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Cellosaurus RPMI-8866 (CVCL_1668)

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Cell line name RPMI-8866
Synonyms RPMI 8866; RPMI8866; Roswell Park Memorial Institute 8866; R8866
Accession CVCL_1668
Resource Identification Initiative To cite this cell line use: RPMI-8866 (RRID:CVCL_1668)
Comments Part of: Cancer Cell Line Encyclopedia (CCLE) project.
Part of: COSMIC cell lines project.
Microsatellite instability: Stable (MSS) (Sanger).
Omics: Deep exome analysis.
Omics: DNA methylation analysis.
Omics: SNP array analysis.
Omics: Transcriptome analysis.
Derived from sampling site: Peripheral blood.
Genome ancestry Source: PubMed=30894373

Origin% genome
Native American0.14
East Asian, North0
East Asian, South0
South Asian3.24
European, North67.29
European, South29.33
Disease Chronic myelogenous leukemia, BCR-ABL1 positive (NCIt: C3174)
Chronic myeloid leukemia (ORDO: Orphanet_521)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Female
Age at sampling 51Y
Category Transformed cell line
STR profile Source(s): Cosmic-CLP; ECACC; PubMed=17254797

TH019.3 (Cosmic-CLP; ECACC)
10 (PubMed=17254797)

Run an STR similarity search on this cell line

Finegold I., Fahey J.L., Granger H.
Synthesis of immunoglobulins by human cell lines in tissue culture.
J. Immunol. 99:839-848(1967)

Moore G.E.
Cell lines from humans with hematopoietic malignancies.
(In) Human tumor cells in vitro; Fogh J. (eds.); pp.299-331; Springer; New York (1975)

PubMed=17254797; DOI=10.1016/j.biologicals.2006.10.001
Azari S., Ahmadi N., Tehrani M.J., Shokri F.
Profiling and authentication of human cell lines using short tandem repeat (STR) loci: report from the National Cell Bank of Iran.
Biologicals 35:195-202(2007)

PubMed=20164919; DOI=10.1038/nature08768
Bignell G.R., Greenman C.D., Davies H., Butler A.P., Edkins S., Andrews J.M., Buck G., Chen L., Beare D., Latimer C., Widaa S., Hinton J., Fahey C., Fu B., Swamy S., Dalgliesh G.L., Teh B.T., Deloukas P., Yang F., Campbell P.J., Futreal P.A., Stratton M.R.
Signatures of mutation and selection in the cancer genome.
Nature 463:893-898(2010)

PubMed=27397505; DOI=10.1016/j.cell.2016.06.017
Iorio F., Knijnenburg T.A., Vis D.J., Bignell G.R., Menden M.P., Schubert M., Aben N., Goncalves E., Barthorpe S., Lightfoot H., Cokelaer T., Greninger P., van Dyk E., Chang H., de Silva H., Heyn H., Deng X., Egan R.K., Liu Q., Mironenko T., Mitropoulos X., Richardson L., Wang J., Zhang T., Moran S., Sayols S., Soleimani M., Tamborero D., Lopez-Bigas N., Ross-Macdonald P., Esteller M., Gray N.S., Haber D.A., Stratton M.R., Benes C.H., Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.
A landscape of pharmacogenomic interactions in cancer.
Cell 166:740-754(2016)

PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747
Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Cancer Res. 79:1263-1273(2019)

Cell line collections ECACC; 95041316
Cell line databases/resources CLDB; cl4186
Cell_Model_Passport; SIDM00482
Cosmic-CLP; 910544
DepMap; ACH-002302
Ontologies BTO; BTO:0004206
CLO; CLO_0008875
Chemistry resources ChEMBL-Cells; CHEMBL3308323
ChEMBL-Targets; CHEMBL2366341
GDSC; 910544
PharmacoDB; RPMI8866_1329_2019
Gene expression databases ArrayExpress; E-MTAB-783
ArrayExpress; E-MTAB-3610
GEO; GSM1670391
Other Wikidata; Q54951275
Polymorphism and mutation databases Cosmic; 910544
IARC_TP53; 21292
Entry history
Entry creation04-Apr-2012
Last entry update23-Sep-2021
Version number27