Cellosaurus RVH-421 (CVCL_1672)

Cell line name RVH-421
Synonyms RVH 421; RVH421
Accession CVCL_1672
Resource Identification Initiative To cite this cell line use: RVH-421 (RRID:CVCL_1672)
Comments Part of: Cancer Cell Line Encyclopedia (CCLE) project.
Doubling time: ~50-60 hours (DSMZ).
Microsatellite instability: Stable (MSS) (Sanger).
Omics: Deep exome analysis.
Omics: DNA methylation analysis.
Omics: SNP array analysis.
Omics: Transcriptome analysis.
Disease Melanoma (NCIt: C3224)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Male
Category Cancer cell line
STR profile Source(s): Cosmic-CLP; DSMZ; PubMed=25877200

Markers:
AmelogeninX,Y
CSF1PO10,12
D13S31711,13 (Cosmic-CLP; DSMZ)
11 (PubMed=25877200)
D16S5399,11
D18S5115,16
D19S43314,16
D21S1130
D2S133819,25
D3S135816,17
D5S81810,14
D7S8207,10
D8S117913,14
FGA21,22
Penta D9,13
Penta E11
TH019.3
TPOX8
vWA14,17
Publications

PubMed=6838761
McCormick D., Wallace I., Kirk J., Dinsmore S., Allen I.
The establishment and characterization of a cell line and mouse xenografts from a human malignant melanoma.
Br. J. Exp. Pathol. 64:103-115(1983)

PubMed=22460905; DOI=10.1038/nature11003
Barretina J.G., Caponigro G., Stransky N., Venkatesan K., Margolin A.A., Kim S., Wilson C.J., Lehar J., Kryukov G.V., Sonkin D., Reddy A., Liu M., Murray L., Berger M.F., Monahan J.E., Morais P., Meltzer J., Korejwa A., Jane-Valbuena J., Mapa F.A., Thibault J., Bric-Furlong E., Raman P., Shipway A., Engels I.H., Cheng J., Yu G.K., Yu J., Aspesi P. Jr., de Silva M., Jagtap K., Jones M.D., Wang L., Hatton C., Palescandolo E., Gupta S., Mahan S., Sougnez C., Onofrio R.C., Liefeld T., MacConaill L., Winckler W., Reich M., Li N., Mesirov J.P., Gabriel S.B., Getz G., Ardlie K., Chan V., Myer V.E., Weber B.L., Porter J., Warmuth M., Finan P., Harris J.L., Meyerson M., Golub T.R., Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.
The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.
Nature 483:603-607(2012)

PubMed=27397505; DOI=10.1016/j.cell.2016.06.017
Iorio F., Knijnenburg T.A., Vis D.J., Bignell G.R., Menden M.P., Schubert M., Aben N., Goncalves E., Barthorpe S., Lightfoot H., Cokelaer T., Greninger P., van Dyk E., Chang H., de Silva H., Heyn H., Deng X., Egan R.K., Liu Q., Mironenko T., Mitropoulos X., Richardson L., Wang J., Zhang T., Moran S., Sayols S., Soleimani M., Tamborero D., Lopez-Bigas N., Ross-Macdonald P., Esteller M., Gray N.S., Haber D.A., Stratton M.R., Benes C.H., Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.
A landscape of pharmacogenomic interactions in cancer.
Cell 166:740-754(2016)

Cross-references
Cell line collections DSMZ; ACC-127
Cell line databases/resources CLDB; cl4207
CCLE; RVH421_SKIN
Cosmic-CLP; 909706
GDSC; 909706
LINCS_HMS; 50475
LINCS_LDP; LCL-1255
Ontologies CLO; CLO_0008902
Biological sample resources BioSample; SAMN03472885
BioSample; SAMN03473412
Chemistry resources ChEMBL-Cells; CHEMBL3308126
ChEMBL-Targets; CHEMBL1075567
Gene expression databases GEO; GSM887554
GEO; GSM888637
GEO; GSM1670395
Polymorphism and mutation databases Cosmic; 909706