysis by microarray.
Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
HLA typing Source: PubMed=6967232
Class I
HLA-AA*02,03
HLA-BB*07
Genome ancestry Source: PubMed=30894373

Origin% genome
African0
Native American0.14
East Asian, North0
East Asian, South0
South Asian3.24
European, North67.29
European, South29.33
Disease Chronic myelogenous leukemia, BCR-ABL1 positive (NCIt: C3174)
Chronic myeloid leukemia (ORDO: Orphanet_521)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Female
Age at sampling 51Y
Category Transformed cell line
STR profile Source(s): Cosmic-CLP; ECACC; PubMed=17254797

Markers:
AmelogeninX
CSF1PO11
D3S135815,16
D5S81812
D7S82011,12
D8S117912,14
D13S31710,14
D16S53911
D18S5112,15
D21S1127,29
FGA22,23
TH019.3 (Cosmic-CLP; ECACC)
10 (PubMed=17254797)
TPOX8,11
vWA14,16

Run an STR similarity search on this cell line
Publications

PubMed=4169031; DOI=10.4049/jimmunol.99.5.839
Finegold I., Fahey J.L., Granger H.
Synthesis of immunoglobulins by human cell lines in tissue culture.
J. Immunol. 99:839-848(1967)

DOI=10.1007/978-1-4757-1647-4_11
Moore G.E.
Cell lines from humans with hematopoietic malignancies.
(In) Human tumor cells in vitro; Fogh J. (eds.); pp.299-331; Springer; New York (1975)

PubMed=6967232; DOI=10.1007/BF01538802
Gladstone P., Pious D.A.
Identification of a trans-acting function regulation HLA-DR expression in a DR-negative B cell variant.
Somatic Cell Genet. 6:285-298(1980)

PubMed=17254797; DOI=10.1016/j.biologicals.2006.10.001
Azari S., Ahmadi N., Tehrani M.J., Shokri F.
Profiling and authentication of human cell lines using short tandem repeat (STR) loci: report from the National Cell Bank of Iran.
Biologicals 35:195-202(2007)

PubMed=20164919; DOI=10.1038/nature08768
Bignell G.R., Greenman C.D., Davies H., Butler A.P., Edkins S., Andrews J.M., Buck G., Chen L., Beare D., Latimer C., Widaa S., Hinton J., Fahey C., Fu B.-Y., Swamy S., Dalgliesh G.L., Teh B.T., Deloukas P., Yang F.-T., Campbell P.J., Futreal P.A., Stratton M.R.
Signatures of mutation and selection in the cancer genome.
Nature 463:893-898(2010)

PubMed=27397505; DOI=10.1016/j.cell.2016.06.017
Iorio F., Knijnenburg T.A., Vis D.J., Bignell G.R., Menden M.P., Schubert M., Aben N., Goncalves E., Barthorpe S., Lightfoot H., Cokelaer T., Greninger P., van Dyk E., Chang H., de Silva H., Heyn H., Deng X.-M., Egan R.K., Liu Q.-S., Mironenko T., Mitropoulos X., Richardson L., Wang J.-H., Zhang T.-H., Moran S., Sayols S., Soleimani M., Tamborero D., Lopez-Bigas N., Ross-Macdonald P., Esteller M., Gray N.S., Haber D.A., Stratton M.R., Benes C.H., Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.
A landscape of pharmacogenomic interactions in cancer.
Cell 166:740-754(2016)

PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747
Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Cancer Res. 79:1263-1273(2019)

PubMed=35839778; DOI=10.1016/j.ccell.2022.06.010
Goncalves E., Poulos R.C., Cai Z.-X., Barthorpe S., Manda S.S., Lucas N., Beck A., Bucio-Noble D., Dausmann M., Hall C., Hecker M., Koh J., Lightfoot H., Mahboob S., Mali I., Morris J., Richardson L., Seneviratne A.J., Shepherd R., Sykes E., Thomas F., Valentini S., Williams S.G., Wu Y.-X., Xavier D., MacKenzie K.L., Hains P.G., Tully B., Robinson P.J., Zhong Q., Garnett M.J., Reddel R.R.
Pan-cancer proteomic map of 949 human cell lines.
Cancer Cell 40:835-849.e8(2022)

Cross-references
Cell line collections (Providers) ECACC; 95041316
Cell line databases/resources CLO; CLO_0008875
CLO; CLO_0009858
CLDB; cl4186
Cell_Model_Passport; SIDM00482
Cosmic-CLP; 910544
DepMap; ACH-002302
LINCS_LDP; LCL-1113
Anatomy/cell type resources BTO; BTO:0004206
Chemistry resources ChEMBL-Cells; CHEMBL3308323
ChEMBL-Targets; CHEMBL2366341
GDSC; 910544
PharmacoDB; RPMI8866_1329_2019
PubChem_Cell_line; CVCL_1668
Encyclopedic resources Wikidata; Q54951275
Gene expression databases ArrayExpress; E-MTAB-783
ArrayExpress; E-MTAB-3610
GEO; GSM1670391
Polymorphism and mutation databases Cosmic; 910544
IARC_TP53; 21292
Proteomic databases PRIDE; PXD030304
Sequence databases EGA; EGAS00001000978
Entry history
Entry creation04-Apr-2012
Last entry update05-Oct-2023
Version number34