Cellosaurus RT-112 (CVCL_1670)

Cell line name RT-112
Synonyms RT 112; RT112
Accession CVCL_1670
Resource Identification Initiative To cite this cell line use: RT-112 (RRID:CVCL_1670)
Comments Part of: Cancer Cell Line Encyclopedia (CCLE) project.
Part of: UBC-40 urothelial bladder cancer cell line index.
Doubling time: 24 hours (PubMed=3708594); 25 hours (PubMed=25984343); ~35 hours (DSMZ).
Microsatellite instability: Stable (MSS) (Sanger).
Omics: CNV analysis.
Omics: Deep exome analysis.
Omics: Deep RNAseq analysis.
Omics: DNA methylation analysis.
Omics: shRNA library screening.
Omics: SNP array analysis.
Omics: Transcriptome analysis.
Disease Bladder carcinoma (NCIt: C4912)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Children: CVCL_2714 (RT112/84); CVCL_6215 (RT112/D21)
Sex of cell Female
Category Cancer cell line
STR profile Source(s): CLS; Cosmic-CLP; DSMZ; PubMed=11416159; PubMed=25877200

Markers:
AmelogeninX
CSF1PO10,11 (CLS; Cosmic-CLP; DSMZ)
10 (PubMed=25877200)
D13S31713,14
D16S53911,13
D18S5115 (CLS)
15,17 (PubMed=25877200)
D21S1127,30
D3S135815
D5S81810,13
D7S82011,12
D8S117913,15
FGA23 (CLS)
23,25 (PubMed=25877200)
Penta D10,11 (CLS)
10 (PubMed=25877200)
Penta E12,16
TH017
TPOX8,11
vWA14,17
Web pages http://faculty.washington.edu/trawets/archive/Human/bladder/rt112/index.html
Publications

PubMed=864752; DOI=10.1093/jnci/58.6.1743
Marshall C.J., Franks L.M., Carbonell A.W.
Markers of neoplastic transformation in epithelial cell lines derived from human carcinomas.
J. Natl. Cancer Inst. 58:1743-1751(1977)

PubMed=870558; DOI=10.1177/25.4.870558
Benham F.J., Cottell D.C., Franks L.M., Wilson P.D.
Alkaline phosphatase activity in human bladder tumor cell lines.
J. Histochem. Cytochem. 25:266-274(1977)

PubMed=6823318; DOI=10.1038/301429a0
O'Toole C.M., Povey S., Hepburn P.J., Franks L.M.
Identity of some human bladder cancer cell lines.
Nature 301:429-430(1983)

PubMed=3708594
Masters J.R.W., Hepburn P.J., Walker L., Highman W.J., Trejdosiewicz L.K., Povey S., Parkar M., Hill B.T., Riddle P.R., Franks L.M.
Tissue culture model of transitional cell carcinoma: characterization of twenty-two human urothelial cell lines.
Cancer Res. 46:3630-3636(1986)

PubMed=2903891; DOI=10.1080/09553008814552341
Peacock J.H., Cassoni A.M., McMillan T.J., Steel G.G.
Radiosensitive human tumour cell lines may not be recovery deficient.
Int. J. Radiat. Biol. 54:945-953(1988)

PubMed=7490993; DOI=10.1016/S0140-6736(95)92474-4
Gaetje R., Kotzian S., Herrmann G., Baumann R., Starzinski-Powitz A.
Invasiveness of endometriotic cells in vitro.
Lancet 346:1463-1464(1995)

PubMed=8873383; DOI=10.1007/BF00295899
Stadler W.M., Olopade O.I.
The 9p21 region in bladder cancer cell lines: large homozygous deletion inactivate the CDKN2, CDKN2B and MTAP genes.
Urol. Res. 24:239-244(1996)

PubMed=11207054; DOI=10.1054/bjoc.2000.1641
Fujiyama C., Jones A., Fuggle S., Bicknell R., Cranston D., Harris A.L.
Human bladder cancer invasion model using rat bladder in vitro and its use to test mechanisms and therapeutic inhibitors of invasion.
Br. J. Cancer 84:558-564(2001)

PubMed=12127398; DOI=10.1016/S0165-4608(01)00648-3
Strefford J.C., Lillington D.M., Steggall M., Lane T.M., Nouri A.M.E., Young B.D., Oliver R.T.D.
Novel chromosome findings in bladder cancer cell lines detected with multiplex fluorescence in situ hybridization.
Cancer Genet. Cytogenet. 135:139-146(2002)

PubMed=22460905; DOI=10.1038/nature11003
Barretina J.G., Caponigro G., Stransky N., Venkatesan K., Margolin A.A., Kim S., Wilson C.J., Lehar J., Kryukov G.V., Sonkin D., Reddy A., Liu M., Murray L., Berger M.F., Monahan J.E., Morais P., Meltzer J., Korejwa A., Jane-Valbuena J., Mapa F.A., Thibault J., Bric-Furlong E., Raman P., Shipway A., Engels I.H., Cheng J., Yu G.K., Yu J., Aspesi P. Jr., de Silva M., Jagtap K., Jones M.D., Wang L., Hatton C., Palescandolo E., Gupta S., Mahan S., Sougnez C., Onofrio R.C., Liefeld T., MacConaill L., Winckler W., Reich M., Li N., Mesirov J.P., Gabriel S.B., Getz G., Ardlie K., Chan V., Myer V.E., Weber B.L., Porter J., Warmuth M., Finan P., Harris J.L., Meyerson M., Golub T.R., Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.
The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.
Nature 483:603-607(2012)

PubMed=24367658; DOI=10.1371/journal.pone.0084411
Ross R.L., Burns J.E., Taylor C.F., Mellor P., Anderson D.H., Knowles M.A.
Identification of mutations in distinct regions of p85 alpha in urothelial cancer.
PLoS ONE 8:E84411-E84411(2013)

PubMed=24018021; DOI=10.1016/j.eururo.2013.08.052
Allory Y., Beukers W., Sagrera A., Flandez M., Marques M., Marquez M., van der Keur K.A., Dyrskjot L., Lurkin I., Vermeij M., Carrato A., Lloreta J., Lorente J.A., Carrillo-de-Santa-Pau E., Masius R.G., Kogevinas M., Steyerberg E.W., van Tilborg A.A.G., Abas C., Orntoft T.F., Zuiverloon T.C.M., Malats N., Zwarthoff E.C., Real F.X.
Telomerase reverse transcriptase promoter mutations in bladder cancer: high frequency across stages, detection in urine, and lack of association with outcome.
Eur. Urol. 65:360-366(2014)

PubMed=25984343; DOI=10.1038/sdata.2014.35
Cowley G.S., Weir B.A., Vazquez F., Tamayo P., Scott J.A., Rusin S., East-Seletsky A., Ali L.D., Gerath W.F.J., Pantel S.E., Lizotte P.H., Jiang G., Hsiao J., Tsherniak A., Dwinell E., Aoyama S., Okamoto M., Harrington W., Gelfand E., Green T.M., Tomko M.J., Gopal S., Wong T.C., Li H., Howell S., Stransky N., Liefeld T., Jang D., Bistline J., Hill Meyers B., Armstrong S.A., Anderson K.C., Stegmaier K., Reich M., Pellman D., Boehm J.S., Mesirov J.P., Golub T.R., Root D.E., Hahn W.C.
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies.
Sci. Data 1:140035-140035(2014)

PubMed=25485619; DOI=10.1038/nbt.3080
Klijn C., Durinck S., Stawiski E.W., Haverty P.M., Jiang Z., Liu H., Degenhardt J., Mayba O., Gnad F., Liu J., Pau G., Reeder J., Cao Y., Mukhyala K., Selvaraj S.K., Yu M., Zynda G.J., Brauer M.J., Wu T.D., Gentleman R.C., Manning G., Yauch R.L., Bourgon R., Stokoe D., Modrusan Z., Neve R.M., de Sauvage F.J., Settleman J., Seshagiri S., Zhang Z.
A comprehensive transcriptional portrait of human cancer cell lines.
Nat. Biotechnol. 33:306-312(2015)

PubMed=25997541; DOI=10.1186/s12864-015-1450-3
Earl J., Rico D., Carrillo-de-Santa-Pau E., Rodriguez-Santiago B., Mendez-Pertuz M., Auer H., Gomez G., Grossman H.B., Pisano D.G., Schulz W.A., Perez-Jurado L.A., Carrato A., Theodorescu D., Chanock S., Valencia A., Real F.X.
The UBC-40 Urothelial Bladder Cancer cell line index: a genomic resource for functional studies.
BMC Genomics 16:403-403(2015)

PubMed=27397505; DOI=10.1016/j.cell.2016.06.017
Iorio F., Knijnenburg T.A., Vis D.J., Bignell G.R., Menden M.P., Schubert M., Aben N., Goncalves E., Barthorpe S., Lightfoot H., Cokelaer T., Greninger P., van Dyk E., Chang H., de Silva H., Heyn H., Deng X., Egan R.K., Liu Q., Mironenko T., Mitropoulos X., Richardson L., Wang J., Zhang T., Moran S., Sayols S., Soleimani M., Tamborero D., Lopez-Bigas N., Ross-Macdonald P., Esteller M., Gray N.S., Haber D.A., Stratton M.R., Benes C.H., Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.
A landscape of pharmacogenomic interactions in cancer.
Cell 166:740-754(2016)

Cross-references
Cell line collections CLS; 300324/p10280_RT-112
DSMZ; ACC-418
Cell line databases/resources CCLE; RT112_URINARY_TRACT
Cosmic-CLP; 909704
GDSC; 909704
LINCS_LDP; LCL-1716
Ontologies BTO; BTO:0003724
CLO; CLO_0008890
EFO; EFO_0006479
Biological sample resources BioSample; SAMN03473091
BioSample; SAMN03473589
Chemistry resources ChEMBL-Cells; CHEMBL3307307
ChEMBL-Targets; CHEMBL614145
Gene expression databases GEO; GSM887552
GEO; GSM888635
GEO; GSM1374857
GEO; GSM1374858
GEO; GSM1574545
GEO; GSM1574581
GEO; GSM1670393
Polymorphism and mutation databases Cosmic; 715739
Cosmic; 760482
Cosmic; 845559
Cosmic; 867837
Cosmic; 909704
Cosmic; 925820
Cosmic; 928823
Cosmic; 1046682
Cosmic; 1068092
Cosmic; 1285124
Cosmic; 1285984
Cosmic; 1819324
Cosmic; 1938478
Cosmic; 1938697
Cosmic; 2037954
Cosmic; 2050459
Cosmic; 2057454
Cosmic; 2444244